Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1428 produits trouvés pour "Autophagie"
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Meglutol
CAS :<p>Meglutol, a cholesterol and triglyceride reducing antilipemic, hinders key enzymes in cholesterol biosynthesis.</p>Formule :C6H10O5Degré de pureté :99.73% - 99.94%Couleur et forme :SolidMasse moléculaire :162.14MRT68921 dihydrochloride
CAS :<p>MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).</p>Formule :C25H36Cl2N6ODegré de pureté :98.91% - 99.92%Couleur et forme :SolidMasse moléculaire :507.499PH-797804
CAS :<p>PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.</p>Formule :C22H19BrF2N2O3Degré de pureté :97.90% - 98.27%Couleur et forme :SolidMasse moléculaire :477.34,4'-Dimethoxychalcone
CAS :<p>4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product.</p>Formule :C17H16O3Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :268.31Hoechst 33342 trihydrochloride
CAS :<p>Hoechst 33342 trihydrochloride (bisBenzimide H 33342 trihydrochloride;HOE 33342 trihydrochloride) is a membrane permeant DNA stain with blue fluorescence.</p>Formule :C27H31Cl3N6ODegré de pureté :98.73% - ≥98%Couleur et forme :SolidMasse moléculaire :561.93Ixazomib citrate
CAS :<p>Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).</p>Formule :C20H23BCl2N2O9Degré de pureté :98.37% - >99.99%Couleur et forme :SolidMasse moléculaire :517.12MG-132
CAS :<p>MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!</p>Formule :C26H41N3O5Degré de pureté :95% - 99.99%Couleur et forme :White To Off-White PowderMasse moléculaire :475.62Vps34-IN-1
CAS :<p>Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.</p>Formule :C21H24ClN7ODegré de pureté :97.04%Couleur et forme :SolidMasse moléculaire :425.91SAR405
CAS :<p>SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.</p>Formule :C19H21ClF3N5O2Degré de pureté :99.42% - 99.79%Couleur et forme :SolidMasse moléculaire :443.85Vacuolin-1
CAS :<p>Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.</p>Formule :C26H24IN7ODegré de pureté :97.20% - 98.45%Couleur et forme :SolidMasse moléculaire :577.42AZ304
CAS :<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Formule :C27H25N5O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :451.52KB-R7943 mesylate
CAS :<p>KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM.</p>Formule :C17H21N3O6S2Degré de pureté :99.88% - ≥95%Couleur et forme :SolidMasse moléculaire :427.5Briciclib
CAS :<p>Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.</p>Formule :C19H23O10PSDegré de pureté :98% - 99.84%Couleur et forme :SolidMasse moléculaire :474.42Hoechst 33342
CAS :<p>Hoechst 33342 (bisBenzimide H 33342) is a benzimidazole fluorescent dye and a cell-permeable fluorescent DNA dye. High-Quality, Low-Cost!</p>Formule :C27H28N6ODegré de pureté :98.12% - 99.75%Couleur et forme :Yellow-Green PowderMasse moléculaire :452.55Brevilin A
CAS :<p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>Formule :C20H26O5Degré de pureté :99.97% - >99.99%Couleur et forme :SolidMasse moléculaire :346.42Isradipine
CAS :<p>Isradipine (PN 200-110), a dihydropyridine, is an antihypertensive calcium channel blocker that dilates arteries and reduces resistance.</p>Formule :C19H21N3O5Degré de pureté :99.84% - 99.95%Couleur et forme :Yellow SolidMasse moléculaire :371.39Actein
CAS :<p>Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.</p>Formule :C37H56O11Degré de pureté :≥98%Couleur et forme :Brown PowderMasse moléculaire :676.83Tempol
CAS :<p>Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.</p>Formule :C9H18NO2Degré de pureté :97% - 99.74%Couleur et forme :4-Hydroxy-Tempo Appears As Orange Flakes Solid FlakesMasse moléculaire :172.25Peretinoin
CAS :<p>Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.</p>Formule :C20H30O2Degré de pureté :97.23%Couleur et forme :SolidMasse moléculaire :302.45LC3-mHTT-IN-AN2
CAS :<p>LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.</p>Formule :C15H10O4Degré de pureté :98.82% - ≥98%Couleur et forme :SolidMasse moléculaire :254.24Rabusertib
CAS :<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Formule :C18H22BrN5O3Degré de pureté :98.86% - 99.87%Couleur et forme :SolidMasse moléculaire :436.3SN-38
CAS :<p>SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).</p>Formule :C22H20N2O5Degré de pureté :98% - 99.97%Couleur et forme :Light-Yellow SolidMasse moléculaire :392.4AM580
CAS :<p>AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )</p>Formule :C22H25NO3Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :351.44AS1842856
CAS :<p>AS1842856 is a Foxo1 inhibitor that blocks the transcriptional activity of Foxo1. AS1842856 has autophagy inhibitory activity. Cost-effective and quality-assured.</p>Formule :C18H22FN3O3Degré de pureté :99.36% - >99.99%Couleur et forme :SolidMasse moléculaire :347.38DMH-1
