Transporteur membranaire/Canal ionique
Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont des composés qui bloquent la fonction des protéines responsables du transport des ions, des nutriments et d'autres molécules à travers les membranes cellulaires. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie cellulaire, la transduction des signaux et la neurotransmission. Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont également importants pour développer des traitements contre des troubles tels que l'épilepsie, les maladies cardiovasculaires et les syndromes métaboliques. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de haute qualité des transporteurs membranaires et des canaux ioniques pour soutenir vos recherches en physiologie, neurosciences et pharmacologie.
Sous-catégories appartenant à la catégorie "Transporteur membranaire/Canal ionique"
- ABC(3 produits)
- ATPase(93 produits)
- Récepteur de l'adiponectine(5 produits)
- CFTR(64 produits)
- Récepteur CGRP(51 produits)
- Canal calcique(493 produits)
- Canal chlorure(49 produits)
- Récepteur GABA(336 produits)
- Transporteur de monoamine(23 produits)
- Transporteur de monocarboxylate(17 produits)
- NKCC(2 produits)
- NPC1L1(3 produits)
- Cotransporteur Na-K-Cl(8 produits)
- OAT(27 produits)
- OCT(7 produits)
- P-gp(53 produits)
- Canal potassique(276 produits)
- Pompe à protons(39 produits)
- SGLT(30 produits)
- Canal sodique(202 produits)
- Canal TRP/TRPV(92 produits)
Affichez 13 plus de sous-catégories
2270 produits trouvés pour "Transporteur membranaire/Canal ionique"
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D-GsMTx4
<p>TRPC1/6 & Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>Couleur et forme :SoildLY393615
<p>LY393615 (NCC1048) is a novel blocker of both neuronal Ca²⁺ (calcium) and Na⁺ (sodium) channels, exhibiting half-maximal inhibitory concentrations (IC₅₀) of 1.9</p>Degré de pureté :98%Couleur et forme :Odour SolidCrofelemer
CAS :<p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>Couleur et forme :SolidTRPA1-IN-1
CAS :<p>TRPA1-IN-1 is a potent, selective antagonist of the TRPA1 channel, demonstrating significant oral bioavailability as a small molecule.</p>Formule :C19H17ClN6O3Couleur et forme :SolidMasse moléculaire :412.83P2X3 antagonist 39
<p>P2X3 antagonist 39 (compound 26a) is a selective P2X3 receptor antagonist with an IC50 of 54.9 nM. It is utilized in the study of neuropathic pain models.</p>Couleur et forme :Odour SolidDendrotoxin K
CAS :<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Formule :C294H462N84O75S6Couleur et forme :SolidMasse moléculaire :6559.66Conantokin-R
CAS :<p>Conantokin-R is an NMDA receptor peptide antagonist (IC50=93 nM); Conantokin-R exhibits anticonvulsant activity; Conantokin-R binds Zn2+ and Mg2+ (Kds 0.15 μM</p>Formule :C127H201N35O49S3Couleur et forme :SolidMasse moléculaire :3098.38Isotachysterol 3
CAS :<p>Isotachysterol 3 boosts calcium transport in gut and bone mobilization in kidneyless rats.</p>Formule :C27H44OCouleur et forme :SolidMasse moléculaire :384.64RN-1665
CAS :<p>RN-1665 is a potent and selective TRPV4 receptor antagonist.</p>Formule :C20H24F5N3O3S2Degré de pureté :>99.99%Couleur et forme :SoildMasse moléculaire :513.54NMDA receptor antagonist 2
CAS :<p>Potent, oral NR2B-selective NMDA receptor antagonist; IC50 of 1.0 nM, Ki of 0.88 nM; used for neuropathic pain and Parkinson's research.</p>Formule :C20H21N7OCouleur et forme :SolidMasse moléculaire :375.436FGIN-1-43
CAS :<p>FGIN-1-43 is a potent and specific ligand for the mitochondrial DBI receptor.</p>Formule :C28H36Cl2N2ODegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :487.5EVT-401
<p>EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1].</p>Formule :C22H20F4N2O3Couleur et forme :SolidMasse moléculaire :436.4Eltanexor
CAS :<p>Eltanexor, an oral XPO1 inhibitor, induces apoptosis in leukemia cells; EC50=60.9 nM.</p>Formule :C17H10F6N6ODegré de pureté :99.6% - ≥98%Couleur et forme :SolidMasse moléculaire :428.29Conantokin G
CAS :<p>GluN2B-specific NMDA receptor blocker; IC50=480 nM in neurons, ~300 nM in oocytes; neuroprotective.</p>Formule :C88H138N26O44Degré de pureté :98%Couleur et forme :White Lyophilised SolidMasse moléculaire :2264.21Chrodrimanin B
CAS :<p>Chrodrimanin B is a useful organic compound for research related to life sciences. The catalog number is T126052 and the CAS number is 132196-54-4.</p>Formule :C27H32O8Couleur et forme :SolidMasse moléculaire :484.545Elgodipine
CAS :<p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>Formule :C29H33FN2O6Degré de pureté :98.95% - 99.50%Couleur et forme :SolidMasse moléculaire :524.58LU-32-176B
CAS :<p>LU32-176B is a bioactive chemical.</p>Formule :C23H24F2N2O2Couleur et forme :SolidMasse moléculaire :398.45Flufiprole
CAS :<p>Flufiprole is used as a phenylpyrazole pesticide. It has enantioselective metabolism in human and rat liver microsomes.</p>Formule :C16H10Cl2F6N4OSCouleur et forme :SolidMasse moléculaire :491.24(R)-IDHP
CAS :<p>(R)-IDHP, a salvia derivative, relaxes blood vessels by blocking calcium channels, aiding cardiovascular research.</p>Formule :C12H16O5Couleur et forme :SolidMasse moléculaire :240.25Chlorotoxin(linear)
<p>Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.</p>Formule :C158H256N52O48S11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4004.764'-hydroxy Trazodone
