Cystéine protéase
Les inhibiteurs de protéases à cystéine sont des composés qui ciblent et inhibent les protéases à cystéine, une classe d'enzymes qui décomposent les protéines en clivant les liaisons peptidiques dans lesquelles un résidu de cystéine agit comme nucléophile. Ces enzymes sont impliquées dans divers processus physiologiques, tels que l'apoptose, la réponse immunitaire et le renouvellement des protéines. Les inhibiteurs de protéases à cystéine sont essentiels pour l'étude de maladies telles que le cancer, les troubles neurodégénératifs et les infections parasitaires. Chez CymitQuimica, nous fournissons des inhibiteurs de protéases à cystéine pour soutenir vos recherches en protéolyse, régulation cellulaire et découverte de médicaments.
96 produits trouvés pour "Cystéine protéase"
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Cathepsin L-IN-3
CAS :<p>Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.</p>Formule :C41H49N7O4SCouleur et forme :SolidMasse moléculaire :735.94Z-Leu-Tyr-Chloromethylketone
CAS :<p>Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].</p>Formule :C24H29ClN2O5Couleur et forme :SolidMasse moléculaire :460.95Z-Arg-Arg-βNA acetate
CAS :<p>Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.</p>Formule :C32H43N9O6Couleur et forme :SolidMasse moléculaire :649.74Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
<p>Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.</p>Couleur et forme :Odour SolidGallinamide A TFA
CAS :<p>Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].</p>Formule :C33H53F3N4O9Couleur et forme :SolidMasse moléculaire :706.79Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Couleur et forme :Odour SolidCathepsin D and E FRET Substrate
CAS :Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Formule :C85H122N22O19Couleur et forme :SolidMasse moléculaire :1756.046Hepcidin-1 (mouse)
CAS :<p>Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.</p>Formule :C111H169N31O35S8Couleur et forme :SolidMasse moléculaire :2754.24N-CBZ-Phe-Arg-AMC
CAS :<p>Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.</p>Formule :C33H36N6O6Degré de pureté :98%Couleur et forme :White To Off-White PowderMasse moléculaire :612.68FGA139
<p>FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.</p>Formule :C48H58BF2N7O5Couleur et forme :SolidMasse moléculaire :861.45605Relacatib
CAS :<p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>Formule :C27H32N4O6SCouleur et forme :SolidMasse moléculaire :540.64Z-FG-NHO-Bz
CAS :<p>Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].</p>Formule :C26H25N3O6Couleur et forme :SolidMasse moléculaire :475.49Cathepsin C-IN-6
<p>Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase</p>Formule :C24H35N5O4·xC2HF3O2Couleur et forme :SolidLeupeptin
CAS :<p>Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.</p>Formule :C20H38N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.562N-CBZ-Phe-Arg-AMC TFA
<p>N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.</p>Formule :C35H37F3N6O8Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :726.7VK13
<p>VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.</p>Formule :C24H28N4O5Couleur et forme :SolidMasse moléculaire :452.5036,6′-Dihydroxythiobinupharidine
CAS :<p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>Formule :C30H42N2O4SCouleur et forme :SolidMasse moléculaire :526.73Z-L(D-Val)G-CHN2
<p>Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.</p>Formule :C22H31N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.51Z-Phe-Tyr(tBu)-diazomethylketone
CAS :<p>Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.</p>Formule :C31H34N4O5Couleur et forme :SolidMasse moléculaire :542.636Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Couleur et forme :Odour Solid
