Produits biochimiques et réactifs

<p>Tenovin-6 Hydrochloride is a peptide inhibitor that binds to the extracellular domain of the alpha-subunit of the human calcitonin receptor, inhibiting its interaction with its ligand. Tenovin-6 Hydrochloride has been shown to inhibit cAMP production and activate intracellular calcium ion channels. The inhibition of calcium ion channels leads to an increase in intracellular calcium concentration and may be associated with the observed anti-inflammatory effects. This peptide has also been shown to inhibit inflammatory cytokine production by activated T cells and upregulate IL-10 production by monocytes and macrophages. Tenovin-6 Hydrochloride is purified from a fermentation process and is suitable for use in research as a reagent or antibody target in cell biology experiments as well as pharmacological studies.</p>

<p>Inhibitor of Janus kinase JAK2</p>

<p>Rac Threo-dihydro bupropion-d9 is a peptide that is used as a research tool. It activates protein kinase C, which regulates ion channels and cell signaling pathways. Rac Threo-dihydro bupropion-d9 also binds to the alpha subunit of the G-protein and can inhibit the activity of various ion channels. This peptide has been shown to inhibit the binding of ligands with receptors, such as dopamine D2 receptor, and to block the action of neurotransmitters in cells. In addition, it inhibits protein interactions with other proteins in cells.</p>

<p>Secergan is a peptide that was originally isolated from the venom of the black widow spider. It has potent activity on ion channels, and is being researched as a potential treatment for epilepsy. Secergan also binds to a receptor called Ligand, which may be involved in regulating neuronal excitability. The protein interactions involving Secergan are not well understood, but it has been shown to have an effect on cell biology and activate receptors. This peptide is used as a research tool for pharmacology and protein interactions, and it can be used to purify antibodies and other proteins. Secergan has a high purity that makes it suitable for use in antibody production.br&gt;<br>Secergan is found in the venom of the black widow spider. It has been shown to have potent activity on ion channels, and is being researched as a potential treatment for epilepsy. Secergan also binds to a receptor called ligand, which may be involved in regulating neuronal excitability. The protein</p>

<p>Imiglitazar is a drug that inhibits the activity of phosphodiesterase 4 (PDE4), an enzyme that breaks down cAMP. This leads to increased levels of cAMP, which has been shown to have beneficial effects on inflammatory bowel disease, chronic pulmonary disease, and congestive heart failure. Imiglitazar is also used as a diagnostic marker for these conditions.</p>

<p>Biotin-dPEG®4-amido-dPEG®24-amido-dPEG®24-DSPE is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Biotin-dPEG®4-amido-dPEG®24-amido-dPEG®24-DSPE is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>DOTA-tris(Acid)-Amido-dPEG®4-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®4-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>MAL-dPEG®24-Tris (-dPEG®24-Tris (m-dPEG®24)3)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®24-Tris (-dPEG®24-Tris (m-dPEG®24)3)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Azido-dPEG®36-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, azido-dPEG®36-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>PIN1 human is a peptidyl-prolyl cis-trans isomerase enzyme, which is derived from human tissues and cellular extracts. This enzyme plays a critical role in the regulation of protein function through isomerization of specific serine/threonine-phosphorylated proline bonds. Its mode of action involves altering the conformation of phosphorylated proteins, affecting their stability, localization, and interaction with other cellular molecules.</p>

<p>16:0 Topfluor cholesterol (16:0-TF) is a fluorescent analog of cholesterol. It is a ligand that binds to the sterol receptor, which is located in the endoplasmic reticulum and plasma membrane. 16:0-TF has been shown to activate ion channels through protein interactions. This compound can be used as a research tool for Cell Biology and other life science applications.</p>

<p>p-MPPI is an amide compound that has inhibitory effects on the 5-ht1a and 5-ht2 receptors. It also inhibits serotonin reuptake from the synapse and can alter serotonergic neurotransmission. p-MPPI binds to serotonergic receptors, which may result in its use as a therapeutic agent for the treatment of depression or anxiety. This drug also has an inhibitory effect on human liver cells and can cause toxicity in animals. p-MPPI has been shown to have irreversible effects on mouse caudate putamen neurons when administered chronically, leading to a decrease in receptor binding.</p>

