Composés deutérés

<p>Applications 1-(Benzyloxy)-3-[[bis(benzyloxy)phosphoryl]oxy]propan-2-ol-13C3 is an intermediate used in the synthesis of (D450537), which is a carbon-13 labelled Dihydroxyacetone phosphate [57-04-5] and involved in a wide variety of metabolic pathways including glycolysis and lipid biosynthesis. In plants, Dihydroxyacetone phosphate is involved with the synthesis of vitamin B6.<br>References Nakamura, Y., et al.: Plant Cell Physiol 30, 833 (1989); Tamabasco-Studart, M., et al.: Proc. Natl. Acad. Sci. USA 102, 13687 (2005)<br></p>

<p>Stability Light Sensitive<br>Applications Acrylonitrile-13C3_x000D_(stabilized with 35-45 ppm 4-hydroxy anisole (H750015)) (cas# 202326-55-4) is a compound useful in organic synthesis.<br> E0<br></p>

<p>Applications 2-Chloropyrimidine-d3 was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state.<br>References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)<br></p>

<p>Applications Quinoxaline-5,6,7,8-d4 (CAS# 64252-08-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications (Ethoxycarbonylmethyl)triphenylphosphonium-13C2 bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.<br>References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),<br></p>

<p>Applications 6-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. This is the labeled analog.<br>References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999);<br></p>

<p>Applications Glyceryl Tri(octanoate-d15) (CAS# 352431-24-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopropane-3,3,3-d3 is labelled 1-Bromopropane (B687135) which is used as a solvent and for the cleaning of metal surfaces, removal of soldering residues from electronic circuit boards. It is anticipated to be human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lingyo Zh., et al.: Toxicology, 304, 76 (2013); Samukawa, M. et al.: Archives Internal Med., 172(16), 1257 (2012);<br></p>

<p>Applications (±)-1,4-Dithiothreitol-d10 (CAS# 203633-21-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Hexyl-d13 Alcohol (CAS# 204244-84-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetracosanoic-9,9,10,10-d4 Acid (CAS# 1219794-61-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ledipasvir-d6 is labelled Ledipasvir (L320100) which is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.<br>References Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications Catechol-13C6 (cas# 115881-16-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,4-Butane-d8-dithiol (CAS# 1219805-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-2-Aminobutyric-2,3,3,4,4,4-d6 Acid (CAS# 350820-17-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications O-Desaryl Ranolazine-d5 is the isotope labelled analog of O-Desaryl Ranolazine (D422050); a metabolite of Ranolazine (R122500).<br>References Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)<br></p>

<p>Applications O-Demethoxypropane Aliskiren-d6 is the labeled analog of O-Demethoxypropane Aliskiren is an impurity of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.<br>References Kumar, N.U., et. al.: Chem. Biol. Interface, 3, 304 (2013); Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000); Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002); Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003); Grandman, A.H., et al.: Circulation, 111, 1012 (2005)<br></p>

<p>Applications O-di-TMS 2-Arachidonyl Glycerol-d5 is an intermediate used in the synthesis of 2-Arachidonyl Glycerol-d5 (A765052), which is a labelled 2-Arachidonoylglycerol (A765050). It is a major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. It plays an inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats.<br>References Yokotani, K., et al.: Eur. J. Pharmacol., 512, 29 (2005), Jensen, R., et al.: Pharmacol. Rev., 60, 1 (2008), Lu, L., et al.: Eur. J. Pharmacol., 590, 177 (2008),<br></p>

<p>Applications 1,2-Cyclohexanedione-13C6 is the isotope labelled analog of 1,2-Cyclohexanedione (C988085), a compound used as a substrate to study enzyme cyclohexane-1,2-dione hydrolase as a new tool to degrade alicyclic compounds.<br>References Fraas, S., et al.: J. Molec. Cataly. B. Enzy., 61, 47 (2009); Steinbach, A., et al.: FEBS. J., 279, 1209 (2012);<br></p>

<p>Applications N-(Ethyl-d2)-N-(propyl-d2)benzenemethanamine is an intermediate in the synthesis of N-Ethyl-N-nitroso-1-propanamine-d4 (E817997) and isotope labelled version of N-Ethyl-N-nitroso-1-propanamine. N-Ethyl-N-nitroso-1-propanamine is a derivative of N-Nitrosodiethylamine (N525465),a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.<br>References Shirakami, Y., et al.: Bitamin, 87, 156 (2013); Fujii, Y., et al.: Toxicol., 305, 30 (2013); Uehara, T., et al.: Toxicol. Sci., 132, 53 (2013);<br></p>

<p>Applications Ethyl-1,2,2,2-d4 Alcohol (CAS# 22544-43-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Carboxymethoxyamine-d2 Hemihydrochloride (cas# 1246817-66-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4,6-Trimethyl-1,3-benzenediamine-15N2 is the isotope labelled analogue of 2,4,6-Trimethyl-1,3-benzenediamine, a compound used in the synthesis of various polymers.<br>References Fritsch, D., et al.: Macromolec. Chem. Phys., 197, 701 (1996);<br></p>

