Protéasome
Les inhibiteurs du protéasome sont des composés qui inhibent le protéasome, un grand complexe protéique responsable de la dégradation des protéines indésirables ou endommagées dans la cellule. L'inhibition du protéasome conduit à l'accumulation de protéines, ce qui peut induire l'arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules à division rapide comme les cellules cancéreuses. Les inhibiteurs du protéasome sont essentiels dans la recherche sur le cancer et la thérapie, en particulier dans le traitement du myélome multiple et d'autres hémopathies malignes. Chez CymitQuimica, nous proposons des inhibiteurs du protéasome pour soutenir vos recherches en oncologie, biologie cellulaire et développement de médicaments.
94 produits trouvés pour "Protéasome"
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Carfilzomib
CAS :<p>Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.</p>Formule :C40H57N5O7Degré de pureté :99.6% - 99.84%Couleur et forme :SolidMasse moléculaire :719.91MDL-28170
CAS :<p>MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.</p>Formule :C22H26N2O4Degré de pureté :95.06%Couleur et forme :SolidMasse moléculaire :382.45ISOGINKGETIN
CAS :<p>ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.</p>Formule :C32H22O10Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :566.51Oprozomib
CAS :<p>Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 - 36 nM; LMP7 - 82 nM.</p>Formule :C25H32N4O7SDegré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :532.61UAMC00039 dihydrochloride
CAS :<p>UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.</p>Formule :C16H26Cl3N3ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :382.76MUN57694
CAS :<p>MUN57694 is an inhibitor of 26S proteasome.</p>Formule :C23H25N3O4Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :407.46Saxagliptin
CAS :<p>Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.</p>Formule :C18H25N3O2Degré de pureté :99.17% - 99.95%Couleur et forme :SolidMasse moléculaire :315.41Tomatine
CAS :<p>Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.</p>Formule :C50H83NO21Degré de pureté :98.42% - 99.94%Couleur et forme :White To Light YellowMasse moléculaire :1034.19MG-101
CAS :<p>MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.</p>Formule :C20H37N3O4Degré de pureté :98% - ≥98%Couleur et forme :SolidMasse moléculaire :383.53Bortezomib-pinanediol
CAS :<p>Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.</p>Formule :C29H39BN4O4Degré de pureté :97.5%Couleur et forme :Yellow SolidMasse moléculaire :518.46DD1
CAS :<p>DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.</p>Formule :C16H14N2O3Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :282.29Tripterin
CAS :<p>Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.</p>Formule :C29H38O4Degré de pureté :98.56% - 99.8%Couleur et forme :Red Crystalline PowderMasse moléculaire :450.61Cilastatin
CAS :<p>Cilastatin (MK0791): protects imipenem from renal breakdown; inhibits leukotriene D4 metabolism.</p>Formule :C16H26N2O5SDegré de pureté :97.76% - 99.71%Couleur et forme :SolidMasse moléculaire :358.45Proteasome inhibitor IX
CAS :<p>Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).</p>Formule :C20H21B2NO5Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :377.01VR23
CAS :<p>VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.</p>Formule :C19H16ClN5O6SDegré de pureté :98.99% - 99.22%Couleur et forme :SolidMasse moléculaire :477.88Anagliptin
CAS :<p>Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.</p>Formule :C19H25N7O2Degré de pureté :97.59% - 99.98%Couleur et forme :SolidMasse moléculaire :383.45Ixazomib
CAS :<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Formule :C14H19BCl2N2O4Degré de pureté :98% - 98.92%Couleur et forme :SolidMasse moléculaire :361.03Trelagliptin succinate
CAS :<p>Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (</p>Formule :C22H26FN5O6Degré de pureté :99.27% - 99.92%Couleur et forme :SolidMasse moléculaire :475.47(R)-MG-132
CAS :<p>(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.</p>Formule :C26H41N3O5Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :475.62Delanzomib
CAS :<p>Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.</p>Formule :C21H28BN3O5Degré de pureté :95.52% - 99.46%Couleur et forme :SolidMasse moléculaire :413.28Sitagliptin phosphate monohydrate
CAS :<p>Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.</p>Formule :C16H15F6N5O·H3PO4·H2ODegré de pureté :99.85% - 99.98%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :523.33KZR-504
CAS :KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Formule :C21H23N3O6Couleur et forme :SolidMasse moléculaire :413.42Diprotin B
CAS :<p>Diprotin B is a dipeptidyl peptidase IV inhibitor.</p>Formule :C16H29N3O4Degré de pureté :98%Couleur et forme :White Lyophilized PowderMasse moléculaire :327.42Gemigliptin Tartrate(911637-19-9 free base)
CAS :<p>Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4).</p>Formule :C22H25F8N5O8Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :639.45BC-23
CAS :<p>BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.</p>Formule :C21H14ClN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.87Z-LLF-CHO
CAS :<p>Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.</p>Formule :C29H39N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.64Proteasome-IN-1
CAS :<p>Proteasome-IN-1 is an inhibitor of proteasome.</p>Formule :C42H35N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :657.7620S Proteasome activator 1
CAS :<p>20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.</p>Formule :C27H19ClF2N2OSDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :492.97Gemigliptin
CAS :<p>Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)</p>Formule :C18H19F8N5O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :489.36Arimoclomol
CAS :<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Formule :C14H20ClN3O3Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :313.78Proteasome-IN-5
CAS :<p>Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].</p>Formule :C20H30BN5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.29Proteasome β2c/i-IN-1
CAS :<p>Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].</p>Formule :C32H48N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.75LU-002i
CAS :<p>LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].</p>Formule :C35H52N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :640.81TCL1
CAS :<p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>Formule :C19H14BrClN4O2SCouleur et forme :SolidMasse moléculaire :477.762ZINC09518833
CAS :<p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47RBx-0597
CAS :<p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>Formule :C19H20F2N4O2Couleur et forme :SolidMasse moléculaire :374.384(2S,4R)-Teneligliptin
CAS :<p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>Formule :C22H30N6OSCouleur et forme :SolidMasse moléculaire :426.578DPP-4-IN-15
CAS :<p>DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.</p>Formule :C17H14F3N3O2SCouleur et forme :SolidMasse moléculaire :381.372Boc3Arg
<p>Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.</p>Formule :C21H39N5O7Couleur et forme :SolidMasse moléculaire :473.56Marizomib
CAS :<p>Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.</p>Formule :C15H20ClNO4Degré de pureté :98.03% - 99.41%Couleur et forme :SolidMasse moléculaire :313.78Immunoproteasome activator 1
CAS :Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.46PB01
CAS :<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Formule :C18H21N5O3Couleur et forme :SolidMasse moléculaire :355.391BI-1942
CAS :<p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>Formule :C24H26N4O4Couleur et forme :SolidMasse moléculaire :434.488Davelizomib
CAS :<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H26BF2N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.25
