PI3K
Les inhibiteurs de PI3K sont des composés qui bloquent l'activité des phosphoinositide 3-kinases (PI3Ks), une famille d'enzymes impliquées dans un large éventail de processus cellulaires, y compris la croissance, la prolifération, la survie et le métabolisme. La voie PI3K/Akt/mTOR est souvent dérégulée dans le cancer, ce qui fait de PI3K une cible clé pour la thérapie anticancéreuse. Les inhibiteurs de PI3K sont des outils essentiels pour étudier la transduction du signal, la biologie du cancer et le développement de thérapies ciblées. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de PI3K pour soutenir vos recherches en signalisation cellulaire, en oncologie et en développement thérapeutique.
242 produits trouvés pour "PI3K"
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Copanlisib dihydrochloride
CAS :<p>Copanlisib dihydrochloride: ATP-competitive PI3K inhibitor, potent for PI3Kα/δ/β/γ, antitumor, 2000x selectivity over other kinases except mTOR.</p>Formule :C23H30Cl2N8O4Degré de pureté :99.05% - 99.16%Couleur et forme :SolidMasse moléculaire :553.44PI4KIIIbeta-IN-9
CAS :<p>PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .</p>Formule :C23H25N3O5S2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :487.59Pictilisib dimethanesulfonate
CAS :<p>Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and</p>Formule :C25H35N7O9S4Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :705.85Thioridazine hydrochloride
CAS :<p>Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4</p>Formule :C21H27ClN2S2Degré de pureté :99.55% - 99.957%Couleur et forme :White To Off-White SolidMasse moléculaire :407.04Sophocarpine monohydrate
CAS :<p>Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Formule :C15H22N2ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :246.35IPI-3063
CAS :<p>IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).</p>Formule :C25H25N7O2Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :455.51Safingol hydrochloride
CAS :<p>Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.</p>Formule :C18H40ClNO2Degré de pureté :99.39% - 99.71%Couleur et forme :SoildMasse moléculaire :337.969Parsaclisib
CAS :<p>Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)</p>Formule :C20H22ClFN6O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :432.88Inavolisib
CAS :<p>Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.</p>Formule :C18H19F2N5O4Degré de pureté :97.36% - 99.87%Couleur et forme :SolidMasse moléculaire :407.37Tenalisib
CAS :<p>Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)</p>Formule :C23H18FN5O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :415.42CGS 15943
CAS :<p>CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.</p>Formule :C13H8ClN5ODegré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :285.69P110δ-IN-1
CAS :<p>P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).</p>Formule :C31H40N8O3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :604.77NSC781406
CAS :<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Formule :C29H27F2N5O5S2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :627.68PI4KIIIbeta-IN-10
CAS :<p>PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).</p>Formule :C22H25N3O5S2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :475.58Recilisib
CAS :<p>Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.</p>Formule :C16H13ClO4SDegré de pureté :98.85% - 98.96%Couleur et forme :SolidMasse moléculaire :336.79FD274
CAS :<p>FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,</p>Formule :C22H14ClFN6O2SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :480.9Duvelisib (R enantiomer) hydrochloride
<p>Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.</p>Formule :C22H18Cl2N6ODegré de pureté :99.88% - >99.99%Couleur et forme :SoildMasse moléculaire :453.32PI3K-IN-46
CAS :<p>PI3K-IN-46 is a specific inhibitor of PI3Kγ.</p>Formule :C13H9N3OSDegré de pureté :97.51%Couleur et forme :SoildMasse moléculaire :255.3(3S)-GSK-F1
CAS :<p>(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.</p>Formule :C27H18F5N5O4SDegré de pureté :99.04%Couleur et forme :SoildMasse moléculaire :603.52PI3Kδ-IN-12
<p>PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4</p>Formule :C20H15Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.27IHMT-PI3K-315
<p>IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.</p>Formule :C22H20F2N6O4Couleur et forme :SolidMasse moléculaire :470.43IHMT-PI3Kδ-372 S-isomer
CAS :<p>IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.</p>Formule :C26H23F2N7O2Degré de pureté :99.97%Couleur et forme :SoildMasse moléculaire :503.5PI3Kγ ligand 1
CAS :<p>PI3Kγ ligand 1 serves as a PROTAC target protein ligand (Ligand for Target Protein for PROTAC).</p>Formule :C26H29N5O3SCouleur et forme :SolidMasse moléculaire :491.61PITCOIN4
<p>PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivity</p>Degré de pureté :98%Couleur et forme :Odour SolidPI3K-IN-41
