Aminopeptidase
Les aminopeptidases sont un groupe d'enzymes qui catalysent la coupure des acides aminés à partir de l'extrémité N-terminale des peptides et des protéines, jouant un rôle crucial dans la maturation et la dégradation des protéines. Ces enzymes sont impliquées dans divers processus physiologiques, notamment le traitement des antigènes, la régulation des hormones peptidiques et l'homéostasie cellulaire. Les inhibiteurs des aminopeptidases présentent un intérêt pour le traitement de maladies telles que le cancer, l'inflammation et les maladies infectieuses. Chez CymitQuimica, nous proposons une variété d'inhibiteurs d'aminopeptidases pour soutenir vos recherches en protéomique, développement de médicaments et traitement des maladies.
76 produits trouvés pour "Aminopeptidase"
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Bufexamac
CAS :Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.Formule :C12H17NO3Degré de pureté :99.73%Couleur et forme :Acicular CrystalMasse moléculaire :223.27ERAP1-IN-1
CAS :ERAP1-IN-1 inhibits and allosterically activates ERAP1, affecting fluorogenic, chromogenic, and nonamer peptide substrates.Formule :C20H21F3N2O5SDegré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :458.45Ref: TM-T11221
1mg87,00€5mg170,00€10mg273,00€25mg449,00€50mg615,00€100mg843,00€200mg1.130,00€1mL*10mM (DMSO)170,00€BDM_92499
BDM_92499 is a nanomolar, selective IRAP inhibitor with an IC50 of 3.4 nM. It also inhibits ERAP1 and ERAP2, with IC50 values of 0.46 μM and 4.2 μM, respectively.Couleur et forme :Odour SolidAmastatin hydrochloride
CAS :Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.Formule :C21H39ClN4O8Couleur et forme :White To Off-White PowderMasse moléculaire :511.01Aclimostat
CAS :Aclimostat (ZGN-1061) is a MetAP2 inhibitor with strong preclinical results, improving obesity-related metrics and gene expression.Formule :C26H42N2O6Couleur et forme :SolidMasse moléculaire :478.63Relzomostat
CAS :Relzomostat inhibits MetAP2, with research potential for obesity and type 2 diabetes.Formule :C24H36F2N2O5Couleur et forme :SolidMasse moléculaire :470.558CD13-IN-1
<p>CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 value of 1.71 μM. It effectively suppresses the proliferation of various tumor cells, demonstrating antitumor activity.</p>Couleur et forme :Odour SolidERAP1 modulator-1
CAS :ERAP1 modulator-1 (Compound 1) is a regulator of endoplasmic reticulum aminopeptidase 1 (ERAP1) with an IC50 of less than 250 nM.Formule :C23H23F3N2O5SCouleur et forme :SolidMasse moléculaire :496.5BAY-277
BAY-277 is a degrader of METAP2, with IC50 values of 5.8 nM for human METAP2 (hMETAP2) and 5.9 nM for mouse METAP2 (mMETAP2).Formule :C44H52N8O5Couleur et forme :SolidMasse moléculaire :772.93JNJ-40929837 succinate
CAS :JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].Formule :C22H24N4O2S·xC4H6O4Couleur et forme :SolidLYS006 hydrochloride
CAS :LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC50 value of 2 nM. It is applicable in the study of inflammatory and autoimmune diseases. For further details, please refer to compound 29 in patent document WO2015092740A1.Formule :C16H15Cl2FN6O3Couleur et forme :SolidMasse moléculaire :429.23NGR peptide Trifluoroacetate
NGR peptide Trifluoroacetate contains an NGR motif recognized by CD13/APN in tumor neovasculature, used for targeted drug delivery in cancer research.Formule :C22H37F3N10O10S2Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :722.72α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
CAS :α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aidedFormule :C23H23NO3Degré de pureté :97.19% - 99.36%Couleur et forme :SoildMasse moléculaire :361.43Ref: TM-T60040
1mg77,00€5mg155,00€10mg220,00€25mg338,00€50mg472,00€100mg632,00€200mg853,00€1mL*10mM (DMSO)163,00€ecMetAP-IN-1
CAS :ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。Formule :C13H11N3Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :209.25NGR peptide