CAS :<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Formule :C24H20N4ODegré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :380.44SP600125
CAS :<p>SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive</p>Formule :C14H8N2ODegré de pureté :97.63% - 99.82%Couleur et forme :SolidMasse moléculaire :220.23Pexmetinib
CAS :<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Formule :C31H33FN6O3Degré de pureté :99.07% - 99.66%Couleur et forme :SolidMasse moléculaire :556.63Vps34-IN-4
CAS :<p>VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)</p>Formule :C21H25N7ODegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :391.47Bakuchiol
CAS :<p>Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.</p>Formule :C18H24ODegré de pureté :98.04% - 99.05%Couleur et forme :Brownish Yellow Liquid ViscousMasse moléculaire :256.38XCT790
CAS :<p>XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).</p>Formule :C23H13F9N4O3SDegré de pureté :99% - 99.61%Couleur et forme :SolidMasse moléculaire :596.4220-DEOXYINGENOL
CAS :<p>20-DEOXYINGENOL is a natual product.</p>Formule :C20H28O4Degré de pureté :99.98% - ≥95%Couleur et forme :SolidMasse moléculaire :332.43Nobiletin
CAS :<p>Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.</p>Formule :C21H22O8Degré de pureté :98.65% - 99.76%Couleur et forme :SolidMasse moléculaire :402.39U0126
CAS :<p>U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.</p>Formule :C18H16N6S2Degré de pureté :99.61%Couleur et forme :White SolidMasse moléculaire :380.49Torin 1
CAS :<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formule :C35H28F3N5O2Degré de pureté :98.3% - 99.33%Couleur et forme :SolidMasse moléculaire :607.62Clinofibrate
CAS :<p>Clinofibrate lowers lipids, blocks HMGCR (IC50: 0.47 mM), and controls cholesterol/triacylglycerides.</p>Formule :C28H36O6Degré de pureté :>99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :468.58Alginic acid
CAS :<p>Alginic acid, a polysaccharide from brown seaweed, has anti-anaphylactic and anti-inflammatory properties and is used in food industry.</p>Formule :C14H22O13Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :398.317IKK 16
CAS :<p>IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.</p>Formule :C28H29N5OSDegré de pureté :98.76% - 99.61%Couleur et forme :SolidMasse moléculaire :483.63Tetrahydrocurcumin
CAS :<p>Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.</p>Formule :C21H24O6Degré de pureté :97.81% - 98.82%Couleur et forme :Solid PowderMasse moléculaire :372.41Salbutamol hemisulfate
CAS :<p>Salbutamol hemisulfate (Albuterol Sulfate) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 μM.</p>Formule :C13H21NO3H2O4SDegré de pureté :99.35%Couleur et forme :White Or Almost White Odourless PowderMasse moléculaire :576.70Lonafarnib
CAS :<p>Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).</p>Formule :C27H31Br2ClN4O2Degré de pureté :98% - 99.94%Couleur et forme :SolidMasse moléculaire :638.82Acumapimod
CAS :<p>Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).</p>Formule :C22H19N5O2Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :385.42Lithocholic acid
CAS :<p>Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a toxic secondary bile acid, They were FXR antagonists (IC50=0.7, 1.4 μM). High-Quality, Low-Cost!</p>Formule :C24H40O3Degré de pureté :99.69% - 99.93%Couleur et forme :Hexagonal Leaflets From Alc Prisms From Acetic Acid Powder (Ntp 1992)Masse moléculaire :376.57Scutellarein
CAS :<p>Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.</p>Formule :C15H10O6Degré de pureté :98.02% - 99.63%Couleur et forme :SolidMasse moléculaire :286.24Vancomycin
CAS :<p>Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibiting</p>Formule :C66H75Cl2N9O24Degré de pureté :98.76% - 99.35%Couleur et forme :Almost White PowderMasse moléculaire :1449.25URB-597
CAS :<p>URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.</p>Formule :C20H22N2O3Degré de pureté :97.20% - 98.24%Couleur et forme :SolidMasse moléculaire :338.4Tropifexor
CAS :<p>Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.</p>Formule :C29H25F4N3O5SDegré de pureté :99.3% - 99.85%Couleur et forme :SolidMasse moléculaire :603.58TG101209
CAS :<p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>Formule :C26H35N7O2SDegré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :509.67Pifithrin-μ
CAS :<p>Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.</p>Formule :C8H7NO2SDegré de pureté :99.33% - 99.79%Couleur et forme :SolidMasse moléculaire :181.21Valinomycin
CAS :<p>Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin</p>Formule :C54H90N6O18Degré de pureté :95.37% - 97.16%Couleur et forme :White SolidMasse moléculaire :1111.32Eupatilin
CAS :<p>Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.</p>Formule :C18H16O7Degré de pureté :98.53% - 99%Couleur et forme :SolidMasse moléculaire :344.32
