Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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AG1557
CAS :<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formule :C16H14IN3O2Degré de pureté :98.61% - 99.23%Couleur et forme :SolidMasse moléculaire :407.21Bimiralisib
CAS :<p>Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.</p>Formule :C17H20F3N7O2Degré de pureté :97.58% - 98.92%Couleur et forme :SolidMasse moléculaire :411.38E-4031 dihydrochloride
CAS :<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Formule :C21H29Cl2N3O3SDegré de pureté :99.31% - 99.87%Couleur et forme :SolidMasse moléculaire :474.44Tyrphostin AG 528
CAS :<p>Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).</p>Formule :C18H14N2O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :306.32Sapanisertib
CAS :<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Formule :C15H15N7ODegré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :309.33Tyrphostin A9
CAS :<p>Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor</p>Formule :C18H22N2ODegré de pureté :98.21% - 99.87%Couleur et forme :Yellow SolidMasse moléculaire :282.38Endoxifen (Z-isomer)
CAS :<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Formule :C25H27NO2Degré de pureté :99.19% - 99.81%Couleur et forme :SolidMasse moléculaire :373.49Gallein
CAS :<p>Gallein (Mordant violet 25) is a small molecule inhibitor of Gβγ activity.</p>Formule :C20H12O7Degré de pureté :85.50% - 95.94%Couleur et forme :SolidMasse moléculaire :364.314-Chloro-2'-bromoacetophenone
CAS :<p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>Formule :C8H6BrClODegré de pureté :98.34% - 99.41%Couleur et forme :White To Beige SolidMasse moléculaire :233.49PP 3
CAS :<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Formule :C11H9N5Degré de pureté :98.61%Couleur et forme :Whit To Off-White SolidMasse moléculaire :211.22KenPaullone
CAS :<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formule :C16H11BrN2ODegré de pureté :97.14% - 98.99%Couleur et forme :Tan SolidMasse moléculaire :327.18Bisindolylmaleimide I
CAS :<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formule :C25H24N4O2Degré de pureté :98.19% - 98.75%Couleur et forme :Orange SolidMasse moléculaire :412.48YKL-06-061
CAS :<p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>Formule :C30H37N7O2Degré de pureté :99.52% - 99.79%Couleur et forme :SolidMasse moléculaire :527.66PKI-166 hydrochloride
CAS :<p>EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>Formule :C20H19ClN4OCouleur et forme :SolidMasse moléculaire :366.85GS87
CAS :<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formule :C16H11N5O2SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :337.36TGX-221
CAS :<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Formule :C21H24N4O2Degré de pureté :99.68% - >99.99%Couleur et forme :SolidMasse moléculaire :364.44Osimertinib
CAS :<p>Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.</p>Formule :C28H33N7O2Degré de pureté :99.32% - >99.99%Couleur et forme :SolidMasse moléculaire :499.61SU 4313
CAS :<p>SU 4313 is a bioactive chemical.</p>Formule :C18H17NODegré de pureté :99.51% - 99.89%Couleur et forme :SolidMasse moléculaire :263.33BQR-695
CAS :<p>BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.</p>Formule :C19H20N4O3Degré de pureté :98.91% - 99.69%Couleur et forme :SolidMasse moléculaire :352.39AZD1080
CAS :<p>AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.</p>Formule :C19H18N4O2Degré de pureté :97.72% - 99.75%Couleur et forme :SolidMasse moléculaire :334.37EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS :<p>EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)</p>Formule :C23H21N3O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :387.43CHIR-98014
CAS :<p>CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.</p>Formule :C20H17Cl2N9O2Degré de pureté :97.25% - 99.59%Couleur et forme :SolidMasse moléculaire :486.31BIO-acetoxime
CAS :<p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>Formule :C18H12BrN3O3Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :398.21ASP4132
CAS :<p>ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.</p>Formule :C46H51F3N6O8S2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :937.06ALSTERPAULLONE
CAS :<p>Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec</p>Formule :C16H11N3O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :293.28MitoBloCK-11 (MB-11)
CAS :<p>MB-11 inhibits mitochondrial protein import, targets Seo1, affects growth in uracil-free media, and disrupts zebrafish development.</p>Formule :C17H12BrN3O4SDegré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :434.26Epitinib
CAS :<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formule :C24H26N6O2Couleur et forme :SolidMasse moléculaire :430.5Bikinin