<p>6-Fluoro-3-indoxyl-beta-D-galactopyranoside is a potent inhibitor of protein interactions. It has been shown to inhibit the binding of peptides to their receptors, and can be used as a research tool for studying protein interactions. 6-Fluoro-3-indoxyl-beta-D-galactopyranoside also has an activator effect on the Ligand Gated Ion Channel (LGC) family. The high purity of 6-Fluoro-3 indoxyl beta D galactopyranoside ensures that it will not interfere with other experiments.</p>

<p>Agn 192403 hydrochloride is a synthetic compound designed as a selective antagonist of the calcitonin gene-related peptide (CGRP) receptor. This product is derived through chemical synthesis, specific to modulating biological pathways related to bone metabolism. Its mode of action involves inhibiting the activity of CGRP, a neuropeptide that plays a significant role in the regulation of bone resorption and vasodilation.</p>

<p>Inhibitor of PI3Kδ  and PI3Kγ kinases</p>

<p>KGA-2727 is a novel, orally administered, non-peptidic, small molecule antidiabetic agent that increases glucose uptake in skeletal muscle cells by inhibiting the sodium-dependent glucose transporter type 2 (SGLT2) and the accompanying sodium-glucose cotransporter. KGA-2727 has been shown to lower blood pressure and increase insulin sensitivity in diabetic mice. Chronic treatment with KGA-2727 has been shown to increase insulin sensitivity in wild-type mice without any adverse effects. This drug also lowers blood sugar levels in patients with type 2 diabetes.</p>

<p>Isobetanin is a natural product that belongs to the class of betalains. It has been shown to inhibit ion channels, such as potassium and calcium channels, which are important for the transmission of nerve impulses. Isobetanin also binds to receptors, such as the Ligand-Gated Ion Channel (LGIC) receptor. It is used as a research tool in pharmacology and protein interactions.</p>

<p>SPI 112 is a small molecule that inhibits the enzyme phosphatase. SPI 112 has been shown to be effective in mouse tumor models, and it has been found to inhibit growth factor-stimulated cell proliferation. This compound binds to the active site of the phosphatase and dephosphorylates the substrate protein. SPI 112 also inhibits epidermal growth factor (EGF) and interferon alfa-2b induced DNA synthesis in fetal bovine cells. It is not yet known if this drug has any effect on cancer cells grown in culture or radiation-induced apoptosis in human breast cancer cells.</p>

<p>SK-216 is a small molecule that inhibits the activation of FoxO1, which is a transcription factor. SK-216 also prevents oxidative injury and mitochondrial dysfunction by inhibiting the production of growth factor-β1, as well as inhibiting the activation of Toll-like receptor 2 (TLR2) and TLR4. SK-216 has been shown to have anti-inflammatory effects and can inhibit cyclin D2 expression, which leads to inhibition of energy metabolism in cancer cells. SK-216 also has an effect on epithelial mesenchymal transition (EMT), leading to suppression of EMT, tumorigenesis, migration, and metastasis.</p>

<p>Carbasulam is an anticancer drug that inhibits the growth of cancer cells by inducing apoptosis. It acts by binding to protein kinases, which are enzymes that play a crucial role in cell signaling and regulation. Carbasulam has been shown to be effective in inhibiting the growth of tumors in human and Chinese hamster ovary cells. It is a medicinal analog of urine-derived kinase inhibitors, which have been used as potential anticancer agents. Carbasulam is a potent inhibitor of several kinases involved in cancer cell proliferation, including Akt, ERK1/2, and JNK1/2. Its ability to selectively target these kinases makes it a promising candidate for the treatment of various types of cancer.</p>

<p>3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine is a networked interface that provides information on the drug's chemical structure, molecular weight, and 3D molecular structure. It also provides information on related drugs, as well as drug targets.</p>

<p>WHI-P180 is a potential anticancer agent that has been shown to be effective in inhibiting the growth of human colon cancer cells (HCT116) and CD-1 mice with cancer. WHI-P180 binds to the intracellular targets of mcf-7, a growth factor involved in cell proliferation, which leads to neuronal death. This agent has also been demonstrated to be cytotoxic against monoclonal antibodies and epidermal growth factor receptor (EGFR). WHI-P180 targets ABCG2, an enzyme involved in drug efflux, which may lead to increased efficacy of this drug.</p>

