PPAR
Les récepteurs activés par les proliférateurs des peroxysomes (PPARs) sont un groupe de protéines réceptrices nucléaires qui fonctionnent comme des facteurs de transcription régulant l'expression des gènes impliqués dans le métabolisme, en particulier le stockage des acides gras et le métabolisme du glucose. Les inhibiteurs des PPARs sont des outils importants pour étudier les troubles métaboliques tels que le diabète, l'obésité et les maladies cardiovasculaires. Ces inhibiteurs peuvent moduler le métabolisme des lipides, la sensibilité à l'insuline et l'inflammation, ce qui les rend précieux dans la recherche thérapeutique. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PPARs pour soutenir vos recherches sur les maladies métaboliques, l'endocrinologie et le développement de médicaments.
164 produits trouvés pour "PPAR"
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Cloxiquine
CAS :<p>Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.</p>Formule :C9H6ClNODegré de pureté :99.82% - 99.87%Couleur et forme :Light Yellow CrystalsMasse moléculaire :179.6MA-0204
CAS :<p>MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human,</p>Formule :C25H27F3N2O4Degré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :476.49Candesartan
CAS :<p>Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.</p>Formule :C24H20N6O3Degré de pureté :98.3% - 99.55%Couleur et forme :Colorless Solid CrystallineMasse moléculaire :440.47Retinoic acid
CAS :<p>Retinoic acid (Tretinoin) binds to and activates RARs, thereby inducing changes in gene expression that lead to inhibition of tumorigenesis.</p>Formule :C20H28O2Degré de pureté :97.21% - 99.6%Couleur et forme :Yellow-Orange PowderMasse moléculaire :300.44Clofibric acid
CAS :<p>Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.</p>Formule :C10H11ClO3Degré de pureté :99.47% - 99.8%Couleur et forme :Pale Yellow SolidMasse moléculaire :214.65GED-0507-34 Levo
CAS :<p>GED-0507-34 Levo,(S)-3-(4-Aminophenyl)-2-methoxypropanoic acid,an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis.</p>Formule :C10H13NO3Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :195.22Fenofibric acid
CAS :<p>Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.</p>Formule :C17H15ClO4Degré de pureté :99.36%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :318.75NSC-87877
CAS :<p>NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.</p>Formule :C19H13N3O7S2Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :459.45Bezafibrate
CAS :<p>Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES.</p>Formule :C19H20ClNO4Degré de pureté :99.56% - 99.82%Couleur et forme :SolidMasse moléculaire :361.82Muraglitazar
CAS :<p>Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.</p>Formule :C29H28N2O7Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :516.54LY518674
CAS :<p>LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.</p>Formule :C23H27N3O4Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :409.48EHP-101
CAS :<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Formule :C28H35NO3Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :433.58NTP42
CAS :<p>NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)</p>Formule :C25H23F2N3O5SDegré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :515.53Gemfibrozil
CAS :<p>Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.</p>Formule :C15H22O3Degré de pureté :99.53% - 99.88%Couleur et forme :Crystals From Hexane SolidMasse moléculaire :250.33Rosiglitazone maleate
CAS :<p>Rosiglitazone maleate (BRL 49653) is an oral antidiabetic and potential anticancer agent.</p>Formule :C22H23N3O7SDegré de pureté :99.33% - 99.51%Couleur et forme :Off-White SolidMasse moléculaire :473.50Anandamide
CAS :<p>Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also</p>Formule :C22H37NO2Degré de pureté :95.037% - 99.22%Couleur et forme :Light Yellow OilMasse moléculaire :347.53Oleoylethanolamide
CAS :<p>Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.</p>Formule :C20H39NO2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :325.53Daidzein
CAS :<p>Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein.</p>Formule :C15H10O4Degré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :254.24Fenofibrate
CAS :<p>Fenofibrate (Lipanthyl) is a PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms. Fenofibrate exhibits antihyperlipidemic activity. Cost-effective and quality-assured.</p>Formule :C20H21ClO4Degré de pureté :99.13% - 99.95%Couleur et forme :Crystals From Isopropanol SolidMasse moléculaire :360.83Mifobate