CAS :<p>Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.</p>Formule :C9H9BrN2O3Degré de pureté :99.86% - >99.99%Couleur et forme :SolidMasse moléculaire :273.08PI-3065
CAS :<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Formule :C27H31FN6OSDegré de pureté :99.84% - ≥95%Couleur et forme :SolidMasse moléculaire :506.64Olmutinib
CAS :<p>Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor</p>Formule :C26H26N6O2SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :486.59PKD-IN-1 dihydrochloride (956121-30-5 free base)
CAS :<p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>Formule :C18H21Cl3N4ODegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :415.75WHI-P180
CAS :<p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>Formule :C16H15N3O3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :297.31Derazantinib dihydrochloride
CAS :<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formule :C29H31Cl2FN4OCouleur et forme :SolidMasse moléculaire :541.49AG 1406
CAS :<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formule :C16H18N2ODegré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :254.33HTH-01-015
CAS :<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Formule :C26H28N8ODegré de pureté :98.38% - 99.70%Couleur et forme :SolidMasse moléculaire :468.55NV-5138 hydrochloride
<p>NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.</p>Formule :C7H14ClF2NO2Couleur et forme :SolidMasse moléculaire :217.64SB 415286
CAS :<p>SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.</p>Formule :C16H10ClN3O5Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :359.72PD158780
CAS :<p>PD 158780 blocks all ErbB receptors: EGFR, ErbB2-4, with IC50s: 8μM, 49-52 nM.</p>Formule :C14H12BrN5Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :330.18BpV(HOpic)
CAS :<p>BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).</p>Formule :C6H4K2NO8VDegré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :347.24SU5204
CAS :<p>SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and</p>Formule :C17H15NO2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :265.31PP2
CAS :<p>PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.</p>Formule :C15H16ClN5Degré de pureté :98% - 98.21%Couleur et forme :White SolidMasse moléculaire :301.77Tyrphostin AG30
CAS :<p>Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.</p>Formule :C10H7NO4Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :205.17PD-161570
CAS :<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Formule :C26H35Cl2N7ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :532.51Lazertinib
CAS :<p>Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.</p>Formule :C30H34N8O3Degré de pureté :98.7% - 99.90%Couleur et forme :SolidMasse moléculaire :554.64β-Hydroxyisovalerylshikonin
CAS :<p>Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor</p>Formule :C21H24O7Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :388.41WYE-687 dihydrochloride
CAS :<p>WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).</p>Formule :C28H34Cl2N8O3Couleur et forme :SolidMasse moléculaire :601.53Oritinib mesylate
CAS :<p>Oritinib mesylate (SH-1028), an oral pyrimidine EGFR blocker with 18 nM IC50, targets both sensitive and T790M resistant mutations.</p>Formule :C32H41N7O5SCouleur et forme :SolidMasse moléculaire :635.78Theliatinib tartrate
CAS :<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formule :C29H32N6O8Couleur et forme :SolidMasse moléculaire :592.6Dorsomorphin
CAS :<p>Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.</p>Formule :C24H25N5ODegré de pureté :98% - 99.06%Couleur et forme :SolidMasse moléculaire :399.49GSK-3β inhibitor 10
CAS :<p>GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.</p>Formule :C12H12N2O3SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :264.3NRC-2694 hydrochloride
CAS :<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formule :C24H27ClN4O3Couleur et forme :SolidMasse moléculaire :454.95AZD2858
CAS :<p>AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.</p>Formule :C21H23N7O3SDegré de pureté :98% - 99.25%Couleur et forme :SolidMasse moléculaire :453.52MAZ51
CAS :<p>MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.</p>Formule :C21H18N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :314.38Gefitinib-based PROTAC 3
CAS :<p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>Formule :C47H57ClFN7O8SDegré de pureté :97.29% - 98.25%Couleur et forme :SolidMasse moléculaire :934.51Dacomitinib hydrate
CAS :<p>Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of</p>Formule :C24H27ClFN5O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :487.96Almonertinib
CAS :<p>Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.</p>Formule :C30H35N7O2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :525.64AZD-7648
CAS :<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formule :C18H20N8O2Degré de pureté :99.03% - 99.85%Couleur et forme :SolidMasse moléculaire :380.4TAS6417