<p>Petesicatib is a neuroprotective agent which has been shown to have nootropic and neuroprotective properties. It has been shown to inhibit the activity of receptor-2, tyrosine kinase, and protein kinase C in vitro. These effects are due to its ability to inhibit the conversion of retinoic acid into its active form by preventing the binding of retinoids to nuclear receptors. Petesicatib also binds to DNA and prevents the expression of proteins that are necessary for cells to divide. This drug is not selective for any one type of cell, but it does protect against toxic effects on neurons and astrocytes in vitro.</p>

<p>PF-04957325 is a drug that inhibits phosphodiesterase enzymes. It has been shown to inhibit cyclic nucleotide phosphodiesterases, which are enzymes that break down cyclic nucleotides, preventing the accumulation of cAMP in cells. This accumulation leads to cell death and cancer cell death. PF-04957325 has shown promising effects in animal models for breast cancer treatment. It also has shown synergistic effect with other drugs, such as camp levels and potential drug targets for autoimmune diseases and brain functions. PF-04957325 is effective against cancer tissues and inhibits phosphorylation of the inhibitor protein (IκB), leading to increased production of proinflammatory cytokines.</p>

<p>PF05020182 is an antibody that binds to the extracellular domain of human epidermal growth factor receptor-2 (HER2) and inhibits HER2 signaling. It is a recombinant protein consisting of heavy chains and light chains. PF05020182 is a research tool used in cell biology, pharmacology, and biochemistry. This antibody has been shown to inhibit the proliferation of breast cancer cells in vitro by targeting HER2 receptors on the surface of tumor cells. The binding affinity for this antibody is high with a Kd = 0.05 nM. PF05020182 also binds to other receptor proteins such as epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and platelet-derived growth factor receptor beta (PDGFβR).</p>

<p>JNJ-28312141 is a potent, selective inhibitor of the receptor tyrosine kinase TIE2 for the treatment of malignant glioma. It has been shown to inhibit tumor growth and induce cell death in vivo in a number of preclinical models of cancer. JNJ-28312141 also inhibits angiogenesis and reduces inflammatory responses in tumor microenvironments. This drug binds to a unique site on TIE2 that is distinct from the binding site for zoledronate, which is used as an anti-angiogenic therapy. Treatment with JNJ-28312141 has been shown to have positive effects in animal models of bone lesions with mesenchymal markers, including assays that are based on kinase selectivity, growth factor receptor activation, or bone metabolism. The efficacy of JNJ-28312141 has been demonstrated in glioma patients who were undergoing surgery and had resection.<br>END&gt;</p>

<p>Daidzein diglucuronide is a glucuronide metabolite of daidzein, which is a natural product. It has shown anticancer activity in vitro and in vivo. Daidzein diglucuronide binds to the enzyme carboxylesterase and inhibits its activity, leading to an increase in the levels of carboxylic acids in the blood. These metabolites are then excreted through urine and bile. Daidzein diglucuronide may also be used as an anti-inflammatory agent due to its ability to inhibit prostaglandin synthesis.</p>

<p>MRS 4062 triethylammonium is a purinergic receptor agonist that can be used for the treatment of cancer and other conditions. The purinergic receptors are G protein-coupled receptors that bind to adenosine or ATP, which are molecules involved in the regulation of many cellular processes. MRS 4062 triethylammonium acts as a stimulatory agent by binding to the purinergic receptor and stimulating cell proliferation. This drug has been shown to increase levels of interferon in cells, which may be due to its ability to stimulate cell proliferation. MRS 4062 triethylammonium is also a potent antagonist of the A1 receptor, which may be useful for treating chronic pain.</p>

<p>L-Phenylalanyl-D-valyl-L-valyl-D-phenylalaninamide is a peptide that acts as an activator of ion channels. LPAVVDA is a synthetic peptide that contains four amino acids and has the sequence L-Phenylalanyl-D-valyl--L--Valyl--D--phenylalaninamide. It was developed to be used as a research tool, but it also has potential uses in antibody production and cell biology. This peptide can be used to study protein interactions, receptor binding, and ligand binding. It also has pharmacological applications for use as an inhibitor of ion channels or for use in protein purification.</p>

<p>AZD5423 is a fatty acid that has inhibitory properties on the cells in the colon. It has been shown to have clinical relevance for the treatment of autoimmune diseases, such as Crohn's disease and ulcerative colitis. AZD5423 also inhibits transrepression in caco-2 cells and reduces the inflammatory response in vivo. The molecule is synthesized by an asymmetric synthesis process with a diameter of 3.7 nm and potent inhibition against particle size of 2.5 nm. Clinical studies are underway to determine the efficacy of this drug in treating inflammatory diseases, including psoriasis and rheumatoid arthritis.</p>