<p>PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV light</p>Formule :C45H39F2N5O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :911.88mTOR inhibitor 9f
CAS :<p>mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.</p>Formule :C25H23N5O2SDegré de pureté :99.18%Couleur et forme :SoildMasse moléculaire :457.55mTOR inhibitor 9e
CAS :<p>mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.</p>Formule :C22H23N5O2SDegré de pureté :98.84%Couleur et forme :SoildMasse moléculaire :421.52mTOR inhibitor 13
CAS :<p>Urea derivative; selective mTOR blocker; IC50: 0.29nM (mTOR), 119nM (PI3Kα).</p>Formule :C24H22N6O2SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :458.54mTOR inhibitor 9c
CAS :<p>mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.</p>Formule :C21H22FN5O2SDegré de pureté :99.23%Couleur et forme :SoildMasse moléculaire :427.5Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidSTX-478
CAS :<p>STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumor</p>Formule :C16H12F5N5O2Degré de pureté :98.31% - 99.78%Couleur et forme :SolidMasse moléculaire :401.29PI3Kδ-IN-18
<p>Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].</p>Degré de pureté :98%Couleur et forme :Odour SolidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Couleur et forme :LiquidPI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Couleur et forme :Odour SolidGSK251
CAS :<p>GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.</p>Formule :C29H37FN6O4SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :584.71PI3Kδ-IN-14
<p>PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of</p>Formule :C26H20ClFN8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.94DA-143
<p>DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.</p>Couleur et forme :Odour SolidBAY1082439
CAS :<p>BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].</p>Formule :C25H30N6O5Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :494.54D-106669
CAS :<p>D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.</p>Formule :C17H18N6OCouleur et forme :SolidMasse moléculaire :322.36PI5P4Ks-IN-2
CAS :<p>PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.</p>Formule :C22H23N5Degré de pureté :98.36% - 99.02%Couleur et forme :SoildMasse moléculaire :357.45PI3Kα-IN-12
<p>PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values</p>Formule :C28H36F2N10O5S3Couleur et forme :SolidMasse moléculaire :726.84PI3Kα-IN-25
<p>PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.</p>Formule :C21H19ClN4O4Couleur et forme :SolidMasse moléculaire :426.853ARUK2001607
CAS :<p>ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.</p>Formule :C14H13N3O2S2Degré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :319.40WYE-687
CAS :<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Formule :C28H32N8O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :528.61PI3K-IN-57
<p>PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.</p>Couleur et forme :Odour SolidPI3K-IN-47
<p>PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)</p>Formule :C50H46F4N8O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1027.07IHMT-PI3K-455
<p>IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for</p>Formule :C26H21F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.49Umbralisib R-enantiomer
CAS :<p>Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.</p>Formule :C31H24F3N5O3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :571.55GSK2292767 FA
<p>GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.</p>Formule :C25H30N6O7SDegré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :558.61PROTAC PI3K/110β degrader-1
CAS :<p>PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.</p>Formule :C51H65N9O9SCouleur et forme :SolidMasse moléculaire :980.18PF-06843195
CAS :<p>PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .</p>Formule :C20H25F3N8O4Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :498.46AS-252424
CAS :<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Formule :C14H8FNO4SDegré de pureté :99.06% - 99.09%Couleur et forme :SolidMasse moléculaire :305.28PF-04691502
CAS :<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formule :C22H27N5O4Degré de pureté :96.27% - ≥95%Couleur et forme :SolidMasse moléculaire :425.48Oroxin B
CAS :<p>Oroxin B (Hypocretin-2) has antioxidant activity.</p>Formule :C27H30O15Degré de pureté :98.22% - 99.81%Couleur et forme :SolidMasse moléculaire :594.52GDC0084
CAS :<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formule :C18H22N8O2Degré de pureté :99.72% - 99.87%Couleur et forme :SolidMasse moléculaire :382.42PIK-294
CAS :<p>PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).</p>Formule :C28H23N7O2Degré de pureté :97.22% - >99.99%Couleur et forme :SolidMasse moléculaire :489.53PF-4989216
CAS :<p>PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.</p>Formule :C18H13FN6OSDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :380.41-Deoxynojirimycin