CAS :<p>Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。</p>Formule :C11H17ClO7P2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :358.655-Aminosalicylic Acid
CAS :<p>5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!</p>Formule :C7H7NO3Degré de pureté :98.88% - 99.49%Couleur et forme :Purplish-Tan Solid PowderMasse moléculaire :153.14Pioglitazone hydrochloride
CAS :<p>Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic</p>Formule :C19H20N2O3S·HClDegré de pureté :99.64% - >99.99%Couleur et forme :White Crystals Or Crystalline PowderMasse moléculaire :392.90MK-0533
CAS :<p>MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.</p>Formule :C28H24F3NO6Degré de pureté :99.03%Couleur et forme :SoildMasse moléculaire :527.49GW7647
CAS :<p>GW 7647 is an effective and highly selective PPARα agonist. GW 7647 can reduce the production of nitric oxide in macrophages. Cost-effective and quality-assured.</p>Formule :C29H46N2O3SDegré de pureté :99.3% - 99.34%Couleur et forme :SolidMasse moléculaire :502.75Pioglitazone
CAS :<p>Pioglitazone (U 72107) is a selective and oral PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively . High-Quality, Low-Cost!</p>Formule :C19H20N2O3SDegré de pureté :95% - 99.57%Couleur et forme :White PowderMasse moléculaire :356.44Arhalofenate
CAS :<p>Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.</p>Formule :C19H17ClF3NO4Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :415.79β-Amyrone
CAS :<p>beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM.</p>Formule :C30H48ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :424.7Magnolol
CAS :<p>Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.</p>Formule :C18H18O2Degré de pureté :99.49%Couleur et forme :A Bioactive Compound Found In The Bark Of The Houpu MagnoliaMasse moléculaire :266.33WAY-620472
CAS :<p>WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.</p>Formule :C23H21N5OSDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :415.51Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidBenzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
CAS :<p>Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM.</p>Formule :C24H23NO5SDegré de pureté :99.59%Couleur et forme :SoildMasse moléculaire :437.51PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Couleur et forme :Odour SolidSP4f
<p>SP4f, an activator of PPAR-γ, exhibits an EC50 value of 826 nM in HK-2 cells.</p>Degré de pureté :98%Couleur et forme :Odour SolidSulotroban potassium
<p>Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.</p>Formule :C16H16KNO5SDegré de pureté :98.02%Couleur et forme :SoildMasse moléculaire :373.46Lipid Metabolism Compound Library
<p>A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).</p>Couleur et forme :Odour Solid8-iso Prostaglandin F1β
CAS :<p>8-iso Prostaglandin F1β,inducet vasoconstrictor effects in (PA), (PV) and (MA) through the activation of TXA2R, tyrosine kinase and Rho kinase.</p>Formule :C20H36O5Couleur et forme :SolidMasse moléculaire :356.58-iso Prostaglandin F1α
CAS :<p>8-iso Prostaglandin F1α induces vasoconstrictor effects in (PA),(PV) and (MA) through activation of TXA2R, tyrosine kinases and Rho kinases.</p>Formule :C20H36O5Couleur et forme :SolidMasse moléculaire :356.5Anti-osteoporosis agent-10
<p>Anti-osteoporosis agent-10 is an inhibitor of osteoporosis that suppresses the formation of osteoclasts with an IC50 of 0.042 μM. It also exhibits antagonistic activity towards PPARγ, with an EC50 value of 0.75 μM.</p>Couleur et forme :Odour SolidSP4e
<p>SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.</p>Formule :C22H17ClN2O2S2Degré de pureté :99.79%Couleur et forme :SoildMasse moléculaire :440.97(±)-CBCQ
CAS :<p>(±)-CBCQ, an oxidation product of cannabidiol, exhibits an EC50 value of 14.7 μM for the activation of peroxisome proliferator-activated receptor γ (PPAR-γ).</p>Formule :C21H28O3Couleur et forme :SolidMasse moléculaire :328.45CC618
CAS :<p>CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.</p>Formule :C20H15F6N3O3S2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :523.47MCC-555
CAS :<p>MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.</p>Formule :C21H16FNO3SDegré de pureté :99.07% - 99.82%Couleur et forme :SolidMasse moléculaire :381.42Sulotroban