<p>Pf-06456384 trihydrochloride is a ligand that binds to the opioid receptor. It has been shown to be an inhibitor of protein interactions, and may be used as research tools for cell biology and ion channels. Pf-06456384 trihydrochloride is also used as a reagent in immunoassays and other biochemical tests, such as radioimmunoassay.</p>

<p>Lin28 1632 is a small non-coding RNA molecule that has been shown to synergize with metformin in the treatment of cancer stem cells. This RNA molecule binds to acceptor molecules in the cell, which may be involved in drug metabolism or gene regulation. Lin28 1632 has also been shown to inhibit tumor growth by inhibiting the production of rRNA and protein synthesis. It has also been shown to have an anti-tumor effect on xenograft tumor models in mice.</p>

<p>Senkyunolide A is a p-glycoprotein (P-gp) inhibitor that has been shown to be effective in treating injuries. Senkyunolide A binds to P-gp and prevents the efflux of anticancer drugs or chemotherapeutic agents from tumor tissue, thus increasing the concentration of these drugs at the site of injury. Senkyunolide A has also been found to be an effective inhibitor of matrix metalloproteinases (MMPs), which are enzymes that degrade the extracellular matrix, leading to cell death. The effect on MMPs is due to senkyunolide's ability to bind to the active site of MMPs and inhibit their catalytic activity. This compound has been shown in vitro to inhibit neuronal death caused by oxygen deprivation and may have use for preventing cerebral injury, such as stroke. Senkyunolide A has been shown in vitro to be an effective inhibitor of polymerase chain reaction (PC</p>

<p>Voltage-gated calcium channel blocker</p>

<p>Diphenylterazine is a red fluorescent dye that belongs to the group of active substances. It is used in plant physiology research as an indicator for the presence of ethylene, which regulates plant growth and development. Diphenylterazine can be detected by chemical ionization in urine samples and has a low elimination rate. This compound inhibits protein synthesis in human liver cells and has been shown to interact with drugs such as warfarin, phenytoin, carbamazepine, and valproic acid. Diphenylterazine inhibits the activity of cytochrome P450 enzymes and may also have an effect on blood pressure.</p>

<p>BI-6C9 is a molecule that has been shown to inhibit the activity of glutamate receptors. It has been shown to increase ATP levels and cause decreased reactive oxygen species in cell culture. BI-6C9 also inhibits mitochondrial membrane potential, leading to necrotic cell death. This compound also induces autophagy, which is the process by which cells break down their own cellular components for energy production. BI-6C9 may be involved in the regulation of toll-like receptor 4 activation and cell proliferation inhibition.</p>

<p>LDN-192960 is a serine/threonine-protein kinase inhibitor that targets the catalytic domain of the enzyme. LDN-192960 inhibits cancer cell growth by inhibiting mitotic activity and histone phosphorylation. LDN-192960 also has been shown to inhibit the catalytic activity of serine/threonine-protein kinases, which are involved in many cellular processes including regulation of transcription, translation, apoptosis, and tumorigenesis. LDN-192960 binds to specific residues on the protein's surface and prevents phosphorylation of these residues, leading to inhibition of its catalytic activity. This drug has high inhibitory potency against mitotic serine/threonine-protein kinases and is currently being researched for its potential use in treating cancer.</p>

<p>Please enquire for more information about 4-Defluoro-4-(1H-1,2,4-triazol-1-yl) fluconazole-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>NTP42 is a nucleophilic compound that belongs to the class of prostanoids. It is a non-selective inhibitor of cyclooxygenase (COX) enzymes, which leads to the production of prostanoids. NTP42 has been shown to have cardiac hypertrophy inhibitory effects in animal models and to reduce systolic pressure. The mechanism of action for these effects is not fully understood, but may be due to its ability to inhibit the formation of reactive oxygen species and metal ion-dependent activation of COX enzymes. The tert-butyl group on this molecule likely increases its potency as an inhibitor by making it more lipophilic and therefore able to penetrate cell membranes more readily.</p>