CAS :Cell-penetrating peptideFormule :C20H36N10O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.69H-Val-βNA
CAS :H-Val-βNA, also known as L-Valine β-naphthylamide, serves as a substrate for aminopeptidase and Valine arylamidase activities.Formule :C15H18N2OCouleur et forme :SolidMasse moléculaire :242.322Lys-psi(CH2NH)-trp(nps)-ome
CAS :Lys-psi(CH2NH)-trp(nps)-ome peptide bond replaced by CH2NH group.Formule :C24H31N5O4SCouleur et forme :SolidMasse moléculaire :485.60Matlystatin A
CAS :Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.Formule :C27H47N5O8SCouleur et forme :SolidMasse moléculaire :601.76DG013A formate
DG013A (formate) is a tripeptide-mimicking inhibitor of hypophosphorous acid. It exhibits IC50 values of 33 nM for ERAP1 and 11 nM for ERAP2. This compound can be utilized in research related to autoimmune diseases and cancer.Formule :C27H37N4O4PCH2O2Couleur et forme :SolidMasse moléculaire :530.99Antho-rwamide I
CAS :Antho-rwamide I is an anthozoan neuropeptide.Formule :C31H46N10O7Couleur et forme :SolidMasse moléculaire :670.76SDUY817
SDUY817 is a dual APN/NEP inhibitor with IC50 values of 0.29 μM for APN and 7.4 μM for NEP. It exhibits analgesic effects in a concentration- and time-dependent manner, making it a potential candidate for research in the field of neuropathic pain disorders.Formule :C18H16IN3O3Couleur et forme :SolidMasse moléculaire :449.24SDUY816
SDUY816 is an orally active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. It exhibits analgesic properties and demonstrates good safety and pharmacokinetic profiles, having an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral, 10 mg/kg). SDUY816 is applicable for research in the field of neuropathic pain disorders.Formule :C18H16IN3O3Couleur et forme :SolidMasse moléculaire :449.24Leuhistin
CAS :Leuhistin is an aminopeptidases N inhibitor isolated from Bacillus laterosporus BMI156-14F1.Formule :C11H19N3O3Degré de pureté :98%Couleur et forme :White To Off-White SolidMasse moléculaire :241.29Probestin
CAS :Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.Formule :C26H38N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.60ERAP1-IN-3
ERAP1-IN-3 (compound 13) is a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), with a pIC50 value of 8.6. ERAP1-IN-3 shows potential for research in cancer immunotherapy and autoimmune disease studies.Formule :C22H22N2O4SCouleur et forme :SolidMasse moléculaire :410.49Aminopeptidase N inhibitor 2
<p>AminopeptidaseN inhibitor 2 is an APN inhibitor (IC50: 4.3 μM) with antitumor properties.</p>Formule :C12H16F2N2O4SCouleur et forme :SolidMasse moléculaire :322.07988LTA4H-IN-4
<p>LTA4H-IN-4 (compound 3) is an orally active inhibitor of LTA4H. It exhibits an IC50 value of 156 μM against hERG and is applicable for inflammation-related research.</p>HFI-142
CAS :HFI-142 is a inhibitor to aminopeptidase N; inhibit leukotriene A4 biosynthesis in red blood cells; inhibit dditional aminopeptidases.Formule :C17H16N2O4Couleur et forme :SolidMasse moléculaire :312.32Apstatin TFA
Apstatin TFA is a potent inhibitor of aminopeptidase P (APP), with Ki values of 2.6 µM for rat APP and 0.64 µM for human APP. This compound also exhibits cardioprotective properties.Formule :C25H34F3N5O7Couleur et forme :SolidMasse moléculaire :573.56N-Acetyl-β-Asp-Glu
CAS :N-Acetyl-β-Asp-Glu is a peptide neurotransmitter, the third most common neurotransmitter in the mammalian nervous system.Formule :C11H16N2O8Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :304.25Tosedostat
CAS :Tosedostat (CHR-2797), an oral M1 aminopeptidase inhibitor, turns into CHR-79888, blocks tumor cell proteins, causing cell death.Formule :C21H30N2O6Degré de pureté :98.14% - 99.84%Couleur et forme :SolidMasse moléculaire :406.47DG051
CAS :DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).Formule :C21H25Cl2NO4Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :426.33Ref: TM-TQ0047