CAS :<p>Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formule :C23H20N6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :396.44RGB-286638 free base
CAS :<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63GDC-0326
CAS :<p>GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).</p>Formule :C19H22N6O3Degré de pureté :99.35% - >99.99%Couleur et forme :SolidMasse moléculaire :382.42G5-7
CAS :<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>Formule :C22H19F2NO3Degré de pureté :97.3%Couleur et forme :SolidMasse moléculaire :383.39Osimertinib mesylate
CAS :<p>Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.</p>Formule :C29H37N7O5SDegré de pureté :99.46% - >99.99%Couleur et forme :SolidMasse moléculaire :595.71TMBIM6 antagonist-1
CAS :<p>TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor</p>Formule :C15H12N2O3Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :268.27NIBR-17
CAS :<p>NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.</p>Formule :C18H20N8O2Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :380.4RG14620
CAS :<p>RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.</p>Formule :C14H8Cl2N2Degré de pureté :99.82% - 99.87%Couleur et forme :SolidMasse moléculaire :275.13AZD8186
CAS :<p>AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).</p>Formule :C24H25F2N3O4Degré de pureté :99.89% - 99.91%Couleur et forme :SolidMasse moléculaire :457.47Zotarolimus
CAS :<p>Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).</p>Formule :C52H79N5O12Degré de pureté :95% - 98.01%Couleur et forme :SolidMasse moléculaire :966.21DMNB
CAS :<p>DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.</p>Formule :C9H9NO5Degré de pureté :97.87%Couleur et forme :Yellow SolidMasse moléculaire :211.17Allitinib tosylate
CAS :<p>Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.</p>Formule :C31H26ClFN4O5SDegré de pureté :98.46% - 98.68%Couleur et forme :SolidMasse moléculaire :621.08Avitinib
CAS :<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Formule :C26H26FN7O2Degré de pureté :99.81% - >99.99%Couleur et forme :SolidMasse moléculaire :487.53CZ415
CAS :<p>CZ415 is a potent and highly selective mTOR inhibitor.</p>Formule :C22H29N5O4SDegré de pureté :97.54% - 98.36%Couleur et forme :SolidMasse moléculaire :459.56GNF4877
CAS :<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Formule :C25H27FN6O4Degré de pureté :98.68% - 99.40%Couleur et forme :SolidMasse moléculaire :494.52VS-5584
CAS :<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Formule :C17H22N8ODegré de pureté :97.82% - 99.54%Couleur et forme :SolidMasse moléculaire :354.41(E/Z)-GSK-3β inhibitor 1
CAS :<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :222.24MOTS-c(Human) Acetate(1627580-64-6 free)
<p>MOTS-c(Human) Acetate is a mitochondrial-derived peptide.</p>Formule :C103H156N28O24S2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :2234.64ETP-46321
CAS :<p>ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).</p>Formule :C20H27N9O3SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :473.55CP-380736
CAS :<p>CP-380736 (PF-00520893) inhibits EGFR, a kinase key in cancer-signaling pathways like MAPK, JNK, and Akt.</p>Formule :C14H18N2O5Degré de pureté :99.68%Couleur et forme :White To Off-White SolidMasse moléculaire :294.3AZ-5104
CAS :<p>AZ5104 is a potent EGFR inhibitor.</p>Formule :C27H31N7O2Degré de pureté :98.40% - 99.59%Couleur et forme :Solid PowderMasse moléculaire :485.58Autophinib
CAS :<p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>Formule :C14H11ClN6O3Degré de pureté :99.25% - 99.41%Couleur et forme :SolidMasse moléculaire :346.73KU-57788
CAS :<p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>Formule :C25H19NO3SDegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :413.49Torin 2
CAS :<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Formule :C24H15F3N4ODegré de pureté :98.31% - 99.32%Couleur et forme :SolidMasse moléculaire :432.4Dacomitinib
CAS :<p>Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.</p>Formule :C24H25ClFN5O2Degré de pureté :99.4% - 99.72%Couleur et forme :SolidMasse moléculaire :469.94Taselisib
CAS :<p>Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.</p>Formule :C24H28N8O2Degré de pureté :99.62% - 99.79%Couleur et forme :SolidMasse moléculaire :460.53Poziotinib hydrochloride
CAS :<p>Oral poziotinib HCl targets EGFR/HER mutants, inhibiting cancer cell growth.</p>Formule :C23H22Cl3FN4O3Degré de pureté :99.69% - 99.81%Couleur et forme :SolidMasse moléculaire :527.8Leniolisib
CAS :<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formule :C21H25F3N6O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :450.46ARN-3236
CAS :<p>ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM</p>Formule :C19H16N2O2SDegré de pureté :98.89% - 99.7%Couleur et forme :SolidMasse moléculaire :336.41BGT226