<p>Applications Isopropylaminosulfoni-d7 Acid is an intermediate in the synthesis of Bentazon-d7 (B120583). Bentazon-d7 is deuterium labelled Bentazon (B120580), which is a herbicide. Isopropylaminosulfoni-d7 Acid is also the labeled form of Isopropylaminosulfonic Acid (I824090), which is an reactant used in the synthesis of N-Alkylsulfamic Acid Derivatives.<br>References Ghirardello, D., et al.: Environ. Sci. Technol., 44, 9010 (2010); Frihauf, J., et al.: Weed Technol., 24, 262 (2010); Rotroff, D., et al.: Toxicol. Sci., 117, 348 (2010)<br></p>

<p>Applications 4-Acetamidobenzene-d4-sulfonyl Chloride is the deuterium labelled form of 4-(Acetylamino)benzenesulfonyl Chloride (A170950), which is a sulfanilamide derivative of Chitosan with antifungal properties.<br>References Tashiro, T., et al.: Bioorg. Med. Chem., 16, 8896 (2008); Alcalde, E., et al.: J. Med. Chem., 52, 675 (2009);<br></p>

<p>Applications 2,5-Dichlorophenol-d3 is the labelled analogue of 2,5-Dichlorophenol (D436105), which is an intermediates in the manufacture of more complex chemical compounds such as fungicides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, F., et al.: Bull. Enviro. Contamin. Toxicol., 89, 316 (2012); Zhong, W., et al.: J. Hazard. Mat., 217, 286 (2012);<br></p>

<p>Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.<br>References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),<br></p>

<p>Applications N,N-Dimethylaniline-d3 (N-methyl-d3) (CAS# 88889-00-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Benzyl- 2-thiophenecarboxylic Acid-d7 is labelled 4-Benzyl- 2-thiophenecarboxylic Acid (B315140) which is a derivative of 2-Thenoic Acid (T343505), used in the synthesis of pharmaceutical and biologically active compounds. 2-Thenoic Acid is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.<br>References huyop, F. Z., et al.: Malaysian J. Biochem. Mol. Bio., 2, 9 (1997)<br></p>

<p>Applications Hexamethyl-d18-disilane (CAS# 61123-71-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications D-Phenyl-d5-alanine-N-t-BOC (CAS# 1213661-19-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4,4,5,5-Tetramethyl-2-[4-(2,2,2-trifluoroethyl)phenyl]-1,3,2-dioxaborolane-d4 is labelled 4,4,5,5-Tetramethyl-2-[4-(2,2,2-trifluoroethyl)phenyl]-1,3,2-dioxaborolane (T305500) which is an intermediate used to prepare fused imidazolone derivatives as possible allosteric modulators for metabotropic glutamate receptor subtype 2 (mGlu2 receptor).<br>References Matsuda, Y., et al.: PCT Int. Appl., WO 2013062074 A1 20130502 (2013)<br></p>

<p>Applications 3-Nitrobenzyl-d6 Alcohol (CAS# 1219795-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-n-Pentyl-d11-phenol (CAS# 1219805-30-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,3-Dimethylphenol-13C8 is an isotope labelled analog of 2,3-Dimethylphenol. 2,3-Dimethylphenol is a useful synthetic intermediate. It was used in the synthesis of hydroxychalcones and flavones with antiinflammatory activities. It was also used to prepare 3,3-bisaryloxindole analogs as mineralocorticoid receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ballesteros, J., et al.: J. Med. Chem., 38, 2794 (1995); Neel, D., et al.: Bioorg. Med. Chem. Lett., 15, 2553 (2005)<br></p>

<p>Applications n-Heptyl-d15 Alcohol (CAS# 194793-95-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-3,5-dichlorobenzene-d3 (CAS# 1219803-83-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Bromo-alpha,alpha,alpha-trifluorotoluene-d4 (CAS# 1219799-09-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-​Methylbutyryl-​d9 Chloride is an intermediate for the synthesis of Isovaleryl L-Carnitine-d9 Chloride (I917582), which is labelled Isovaleryl L-Carnitine Chloride (I917580), and it is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.<br>References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Applications 2-Chloroacetonitrile-13C2 is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications Tetrahydrofuran-2,2,5,5-d4 (CAS# 20665-63-8) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(2-Propynyloxy)tetrahydropyran-13C3 is an intermediate in the synthesis of N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 (A173713). N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 is labelled N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (A173710), which is a metabolite of butadiene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heavner, D., et al.: J. Pharm. Biomed. Anal., 40, 928 (2006); Carmella, S., et al.: Chem. Res. Toxicol., 22, 734 (2009)<br></p>

