Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1428 produits trouvés pour "Autophagie"
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Torkinib
CAS :<p>Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).</p>Formule :C16H16N6ODegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :308.34yangonin
CAS :<p>Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.</p>Formule :C15H14O4Degré de pureté :98.82% - 99.55%Couleur et forme :Pale Yellow PowderMasse moléculaire :258.27Andrographolide
CAS :<p>Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential</p>Formule :C20H30O5Degré de pureté :99.39% - 99.97%Couleur et forme :PowderMasse moléculaire :350.45Pogostone
CAS :<p>Pogostone: anti-bacterial/fungal, blocks T-cells, modulates cytokines, protects against gastric ulcers, boosts antioxidants/PGE2/NP-SH.</p>Formule :C12H16O4Degré de pureté :98.46% - 99.03%Couleur et forme :SolidMasse moléculaire :224.25PFK-015
CAS :<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>Formule :C17H12N2ODegré de pureté :99.7% - 99.85%Couleur et forme :SolidMasse moléculaire :260.29Saracatinib
CAS :<p>Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.</p>Formule :C27H32ClN5O5Degré de pureté :98% - 99.63%Couleur et forme :SolidMasse moléculaire :542.03Linifanib
CAS :<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Formule :C21H18FN5ODegré de pureté :98% - 98.24%Couleur et forme :SolidMasse moléculaire :375.4Ginkgetin
CAS :<p>Ginkgetin: antiviral, antifungal, anti-inflammatory; COX-2 reducer; STAT3 inhibitor; pro-apoptotic in cancer; neuroprotective in Parkinson's.</p>Formule :C32H22O10Degré de pureté :98.63% - 99.94%Couleur et forme :SolidMasse moléculaire :566.51DC661
CAS :<p>DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.</p>Formule :C31H39Cl2N5Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :552.58PF-04691502
CAS :<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formule :C22H27N5O4Degré de pureté :96.27% - ≥95%Couleur et forme :SolidMasse moléculaire :425.48GW786034B
CAS :<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Formule :C21H23N7O2S·HClDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :473.98Rilmenidine Phosphate
CAS :<p>Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.</p>Formule :C10H19N2O5PDegré de pureté :99.87% - ≥95%Couleur et forme :SolidMasse moléculaire :278.24Samotolisib
CAS :<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formule :C23H26N4O3Degré de pureté :98.41% - 99.69%Couleur et forme :SolidMasse moléculaire :406.48Cabazitaxel
<p>Cabazitaxel (XRP6258) is a taxane used for castration-resistant metastatic prostate cancer post-docetaxel failure.</p>Formule :C45H57NO14Degré de pureté :98% - 99.93%Couleur et forme :SolidMasse moléculaire :835.93Topotecan
CAS :<p>Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.</p>Formule :C23H23N3O5Degré de pureté :96.14% - 98.23%Couleur et forme :Light Yellow Needle Crystal Or Crystalline PowderMasse moléculaire :421.45Oroxin B
CAS :<p>Oroxin B (Hypocretin-2) has antioxidant activity.</p>Formule :C27H30O15Degré de pureté :98.22% - 99.81%Couleur et forme :SolidMasse moléculaire :594.52Neferine
CAS :<p>Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.</p>Formule :C38H44N2O6Degré de pureté :98.81% - 99.65%Couleur et forme :SolidMasse moléculaire :624.77Betulinic acid
CAS :<p>Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.</p>Formule :C30H48O3Degré de pureté :99.12% - 99.7%Couleur et forme :White Crystalline PowderMasse moléculaire :456.7Isoalantolactone
CAS :<p>Isoalantolactone (Isohelenin), isolated from Inula spp., can inhibit the growth of several types of Y cells.</p>Formule :C15H20O2Degré de pureté :99.75% - 99.94%Couleur et forme :SolidMasse moléculaire :232.32Carbamazepine
CAS :<p>Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.</p>Formule :C15H12N2ODegré de pureté :99.78% - 99.79%Couleur et forme :SolidMasse moléculaire :236.27Metformin
CAS :<p>Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability.</p>Formule :C4H11N5Degré de pureté :99.77% - >99.99%Couleur et forme :SolidMasse moléculaire :129.16Vandetanib
CAS :<p>Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM). It also inhibits VEGFR3 and EGFR.</p>Formule :C22H24BrFN4O2Degré de pureté :99.7% - >99.99%Couleur et forme :White SolidMasse moléculaire :475.35Calcimycin
CAS :<p>Calcimycin (A-23187) is a polyether antibiotic that transports Ca²⁺, uncouples phosphorylation, and inhibits ATPase in mitochondria.</p>Formule :C29H37N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.62ABT-737
CAS :<p>ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits antitumor activity and anti-aging activity. Cost-effective and quality-assured.</p>Formule :C42H45ClN6O5S2Degré de pureté :98.15% - >99.99%Couleur et forme :SolidMasse moléculaire :813.43Brefeldin A