CAS :<p>1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.</p>Formule :C6H13NO4Degré de pureté :99.65% - 99.98%Couleur et forme :White-Beige Solid CrystallineMasse moléculaire :163.17MTX-211
CAS :<p>MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.</p>Formule :C20H14Cl2FN5O2SDegré de pureté :97.6% - >99.99%Couleur et forme :SolidMasse moléculaire :478.33Esculetin
CAS :<p>Esculetin: a coumarin from plants with anti-edema, anti-inflammatory, anti-tumor properties; inhibits LOs.</p>Formule :C9H6O4Degré de pureté :98.03% - 99.76%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :178.14Alpelisib
CAS :<p>Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.</p>Formule :C19H22F3N5O2SDegré de pureté :98% - 99.73%Couleur et forme :SolidMasse moléculaire :441.47GSK1059615
CAS :<p>GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.</p>Formule :C18H11N3O2SDegré de pureté :99.3% - ≥95%Couleur et forme :SolidMasse moléculaire :333.36Wortmannin
CAS :<p>Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.</p>Formule :C23H24O8Degré de pureté :95.84% - 99.76%Couleur et forme :White SolidMasse moléculaire :428.433-Methyladenine
CAS :<p>3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).</p>Formule :C6H7N5Degré de pureté :98.02% - 99.65%Couleur et forme :SolidMasse moléculaire :149.15PI-103
CAS :<p>PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).</p>Formule :C19H16N4O3Degré de pureté :97.79% - 99.3%Couleur et forme :SolidMasse moléculaire :348.36Erucic acid
CAS :<p>Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).</p>Formule :C22H42O2Degré de pureté :99.64%Couleur et forme :Needles From Alcohol Liquid OthersolidMasse moléculaire :338.57Brevianamide F
CAS :<p>Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.</p>Formule :C16H17N3O2Degré de pureté :97.30% - 98.82%Couleur et forme :SolidMasse moléculaire :283.33PIK-108
CAS :<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Formule :C22H24N2O3Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :364.44LY294002
CAS :<p>LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).</p>Formule :C19H17NO3Degré de pureté :98% - 99.96%Couleur et forme :Pale Yellow SolidMasse moléculaire :307.34Dihydrocapsaicin
CAS :<p>Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.</p>Formule :C18H29NO3Degré de pureté :99.61% - ≥95%Couleur et forme :White CrystalMasse moléculaire :307.43Copanlisib
CAS :<p>Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.</p>Formule :C23H28N8O4Degré de pureté :99% - 99.88%Couleur et forme :SolidMasse moléculaire :480.52Bimiralisib
CAS :<p>Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.</p>Formule :C17H20F3N7O2Degré de pureté :97.58% - 98.92%Couleur et forme :SolidMasse moléculaire :411.38Sapanisertib
CAS :<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Formule :C15H15N7ODegré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :309.33Idelalisib
CAS :<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formule :C22H18FN7ODegré de pureté :98% - 99.39%Couleur et forme :SolidMasse moléculaire :415.42Hederacolchiside A1
CAS :<p>Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.</p>Formule :C47H76O16Degré de pureté :98.76% - 99.92%Couleur et forme :SolidMasse moléculaire :897.1ZSTK474
CAS :<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formule :C19H21F2N7O2Degré de pureté :98.29% - 99.95%Couleur et forme :White PowderMasse moléculaire :417.41Omipalisib
CAS :<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formule :C25H17F2N5O3SDegré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :505.5Rigosertib
CAS :<p>Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.</p>Formule :C21H25NO8SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :451.49YS-49
CAS :<p>YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).</p>Formule :C20H20BrNO2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :386.28Periplocin
CAS :<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Formule :C36H56O13Degré de pureté :99.66% - 99.74%Couleur et forme :SolidMasse moléculaire :696.82TGX-221
CAS :<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Formule :C21H24N4O2Degré de pureté :99.68% - >99.99%Couleur et forme :SolidMasse moléculaire :364.44LX2343
CAS :<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Formule :C22H19ClN2O6SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :474.91BQR-695
CAS :<p>BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.</p>Formule :C19H20N4O3Degré de pureté :98.91% - 99.69%Couleur et forme :SolidMasse moléculaire :352.39PI-3065
CAS :<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Formule :C27H31FN6OSDegré de pureté :99.84% - ≥95%Couleur et forme :SolidMasse moléculaire :506.64Fimepinostat
CAS :<p>Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.</p>Formule :C23H24N8O4SDegré de pureté :98.27% - 99.87%Couleur et forme :SolidMasse moléculaire :508.55TASP0415914
