LRRK2
Les inhibiteurs de LRRK2 sont des composés qui ciblent et inhibent l'activité de la Leucine-Rich Repeat Kinase 2 (LRRK2), une enzyme impliquée dans plusieurs processus cellulaires, y compris l'autophagie, le trafic vésiculaire et l'inflammation. Les mutations du gène LRRK2 sont associées à un risque accru de développer la maladie de Parkinson, ce qui fait de LRRK2 une cible importante pour la recherche sur les maladies neurodégénératives. Les inhibiteurs de LRRK2 sont essentiels pour explorer son rôle dans la maladie de Parkinson et pour développer des stratégies thérapeutiques potentielles. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de LRRK2 pour soutenir vos recherches en neurodégénérescence, signalisation des kinases et développement thérapeutique.
43 produits trouvés pour "LRRK2"
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MLi-2
CAS :MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.Formule :C21H25N5O2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :379.46Ref: TM-T16115
1mg55,00€2mg84,00€5mg126,00€10mg178,00€25mg409,00€50mg618,00€100mg880,00€1mL*10mM (DMSO)135,00€BIX 02565
CAS :BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Formule :C26H30N6O2Degré de pureté :97.44% - 99.7%Couleur et forme :SolidMasse moléculaire :458.56Ref: TM-T5428
1mg56,00€2mg79,00€5mg118,00€10mg177,00€25mgÀ demander50mgÀ demander1mL*10mM (DMSO)145,00€RN277
RN277 is an inhibitor of LRRK2 type II kinase (LRRK2type II kinase). It serves as a cellular tool targeting the inactive state of LRRK2. In vitro, RN277 inhibits LRRK1 kinase activity and the kinase activity of LRRK2, with an IC50 of 70 nM. Additionally, it reduces Rab8a phosphorylation in a dose-dependent manner. RN277 is useful for Parkinson's disease research.Couleur et forme :Odour SolidXL01126
XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.Formule :C50H64ClFN10O6S2Couleur et forme :SolidMasse moléculaire :1019.69JH-XII-03-02
CAS :JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PDFormule :C43H51N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :853.92Nictide
CAS :Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.Formule :C123H193N45O28Couleur et forme :SolidMasse moléculaire :2750.13RN341
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM). It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.Couleur et forme :Odour SolidEB-42486
CAS :EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Formule :C22H22N8ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :414.46Ref: TM-T39972
1mg66,00€2mg87,00€5mg147,00€10mg215,00€25mg388,00€50mg577,00€100mg820,00€200mg1.099,00€1mL*10mM (DMSO)161,00€CC-3240
CAS :CC-3240 (compound 13), a molecular glue degrader of CaMKK2 based on CC-8977, has an IC50 of 9 nM [1].Formule :C52H64N6O7SMasse moléculaire :917.17LRRK2 inhibitor 1
CAS :LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.Formule :C20H23N5O4Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :397.43Ref: TM-T11878
1mg74,00€2mg97,00€5mg160,00€10mg264,00€25mg557,00€50mg944,00€100mg1.491,00€1mL*10mM (DMSO)170,00€CZC-54252 hydrochloride
CAS :CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Formule :C22H26Cl2N6O4SDegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :541.45Ref: TM-T39202
5mg52,00€10mg75,00€25mg135,00€50mg215,00€100mg319,00€200mg449,00€1mL*10mM (DMSO)64,00€Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Couleur et forme :Odour LiquidPFE-360
CAS :PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
Formule :C16H16N6ODegré de pureté :98.14% - 99.73%Couleur et forme :SolidMasse moléculaire :308.34GNE-7915 tosylate
CAS :GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.Formule :C26H29F4N5O6SCouleur et forme :SolidMasse moléculaire :615.6CZC-25146 hydrochloride
CAS :CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
Formule :C22H26ClFN6O4SDegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :525LRRK2-IN-1
CAS :LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Formule :C31H38N8O3Degré de pureté :98% - 98.82%Couleur et forme :SolidMasse moléculaire :570.69HG-10-102-01
CAS :HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formule :C17H20ClN5O3Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :377.83Ref: TM-T7196
2mg35,00€5mg55,00€10mg89,00€25mg161,00€50mg250,00€100mg360,00€200mg512,00€1mL*10mM (DMSO)62,00€GNE0877
CAS :GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).Formule :C14H16F3N7Degré de pureté :98.01% - 99.97%Couleur et forme :SolidMasse moléculaire :339.32Ref: TM-T6031
1mg44,00€2mg57,00€5mg113,00€10mg177,00€25mg356,00€50mg532,00€100mg760,00€500mg1.558,00€1mL*10mM (DMSO)90,00€PF-06454589
CAS :PF-06454589 is a potent inhibitor of LRRK2.Formule :C14H16N6ODegré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :284.32Ref: TM-T7729
2mg34,00€5mg52,00€10mg75,00€25mg128,00€50mg187,00€100mg290,00€200mg419,00€1mL*10mM (DMSO)52,00€PF-06447475
CAS :PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Formule :C17H15N5ODegré de pureté :98.61% - 99.62%Couleur et forme :SolidMasse moléculaire :305.33
