Anhydrase carbonique
L'anhydrase carbonique est une enzyme qui catalyse la conversion réversible du dioxyde de carbone et de l'eau en bicarbonate et protons. Cette enzyme joue un rôle crucial dans le maintien de l'équilibre acido-basique, la respiration et le transport du dioxyde de carbone dans le sang. Les inhibiteurs de l'anhydrase carbonique sont utilisés dans le traitement du glaucome, de l'épilepsie et du mal des montagnes, ainsi que dans la recherche sur l'homéostasie acido-basique et les échanges gazeux. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de l'anhydrase carbonique et de réactifs de haute qualité pour soutenir vos recherches en enzymologie, physiologie respiratoire et développement thérapeutique.
221 produits trouvés pour "Anhydrase carbonique".
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Acipimox
CAS :Acipimox (K-9321), a niacin derivative, treats hyperlipidemia in type 2 diabetics.Formule :C6H6N2O3Degré de pureté :98.98% - 99.71%Couleur et forme :SolidMasse moléculaire :154.1234Benzthiazide
CAS :Benzthiazide treats edema and hypertension by promoting diuresis and inhibiting kidney Na+/Cl- reuptake, but may reduce potassium and raise uric acid.Formule :C15H14ClN3O4S3Degré de pureté :98.48% - 99.79%Couleur et forme :White SolidMasse moléculaire :431.937Hydrochlorothiazide
CAS :Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。Formule :C7H8ClN3O4S2Degré de pureté :99.43% - 99.50%Couleur et forme :White SolidMasse moléculaire :297.739Methazolamide
CAS :Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.Formule :C5H8N4O3S2Degré de pureté :99.31% - 99.77%Couleur et forme :SolidMasse moléculaire :236.27Actarit
CAS :Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.Formule :C10H11NO3Degré de pureté :99.64% - 99.74%Couleur et forme :White Or Off-White Crystal Or Crystalline SolidMasse moléculaire :193.1992Brinzolamide
CAS :Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.Formule :C12H21N3O5S3Degré de pureté :99.84% - >99.99%Couleur et forme :SolidMasse moléculaire :383.51Girentuximab
CAS :Girentuximab (G250) is an anti-carbonic anhydrase IX (CAIX) monoclonal antibody with anti-cancer activity for the study of uroepithelial carcinoma PET (ZiPUP).Couleur et forme :Transparent LiquidMasse moléculaire :145.55 kDa (Predicted)Methocarbamol
CAS :Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established.Formule :C11H15NO5Degré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :241.2405Zonisamide
CAS :Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.Formule :C8H8N2O3SDegré de pureté :99.05% - 99.9%Couleur et forme :SolidMasse moléculaire :212.226Topiramate
CAS :Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.Formule :C12H21NO8SDegré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :339.36CAIX Inhibitor S4
CAS :CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively.Formule :C15H17N3O4SDegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :335.38Tioxolone
CAS :Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.Formule :C7H4O3SDegré de pureté :97.79%Couleur et forme :White SolidMasse moléculaire :168.17pNNP
CAS :pNNP is a substrate for PP2C assays and inhibits β-carbonic anhydrase, α-carbonate dehydrogenase, and H. pylori.Formule :C6H6NO6PDegré de pureté :99.82%Couleur et forme :White SolidMasse moléculaire :219.09hCA-IN-1
hCA-IN-1 (Compound 5u) is an hCA inhibitor with Ki values of 159.2 nM for hCA I, 4.8 nM for hCA II, 15.5 nM for CAIX, and 2 nM for CAXII. It demonstrates broad-spectrum anticancer activity against melanoma, breast cancer, and colon cancer cells. ADME predictions indicate that hCA-IN-1 has good solubility and oral bioavailability. This compound is useful in tumor research.Carbonic anhydrase-IN-37
Carbonic anhydrase-IN-37 (compound 9a) is a potent and orally active inhibitor of carbonic anhydrase (CA), exhibiting Ki values of 9.7 nM for hCA VA and 1.0 nM for hCA VB. It demonstrates anti-hyperalgesic and anti-allodynic properties in a mouse model of paclitaxel-induced neuropathic pain, making it useful for neuropathic pain research.hCAIX-IN-22
hCAIX-IN-22 is a highly selective inhibitor of the human carbonic anhydrase (hCA) XII subtype, exhibiting anticancer activity with an inhibition constant (Ki) of 9.7 nM.DOTA-XYIMSR-01
CAS :DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.Formule :C61H88N16O22S2Couleur et forme :SolidMasse moléculaire :1461.57IPM-N001
IPM-N001 is a ligand for carbonic anhydrase IX (CAIX) with a Kd value of less than 0.0337 nM for hCAIX. When radiolabeled with 68Ga, it serves as a CAIX-targeting radionuclide tracer. [68Ga]Ga-IPM-N001 demonstrates excellent tumor uptake and significantly enhances the tumor-to-background ratio in PET/CT imaging studies using OS-RC-2 tumor-bearing mice. IPM-N001 is applicable for research on clear cell renal cell carcinoma.CA IX-IN-5
CAIX-IN-5 (compound 9) is an inhibitor of human carbonic anhydrase IX (hCA IX), exhibiting a Ki of 7.4 nM for hCA IX and a Ki of 25.0 nM for hCA II. It effectively inhibits the isoenzymes hCA IX and hCA II, showing higher selectivity for hCA IX than hCA II. CAIX-IN-5 is used in research related to breast cancer, colorectal cancer, glioblastoma, lung cancer, head and neck cancer, and cervical cancer.CAIX/CAXII-IN-2
CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, exhibiting Ki values of 8.9 nM for CAIX and 5.3 nM for CAXII. It is applicable in cancer research.Formule :C16H14N4O2SMasse moléculaire :326.08375