CAS :<p>TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T</p>Formule :C13H17N5O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :323.37Flavanomarein
CAS :<p>Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.</p>Formule :C21H22O11Degré de pureté :98.63% - 99.54%Couleur et forme :SolidMasse moléculaire :450.39Taurolithocholic acid sodium salt
CAS :<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>Formule :C26H44NNaO5SDegré de pureté :99.79% - 99.93%Couleur et forme :SolidMasse moléculaire :505.69Desmethylglycitein
CAS :<p>Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has</p>Formule :C15H10O5Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :270.24AZD-7648
CAS :<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formule :C18H20N8O2Degré de pureté :99.03% - 99.85%Couleur et forme :SolidMasse moléculaire :380.41-Deoxynojirimycin hydrochloride
CAS :<p>1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.</p>Formule :C6H14ClNO4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :199.63NIBR-17
CAS :<p>NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.</p>Formule :C18H20N8O2Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :380.4Glaucocalyxin A
CAS :<p>Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.</p>Formule :C20H28O4Degré de pureté :99.55% - 99.80%Couleur et forme :SolidMasse moléculaire :332.43PIK-75 hydrochloride
CAS :<p>PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.</p>Formule :C16H14BrN5O4S·HClDegré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :488.74Apitolisib
CAS :<p>Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).</p>Formule :C23H30N8O3SDegré de pureté :98.28% - 99.64%Couleur et forme :SolidMasse moléculaire :498.6Flupentixol dihydrochloride
CAS :<p>Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.</p>Formule :C23H27Cl2F3N2OSDegré de pureté :98.76% - >99.99%Couleur et forme :White Or Off-White SolidMasse moléculaire :507.43VS-5584
CAS :<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Formule :C17H22N8ODegré de pureté :97.82% - 99.54%Couleur et forme :SolidMasse moléculaire :354.41ETP-46321
CAS :<p>ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).</p>Formule :C20H27N9O3SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :473.55Autophinib
CAS :<p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>Formule :C14H11ClN6O3Degré de pureté :99.25% - 99.41%Couleur et forme :SolidMasse moléculaire :346.73Taselisib
CAS :<p>Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.</p>Formule :C24H28N8O2Degré de pureté :99.62% - 99.79%Couleur et forme :SolidMasse moléculaire :460.53IITZ-01
CAS :<p>IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)</p>Formule :C26H23FN8ODegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :482.51Lupiwighteone
CAS :<p>Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.</p>Formule :C20H18O5Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :338.35Leniolisib
CAS :<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formule :C21H25F3N6O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :450.46Arnicolide D
CAS :<p>Arnicolide D is a sesquiterpene lactone.</p>Formule :C19H24O5Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :332.39BGT226
CAS :<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formule :C28H25F3N6O2Degré de pureté :95.74% - 99.51%Couleur et forme :SolidMasse moléculaire :534.53NIH-12848
CAS :<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Formule :C20H14F3N3SDegré de pureté :99.84% - 99.9%Couleur et forme :SolidMasse moléculaire :385.41GNE-493
CAS :<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Formule :C17H20N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.44Rigosertib sodium
CAS :<p>Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.</p>Formule :C21H24NNaO8SDegré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :473.47SKI V
CAS :<p>SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),</p>Formule :C15H10O4Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :254.24Quercetin
CAS :<p>Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.</p>Formule :C15H10O7Degré de pureté :96.29% - 98.05%Couleur et forme :Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Masse moléculaire :302.24MOMIPP
CAS :<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Formule :C18H16N2O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :292.33(+)-Nortrachelogenin
CAS :<p>(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.</p>Formule :C20H22O7Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :374.38Samotolisib
CAS :<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formule :C23H26N4O3Degré de pureté :98.41% - 99.69%Couleur et forme :SolidMasse moléculaire :406.48Heterophyllin B
CAS :<p>Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.</p>Formule :C40H58N8O8Degré de pureté :99.12% - 99.85%Couleur et forme :SolidMasse moléculaire :778.94AMG319