<p>Inhibitor of glycogen phosphorylase</p>

<p>Lodelaben is a polymeric matrix that contains a mixture of fatty acids and fatty alcohols. Lodelaben is reconstituted with saline solution and implanted subcutaneously to provide sustained release of the active ingredient. Lodelaben has been shown to have a noncompetitive inhibition with plasma concentrations in rats, suggesting that it could be used as a diagnostic agent for monitoring drug levels in the blood. Lodelaben also has been shown to contain conjugates of alginic acid, which are used as pharmaceutical dosage forms for therapeutic drugs.</p>

<p>HBB MS Calibrator is a research tool that is used to calibrate mass spectrometry. It is an activator of Ligand and Receptor, which are proteins that play a role in cell biology. HBB MS Calibrator binds to ion channels and inhibits the opening of these channels. This leads to a decrease in the flow of ions through the channel, which can affect a number of cellular processes. HBB MS Calibrator also has pharmacological properties that are used for drug discovery and peptide production.</p>

<p>Ezetimibe-d4 is a reference standard for pharmacokinetic bioanalysis, which is used to validate analytical methods for the determination of ezetimibe in plasma. Ezetimibe-d4 is prepared by isotopic dilution, and its purity and potency are determined by high-performance liquid chromatography (HPLC) and mass spectrometry. The analyte can be detected in plasma samples that are collected orally. Analytical methods that use this reference material will have an abscissa of 0.5 to 1.5 hours post-dose, with a regression line that has a slope of -1/2 to -1/6 and an intercept at the origin.</p>

<p>WYE 687 dihydrochloride is a small molecule that is structurally related to activin, which belongs to the family of proteins that regulate cell growth. It has been shown to have a variety of physiological functions including muscle, brain, and erythropoiesis. WYE 687 dihydrochloride also regulates the expression of genes by binding to the promoter region of regulatory genes such as activin and myostatin. This compound also has an effect on protein synthesis in tissues such as the photoreceptor cells in the eye and neurons in the central nervous system.</p>

<p>Brain-derived neurotrophic factor (BDNF) is a protein that belongs to the neurotrophin family of growth factors. It regulates the growth, differentiation, and survival of neurons in the brain and spinal cord. BDNF is produced by neural cells in response to neuronal activity, or by nerve injury. BDNF has been shown to be involved in cellular proliferation and inhibition of apoptosis in tumors. BDNF regulates transcriptional regulation and mRNA splicing, as well as neurotransmission.br&gt; <br>BDNF acts as a regulator for non-small-cell lung cancer tumor growth. It can bind to other proteins such as tropomyosin, which are found on cell surfaces and inside cells. This binding modifies the activity of these proteins and alters their interactions with other proteins that regulate cell functions such as contraction and secretion.</p>

<p>CPI-1612 is a contactor that is used to measure the optical constants of chemical substances. It is often used to measure the optical properties of fatty acids and carbon sources. The CPI-1612 can be used in vivo bioavailability, as well as protein synthesis and growth rate measurements. It can also be used for primary cell culture studies. This device is capable of measuring the optical properties of a substance with an accuracy of ±0.005%.</p>

<p>1,2-Distearoyl-sn-glycero-3-phosphoinositol ammonium is a synthetic phospholipid utilized in numerous scientific and medical applications. It is derived from glycerophospholipids, which are integral components of cellular membranes. These phospholipids can be synthesized to include specific fatty acids like stearic acid to enhance their functional properties.</p>

<p>FC 131 is a cyclic peptide with potent chemoattractant properties. It has been shown to cause cell lysis in HL-60 cells, which is a type of white blood cell. FC 131 also inhibits the binding of CXCR4 ligands to their receptor and blocks migration of hematopoietic cells. These effects have been shown to be dose-dependent and time-dependent, as well as reversible in some cases. This chemokine has been shown to be clinically relevant for the treatment of autoimmune and inflammatory diseases, cancer, HIV infection, and other conditions where chemotaxis plays an important role. The potential therapeutic use of FC 131 is limited by its short half life in vivo.</p>

<p>HBC514 is a protein inhibitor that has shown promising results in the treatment of tumors. It induces apoptosis, or programmed cell death, in human cancer cells and Chinese hamster ovary (CHO) cells. HBC514 is an analog of kinase inhibitors and specifically targets cyclin-dependent kinases (CDKs), which are involved in regulating the cell cycle. This drug has shown to be effective against various types of cancer cells, making it a potential anticancer agent. HBC514 can be detected in urine samples, which makes it a useful tool for monitoring drug efficacy and toxicity. Overall, HBC514 is a promising new therapy for those battling cancer.</p>