CAS :<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Formule :C16H17NO5SDegré de pureté :98.86% - 99.88%Couleur et forme :SolidMasse moléculaire :335.37AZD-9574
CAS :<p>AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs.</p>Formule :C21H22F2N6O2Degré de pureté :98.46% - 99.39%Couleur et forme :SolidMasse moléculaire :428.44E0924G
CAS :<p>E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.</p>Formule :C12H12N2O3Couleur et forme :SolidMasse moléculaire :232.24Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Formule :C21H22N2O6Couleur et forme :SolidMasse moléculaire :398.409PPARγ agonist 15
<p>PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.</p>Formule :C21H16N4O3S2Couleur et forme :SolidMasse moléculaire :436.51PPARγ agonist 16
CAS :<p>PPARγ agonist16 (Compound 4G) is a PPARγ agonist that competitively binds to the ligand-binding domain (LBD) of PPARγ with an IC50 of 1790 nM. It reduces ear swelling in mouse models and exhibits antihyperglycemic activity in mice with Streptozotocin-induced diabetes.</p>Formule :C19H14BrNO4SCouleur et forme :SolidMasse moléculaire :432.29Mavodelpar free acid hydrochloride
<p>Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.</p>Formule :C31H31ClFNO5Degré de pureté :98.13%Couleur et forme :SoildMasse moléculaire :552.03CUDA
CAS :<p>CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.</p>Formule :C19H36N2O3Degré de pureté :97.585%Couleur et forme :SolidMasse moléculaire :340.5GW590735
CAS :<p>GW590735: PPARα agonist, EC50=4 nM, >500x selective over PPARδ/γ, for dyslipidemia research.</p>Formule :C23H21F3N2O4SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :478.48PPARγ-IN-3
<p>PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.</p>Formule :C23H28FN7O3Couleur et forme :SolidMasse moléculaire :469.51GQ-16
CAS :<p>GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.</p>Formule :C19H16BrNO3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :418.3CP-868388 free base
CAS :<p>CP-868388 free base (CP-868388) is a PPARα agonist with hypolipidemic and anti-inflammatory activity and is used in the study of dyslipidemia.</p>Formule :C26H33NO5Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :439.54PPAR α/PPARA Protein, Human, Recombinant (His)
<p>PPAR alpha/PPARA Protein, Human, Recombinant (His) is expressed in E.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :31.36 kDa (predicted)PPAR α/PPARA Protein, Mouse, Recombinant (His)
<p>PPAR alpha/PPARA Protein, Mouse, Recombinant (His) is expressed in E.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :31.49 kDa (predicted)Balaglitazone
CAS :<p>Balaglitazone is a PPARγ agonist that regulates blood glucose and is used in studies of heart failure and myocardial infarction.</p>Formule :C20H17N3O4SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :395.43Ciprofibrate
CAS :<p>Ciprofibrate (Win35833) is a fibrate derivative with antilipidemic activity.</p>Formule :C13H14Cl2O3Degré de pureté :99.63% - >99.99%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :289.15Avicularin
CAS :<p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>Formule :C20H18O11Degré de pureté :97.02% - 99.94%Couleur et forme :White PowderMasse moléculaire :434.35MK-886
CAS :<p>MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP).</p>Formule :C27H34ClNO2SDegré de pureté :99.23% - 99.84%Couleur et forme :SolidMasse moléculaire :472.08LJ570
CAS :<p>LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[)</p>Formule :C27H22O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :394.46Choline Fenofibrate
CAS :<p>Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic</p>Formule :C22H28ClNO5Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :421.91Rosiglitazone
CAS :<p>Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.</p>Formule :C18H19N3O3SDegré de pureté :98.61% - 99.87%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :357.43NPC 15199
CAS :<p>NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.</p>Formule :C21H23NO4Degré de pureté :99.93% - 99.94%Couleur et forme :White Crystalline PowderMasse moléculaire :353.41Seladelpar
CAS :<p>Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.</p>Formule :C21H23F3O5SDegré de pureté :99.18% - 99.41%Couleur et forme :SolidMasse moléculaire :444.46Norathyriol
CAS :<p>Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.</p>Formule :C13H8O6Degré de pureté :99.35% - 99.55%Couleur et forme :SolidMasse moléculaire :260.2Pirinixic Acid