CAS :<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formule :C28H25F3N6O2Degré de pureté :95.74% - 99.51%Couleur et forme :SolidMasse moléculaire :534.53NIH-12848
CAS :<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Formule :C20H14F3N3SDegré de pureté :99.84% - 99.9%Couleur et forme :SolidMasse moléculaire :385.41GNE-493
CAS :<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Formule :C17H20N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.44HG-14-10-04
CAS :<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formule :C29H34ClN7ODegré de pureté :99.75% - >99.99%Couleur et forme :SolidMasse moléculaire :532.08OSI-027
CAS :<p>OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.</p>Formule :C21H22N6O3Degré de pureté :97.42%Couleur et forme :SolidMasse moléculaire :406.44UCB9608
CAS :<p>UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.</p>Formule :C20H26N8O2Degré de pureté :97.53% - 99.59%Couleur et forme :SolidMasse moléculaire :410.47YKL-05-099
CAS :<p>YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. It can inhibit the activity of SIK1 and SIK3.Cost-effective and quality-assured.</p>Formule :C32H34ClN7O3Degré de pureté :99.57% - 99.66%Couleur et forme :SolidMasse moléculaire :600.11Saracatinib
CAS :<p>Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.</p>Formule :C27H32ClN5O5Degré de pureté :98% - 99.63%Couleur et forme :SolidMasse moléculaire :542.03Butein
CAS :<p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>Formule :C15H12O5Degré de pureté :98.76% - >99.99%Couleur et forme :SolidMasse moléculaire :272.25Tuxobertinib
CAS :<p>Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.</p>Formule :C29H29ClN6O4Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :561.03AR-A014418
CAS :<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Formule :C12H12N4O4SDegré de pureté :>99.99% - ≥95%Couleur et forme :SolidMasse moléculaire :308.31Olafertinib
CAS :<p>Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.</p>Formule :C29H28F2N6O2Degré de pureté :98.62% - 99.706%Couleur et forme :SolidMasse moléculaire :530.57GDC0084
CAS :<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formule :C18H22N8O2Degré de pureté :99.72% - 99.87%Couleur et forme :SolidMasse moléculaire :382.42PIK-294
CAS :<p>PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).</p>Formule :C28H23N7O2Degré de pureté :97.22% - >99.99%Couleur et forme :SolidMasse moléculaire :489.53Buformin hydrochloride
CAS :<p>Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.</p>Formule :C6H16ClN5Degré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :193.68FIIN-3
CAS :<p>FIIN-3 is an irreversible inhibitor of FGFR.</p>Formule :C34H36Cl2N8O4Degré de pureté :97.63% - 98.92%Couleur et forme :SolidMasse moléculaire :691.61WZ8040
CAS :<p>WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).</p>Formule :C24H25ClN6OSDegré de pureté :97.42% - 99.785%Couleur et forme :SolidMasse moléculaire :481.01PD153035 hydrochloride
CAS :<p>PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.</p>Formule :C16H15BrClN3O2Degré de pureté :99.39% - ≥95%Couleur et forme :SolidMasse moléculaire :396.67Eganelisib
CAS :<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formule :C30H24N8O2Degré de pureté :99.04% - 99.28%Couleur et forme :SolidMasse moléculaire :528.56AMG 511
CAS :<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Formule :C22H28FN9O3SDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :517.58ZM39923 hydrochloride
CAS :<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91SB 216763
CAS :<p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>Formule :C19H12Cl2N2O2Degré de pureté :98.9% - 99.13%Couleur et forme :SolidMasse moléculaire :371.22WZ4003
CAS :<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Formule :C25H29ClN6O3Degré de pureté :99.65% - >99.99%Couleur et forme :SolidMasse moléculaire :496.99SU5214
CAS :<p>SU5214 is a modulator of tyrosine kinase signal transduction.</p>Formule :C16H13NO2Degré de pureté :99.45% - 99.55%Couleur et forme :SolidMasse moléculaire :251.28EAI045
CAS :<p>EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.</p>Formule :C19H14FN3O3SDegré de pureté :98.00% - 99.12%Couleur et forme :SolidMasse moléculaire :383.4iMDK
CAS :<p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>Formule :C21H13FN2O2SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :376.4Vps34-PIK-III
CAS :<p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>Formule :C17H17N7Degré de pureté :98.39% - 98.43%Couleur et forme :SolidMasse moléculaire :319.36Chrysophanol
CAS :<p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>Formule :C15H10O4Degré de pureté :99.44% - 99.91%Couleur et forme :Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMasse moléculaire :254.24Indirubin-3'-monoxime