<p>N-((3R,4R,5S)-5-(3,6-Dichloro-9H-carbazol-9-yl)-4-hydroxytetrahydro-2H-pyran-3-yl)-4-(trifluoromethoxy)benzenesulfonamide is a potent activator of the glycine receptor. It binds to the glycine site of the receptor and activates it by increasing ion flow through the ion channel. N-(3R,4R,5S)-5-(3,6-Dichloro-9H-carbazol-9-yl)-4-(trifluoromethoxy)benzenesulfonamide has been shown to be a ligand for a variety of receptors including but not limited to Ligand binding domain (LBD), Ion channels, High purity, Protein interactions. This compound can be used as a research tool in pharmac</p>

<p>Sarcolysin hydrochloride is an antitumor immunotherapeutic agent that inhibits the function of nuclear DNA by selectively binding to the nucleic acid. As a result, sarcolysin hydrochloride induces apoptosis of cancer cells in vitro and in vivo. It has been shown to synergize with chemotherapy agents such as melphalan, which inhibit the growth of tumor cells by blocking the activity of enzymes called Egfr inhibitors. Sarcolysin hydrochloride also exhibits cytotoxicity against melanoma cells and myeloma cells.</p>

<p>BAY 59-9435 is a highly selective small molecule activator of PPARβ/δ. BAY 59-9435 has been shown to increase mitochondrial biogenesis and fatty acid oxidation in vitro, as well as improve insulin sensitivity in vivo. These effects are mediated by the activation of PPARβ/δ, which is an important regulator of metabolic processes. The activation of PPARβ/δ also decreases inflammatory gene expression such as toll-like receptors, camp levels, and sphingosine kinase. The mechanism by which BAY 59-9435 increases mitochondrial biogenesis may involve upregulation of transcription factor peroxisome proliferator-activated receptor gamma coactivator 1α (PGC1α) and other genes that encode proteins involved in mitochondrial biogenesis.</p>

<p>JIP-1 (153-163) is a peptide that is involved in the regulation of insulin-like growth factor and insulin receptor signaling. JIP-1 (153-163) has been shown to function as a phosphatase by dephosphorylating phosphatidylinositol 3,4,5 trisphosphate at the cell membrane. It also regulates the spacing between cells, which may be due to its ability to stimulate nuclear factor-kappaB (NFκB). JIP-1 (153-163) has been shown to be a growth factor for hepatocytes and autocrine factors for mammalian cells. This peptide can be optimized for use in cell culture studies.</p>

<p>Ilepatril is a research tool that can be used as an activator, ligand, or receptor. Ilepatril is a small molecule that binds to ion channels and alters their activity. It is also a high-purity small molecule with pharmacological potential that interacts with peptides and proteins. Ilepatril has been shown to inhibit the voltage-gated sodium channel Nav1.7 (SCN9A) in cell culture studies on human dorsal root ganglion neurons from patients with neuropathic pain.</p>

<p>25:0 Coenzyme A is a natural long-chain fatty acid that is found in the human body and has been shown to be an inhibitor of antibody production. It has also been used as a research tool for cell biology, pharmacology, and ligand binding. 25:0 Coenzyme A can activate ion channels and control the movement of ions across the cell membrane. This molecule is also involved in protein interactions and receptor activation.</p>

<p>Proteomass insulin chain B oxidized MALDI-ms standard is a molecular weight marker for proteins. It is a peptide with a molecular weight of 3,000 Da that is immobilized on magnetic particles and used in size exclusion chromatography. Proteomics has been applied to the study of insulin resistance in humans. The insulin resistance index (IRI) is calculated using plasma mass spectrometry and trifluoroacetic acid to measure the amount of insulin that binds to its receptor. This index can be correlated with the size of an individual's proteomass insulin chain B oxidized MALDI-ms standard.</p>

<p>CCK-Tetrapeptide (30-33) is a peptide hormone that is structurally related to cholecystokinin. It has been shown to inhibit the activity of adenylate cyclase and phosphodiesterase, which are enzymes that are involved in cellular signaling. CCK-Tetrapeptide (30-33) has significant interactions with other drugs and can cause symptoms such as nausea, vomiting, diarrhea, or headache.</p>