CAS :<p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.</p>Formule :C21H16FN7Degré de pureté :98.9% - 99.24%Couleur et forme :Crystalline SolidMasse moléculaire :385.4P7C3-A20
CAS :<p>P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.</p>Formule :C22H19Br2FN2ODegré de pureté :96.83% - ≥98%Couleur et forme :SolidMasse moléculaire :506.21Voxtalisib
CAS :<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formule :C13H14N6ODegré de pureté :98.21% - 99.69%Couleur et forme :SolidMasse moléculaire :270.29Umbralisib
CAS :<p>Umbralisib (TGR 1202) is a PI3Kδ inhibitor.</p>Formule :C31H24F3N5O3Degré de pureté :99.56% - 99.56%Couleur et forme :White SolidMasse moléculaire :571.55AZD-8835
CAS :<p>AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).</p>Formule :C22H31N9O3Degré de pureté :98.22% - 99.88%Couleur et forme :SolidMasse moléculaire :469.54AS-604850
CAS :<p>AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.</p>Formule :C11H5F2NO4SDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :285.22PIK-93
CAS :PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formule :C14H16ClN3O4S2Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :389.88CH5132799
CAS :<p>CH5132799 has been used in trials studying the treatment of Solid Tumors.</p>Formule :C15H19N7O3SDegré de pureté :99.41% - 99.87%Couleur et forme :SolidMasse moléculaire :377.42Seletalisib
CAS :<p>Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).</p>Formule :C23H14ClF3N6ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :482.85α-Linolenic acid
CAS :<p>α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.</p>Formule :C18H30O2Degré de pureté :97.05% - 99.81%Couleur et forme :Physical Description Clear Colorless Liquid (Ntp 1992)Masse moléculaire :278.43GSK2636771
CAS :<p>GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and</p>Formule :C22H22F3N3O3Degré de pureté :98.58% - ≥95%Couleur et forme :SolidMasse moléculaire :433.42Vps34-IN-1
CAS :<p>Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.</p>Formule :C21H24ClN7ODegré de pureté :97.04%Couleur et forme :SolidMasse moléculaire :425.91SAR405
CAS :<p>SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.</p>Formule :C19H21ClF3N5O2Degré de pureté :99.42% - 99.79%Couleur et forme :SolidMasse moléculaire :443.85PIK-90
CAS :<p>PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .</p>Formule :C18H17N5O3Degré de pureté :98.25% - ≥95%Couleur et forme :SolidMasse moléculaire :351.36A66
CAS :<p>A66 is a specific and effective p110α inhibitor(IC50=32 nM).</p>Formule :C17H23N5O2S2Degré de pureté :99.51% - ≥95%Couleur et forme :SolidMasse moléculaire :393.53Linperlisib
CAS :<p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>Formule :C28H37FN6O5SDegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :588.69Vps34-IN-4
CAS :<p>VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)</p>Formule :C21H25N7ODegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :391.47CAY10505
CAS :<p>CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).</p>Formule :C14H8FNO3SDegré de pureté :99.69% - 99.74%Couleur et forme :SolidMasse moléculaire :289.28GDC-0326
CAS :<p>GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).</p>Formule :C19H22N6O3Degré de pureté :99.35% - >99.99%Couleur et forme :SolidMasse moléculaire :382.42AZD8186
CAS :<p>AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).</p>Formule :C24H25F2N3O4Degré de pureté :99.89% - 99.91%Couleur et forme :SolidMasse moléculaire :457.47Selective PI3Kδ Inhibitor 1
CAS :<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Formule :C23H20FN7ODegré de pureté :97.96%Couleur et forme :SolidMasse moléculaire :429.45Pilaralisib analogue
CAS :<p>Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.</p>Formule :C21H16N6O2S2Degré de pureté :99.3% - 99.72%Couleur et forme :SolidMasse moléculaire :448.52AZD 6482
CAS :<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Formule :C22H24N4O4Degré de pureté :99.79% - 99.95%Couleur et forme :SolidMasse moléculaire :408.45PIK-293
CAS :<p>PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.</p>Formule :C22H19N7ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :397.43ETP-45658
CAS :<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Formule :C16H17N5O2Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :311.34Dactolisib
CAS :<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formule :C30H23N5ODegré de pureté :97.64% - 99.85%Couleur et forme :SolidMasse moléculaire :469.54Pectolinarin
CAS :<p>Pectolinarin is a Cirsium isolate with anti-inflammatory activity.</p>Formule :C29H34O15Degré de pureté :98% - 99.79%Couleur et forme :SolidMasse moléculaire :622.57GNE-317
CAS :<p>GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).</p>Formule :C19H22N6O3SDegré de pureté :98.42% - 99.54%Couleur et forme :SolidMasse moléculaire :414.48Pictilisib