CAS :<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Formule :C16H11N3O2Degré de pureté :99.55%Couleur et forme :Dark Red SolidMasse moléculaire :277.28MK-3903
CAS :<p>MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).</p>Formule :C27H19ClN2O3Degré de pureté :98.63% - 99.75%Couleur et forme :SolidMasse moléculaire :454.9SYR127063
CAS :<p>SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.</p>Formule :C23H20ClF3N4O3Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :492.88CP-724714
CAS :<p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>Formule :C27H27N5O3Degré de pureté :97.1% - 98.82%Couleur et forme :SolidMasse moléculaire :469.54CP21R7
CAS :<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Formule :C19H15N3O2Degré de pureté :96.14% - 99.16%Couleur et forme :SolidMasse moléculaire :317.34AZ7550
CAS :<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.58GNE-477
CAS :<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Formule :C21H28N8O3S2Degré de pureté :98.88% - 99.55%Couleur et forme :SolidMasse moléculaire :504.63O-304
CAS :<p>O-304 is a pan-activator of AMP-activated protein kinase (AMPK).</p>Formule :C16H11Cl2N3O2SDegré de pureté :99.84% - ≥98%Couleur et forme :SolidMasse moléculaire :380.25TG 100713
CAS :<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Formule :C12H10N6ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :254.25BEBT-908
CAS :<p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>Formule :C23H25N9O3SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :507.57PI3K-IN-1
CAS :<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Formule :C31H29N5O6SDegré de pureté :97.03% - 98%Couleur et forme :SolidMasse moléculaire :599.66Dorsomorphin dihydrochloride
CAS :<p>Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on</p>Formule :C24H25N5O·2HClDegré de pureté :97.74% - 99.89%Couleur et forme :SolidMasse moléculaire :472.41VP3.15 dihydrobromide
CAS :<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Formule :C20H24Br2N4OSDegré de pureté :99.67% - ≥95%Couleur et forme :SolidMasse moléculaire :528.3MHY1485
CAS :<p>MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.</p>Formule :C17H21N7O4Degré de pureté :97.74% - >99.99%Couleur et forme :SolidMasse moléculaire :387.39PS 48
CAS :<p>PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).</p>Formule :C17H15ClO2Degré de pureté :99.96% - ≥95%Couleur et forme :SolidMasse moléculaire :286.75mTOR inhibitor-1
CAS :<p>C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.</p>Formule :C16H15BrN2O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :363.21Epidermal Growth Factor
CAS :<p>EGF binds EGFR, promotes cell growth & heals diabetic foot ulcers.</p>Formule :C270H401N73O83S7Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :6222lavendustin C
CAS :<p>lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.</p>Formule :C14H13NO5Degré de pureté :98.06%Couleur et forme :Yellow To Tan PowderMasse moléculaire :275.26Canertinib
CAS :<p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>Formule :C24H25ClFN5O3Degré de pureté :98% - >99.99%Couleur et forme :White Or Similar To White Crystalline PowderMasse moléculaire :485.94Tyrphostin 23
CAS :<p>Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.</p>Formule :C10H6N2O2Degré de pureté :99.7% - 99.86%Couleur et forme :Yellow-Tan SolidMasse moléculaire :186.17AS-605240
CAS :<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Formule :C12H7N3O2SDegré de pureté :97% - 99.91%Couleur et forme :SolidMasse moléculaire :257.27Tyrphostin AG 879
CAS :<p>Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.</p>Formule :C18H24N2OSDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :316.46EGFR-IN-12
CAS :<p>EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.</p>Formule :C21H18F3N5ODegré de pureté :98.3% - 99.76%Couleur et forme :SolidMasse moléculaire :413.4Serabelisib
CAS :<p>Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).</p>Formule :C19H17N5O3Degré de pureté :98.41% - 99.5%Couleur et forme :SolidMasse moléculaire :363.37PS210
CAS :<p>PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.</p>Formule :C19H15F3O5Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :380.31PD168393
CAS :<p>PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.</p>Formule :C17H13BrN4ODegré de pureté :99.13% - 99.83%Couleur et forme :SolidMasse moléculaire :369.22TG100-115
CAS :<p>TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.</p>Formule :C18H14N6O2Degré de pureté :99.22% - 99.26%Couleur et forme :SolidMasse moléculaire :346.34NS309
CAS :<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Formule :C8H4Cl2N2O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :231.04Cetuximab
CAS :<p>Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).</p>Formule :C107H179N35O36S7Degré de pureté :95 - 98.60%Couleur et forme :LiquidMasse moléculaire :152 kDaONO-7475