2mg37,00€5mg74,00€10mg116,00€25mg239,00€50mg380,00€100mg610,00€200mg815,00€1mL*10mM (DMSO)84,00€Acebilustat
CAS :Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.Formule :C29H27N3O4Degré de pureté :99.59% - 99.88%Couleur et forme :SolidMasse moléculaire :481.54Ref: TM-T3715
2mg38,00€5mg58,00€10mg80,00€25mg145,00€50mg225,00€100mg334,00€200mg467,00€1mL*10mM (DMSO)65,00€L(+)-Leucinol
CAS :L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.Formule :C6H15NODegré de pureté :98%Couleur et forme :Clear Colorless To Slightly Yellow LiquidMasse moléculaire :117.19Bestatin trifluoroacetate
CAS :Bestatin trifluoroacetate inhibits CD13/APN and leukotriene A4 hydrolase, used in cancer research.Formule :C18H25F3N2O6Couleur et forme :SolidMasse moléculaire :422.401ARM1
CAS :ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.Formule :C16H14N2SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :266.36Adamantanine
CAS :Adamantanine (NSC-145160) is an amino acid transport inhibitor.Formule :C11H17NO2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :195.26DG-051
CAS :DG-051 is a novel leukotriene A4 (LTA4H) hydrolase inhibitor of leukotriene B4 biosynthesis.Formule :C21H24ClNO4Couleur et forme :SolidMasse moléculaire :389.87Firibastat
CAS :<p>Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33.</p>Formule :C8H20N2O6S4Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :368.51Methyl arachidate
CAS :Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acidFormule :C21H42O2Degré de pureté :≥95%Couleur et forme :White PowderMasse moléculaire :326.56Puromycin aminonucleoside
CAS :Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.Formule :C12H18N6O3Degré de pureté :99.85% - 99.9%Couleur et forme :SolidMasse moléculaire :294.31SC-57461A
CAS :SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.Formule :C20H26ClNO3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :363.9Bestatin hydrochloride
CAS :Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.Formule :C16H25ClN2O4Degré de pureté :98% - 99.93%Couleur et forme :SolidMasse moléculaire :344.84Ref: TM-T3529
5mg51,00€10mg74,00€25mg106,00€50mg168,00€100mg279,00€200mg426,00€500mg692,00€1mL*10mM (DMSO)57,00€Bestatin
CAS :Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.Formule :C16H24N2O4Degré de pureté :98% - 99.63%Couleur et forme :White Crystalline PowderMasse moléculaire :308.37Ref: TM-T1257
2mg35,00€5mg50,00€10mg67,00€25mg104,00€50mg165,00€100mg235,00€200mg349,00€1mL*10mM (DMSO)62,00€ERAP2-IN-1
CAS :ERAP2-IN-1 is a specific non-competitive ERAP2 inhibitor with IC50s of 27 μM for Arg-AMC and 44 μM for peptides.Formule :C20H21F3N2O5SCouleur et forme :SolidMasse moléculaire :458.45M8891
CAS :M8891: Oral, reversible MetAP-2 inhibitor, brain-penetrant (IC50: 54nM; Ki: 4.33nM), hinders endothelial & tumor cell growth, antiangiogenic & antitumor.Formule :C20H17F2N3O3Couleur et forme :SolidMasse moléculaire :385.36Aminopeptidase-IN-1
CAS :Aminopeptidase-IN-1: potent IRAP blocker, Ki 7.7 μM, useful for cognitive/memory disorder research.Formule :C18H16N2O6Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :356.33TP-004
CAS :TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).Formule :C17H16F3N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :363.34HFI-437
CAS :HFI-437 is a potent, non-peptidic, insulin-regulated aminopeptidase (IRAP) inhibitor with a K i of 20 nM and functions as a cognitive enhancer [1].Formule :C23H20N2O5Couleur et forme :SolidMasse moléculaire :404.42Aminopeptidase N Inhibitor
CAS :AP-N inhibitor: reversible, selective for AP-N/CD13 (IC50=25 μM), non-toxic to U937 cells at 100 μM.Formule :C17H10N2O8Couleur et forme :SolidMasse moléculaire :370.27BDM14471
CAS :BDM14471 is a selective inhibitor of hydroxamate PfAM1.Formule :C17H15FN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :314.31LYS006