CAS :<p>Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).</p>Formule :C23H27N7O3S2Degré de pureté :98.69% - 99.97%Couleur et forme :SolidMasse moléculaire :513.64Sincalide
CAS :<p>Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.</p>Formule :C49H62N10O16S3Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :1143.27IC-87114
CAS :<p>IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).</p>Formule :C22H19N7ODegré de pureté :99.30% - >99.99%Couleur et forme :SolidMasse moléculaire :397.43Orobol
CAS :<p>Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover.</p>Formule :C15H10O6Degré de pureté :98% - 98%Couleur et forme :SolidMasse moléculaire :286.24Musk ketone
CAS :<p>Musk ketone may suppress cancer cell growth, induce apoptosis, and boost glutathione S-transferase, potentially aiding cancer protection.</p>Formule :C14H18N2O5Degré de pureté :99.85%Couleur et forme :Yellow Crystals Physical Description Light Yellow Crystalline Solid Insoluble In Water (Ntp 1992)Masse moléculaire :294.30AS-041164
CAS :<p>AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.</p>Formule :C11H7NO4SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :249.24PQR530
CAS :<p>PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.</p>Formule :C18H23F2N7O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :407.42YM-201636
CAS :<p>YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.</p>Formule :C25H21N7O3Degré de pureté :93.28% - 98.3%Couleur et forme :SolidMasse moléculaire :467.48Polygalasaponin F
CAS :<p>Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.</p>Formule :C53H86O23Degré de pureté :98% - 99.83%Couleur et forme :SolidMasse moléculaire :1091.24Isorhamnetin
CAS :<p>Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.</p>Formule :C16H12O7Degré de pureté :99.20% - >99.99%Couleur et forme :SolidMasse moléculaire :316.26Pilaralisib
CAS :<p>Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).</p>Formule :C25H25ClN6O4SDegré de pureté :98.51% - 99.61%Couleur et forme :SolidMasse moléculaire :541.02SF2523
CAS :<p>SF2523 is a highly selective and potent inhibitor.</p>Formule :C19H17NO5SDegré de pureté :99.1% - 99.51%Couleur et forme :SolidMasse moléculaire :371.41LY-294002 hydrochloride
CAS :<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Formule :C19H17NO3·HClDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :343.81DS-7423
CAS :<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Formule :C22H27F3N10O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :520.51Gedatolisib
CAS :<p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>Formule :C32H41N9O4Degré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :615.73KU-0060648
CAS :<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Formule :C33H34N4O4SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :582.71Desmethyl-VS-5584
CAS :<p>Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.</p>Formule :C16H20N8ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :340.38Duvelisib
CAS :<p>Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.</p>Formule :C22H17ClN6ODegré de pureté :98.87% - 99.74%Couleur et forme :SolidMasse moléculaire :416.86PIK-75
CAS :<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Formule :C16H14BrN5O4SDegré de pureté :98.52% - >99.99%Couleur et forme :SolidMasse moléculaire :452.28Vacuolin-1
CAS :<p>Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.</p>Formule :C26H24IN7ODegré de pureté :97.20% - 98.45%Couleur et forme :SolidMasse moléculaire :577.42CZC24832
CAS :<p>CZC24832 is a selective inhibitor of PI 3-kinase γ.</p>Formule :C15H17FN6O2SDegré de pureté :99.08% - 99.12%Couleur et forme :SolidMasse moléculaire :364.4Deoxyelephantopin
CAS :<p>Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.</p>Formule :C19H20O6Degré de pureté :99.6% - 99.71%Couleur et forme :SolidMasse moléculaire :344.36Acalisib
CAS :<p>Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.</p>Formule :C21H16FN7ODegré de pureté :98.99% - ≥95%Couleur et forme :SolidMasse moléculaire :401.4Parsaclisib hydrochloride
CAS :<p>Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.</p>Formule :C20H23Cl2FN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.34Eganelisib
CAS :<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formule :C30H24N8O2Degré de pureté :99.04% - 99.28%Couleur et forme :SolidMasse moléculaire :528.56AMG 511
CAS :<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Formule :C22H28FN9O3SDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :517.58(E)-Akt inhibitor-IV
CAS :<p>(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.</p>Formule :C31H29IN4SDegré de pureté :99.74% - 99.9%Couleur et forme :SolidMasse moléculaire :616.56iMDK
CAS :<p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>Formule :C21H13FN2O2SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :376.4Vps34-PIK-III
CAS :<p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>Formule :C17H17N7Degré de pureté :98.39% - 98.43%Couleur et forme :SolidMasse moléculaire :319.36GNE-477