<p>Stability Volatile<br>Applications Cyclopentane-d10 (CAS# 7426-92-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glyceryl Tri(octadecanoate-18,18,18-d3) (CAS# 285979-76-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(2-hydroxyethyl)-1,1,2,2-d4-amine (CAS# 352431-07-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347 (1982),<br></p>

<p>Applications Labelled α-Methyl-1-pyrenemethanol is used in the synthesis of colorimetric and fluorescent ratiometric mercury sensors. This is applicable to the quantification of transition metals in the environment as well as biological systems.<br>References Weng, J. et al.: Tetra., 68, 3129 (2012);<br></p>

<p>Applications Anisole-2,3,4,5,6-d5 (CAS# 50629-14-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Hydroxyhexanoic-6,6,6-d3 Acid (CAS# 1219798-84-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromotetradecane-14,14,14-d3 (CAS# 347840-09-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications (3,4-Dinitrophenyl)(phenyl-d5)methanone is an intermediate for the synthesis of Mebendazole-d8 (M200502), which is labelled Mebendazole (M200500). Anthelmintic (Nematodes).<br>References Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 16, 291 (1987)<br></p>

<p>Applications 2-Ethyl-1-hexanamine-D5 is an intermediate in the synthesis of Alexidine-d10 Dihydrochloride (A525002), which has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.<br>References Coburn, R.A., et al.: J. Med. Chem., 21, 8, 829 (1978), Takayama, K., et al.: J. Biol. Chem., 269, 2241 (1994), Faure, P., et al.: Biochimie, 86, 411 (2004),<br></p>

<p>Applications 1,3-Dichloropropene-d4 (cis/trans mixture) (CAS# 202656-23-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications (Bromomethyl)cyclohexane-d11 is the isotope labelled analog of (Bromomethyl)cyclohexane. (Bromomethyl)cyclohexane is a reagent that is used in the synthesis of cyano thiouracils as SecA inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chaudhary, A. S., et al.: Bioorg. Med. Chem., 23, 105 (2015);<br></p>

<p>Applications Lys-SMCC-DM1-D9 is deuterium labelled Lys-SMCC-DM1 (L488780). Lys-SMCC-DM1 (L488780) is designed to eradicate cancer cells that express the target antigen on their cell surface.<br>References Erickson, H., et al.: Bioconjugate Chem., 21, 84 (2010)<br></p>

<p>Applications 3,5-Difluorobenzoic-d3 Acid (CAS# 934397-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(Methyl-d3-amino)butyric-2,2,3,3,4,4-d6 Acid HCl (CAS# 1219805-36-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Alkyl Diphenyl Phosphate-d10 is the deuterated form of Alkyl Diphenyl Phosphate (A575133), which is a phosphorus flame retardant additive.<br>References Miyachi, Y., et al.: Materiaru Raifu, 10, 137 (1998);<br></p>

<p>Applications 1,6-Hexane-1,1,6,6-d4-diol (CAS# 6843-76-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Cholesten-3-one-4-13C (CAS# 68165-57-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetyl-2,6-dichlorodiphenylamine-d5 is labelled N-Acetyl-2,6-dichlorodiphenylamine (A173570) which is an impurity of diclofenac (D436450, Na salt), a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor.<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004); Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)<br></p>

<p>Applications n-Hexyl 4-Methyl-2-pentyl Phthalate, is the labeled analogue of n-Hexyl 4-Methyl-2-pentyl Phthalate (H297165), a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties.<br>References Wang, Zh., et al.: Guocheng Gongcheng Xuebao, 5 (6), 670 (2005);<br></p>

<p>Applications Isotope labelled N-(Phenyl)-1-napthyl Amine is a chemical reactant used in the preparation of aryl halides and diarylamines. Also forms oligomers used as hole transport for green electrophosphorescence.<br>References Yamamoto, T. et al.: Tetrahedron Lett., 39, 2367 (1998); Zhang, S. et al.: Dyes and Pigments., 118, 1 (2015);<br></p>

<p>Applications Thiophene-2,5-d2 (CAS# 2041-42-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-​(Dimethyloxidoamino)​butanoic Acid-d6 Hydrochloride is the labelled form of 4-​(Dimethyloxidoamino)​butanoic Acid (D447160). 4-​(Dimethyloxidoamino)​butanoic Acid is a metabolite of Lauramine Oxide (L178530), which is a frequently used amine oxide surfactant. It is strongly hydrophilic , and it forms normal micelles and normal liquid crystalline phases.<br>References Kocherbitov, v., et al.: J. Molec. Struct.: Theochem., 808, 111 (2007); Kocherbitov, v., et al.: J. Phys. Chem. B., 110 (27), 13649 (2006); Turan, T.S., et al.: Xenobiotica, 11, 447 (1981)<br></p>