Transporteur membranaire/Canal ionique
Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont des composés qui bloquent la fonction des protéines responsables du transport des ions, des nutriments et d'autres molécules à travers les membranes cellulaires. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie cellulaire, la transduction des signaux et la neurotransmission. Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont également importants pour développer des traitements contre des troubles tels que l'épilepsie, les maladies cardiovasculaires et les syndromes métaboliques. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de haute qualité des transporteurs membranaires et des canaux ioniques pour soutenir vos recherches en physiologie, neurosciences et pharmacologie.
Sous-catégories appartenant à la catégorie "Transporteur membranaire/Canal ionique"
- ABC(3 produits)
- ATPase(93 produits)
- Récepteur de l'adiponectine(5 produits)
- CFTR(64 produits)
- Récepteur CGRP(51 produits)
- Canal calcique(493 produits)
- Canal chlorure(49 produits)
- Récepteur GABA(336 produits)
- Transporteur de monoamine(23 produits)
- Transporteur de monocarboxylate(17 produits)
- NKCC(2 produits)
- NPC1L1(3 produits)
- Cotransporteur Na-K-Cl(8 produits)
- OAT(27 produits)
- OCT(7 produits)
- P-gp(53 produits)
- Canal potassique(276 produits)
- Pompe à protons(39 produits)
- SGLT(30 produits)
- Canal sodique(202 produits)
- Canal TRP/TRPV(92 produits)
Affichez 13 plus de sous-catégories
2272 produits trouvés pour "Transporteur membranaire/Canal ionique"
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AMPA-IN-1
CAS :<p>AMPA-IN-1: Potent AMPA receptor inhibitor; key in regulating brain excitatory transmission and plasticity.</p>Formule :C23H12F2N4O2Couleur et forme :SolidMasse moléculaire :414.36KCa1.1 channel activator-1
<p>A selective vascular KCa1.1 channel stimulator with CaV1.2 blocking ability and mild myorelaxant effects.</p>Formule :C25H16O10Couleur et forme :SolidMasse moléculaire :476.39L-822179
CAS :<p>L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.</p>Formule :C17H14N8O2Degré de pureté :98.5% - 99.61%Couleur et forme :SolidMasse moléculaire :362.35GABAA receptor agent 2 TFA
CAS :<p>Potent GABAA antagonist; IC50: 24 nM (α1β2γ2), Ki: 28 nM (rat); inactive on human GABA transporters.</p>Formule :C22H22F3N3O3Couleur et forme :SolidMasse moléculaire :433.426-Iodoamiloride
CAS :<p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>Formule :C6H8IN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.08A 425619
CAS :<p>A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonist</p>Formule :C18H14F3N3ODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :345.32APS3
CAS :<p>APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].</p>Formule :C18H7Cl2F6N5O5S2Couleur et forme :SolidMasse moléculaire :622.31Bupivacaine hydrochloride monohydrate
CAS :<p>Bupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor that inhibits SCN5A channels and is commonly used in the study of chronic pain.</p>Formule :C18H31ClN2O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :342.9Funapide
CAS :<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Formule :C22H14F3NO5Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :429.35Maralixibat Chloride
CAS :<p>Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.</p>Formule :C40H56ClN3O4SDegré de pureté :99.19% - 99.65%Couleur et forme :SolidMasse moléculaire :710.41C 101248
CAS :<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Formule :C15H12N6ODegré de pureté :99.14% - 99.31%Couleur et forme :SolidMasse moléculaire :292.3VGSCs-IN-1
CAS :<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Formule :C12H12F3N3OSDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :303.3CE-224535
CAS :<p>CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.</p>Formule :C22H29ClN4O6Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :480.94LE135
CAS :<p>LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).</p>Formule :C29H30N2O2Degré de pureté :97.94%Couleur et forme :SolidMasse moléculaire :438.56AMG-0347
CAS :<p>AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.</p>Formule :C24H26F3N3O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :445.48Kv3 modulator 1
CAS :<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Formule :C20H20N4O4Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :380.4CFTR corrector 4
CAS :<p>Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.</p>Formule :C29H27F2NO7Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :539.52MCT1-IN-3
CAS :<p>MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor.</p>Formule :C22H19N3O4Degré de pureté :99.35%Couleur et forme :SoildMasse moléculaire :389.4Soraprazan
CAS :<p>BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that can be used to synthesize antibody-coupled active molecules.</p>Formule :C21H25N3O3Degré de pureté :97.69% - 99.84%Couleur et forme :SolidMasse moléculaire :367.44L-DABA hydrobromide
CAS :<p>L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) , GABA transaminase inhibitor with antitumor and anticonvulsant activity.</p>Formule :C4H11BrN2O2Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :199.05Aneratrigine hydrochloride
CAS :<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Formule :C19H21Cl2F2N5O2S2Degré de pureté :98.37% - 99.16%Couleur et forme :SolidMasse moléculaire :524.43EMD57033