CAS :<p>Pirinixic Acid (NSC 310038) is a synthetic thiacetic acid derivative used in biomedical research, a peroxisome proliferator that activates specific PPAR.</p>Formule :C14H14ClN3O2SDegré de pureté :98.27% - 99.92%Couleur et forme :SolidMasse moléculaire :323.8Bilobetin
CAS :<p>Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.</p>Formule :C31H20O10Degré de pureté :97.74% - 99.69%Couleur et forme :SolidMasse moléculaire :552.48GW 501516
CAS :<p>GW 501516 (Endurobol) is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.</p>Formule :C21H18F3NO3S2Degré de pureté :98.91% - 99.64%Couleur et forme :White SolidMasse moléculaire :453.50OPHIOPOGONIN D
CAS :<p>Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.</p>Formule :C44H70O16Degré de pureté :99.46% - ≥95%Couleur et forme :SolidMasse moléculaire :855.02BMS-687453
CAS :<p>BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma</p>Formule :C22H21ClN2O6Degré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :444.86Licarin B
CAS :<p>1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.</p>Formule :C20H20O4Degré de pureté :99.82% - ≥95%Couleur et forme :SolidMasse moléculaire :324.37Eupatilin
CAS :<p>Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.</p>Formule :C18H16O7Degré de pureté :98.53% - 99%Couleur et forme :SolidMasse moléculaire :344.32GW9662
CAS :<p>GW9662 (TIMTEC-BB SBB006523) is a PPARγ antagonist (IC50=3.3 nM) with selectivity. GW9662 has anti-tumor effect. High-Quality, Low-Cost!</p>Formule :C13H9ClN2O3Degré de pureté :98% - 99.95%Couleur et forme :Off-White SolidMasse moléculaire :276.68SR1664
CAS :<p>SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity.</p>Formule :C33H29N3O5Degré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :547.6FH535
CAS :<p>FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.</p>Formule :C13H10Cl2N2O4SDegré de pureté :98.25% - 99.5%Couleur et forme :SolidMasse moléculaire :361.2Icariin
CAS :<p>Icariin (Ieariline) is a flavonol glycoside that inhibits PDE5 and PDE4 activity and is a PPARα activator. Cost-effective and quality-assured.</p>Formule :C33H40O15Degré de pureté :97.82% - 98.3%Couleur et forme :SolidMasse moléculaire :676.66Glabrone
CAS :<p>Glabrone shows antiviral activity against influenza virus.</p>Formule :C20H16O5Degré de pureté :99.08% - 99.55%Couleur et forme :SolidMasse moléculaire :336.34GW6471
CAS :<p>GW6471 is an antagonist of PPARα. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.</p>Formule :C35H36F3N3O4Degré de pureté :98.23% - 99.55%Couleur et forme :SolidMasse moléculaire :619.67Palmitelaidic Acid
CAS :<p>Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.</p>Formule :C16H30O2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :254.41NSC-87877 disodium
CAS :<p>NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.</p>Formule :C19H13N3O7S2·2NaDegré de pureté :97.89%Couleur et forme :SolidMasse moléculaire :503.42SR 16832
CAS :<p>SR 16832: Dual-site PPARγ inhibitor; outperforms GW 9662, T 0070907 in ligand binding, transcription inhibition.</p>Formule :C17H12ClN3O4Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :357.75GW0742
CAS :<p>GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).</p>Formule :C21H17F4NO3S2Degré de pureté :99.75% - 99.85%Couleur et forme :SolidMasse moléculaire :471.49CDDO-Im
CAS :<p>CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).</p>Formule :C34H43N3O3Degré de pureté :98.3% - 99.61%Couleur et forme :SolidMasse moléculaire :541.72SC-236
CAS :<p>SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).</p>Formule :C16H11ClF3N3O2SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :401.79Raspberry ketone
CAS :<p>1.</p>Formule :C10H12O2Degré de pureté :99.84% - 99.89%Couleur et forme :White Solid CrystallineMasse moléculaire :164.2Fisetin
CAS :<p>Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.</p>Formule :C15H10O6Degré de pureté :94.14% - 99.05%Couleur et forme :Yellow To Brown Crystalline PowderMasse moléculaire :286.24Ginsenoside Rh1
CAS :<p>Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.</p>Formule :C36H62O9Degré de pureté :99% - 99.77%Couleur et forme :SolidMasse moléculaire :638.87Alpinetin
CAS :<p>Alpinetin: antibacterial, anti-inflammatory, boosts HepG2 sensitivity to CDDP, fights hepatoma/pancreatic cancer, inhibits cell growth & activates caspases.</p>Formule :C16H14O4Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :270.28Glabridin
