Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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(E/Z)-GSK-3β inhibitor 1
CAS :<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :222.24ZSTK474
CAS :<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formule :C19H21F2N7O2Degré de pureté :98.29% - 99.95%Couleur et forme :White PowderMasse moléculaire :417.41mTOR inhibitor-1
CAS :<p>C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.</p>Formule :C16H15BrN2O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :363.21Tyrphostin 23
CAS :<p>Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.</p>Formule :C10H6N2O2Degré de pureté :99.7% - 99.86%Couleur et forme :Yellow-Tan SolidMasse moléculaire :186.17Dacomitinib hydrate
CAS :<p>Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of</p>Formule :C24H27ClFN5O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :487.96Neratinib
CAS :<p>Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.</p>Formule :C30H29ClN6O3Degré de pureté :96.17% - 99.85%Couleur et forme :SolidMasse moléculaire :557.04Almonertinib
CAS :<p>Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.</p>Formule :C30H35N7O2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :525.64AZD8931 diFuMaric acid
CAS :<p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>Formule :C31H33ClFN5O11Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :706.1VP3.15 dihydrobromide
CAS :<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Formule :C20H24Br2N4OSDegré de pureté :99.67% - ≥95%Couleur et forme :SolidMasse moléculaire :528.3KenPaullone
CAS :<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formule :C16H11BrN2ODegré de pureté :97.14% - 98.99%Couleur et forme :Tan SolidMasse moléculaire :327.18MHY1485
CAS :<p>MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.</p>Formule :C17H21N7O4Degré de pureté :97.74% - >99.99%Couleur et forme :SolidMasse moléculaire :387.39CC-115 hydrochloride
CAS :<p>CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.</p>Formule :C16H17ClN8OCouleur et forme :SolidMasse moléculaire :372.82PIK-108
CAS :<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Formule :C22H24N2O3Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :364.44SB 415286
CAS :<p>SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.</p>Formule :C16H10ClN3O5Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :359.72AG-494
CAS :<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Formule :C16H12N2O3Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :280.28PD158780
CAS :<p>PD 158780 blocks all ErbB receptors: EGFR, ErbB2-4, with IC50s: 8μM, 49-52 nM.</p>Formule :C14H12BrN5Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :330.18PI3K-IN-1
CAS :<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Formule :C31H29N5O6SDegré de pureté :97.03% - 98%Couleur et forme :SolidMasse moléculaire :599.66JCN037
CAS :<p>JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).</p>Formule :C16H11BrFN3O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :376.18Torin 1
CAS :<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formule :C35H28F3N5O2Degré de pureté :98.3% - 99.33%Couleur et forme :SolidMasse moléculaire :607.62Torin 2
CAS :<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Formule :C24H15F3N4ODegré de pureté :98.31% - 99.32%Couleur et forme :SolidMasse moléculaire :432.4Idelalisib
CAS :<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formule :C22H18FN7ODegré de pureté :98% - 99.39%Couleur et forme :SolidMasse moléculaire :415.42ARN-3236
CAS :<p>ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM</p>Formule :C19H16N2O2SDegré de pureté :98.89% - 99.7%Couleur et forme :SolidMasse moléculaire :336.41Dorsomorphin dihydrochloride
CAS :<p>Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on</p>Formule :C24H25N5O·2HClDegré de pureté :97.74% - 99.89%Couleur et forme :SolidMasse moléculaire :472.41PS 48
CAS :<p>PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).</p>Formule :C17H15ClO2Degré de pureté :99.96% - ≥95%Couleur et forme :SolidMasse moléculaire :286.75BpV(HOpic)
CAS :<p>BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).</p>Formule :C6H4K2NO8VDegré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :347.24KY19382
CAS :<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formule :C17H11Cl2N3O2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :360.19PQR620
CAS :<p>PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.</p>Formule :C21H25F2N7O2Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :445.47Tesevatinib
CAS :<p>Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formule :C24H25Cl2FN4O2Degré de pureté :97.89% - 98.66%Couleur et forme :SolidMasse moléculaire :491.39TDZD-8
CAS :<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formule :C10H10N2O2SDegré de pureté :97.13% - 99.61%Couleur et forme :White SolidMasse moléculaire :222.26HTH-01-015
CAS :<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Formule :C26H28N8ODegré de pureté :98.38% - 99.70%Couleur et forme :SolidMasse moléculaire :468.55AG 1406
CAS :<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formule :C16H18N2ODegré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :254.33ZD-4190
CAS :<p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>Formule :C19H16BrFN6O2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :459.27PP 3
CAS :<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Formule :C11H9N5Degré de pureté :98.61%Couleur et forme :Whit To Off-White SolidMasse moléculaire :211.22TAS6417