CAS :LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor,for neutrophil-driven inflammatory diseases ulcerative colitis.Formule :C16H14ClFN6O3Degré de pureté :99.33%Couleur et forme :SoildMasse moléculaire :392.77Ref: TM-T9690
1mg74,00€5mg160,00€10mg264,00€25mg525,00€50mg848,00€100mg1.349,00€200mg1.795,00€1mL*10mM (DMSO)170,00€Acetyltrialanine
CAS :Acetyltrialanine is a dipeptide compound that binds at two sites on the Tb+3-pancreatic elastase complex and can be used as a nitrogen source.Formule :C11H19N3O5Degré de pureté :97.03%Couleur et forme :White PowderMasse moléculaire :273.29Leucinal
CAS :Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen.Formule :C6H13NOCouleur et forme :SolidMasse moléculaire :115.17SC-22716
CAS :SC-22716 is a LTA4 hydrolase inhibitor.SC-22716 has anti-inflammatory activity and may be used in the study of inflammatory bowel disease and psoriasis.Formule :C18H21NODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :267.37Amastatin
CAS :Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 μM .Formule :C21H38N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.55Anticancer agent 51
CAS :Compound 3d (Anticancer agent 51) has a Ki of 731.62 nM, showing promise for prostate cancer research.Formule :C22H20F3N3O2SCouleur et forme :SolidMasse moléculaire :447.47JNJ-26993135
CAS :JNJ-26993135 is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor.Formule :C20H20N2O3SCouleur et forme :SolidMasse moléculaire :368.45MetAP2-IN-1
CAS :MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].Formule :C8H6BrN3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :224.06JNJ-40929837
CAS :JNJ-40929837 is an oral inhibitor of LTA4 hydrolase, which catalyzes LTB4 production.Formule :C22H24N4O2SCouleur et forme :SolidMasse moléculaire :408.52RB 101
CAS :RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.Formule :C31H38N2O3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.84Ketomethylenebestatin
CAS :Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.Formule :C17H25NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :307.38Arphamenine A
CAS :Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).Formule :C16H24N4O3Couleur et forme :SolidMasse moléculaire :320.387TNP-470
CAS :<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Formule :C19H28ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.884-MDM
CAS :<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Formule :C14H14OCouleur et forme :SolidMasse moléculaire :198.26ERAP1 modulator-2
CAS :<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Formule :C22H25F3N2O4SCouleur et forme :SolidMasse moléculaire :470.505QGC583
CAS :QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.Formule :C13H20NO5PCouleur et forme :SolidMasse moléculaire :301.28SDX-7539
CAS :<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formule :C23H38N2O5Masse moléculaire :422.56DG013A
CAS :DG013A inhibits ERAP1 & ERAP2 (IC50: 33 nM & 11 nM) to research autoimmune diseases & cancer.Formule :C27H37N4O4PCouleur et forme :SolidMasse moléculaire :512.58Bestatin methyl ester
CAS :Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.Formule :C17H26N2O4Couleur et forme :SolidMasse moléculaire :322.4LTA4H-IN-2
CAS :LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].Formule :C20H19FN6O2Couleur et forme :SolidMasse moléculaire :394.4PPI-2458
CAS :PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.Formule :C22H36N2O6Couleur et forme :SolidMasse moléculaire :424.53Beloranib
CAS :Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.Formule :C29H41NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.64LTA4H-IN-3
CAS :LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].Formule :C17H15ClN4O3Couleur et forme :SolidMasse moléculaire :358.78A-800141
CAS :A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.Formule :C24H30N2O4SCouleur et forme :SolidMasse moléculaire :442.571EC33
CAS :EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].Formule :C4H11NO3S2Couleur et forme :SolidMasse moléculaire :185.27