CAS :<p>Glabridin aids in diabetes by reducing inflammation and glucose levels and may prevent liver cancer spread.</p>Formule :C20H20O4Degré de pureté :99.78% - 99.99%Couleur et forme :Light Yellow Powder Insoluble In WaterMasse moléculaire :324.37Convallatoxin
CAS :<p>Convallatoxin is a natural product.</p>Formule :C29H42O10Degré de pureté :99.27% - 99.53%Couleur et forme :Prisms From Methanol + Ether SolidMasse moléculaire :550.64Methyl oleanonate
CAS :<p>3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.</p>Formule :C31H48O3Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :468.71Astaxanthin
CAS :<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>Formule :C40H52O4Degré de pureté :95.1% - 99.79%Couleur et forme :Needles From Acetone/Light Petroleum SolidMasse moléculaire :596.84Agrimol B
CAS :<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formule :C37H46O12Degré de pureté :99.06% - ≥95%Couleur et forme :SolidMasse moléculaire :682.75(E/Z)-Elafibranor
CAS :<p>GFT505 (Elafibranor) (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.</p>Formule :C22H24O4SDegré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :384.49Adelmidrol
CAS :<p>Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.</p>Formule :C13H26N2O4Degré de pureté :99.35% - 99.73%Couleur et forme :SolidMasse moléculaire :274.36GW1929
CAS :<p>GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).</p>Formule :C30H29N3O4Degré de pureté :98.1% - 98.21%Couleur et forme :SolidMasse moléculaire :495.57Bocidelpar
CAS :<p>Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells.</p>Formule :C25H27F3N2O3Degré de pureté :97.77%Couleur et forme :SolidMasse moléculaire :460.49Troglitazone
CAS :<p>Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.</p>Formule :C24H27NO5SDegré de pureté :98% - 99.8%Couleur et forme :Yellow SolidMasse moléculaire :441.54Tetradecylthioacetic acid
CAS :<p>Synthetic fatty acid TTA has β-sulfur, resists β-oxidation, and activates PPARs, especially PPARα.</p>Formule :C16H32O2SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :288.49T0070907
CAS :<p>T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.</p>Formule :C12H8ClN3O3Degré de pureté :98.25% - 99.98%Couleur et forme :SolidMasse moléculaire :277.66Angeloylgomisin H
CAS :<p>Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.</p>Formule :C28H36O8Degré de pureté :99.84% - 99.95%Couleur et forme :SolidMasse moléculaire :500.58Oleuropein
CAS :<p>Oleuropein is an antioxidant polyphenol isolated from olive leaf.</p>Formule :C25H32O13Degré de pureté :98% - 99.95%Couleur et forme :Brown PowderMasse moléculaire :540.51GSK0660
CAS :<p>GSK0660 is an antagonist and inverse agonist of PPARβ/δ.</p>Formule :C19H18N2O5S2Degré de pureté :99.26% - ≥95%Couleur et forme :SolidMasse moléculaire :418.49Rosiglitazone hydrochloride
CAS :<p>Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.</p>Formule :C18H19N3O3S·HClDegré de pureté :99.63% - 99.79%Couleur et forme :SolidMasse moléculaire :393.89EPI-001
CAS :<p>EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.</p>Formule :C21H27ClO5Degré de pureté :99% - 99.67%Couleur et forme :SolidMasse moléculaire :394.89Clofibrate
CAS :<p>Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.</p>Formule :C12H15ClO3Degré de pureté :98.77%Couleur et forme :Oil LiquidMasse moléculaire :242.70DG172 dihydrochloride
CAS :<p>DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).</p>Formule :C20H22BrCl2N3Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :455.2L-165041
CAS :<p>L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)</p>Formule :C22H26O7Degré de pureté :97.97%Couleur et forme :SolidMasse moléculaire :402.44GSK3787
CAS :<p>GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）.</p>Formule :C15H12ClF3N2O3SDegré de pureté :98% - 99.56%Couleur et forme :SolidMasse moléculaire :392.78Oroxin A
CAS :<p>Oroxin A (Baicalein 7-O-glucoside) has antitussive and expectorant effects.</p>Formule :C21H20O10Degré de pureté :98.05% - 99.74%Couleur et forme :SolidMasse moléculaire :432.38AMG131
CAS :<p>AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for</p>Formule :C21H12Cl4N2O3SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :514.21Gypenoside XLIX