CAS :<p>Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formule :C23H20N6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :396.44Derazantinib dihydrochloride
CAS :<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formule :C29H31Cl2FN4OCouleur et forme :SolidMasse moléculaire :541.494-Chloro-2'-bromoacetophenone
CAS :<p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>Formule :C8H6BrClODegré de pureté :98.34% - 99.41%Couleur et forme :White To Beige SolidMasse moléculaire :233.49WHI-P180
CAS :<p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>Formule :C16H15N3O3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :297.31MAZ51
CAS :<p>MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.</p>Formule :C21H18N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :314.38TG 100713
CAS :<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Formule :C12H10N6ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :254.25AZD2858
CAS :<p>AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.</p>Formule :C21H23N7O3SDegré de pureté :98% - 99.25%Couleur et forme :SolidMasse moléculaire :453.52AMG319
CAS :<p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.</p>Formule :C21H16FN7Degré de pureté :98.9% - 99.24%Couleur et forme :Crystalline SolidMasse moléculaire :385.4AZD-7648
CAS :<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formule :C18H20N8O2Degré de pureté :99.03% - 99.85%Couleur et forme :SolidMasse moléculaire :380.4CP21R7
CAS :<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Formule :C19H15N3O2Degré de pureté :96.14% - 99.16%Couleur et forme :SolidMasse moléculaire :317.34CL-387785
CAS :<p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>Formule :C18H13BrN4ODegré de pureté :99.56% - 99.62%Couleur et forme :SolidMasse moléculaire :381.23SYR127063
CAS :<p>SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.</p>Formule :C23H20ClF3N4O3Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :492.88CP-724714
CAS :<p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>Formule :C27H27N5O3Degré de pureté :97.1% - 98.82%Couleur et forme :SolidMasse moléculaire :469.54AZ7550
CAS :<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.58NRC-2694 hydrochloride
CAS :<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formule :C24H27ClN4O3Couleur et forme :SolidMasse moléculaire :454.95PKD-IN-1 dihydrochloride (956121-30-5 free base)
CAS :<p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>Formule :C18H21Cl3N4ODegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :415.75WHI-P154
CAS :<p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>Formule :C16H14BrN3O3Degré de pureté :98% - 99.67%Couleur et forme :SolidMasse moléculaire :376.2MK-3903
CAS :<p>MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).</p>Formule :C27H19ClN2O3Degré de pureté :98.63% - 99.75%Couleur et forme :SolidMasse moléculaire :454.9GNE-477
CAS :<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Formule :C21H28N8O3S2Degré de pureté :98.88% - 99.55%Couleur et forme :SolidMasse moléculaire :504.63Olmutinib
CAS :<p>Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor</p>Formule :C26H26N6O2SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :486.59Gallein
CAS :<p>Gallein (Mordant violet 25) is a small molecule inhibitor of Gβγ activity.</p>Formule :C20H12O7Degré de pureté :85.50% - 95.94%Couleur et forme :SolidMasse moléculaire :364.31(E)-AG 99
CAS :<p>(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).</p>Formule :C10H8N2O3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :204.18Theliatinib tartrate
CAS :<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formule :C29H32N6O8Couleur et forme :SolidMasse moléculaire :592.6Selective PI3Kδ Inhibitor 1
CAS :<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Formule :C23H20FN7ODegré de pureté :97.96%Couleur et forme :SolidMasse moléculaire :429.45ETP-45658
CAS :<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Formule :C16H17N5O2Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :311.34WS6
CAS :<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formule :C29H31F3N6O3Degré de pureté :97.65% - 99.95%Couleur et forme :SolidMasse moléculaire :568.59AZ-5104
CAS :<p>AZ5104 is a potent EGFR inhibitor.</p>Formule :C27H31N7O2Degré de pureté :98.40% - 99.59%Couleur et forme :Solid PowderMasse moléculaire :485.58PD-161570
CAS :<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Formule :C26H35Cl2N7ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :532.51Indirubin-3′-oxime
CAS :<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Formule :C16H11N3O2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :277.28Endoxifen (Z-isomer)
CAS :<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Formule :C25H27NO2Degré de pureté :99.19% - 99.81%Couleur et forme :SolidMasse moléculaire :373.49Voxtalisib
CAS :<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formule :C13H14N6ODegré de pureté :98.21% - 99.69%Couleur et forme :SolidMasse moléculaire :270.29Tyrphostin A9
CAS :<p>Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor</p>Formule :C18H22N2ODegré de pureté :98.21% - 99.87%Couleur et forme :Yellow SolidMasse moléculaire :282.38R547
CAS :<p>R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.</p>Formule :C18H21F2N5O4SDegré de pureté :90% - 99.64%Couleur et forme :SolidMasse moléculaire :441.45(S)-Sunvozertinib
CAS :<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08Autophinib
