FXR
Le récepteur X des farnésoïdes (FXR) est un récepteur nucléaire qui joue un rôle clé dans la régulation de l'homéostasie des acides biliaires, du métabolisme des lipides et de la régulation du glucose. FXR est une cible thérapeutique potentielle pour le traitement des maladies du foie, des troubles métaboliques et des maladies cardiovasculaires. Les inhibiteurs de FXR peuvent moduler ces voies, offrant des perspectives sur les mécanismes des maladies et les stratégies thérapeutiques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de FXR pour soutenir vos recherches en hépatologie, métabolisme et développement de médicaments.
58 produits trouvés pour "FXR"
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LY2562175
CAS :<p>LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).</p>Formule :C28H27Cl2N3O4Degré de pureté :99.16% - 99.78%Couleur et forme :SolidMasse moléculaire :540.44Ursodeoxycholic acid
CAS :<p>Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!</p>Formule :C24H40O4Degré de pureté :99.74% - ≥95%Couleur et forme :White - Almost White Solid PowderMasse moléculaire :392.57Chenodeoxycholic acid
CAS :<p>Chenodeoxycholic acid (CDCA) is a bile acid that inhibits 11β-HSD2 with an IC50 value of 22 mM. High-Quality, Low-Cost!</p>Formule :C24H40O4Degré de pureté :99.70% - 99.93%Couleur et forme :White - Almost White Solid PowderMasse moléculaire :392.57ZLY28
<p>ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1.</p>Formule :C29H23Cl2NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.4Alismanol M
CAS :<p>Alismanol M: FXR agonist, EC50 of 50.25 μM, from Alisma orientale, for cholestasis & NASH research.</p>Formule :C30H48O6Couleur et forme :SolidMasse moléculaire :504.7FXR antagonist 2
CAS :<p>Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.</p>Formule :C22H26Cl2N2O2Couleur et forme :SolidMasse moléculaire :421.36LZ-007
CAS :<p>LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.</p>Formule :C27H29F3N2O5Couleur et forme :SolidMasse moléculaire :518.53FXR agonist 11
CAS :<p>FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.</p>Formule :C18H16N2O5Couleur et forme :SolidMasse moléculaire :340.33Fexarene
CAS :<p>Fexarene is a non-steroidal FXR agonist.</p>Formule :C32H33NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.62LH10
<p>LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).</p>Formule :C34H33N3O2Couleur et forme :SolidMasse moléculaire :515.64FXR agonist 10
<p>FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.</p>Formule :C15H22O4Couleur et forme :SolidMasse moléculaire :266.33FXR/TGR5 agonist 1
CAS :<p>FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.</p>Formule :C31H32ClN3O3Couleur et forme :SolidMasse moléculaire :530.07FXR agonist 5
CAS :<p>FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.</p>Formule :C40H53N5O5Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :683.88Tauro-β-muricholic acid sodium
CAS :<p>Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).</p>Formule :C26H44NNaO7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.69Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidNR1H4 Protein, Mouse, Recombinant (His)
<p>NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :27.80 kDa (predicted)NR1H4 Protein, Human, Recombinant (His)
<p>NR1H4 Protein, Human, Recombinant (His) is expressed in E.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :27.83 kDa (predicted)NDB
CAS :<p>NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.</p>Formule :C26H28Cl2N2O2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :471.42FXR agonist 3
<p>FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.</p>Formule :C28H28BrNO4Degré de pureté :95.04%Couleur et forme :SolidMasse moléculaire :521.12Sevelamer hydrochloride
CAS :<p>Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption</p>Formule :(C3H7N·C3H5ClO·HCl)xDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :186.08