CAS :<p>Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition</p>Formule :C52H86O21Degré de pureté :97.05% - 99.78%Couleur et forme :SolidMasse moléculaire :1047.23Elafibranor
CAS :<p>Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with</p>Formule :C22H24O4SDegré de pureté :98.42% - 98.78%Couleur et forme :SolidMasse moléculaire :384.49Cinnamyl alcohol
CAS :<p>Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.</p>Formule :C9H10ODegré de pureté :99.00%Couleur et forme :Colourless LiquidMasse moléculaire :134.18Tesaglitazar
CAS :<p>Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα</p>Formule :C20H24O7SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :408.47Pparδ agonist 2
CAS :<p>Pparδ agonist 2 is an agonist of PPARδ.</p>Formule :C20H18F3N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.44FTX-6746
CAS :<p>FTX-6746 is an orally active and selective PPARG reverse inhibitor with anticancer activity. It can be used in research on urothelial carcinoma.</p>Formule :C16H7ClF2N2ODegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :316.6913-Oxo-9E,11E-octadecadienoic acid
CAS :<p>13-Oxo-9E,11E-octadecadienoic acid from tomato juice, an isomer of 9-oxo-ODA, activates PPARα and lowers triglycerides in diabetic mice.</p>Formule :C18H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :294.43Peliglitazar racemate
CAS :<p>Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity</p>Formule :C30H30N2O7Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :530.57Daltroban
CAS :<p>Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.</p>Formule :C16H16ClNO4SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :353.82GW 9578
CAS :<p>GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.</p>Formule :C26H34F2N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.62ARH-049020
CAS :<p>ARH-049020, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of insulin resistance and type 2 diabetes.</p>Formule :C24H31NO6Degré de pureté :97.19% - 99.82%Couleur et forme :SolidMasse moléculaire :429.51Reglitazar
CAS :<p>Reglitazar, a dual PPARα/γ agonist, enhances insulin signaling, reduces insulin resistance, and lowers hypertriglyceridemia in obese rats.</p>Formule :C22H20N2O5Degré de pureté :97.07% - 98.72%Couleur et forme :SolidMasse moléculaire :392.4THR-0921
CAS :<p>THR-0921 (CLX-0921) is a peroxisome proliferator-activated receptor (PPAR) agonist that can be used to study cardiovascular and metabolic diseases.</p>Formule :C28H25NO7SDegré de pureté :100% - 99.83%Couleur et forme :SolidMasse moléculaire :519.57AVE-8134
CAS :<p>AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.</p>Formule :C22H23NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.42PPARα-MO-1
CAS :<p>PPARα-MO-1 is a potent modulator of PPARα.</p>Formule :C27H37NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.59LG100754
CAS :<p>LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.</p>Formule :C26H36O3Couleur et forme :SolidMasse moléculaire :396.56Chiglitazar
CAS :<p>Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.</p>Formule :C36H29FN2O4Couleur et forme :SolidMasse moléculaire :572.63Inolitazone dihydrochloride
CAS :<p>Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth.</p>Formule :C27H28Cl2N4O4SCouleur et forme :SolidMasse moléculaire :575.51Saroglitazar
CAS :<p>Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.</p>Formule :C25H29NO4SDegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :439.57GSK376501A
CAS :<p>GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.</p>Formule :C32H37NO6Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :531.64Indeglitazar
CAS :<p>Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).</p>Formule :C19H19NO6SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :389.42K-111
CAS :<p>K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.</p>Formule :C18H25Cl3O2Degré de pureté :99.64% - 99.88%Couleur et forme :SolidMasse moléculaire :379.75Farglitazar
CAS :<p>Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer used in the study of diabetes.</p>Formule :C34H30N2O5Degré de pureté :99.4% - 99.52%Couleur et forme :SolidMasse moléculaire :546.61Cevoglitazar
CAS :<p>Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.</p>Formule :C27H21F3N2O6SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :558.53Dazmegrel
CAS :<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Formule :C16H17N3O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :283.33BAY-0069