CAS :<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Formule :C32H26N4O6Degré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :562.57WH-4-025
CAS :<p>WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.</p>Formule :C39H38F3N7O5Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :741.76Methyl 2,5-dihydroxycinnamate
CAS :<p>Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.</p>Formule :C10H10O4Degré de pureté :99.60%Couleur et forme :CrystallineMasse moléculaire :194.18PS47
CAS :<p>PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.</p>Formule :C17H15ClO2Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :286.75PIK-293
CAS :<p>PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.</p>Formule :C22H19N7ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :397.43ALK-IN-1
CAS :<p>ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.</p>Formule :C26H34ClN6O2PDegré de pureté :99.74% - 99.80%Couleur et forme :SolidMasse moléculaire :529.01ETP-45658
CAS :<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Formule :C16H17N5O2Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :311.34Zorifertinib
CAS :<p>Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.</p>Formule :C22H23ClFN5O3Degré de pureté :98.20% - 99.36%Couleur et forme :White To Off-White SolidMasse moléculaire :459.9MTX-211
CAS :<p>MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.</p>Formule :C20H14Cl2FN5O2SDegré de pureté :97.6% - >99.99%Couleur et forme :SolidMasse moléculaire :478.33Desmethyl Erlotinib hydrochloride
CAS :<p>Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.</p>Formule :C21H21N3O4·HClDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :415.87PF-06409577
CAS :<p>PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).</p>Formule :C19H16ClNO3Degré de pureté :95.17% - 98.21%Couleur et forme :SolidMasse moléculaire :341.79R547
CAS :<p>R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.</p>Formule :C18H21F2N5O4SDegré de pureté :90% - 99.64%Couleur et forme :SolidMasse moléculaire :441.455-Bromoindole
CAS :<p>5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate</p>Formule :C8H6BrNDegré de pureté :99.99%Couleur et forme :White To Beige Crystalline PowderMasse moléculaire :196.04AG-1478
CAS :<p>AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.</p>Formule :C16H14ClN3O2Degré de pureté :99.03% - 99.71%Couleur et forme :SolidMasse moléculaire :315.75AG 555
CAS :<p>AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.</p>Formule :C19H18N2O3Degré de pureté :98.02% - 99.94%Couleur et forme :SolidMasse moléculaire :322.36PF-04802367
CAS :<p>PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.</p>Formule :C16H16ClN5O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :361.78DMH-25
CAS :<p>DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.</p>Formule :C15H8Br3NO3Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :489.94OTSSP167
CAS :<p>OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.</p>Formule :C25H28Cl2N4O2Degré de pureté :98.22% - 99.47%Couleur et forme :SolidMasse moléculaire :487.42AS-041164
CAS :<p>AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.</p>Formule :C11H7NO4SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :249.24Desmethyl Erlotinib
CAS :<p>Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).</p>Formule :C21H21N3O4Degré de pureté :97.92% - 98.62%Couleur et forme :SolidMasse moléculaire :379.41WHI-P258
CAS :<p>WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.</p>Formule :C16H15N3O2Degré de pureté :99.66% - 99.92%Couleur et forme :SolidMasse moléculaire :281.31IC-87114
CAS :<p>IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).</p>Formule :C22H19N7ODegré de pureté :99.30% - >99.99%Couleur et forme :SolidMasse moléculaire :397.43PQR620
CAS :<p>PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.</p>Formule :C21H25F2N7O2Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :445.47CC-115
CAS :<p>CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).</p>Formule :C16H16N8ODegré de pureté :86.79% - 99.01%Couleur et forme :SolidMasse moléculaire :336.35PQR530
CAS :<p>PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.</p>Formule :C18H23F2N7O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :407.42EX229
CAS :<p>EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.</p>Formule :C24H18ClN3O3Degré de pureté :99.20% - 99.36%Couleur et forme :SolidMasse moléculaire :431.87Olmutinib
CAS :<p>Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.</p>Formule :C26H26N6O2SDegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :486.59A-769662
CAS :<p>A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).</p>Formule :C20H12N2O3SDegré de pureté :97.52% - 99.58%Couleur et forme :SolidMasse moléculaire :360.39EBE-A22
CAS :<p>EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.</p>Formule :C17H16BrN3O2Degré de pureté :99.087% - 99.88%Couleur et forme :SolidMasse moléculaire :374.23Tesevatinib