CAS :<p>EMD57033 activates cardiac troponin C, enhances Ca2+ sensitivity to boost heart contraction.</p>Formule :C22H23N3O4SDegré de pureté :99.72% - >99.99%Couleur et forme :SolidMasse moléculaire :425.5Reldesemtiv
CAS :<p>Reldesemtiv (CK-2127107) boosts exercise capacity, targeting fast muscle troponin, EC50 3.4 μM.</p>Formule :C19H18F2N6ODegré de pureté :97.27%Couleur et forme :SolidMasse moléculaire :384.38AMG2850
CAS :<p>AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).</p>Formule :C19H17F6N3ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :417.35(RS)-AMPA hydrobromide
CAS :<p>AMPAR agonist</p>Formule :C7H11BrN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.08Detajmium
CAS :<p>Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.</p>Formule :C27H42N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.64Butein tetramethyl ether
CAS :<p>Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein / ATP-binding cassette sub-family G member 2 (BCRP/ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.</p>Formule :C19H20O5Couleur et forme :SolidMasse moléculaire :328.359Leualacin
CAS :<p>Leualacin is a novel calcium blocker from Hapsidospora irregularis.</p>Formule :C31H47N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.72Tamitinol
CAS :<p>Tamitinol is a neurotropic drug. It has been found to help symptoms of obsessive rumination in conjunction with maprotiline.</p>Formule :C12H20N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :240.37EF1502 free base
CAS :<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Formule :C22H26N2O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.58(R)-KMH-233
CAS :<p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>Formule :C32H25N7O5Masse moléculaire :587.58Caged MK801
CAS :<p>Caged MK801 (cMK801) is a selective, noncompetitive, and irreversible blocker of the NMDA receptor open channel. The NVOC cage is compatible in neuropharmacology and does not alter the intrinsic activity of the molecule.</p>Formule :C26H24N2O6Couleur et forme :SolidMasse moléculaire :460.48CFTR corrector 17
CAS :<p>CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.</p>Formule :C18H15FN2O2Couleur et forme :SolidMasse moléculaire :310.32BGT1-IN-1
CAS :<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Formule :C6H9NO2Couleur et forme :SolidMasse moléculaire :127.14S9-A13
CAS :<p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>Formule :C20H18ClN3O2SCouleur et forme :SolidMasse moléculaire :399.89H052
CAS :<p>H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.</p>Formule :C21H15ClFN3O4SCouleur et forme :SolidMasse moléculaire :459.88EU 1622-240
CAS :<p>EU 1622-240 is an allosteric modulator with a preference for GluN2B, GluN2C, and GluN2D, exhibiting EC50 values of 0.57, 0.82, and 1.1 μM, respectively. It possesses favorable physicochemical properties, along with in vitro stability and permeability.</p>Formule :C20H14BrF2N3O2SCouleur et forme :SolidMasse moléculaire :478.31Cyproflanilide
CAS :<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Formule :C28H17BrF12N2O2Couleur et forme :SolidMasse moléculaire :721.33Vormatrigine
CAS :<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Formule :C16H12F6N4O2Couleur et forme :SolidMasse moléculaire :406.28Kv7.2/Kv7.3 agonist 1
CAS :<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Formule :C14H14FN3O2Couleur et forme :SolidMasse moléculaire :275.28NMD670
CAS :<p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>Formule :C12H10BrNO4Couleur et forme :SolidMasse moléculaire :312.12CRM1-IN-3
CAS :<p>CRM1-IN-3 (B28), a noncovalent inhibitor of CRM1, is utilized in the research of protein localization and tumor studies [1].</p>Formule :C26H26ClN3O3Couleur et forme :SolidMasse moléculaire :463.96Sp-8-Br-cGMPS
CAS :<p>Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.</p>Formule :C10H11BrN5O6PSCouleur et forme :SolidMasse moléculaire :440.17TRPV1 antagonist 10
CAS :<p>TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.</p>Formule :C16H14N2O5Couleur et forme :SolidMasse moléculaire :314.293TRPA1 Antagonist 1
CAS :<p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>Formule :C24H20F6N5Na2O7PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :713.45pan-HCN-IN-1
CAS :<p>Pan-HCN-IN-1 (Compound J&J12e) is an inhibitor of the hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with an IC50 of 58 nM. Pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rat brain slices [1].</p>Formule :C23H37N3O2Couleur et forme :SolidMasse moléculaire :387.56Sesamodil
CAS :<p>Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.</p>Formule :C29H32N2O6SDegré de pureté :98.58% - 99.01%Couleur et forme :SolidMasse moléculaire :536.64ABCA1 inducer 2
CAS :<p>ABCA1 inducer 2 is a non-lipogenic inducer of ABCA1. It increases the expression of ABCA1 by targeting the LXR pathway, thereby reducing lipid accumulation induced by ox-LDL and inhibiting foam cell formation. ABCA1 inducer 2 holds potential as an anti-atherosclerotic agent.</p>Formule :C16H11BrN2OCouleur et forme :SolidMasse moléculaire :327.175MRS4738
<p>MRS4738 is a potent antagonist with high affinity for the P2Y14R receptor. It demonstrates in vivo anti-hyperallodynic and antiasthmatic activity [1].</p>Formule :C30H24F3NO2Couleur et forme :SolidMasse moléculaire :487.51GABAA receptor agonist 1
<p>Compound 3e, a potent GABAA agonist, targets GABA sites and has potential anti-depressive effects in mice.</p>Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.45