CAS :<p>Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM).</p>Formule :C16H24O4Degré de pureté :96.45% - 99.89%Couleur et forme :White SolidMasse moléculaire :280.36Schisandrol B
CAS :<p>Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.</p>Formule :C23H28O7Degré de pureté :99.14% - 99.95%Couleur et forme :SolidMasse moléculaire :416.46Diosgenin glucoside
CAS :<p>Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis</p>Formule :C33H52O8Degré de pureté :97.17% - 99.44%Couleur et forme :SolidMasse moléculaire :576.76MK-2206 dihydrochloride
CAS :<p>MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and</p>Formule :C25H23Cl2N5ODegré de pureté :99.228% - 99.94%Couleur et forme :SolidMasse moléculaire :480.39Tubastatin A
CAS :<p>Tubastatin A: Selective HDAC6 inhibitor, IC50 of 15 nM, 1000x less effective on other isozymes except HDAC8.</p>Formule :C20H21N3O2Degré de pureté :97.22% - 99.51%Couleur et forme :SolidMasse moléculaire :335.4Indomethacin farnesil
CAS :<p>Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.</p>Formule :C34H40ClNO4Degré de pureté :97.29%Couleur et forme :SolidMasse moléculaire :562.14Alisertib
CAS :<p>Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.</p>Formule :C27H20ClFN4O4Degré de pureté :98.31% - >99.99%Couleur et forme :SolidMasse moléculaire :518.92LC3-mHTT-IN-AN1
CAS :<p>LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.</p>Formule :C15H9Br2NO3Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :411.04SB 202190
CAS :<p>SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.</p>Formule :C20H14FN3ODegré de pureté :98% - 99.84%Couleur et forme :Pale YellowMasse moléculaire :331.34CaMKII-IN-1
CAS :<p>CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM).</p>Formule :C29H30ClN5O2SDegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :548.1Dihydromyricetin
CAS :<p>Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.</p>Formule :C15H12O8Degré de pureté :96.68% - 98.229%Couleur et forme :SolidMasse moléculaire :320.25Rasagiline Mesylate
CAS :<p>Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.</p>Formule :C13H17NO3SDegré de pureté :99.33%Couleur et forme :White PowderMasse moléculaire :267.34Typhaneoside
CAS :<p>Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.</p>Formule :C34H42O20Degré de pureté :98.92% - 99.95%Couleur et forme :SolidMasse moléculaire :770.69sbp-7455
CAS :<p>SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.</p>Formule :C16H17F3N4O2Degré de pureté :97.90% - 99.842%Couleur et forme :SolidMasse moléculaire :354.33BC1618
CAS :<p>BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.</p>Formule :C24H24F3NO2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :415.45Obeticholic Acid
CAS :<p>Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.</p>Formule :C26H44O4Degré de pureté :99.88% - 99.97%Couleur et forme :SolidMasse moléculaire :420.63JZL195
CAS :<p>JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.</p>Formule :C24H23N3O5Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :433.46MHY1485
CAS :<p>MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.</p>Formule :C17H21N7O4Degré de pureté :97.74% - >99.99%Couleur et forme :SolidMasse moléculaire :387.39Oleanolic Acid
CAS :<p>Oleanolic Acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.</p>Formule :C30H48O3Degré de pureté :97.04% - 98.51%Couleur et forme :SolidMasse moléculaire :456.7Pseudolaric Acid B
CAS :<p>Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.</p>Formule :C23H28O8Degré de pureté :98.91% - 99.84%Couleur et forme :SolidMasse moléculaire :432.463BDO
CAS :<p>3BDO is a new mTOR activator. 3BDO inhibits autophagy.</p>Formule :C18H17NO5Degré de pureté :97.76%Couleur et forme :SolidMasse moléculaire :327.33(-)-Epicatechin gallate
CAS :<p>(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.</p>Formule :C22H18O10Degré de pureté :99.16% - 99.93%Couleur et forme :SolidMasse moléculaire :442.37Ethyl 3,4-dihydroxybenzoate
CAS :<p>Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.</p>Formule :C9H10O4Degré de pureté :99.88%Couleur et forme :White Crystal Or PowderMasse moléculaire :182.17Ponatinib
CAS :<p>Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively</p>Formule :C29H27F3N6ODegré de pureté :98% - 99.60%Couleur et forme :SolidMasse moléculaire :532.56JNJ-42165279
CAS :<p>JNJ-42165279 selectively inactivates FAAH without notably affecting other enzymes, ion channels, receptors, or CYPs/hERG at 10 μM.</p>Formule :C18H17ClF2N4O3Degré de pureté :99.67% - 99.88%Couleur et forme :SolidMasse moléculaire :410.8Galangin
CAS :<p>Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.</p>Formule :C15H10O5Degré de pureté :98.24% - 99.93%Couleur et forme :Yellowish Needle-Like CrystalMasse moléculaire :270.24