CAS :<p>BAY-0069 is a potent and selective PPARγ transactivator that inhibits human PPARγ and murine PPARγ with IC50s of 6.3 nM and 24 nM, respectively.BAY-0069 can be</p>Formule :C22H16BrN3O4Degré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :466.28Linotroban
CAS :<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Formule :C14H15NO5S2Degré de pureté :97.95% - >99.99%Couleur et forme :SolidMasse moléculaire :341.4BAY-4931
CAS :<p>BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.</p>Formule :C22H16ClN3O4Degré de pureté :99.47%Couleur et forme :SoildMasse moléculaire :421.83Edaglitazone
CAS :<p>Edaglitazone (R-483) is a PPARγ agonist with antiplatelet activity that can be used in studies of diabetes and obesity.</p>Formule :C24H20N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.56LCB-2853
CAS :<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Formule :C21H24ClNO4SDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :421.94Imiglitazar
CAS :<p>Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects.</p>Formule :C28H26N2O5Degré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :470.52PPAR agonist 1
CAS :<p>PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.</p>Formule :C20H25NO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.48U-46619
CAS :<p>U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (</p>Formule :C21H34O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.49KD-3010
CAS :<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Formule :C30H33F3N2O8S2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :670.72CRX000227
CAS :<p>CRX000227 is a PPAR modulator suitable for researching metabolic and cell proliferative disorders [1].</p>Formule :C25H24N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.55PPARγ agonist 8
CAS :<p>PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator</p>Formule :C19H12F4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.36Darglitazone
CAS :<p>Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions.</p>Formule :C23H20N2O4SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :420.48PPARδ agonist 9
CAS :<p>PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic</p>Formule :C26H28ClF3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :569.04Ragaglitazar
CAS :<p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>Formule :C25H25NO5Degré de pureté :97.46% - 98.56%Couleur et forme :SolidMasse moléculaire :419.47Inolitazone
CAS :<p>Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.</p>Formule :C27H26N4O4SDegré de pureté :99.41% - 99.53%Couleur et forme :SolidMasse moléculaire :502.58Fonadelpar
CAS :<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Formule :C25H23F3N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.52Anti-NASH agent 2
CAS :<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Formule :C32H51N3O2Couleur et forme :SolidMasse moléculaire :509.766PPARγ agonist 17
CAS :<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Formule :C48H63NO7Couleur et forme :SolidMasse moléculaire :766.016PPARγ modulator-2
CAS :<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Formule :C26H21NO7S3SeCouleur et forme :SolidMasse moléculaire :634.6Amezalpat
CAS :<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Formule :C34H41N3O4Couleur et forme :SolidMasse moléculaire :555.707PPARγ-IN-5
CAS :<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Formule :C22H23ClO7Couleur et forme :SolidMasse moléculaire :434.867PPARα/δ agonist 3
CAS :<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Formule :C23H25F3N2O4Couleur et forme :SolidMasse moléculaire :450.451PPARδ agonist 11
CAS :<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Formule :C19H15F3N2O3S2Couleur et forme :SolidMasse moléculaire :440.46Aleglitazar
CAS :<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>Formule :C24H23NO5SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :437.51Anti-NASH agent 1
CAS :<p>Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH).</p>Formule :C26H33NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.54PPARγ-IN-2
CAS :<p>"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes.</p>Formule :C19H21N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.4Mavodelpar free base
CAS :<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Formule :C31H30FNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.57
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