CAS :<p>Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formule :C24H25Cl2FN4O2Degré de pureté :97.89% - 98.66%Couleur et forme :SolidMasse moléculaire :491.39YU238259
CAS :<p>YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.</p>Formule :C22H22ClN3O4SDegré de pureté :99.28% - 99.56%Couleur et forme :SolidMasse moléculaire :459.95Cyasterone
CAS :<p>Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising</p>Formule :C29H44O8Degré de pureté :99.32% - 99.70%Couleur et forme :SolidMasse moléculaire :520.65KU-0060648
CAS :<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Formule :C33H34N4O4SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :582.71Genistein
CAS :<p>Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.</p>Formule :C15H10O5Degré de pureté :98.22% - 99.64%Couleur et forme :Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether SolidMasse moléculaire :270.24Rostafuroxin
CAS :<p>Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.</p>Formule :C23H34O4Degré de pureté :99.08% - >99.99%Couleur et forme :SolidMasse moléculaire :374.51WZ-3146
CAS :<p>WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).</p>Formule :C24H25ClN6O2Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :464.95Almonertinib mesylate
CAS :<p>Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.</p>Formule :C31H39N7O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :621.75Desmethyl-VS-5584
CAS :<p>Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.</p>Formule :C16H20N8ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :340.38CZC-8004
CAS :<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Formule :C17H16FN5Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :309.34LY-294002 hydrochloride
CAS :<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Formule :C19H17NO3·HClDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :343.81MHY-1685
CAS :<p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>Formule :C11H8N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :232.19GSK 3 Inhibitor IX
CAS :<p>GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.</p>Formule :C16H10BrN3O2Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :356.17(Rac)-JBJ-04-125-02
CAS :<p>(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.</p>Formule :C29H26FN5O3SDegré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :543.61TWS119
CAS :<p>TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation</p>Formule :C18H14N4O2Degré de pureté :98.14% - 99.63%Couleur et forme :SolidMasse moléculaire :318.33Leptomycin B
CAS :<p>Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.</p>Formule :C33H48O6Degré de pureté :97.10% - 99.04%Couleur et forme :White Crystalline SolidMasse moléculaire :540.73GSK3i XIII
CAS :<p>GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.</p>Formule :C18H19N5Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :305.38Pilaralisib
CAS :<p>Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).</p>Formule :C25H25ClN6O4SDegré de pureté :98.51% - 99.61%Couleur et forme :SolidMasse moléculaire :541.02SF2523
CAS :<p>SF2523 is a highly selective and potent inhibitor.</p>Formule :C19H17NO5SDegré de pureté :99.1% - 99.51%Couleur et forme :SolidMasse moléculaire :371.41DS-7423
CAS :<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Formule :C22H27F3N10O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :520.51OTSSP167 hydrochloride
CAS :<p>OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).</p>Formule :C25H29Cl3N4O2Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :523.88Gedatolisib
CAS :<p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>Formule :C32H41N9O4Degré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :615.73Pelitinib
CAS :<p>Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).</p>Formule :C24H23ClFN5O2Degré de pureté :98.37% - 99.84%Couleur et forme :Off-White SolidMasse moléculaire :467.92CNX-2006
CAS :<p>CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.</p>Formule :C26H27F4N7O2Degré de pureté :98.85% - 99.16%Couleur et forme :SolidMasse moléculaire :545.53Sapitinib
CAS :<p>Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or</p>Formule :C23H25ClFN5O3Degré de pureté :98.89% - 99.83%Couleur et forme :SolidMasse moléculaire :473.93Mobocertinib
CAS :<p>Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent</p>Formule :C32H39N7O4Degré de pureté :99.47% - 99.97%Couleur et forme :SolidMasse moléculaire :585.7CUDC-101
CAS :<p>CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.</p>Formule :C24H26N4O4Degré de pureté :95.76% - 99.17%Couleur et forme :SolidMasse moléculaire :434.49Afatinib
CAS :<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formule :C24H25ClFN5O3Degré de pureté :98.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94