CAS :<p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>Formule :C14H11ClN6O3Degré de pureté :99.25% - 99.41%Couleur et forme :SolidMasse moléculaire :346.73O-304
CAS :<p>O-304 is a pan-activator of AMP-activated protein kinase (AMPK).</p>Formule :C16H11Cl2N3O2SDegré de pureté :99.84% - ≥98%Couleur et forme :SolidMasse moléculaire :380.255-Bromoindole
CAS :<p>5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate</p>Formule :C8H6BrNDegré de pureté :99.99%Couleur et forme :White To Beige Crystalline PowderMasse moléculaire :196.04BEBT-908
CAS :<p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>Formule :C23H25N9O3SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :507.57AEE788
CAS :<p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>Formule :C27H32N6Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :440.58iMDK
CAS :<p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>Formule :C21H13FN2O2SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :376.4Lazertinib
CAS :<p>Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.</p>Formule :C30H34N8O3Degré de pureté :98.7% - 99.90%Couleur et forme :SolidMasse moléculaire :554.64AG490
CAS :<p>AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>Formule :C17H14N2O3Degré de pureté :98.6% - 99.39%Couleur et forme :Yellow SolidMasse moléculaire :294.3Sapanisertib
CAS :<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Formule :C15H15N7ODegré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :309.33GDC-0326
CAS :<p>GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).</p>Formule :C19H22N6O3Degré de pureté :99.35% - >99.99%Couleur et forme :SolidMasse moléculaire :382.42β-Hydroxyisovalerylshikonin
CAS :<p>Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor</p>Formule :C21H24O7Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :388.41Vps34-PIK-III
CAS :<p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>Formule :C17H17N7Degré de pureté :98.39% - 98.43%Couleur et forme :SolidMasse moléculaire :319.36EAI045
CAS :<p>EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.</p>Formule :C19H14FN3O3SDegré de pureté :98.00% - 99.12%Couleur et forme :SolidMasse moléculaire :383.4Chrysophanol
CAS :<p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>Formule :C15H10O4Degré de pureté :99.44% - 99.91%Couleur et forme :Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMasse moléculaire :254.24PI-3065
CAS :<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Formule :C27H31FN6OSDegré de pureté :99.84% - ≥95%Couleur et forme :SolidMasse moléculaire :506.64TBB
CAS :<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Formule :C6HBr4N3Degré de pureté :98.51% - 99.45%Couleur et forme :Off-White SolidMasse moléculaire :434.71Linperlisib
CAS :<p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>Formule :C28H37FN6O5SDegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :588.69WZ4003
CAS :<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Formule :C25H29ClN6O3Degré de pureté :99.65% - >99.99%Couleur et forme :SolidMasse moléculaire :496.99TGX-221
CAS :<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Formule :C21H24N4O2Degré de pureté :99.68% - >99.99%Couleur et forme :SolidMasse moléculaire :364.44SU5214
CAS :<p>SU5214 is a modulator of tyrosine kinase signal transduction.</p>Formule :C16H13NO2Degré de pureté :99.45% - 99.55%Couleur et forme :SolidMasse moléculaire :251.28RSVA405
CAS :<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Formule :C17H20N4O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :312.37OTSSP167
CAS :<p>OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.</p>Formule :C25H28Cl2N4O2Degré de pureté :98.22% - 99.47%Couleur et forme :SolidMasse moléculaire :487.42Bikinin
CAS :<p>Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.</p>Formule :C9H9BrN2O3Degré de pureté :99.86% - >99.99%Couleur et forme :SolidMasse moléculaire :273.08Tyrphostin AG 528
CAS :<p>Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).</p>Formule :C18H14N2O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :306.32Eganelisib
CAS :<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formule :C30H24N8O2Degré de pureté :99.04% - 99.28%Couleur et forme :SolidMasse moléculaire :528.56Epitinib
CAS :<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formule :C24H26N6O2Couleur et forme :SolidMasse moléculaire :430.5AMG 511
CAS :<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Formule :C22H28FN9O3SDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :517.58PD153035 hydrochloride
CAS :<p>PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.</p>Formule :C16H15BrClN3O2Degré de pureté :99.39% - ≥95%Couleur et forme :SolidMasse moléculaire :396.67PI-103
CAS :<p>PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).</p>Formule :C19H16N4O3Degré de pureté :97.79% - 99.3%Couleur et forme :SolidMasse moléculaire :348.36Gefitinib-based PROTAC 3
CAS :<p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>Formule :C47H57ClFN7O8SDegré de pureté :97.29% - 98.25%Couleur et forme :SolidMasse moléculaire :934.51ZM39923 hydrochloride
CAS :<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91A66
CAS :<p>A66 is a specific and effective p110α inhibitor(IC50=32 nM).</p>Formule :C17H23N5O2S2Degré de pureté :99.51% - ≥95%Couleur et forme :SolidMasse moléculaire :393.53WZ8040
CAS :<p>WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).</p>Formule :C24H25ClN6OSDegré de pureté :97.42% - 99.785%Couleur et forme :SolidMasse moléculaire :481.01
