NAMPT
La nicotinamide phosphoribosyltransférase (NAMPT) est une enzyme impliquée dans la biosynthèse du nicotinamide adénine dinucléotide (NAD+), un coenzyme essentiel au métabolisme cellulaire et à la production d'énergie. Les inhibiteurs de la NAMPT suscitent un intérêt particulier en recherche sur le cancer, en raison de leur capacité à perturber le métabolisme du NAD+ et à induire la mort des cellules cancéreuses. Ces inhibiteurs sont également étudiés dans le contexte des troubles métaboliques et du vieillissement. Chez CymitQuimica, nous proposons des inhibiteurs de la NAMPT pour soutenir vos recherches en biologie du cancer, métabolisme et vieillissement.
36 produits trouvés pour "NAMPT"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
SBI-797812
CAS :<p>SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).</p>Formule :C19H22N4O4SDegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :402.47Nampt-IN-5
CAS :<p>Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .</p>Formule :C25H25N5O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :427.5Nampt activator-1
CAS :<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>Formule :C16H17N3O3Degré de pureté :99.84% - 99.98%Couleur et forme :SoildMasse moléculaire :299.32CB 300919
CAS :<p>CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.</p>Formule :C32H34ClN7O2Couleur et forme :SolidMasse moléculaire :584.11NAMPT degrader-3
<p>NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.</p>Formule :C56H74N8O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1003.3Nampt degrader-2
<p>Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.</p>Formule :C59H73N9O7SCouleur et forme :SolidMasse moléculaire :1052.33NAMPT activator-7
<p>NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.</p>Formule :C21H17ClN4O3Masse moléculaire :408.09892Nampt-IN-10 trihydrochloride
<p>Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.</p>Formule :C27H31Cl3FN5O2Couleur et forme :SolidMasse moléculaire :582.92LYP-8
<p>LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.</p>Formule :C56H74N8O10SMasse moléculaire :1050.52486PROTAC NAMPT Degrader-1
<p>PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.</p>Formule :C57H69N13O8S2Masse moléculaire :1127.48335ALT-100 (Human IgG1)
<p>ALT-100 (HumanIgG1) is a human-derived IgG1 monoclonal antibody that targets NAMPT. For its isotype control, please refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidNAMPT Protein, Human, Recombinant (His)
<p>Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but</p>Degré de pureté :94% - 94%Couleur et forme :Lyophilized PowderMasse moléculaire :55 KDa (reducing condition)NAT
CAS :<p>NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.</p>Formule :C18H21NO3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :299.36CHS-828
CAS :<p>CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).</p>Formule :C19H22ClN5ODegré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :371.86STF-118804
CAS :<p>STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.</p>Formule :C25H23N3O4SDegré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :461.53GNE-617
CAS :<p>GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.</p>Formule :C21H15F2N3O3SDegré de pureté :99.28% - 99.71%Couleur et forme :SolidMasse moléculaire :427.42LB-60-OF61 hydrochloride
CAS :<p>LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.</p>Formule :C29H31ClN6O2Couleur et forme :SolidMasse moléculaire :531.06KPT9274
CAS :<p>KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.</p>Formule :C35H29F3N4O3Degré de pureté :99.75% - 99.93%Couleur et forme :SolidMasse moléculaire :610.62GNE-617 hydrochloride
CAS :<p>GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).</p>Formule :C21H16ClF2N3O3SCouleur et forme :SolidMasse moléculaire :463.88Nampt-IN-1
CAS :<p>Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.</p>Formule :C20H25N3O5SDegré de pureté :99.28% - 99.4%Couleur et forme :SolidMasse moléculaire :419.49