CAS :<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Formule :C21H28N8O3S2Degré de pureté :98.88% - 99.55%Couleur et forme :SolidMasse moléculaire :504.63TG 100713
CAS :<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Formule :C12H10N6ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :254.25BEBT-908
CAS :<p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>Formule :C23H25N9O3SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :507.57PI3K-IN-1
CAS :<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Formule :C31H29N5O6SDegré de pureté :97.03% - 98%Couleur et forme :SolidMasse moléculaire :599.661,3-Dicaffeoylquinic acid
CAS :<p>1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.</p>Formule :C25H24O12Degré de pureté :98% - 98.81%Couleur et forme :SolidMasse moléculaire :516.45Euscaphic acid
CAS :<p>Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.</p>Formule :C30H48O5Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :488.7AS-605240
CAS :<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Formule :C12H7N3O2SDegré de pureté :97% - 99.91%Couleur et forme :SolidMasse moléculaire :257.27HS-173
CAS :<p>HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).</p>Formule :C21H18N4O4SDegré de pureté :99.33% - 99.64%Couleur et forme :SolidMasse moléculaire :422.46Serabelisib
CAS :<p>Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).</p>Formule :C19H17N5O3Degré de pureté :98.41% - 99.5%Couleur et forme :SolidMasse moléculaire :363.37TG100-115
CAS :<p>TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.</p>Formule :C18H14N6O2Degré de pureté :99.22% - 99.26%Couleur et forme :SolidMasse moléculaire :346.34Sophocarpine
CAS :<p>Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Formule :C15H22N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :246.35Quercetin Dihydrate
CAS :<p>Quercetin Dihydrate (Sophoretin) is a flavonoid natural product that activates or inhibits the activity of many proteins. It activates SIRT1 and inhibits PI3K.</p>Formule :C15H10O7·2H2ODegré de pureté :97.77%Couleur et forme :Yellow SolidMasse moléculaire :338.2725(R,S)-Ruscogenin
CAS :<p>25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.</p>Formule :C27H42O4Degré de pureté :99.32% - 99.89%Couleur et forme :SolidMasse moléculaire :430.62Buparlisib
CAS :<p>Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).</p>Formule :C18H21F3N6O2Degré de pureté :95.32% - 98.45%Couleur et forme :SolidMasse moléculaire :410.39RLY-2608
CAS :<p>RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.</p>Formule :C29H14ClF5N6O2Degré de pureté :98.62% - 98.7%Couleur et forme :SolidMasse moléculaire :608.91740 Y-P
CAS :<p>740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!</p>Formule :C141H222N43O39PS3Degré de pureté :98.3% - 99.87%Couleur et forme :SolidMasse moléculaire :3270.7BGT226 maleate
CAS :<p>BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .</p>Formule :C28H25F3N6O2·C4H4O4Degré de pureté :97.75% - 98.78%Couleur et forme :SolidMasse moléculaire :650.6GSK2292767
CAS :<p>GSK2292767 is a potent and selective PI3Kδ inhibitor.</p>Formule :C24H28N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.58CNX-1351
CAS :<p>CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.</p>Formule :C30H35N7O3SDegré de pureté :99.66% - 99.83%Couleur et forme :SolidMasse moléculaire :573.71AZ2
CAS :<p>AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.</p>Formule :C20H23N3O2SDegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :369.48Nemiralisib
CAS :<p>Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.</p>Formule :C26H28N6ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :440.54PI3Kγ inhibitor 7
CAS :<p>PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].</p>Formule :C31H25N9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.59CAL-130
CAS :<p>CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formule :C23H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.47FD2056
CAS :<p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>Formule :C23H17ClN6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.94PI3K-IN-9
CAS :<p>PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).</p>Formule :C19H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.43PI3Kdelta inhibitor 1
CAS :<p>PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.</p>Formule :C27H38N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.69PI3Kδ-IN-3
CAS :<p>PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.</p>Formule :C28H24N6O3Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :492.53Vps34-IN-2
CAS :<p>Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).</p>Formule :C18H25F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.41PI3K/mTOR Inhibitor-2
CAS :<p>Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.</p>Formule :C20H13ClF2N4O4SDegré de pureté :96.16%Couleur et forme :SolidMasse moléculaire :478.86