CAS :<p>4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is</p>Formule :C19H22ClN5O2Couleur et forme :SolidMasse moléculaire :387.87AQP4 (205-215) TFA
<p>AQP4 (205-215) TFA is a fragment of the water channel protein-4 (AQP4). AQP4 acts as an autoimmune antigen in neuromyelitis optica, upregulating and presenting in B cells upon binding with CD40. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>Couleur et forme :Odour SolidTRPA1 Antagonist 3
CAS :<p>TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.</p>Formule :C11H8ClN3Couleur et forme :SolidMasse moléculaire :217.66Huwentoxin I
CAS :<p>Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.</p>Formule :C161H246N48O44S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3750.36MS7710
<p>MS7710 is a brain-penetrant inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. It reduces Ih current by inhibiting HCN channels, thereby decreasing the activity of dopamine neurons in the ventral tegmental area (VTA). MS7710 effectively improves social interaction deficits and reward-related cognitive flexibility in mouse models of chronic social defeat stress (CSDS) and shows promise for depression research.</p>Couleur et forme :Odour Solidω-Conotoxin GVIA
CAS :<p>Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.</p>Formule :C120H182N38O43S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3037P-gp/BCRP-IN-2
<p>P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP</p>Formule :C32H35N3O6Couleur et forme :SolidMasse moléculaire :557.64Myomodulin
CAS :<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Formule :C36H67N11O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :846.12ML353
<p>ML353 activates TREK-1/2, binds mGlu5 SAM (Ki=18.2 nM), surpasses 5mpep, may address SAM activity/blocking.</p>Formule :C19H15FN2ODegré de pureté :99.98% - 99.98%Couleur et forme :SoildMasse moléculaire :306.33Oleoyl-D-lysine
CAS :<p>Oleoyl-D-lysine: lipid-based GlyT2 inhibitor, eases neuropathic pain in mice, safe, non-sedative, no respiratory depression.</p>Formule :C24H46N2O3Couleur et forme :SolidMasse moléculaire :410.63Carbonic anhydrase inhibitor 32
<p>Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.</p>Formule :C17H16N6O3SCouleur et forme :SolidMasse moléculaire :384.41GYKI-47261 dihydrochloride
CAS :<p>GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.</p>Formule :C18H17Cl3N4Degré de pureté :98.32% - 99.14%Couleur et forme :SolidMasse moléculaire :395.71Chlorocresol
CAS :<p>Chlorocresol (4-Chloro-3-methylphenol) is an antiseptic medication.</p>Formule :C7H7ClOCouleur et forme :SolidMasse moléculaire :142.58L-R4W2
CAS :<p>Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.</p>Formule :C46H71N21O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1014.2Cavα2δ-IN-1
CAS :<p>Cavα2δ-IN-1 demonstrates exceptional specificity for voltage-gated calcium channels Cavα2δ-1 (with a Ki value of 6 nM), in comparison to Cavα2δ-2 (with a Ki</p>Formule :C18H27N5OCouleur et forme :SolidMasse moléculaire :329.448AmmTX3
<p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>Formule :C158H262N50O48S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.47(±)17-HETE
CAS :<p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.473Ruzinurad
CAS :<p>Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.</p>Formule :C14H12BrNO2SCouleur et forme :SolidMasse moléculaire :338.22AChE/Aβ-IN-2
<p>AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM.</p>Formule :C20H25ClN4Couleur et forme :SolidMasse moléculaire :356.89(±)16-HETE
CAS :<p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.473ω-Conotoxin MVIIC
CAS :<p>Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.</p>Formule :C106H178N40O32S7Degré de pureté :98%Couleur et forme :White Lyophilised SolidMasse moléculaire :2749NF110
CAS :<p>P2X3 antagonist</p>Formule :C41H32N6NaO17S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1031.97AZ1422
<p>AZ1422 is a selective MCT4 inhibitor, applicable for cancer research.</p>Formule :C31H40N2O6Masse moléculaire :536.28864Venturicidin A
CAS :<p>Venturicidin A is a macrolide antibiotic.</p>Formule :C41H67NO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :749.97BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formule :C22H23F7N2O3Couleur et forme :SolidMasse moléculaire :496.418Phe-Met-Arg-Phe amide trifluoroacetate
CAS :<p>Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.</p>Formule :C33H44F6N8O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :826.81Ins(1,4,5)-P3 hexapotassium salt
CAS :<p>D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.</p>Formule :C6H9K6O15P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :648.64PCO 400
CAS :<p>PCO 400 is an analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener.</p>Formule :C17H17NO4Degré de pureté :97.29% - 97.8%Couleur et forme :SolidMasse moléculaire :299.32Ryanodine
CAS :<p>Ryanodine: a diterpenoid modulating Ca2+ release via ryanodine receptors; concentration-dependent effects; found in Ryania speciosa; toxic.</p>Formule :C25H35NO9Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :493.553Cyclocreatine
CAS :<p>Cyclocreatine, a creatine analogue and substrate for creatine kinase, inhibits creatine metabolism and prostate cancer cell proliferation.</p>Formule :C5H9N3O2Degré de pureté :99.864%Couleur et forme :SolidMasse moléculaire :143.14