<p>LY2955303 is a synthetic retinoid that has been shown to be effective in the treatment of pancreatic cancer. LY2955303 acts by binding to all-trans retinoic acid receptors, which are expressed on the surface of cancer cells. This drug binds to the receptor and inhibits proliferation and induces apoptosis in pancreatic cancer cells. LY2955303 also inhibits esophageal adenocarcinoma cell proliferation, as well as inducing apoptosis via the same mechanism. The crystal structure of LY2955303 bound to an all-trans retinoic acid receptor has been determined using X-ray crystallography. The structure reveals that this drug interacts with a hydrophobic pocket on the surface of the receptor, preventing it from activating transcription factors inside the cell nucleus. LY2955303 also has pharmacokinetic properties similar to those of other retinoids, with a rapid absorption rate that is followed by a slow elimination phase.</p>

<p>Tolterodine dimer (TD) is a drug formulation that contains propanol, hydrophobic and diisopropylamine. TD is an acidic non-polymeric dimer of tolterodine tartrate. TD has a chemical structure that is chemically similar to the drug composition, tolterodine tartrate. TD is used as a reagent for the isolation and structural formula of other drugs.</p>

<p>Tubulin binding agent; targets tumour vasculature</p>

<p>UK 370106 is a matrix metalloproteinase inhibitor, which inhibits the activity of enzymes that break down collagen and other proteins in the extracellular matrix. This inhibition leads to a reduction in the production of tumor necrosis factor-α (TNF-α) and other inflammatory cytokines. UK 370106 has been shown to inhibit both proenzyme MMP-1 and active enzyme MMP-1 in cancer cell lines and monoclonal antibody-producing cells. This drug also synergistically interacts with colchicine and 5-fluorouracil, two chemotherapeutic drugs used in cancer therapy. UK 370106 also has been shown to inhibit collagen degradation by human neutrophils, thereby preventing inflammation.</p>

<p>ML-10 is a molecule that inhibits the growth of cancer cells. It has been shown to reduce tumor size and inhibit tumor growth in various types of cancers, including breast and prostate cancer. ML-10 also reduces the uptake of fatty acids by cancer cells, which leads to apoptosis. This drug has a long safety profile and is well tolerated in clinical trials with no serious adverse effects reported. The best results are obtained when combined with temozolomide chemotherapy. ML-10 binds to cellular membranes, causing changes in cell shape, membrane permeability and metabolic activity.</p>

<p>Please enquire for more information about Acrylic acid-13C3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Nociceptin is a neuropeptide of the tachykinin family that is primarily expressed in the brain. It has been shown to have an important role in long-term treatment of depression and pain. Nociceptin is a bifunctional molecule with both antinociceptive and excitatory effects. Its analgesic properties are mediated by its ability to inhibit the release of substance P and calcitonin gene-related peptide, which are neurotransmitters involved in pain transmission. Nociceptin also has excitatory effects on tissues such as the stomach, pancreas, heart, and bladder. It may also be able to reduce inflammation by inhibiting histamine release from mast cells.</p>

<p>Cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor</p>

<p>RS 25344 hydrochloride is a selective and activating phosphoinositide 3-kinase (PI3K) inhibitor. It has been shown to selectively inhibit the PI3K pathway, which is involved in cancer development and progression. RS 25344 hydrochloride induces cancer stem cells by inhibiting the activation of protein kinase B (Akt), which plays an important role in cell proliferation, differentiation, and apoptosis. In addition, this drug inhibits mesenchymal-epithelial transition by blocking the activation of the protein kinase C alpha (PKCα), which is involved in epithelial-mesenchymal transition. RS 25344 hydrochloride also induces cancer cells to transition from a stem cell phenotype into a non-stem cell phenotype by inhibiting the function of protein kinase A (PKA).</p>

<p>Glutamate antagonist</p>

<p>NG 25 trihydrochloride is a potent and selective inhibitor of the nicotinic acetylcholine receptor. It has been shown to inhibit the activity of the receptor in vitro, with IC50 values of 1.1 nM against α7-nicotinic acetylcholine receptors and 4.3 μM against β2-nicotinic acetylcholine receptors. NG 25 trihydrochloride has also been shown to be an agonist at α7-nicotinic acetylcholine receptors and a partial agonist at β2-nicotinic acetylcholine receptors in vivo. This product may be used as a research tool for investigating the role of ion channels in cell biology.</p>

<p>Kauran-16,17-diol is a natural product that is found in the leaves of the plant Isodon. Kauran-16,17-diol has been shown to stimulate germination and growth by binding to gibberellin receptors. It also has potent antioxidant properties. Kauran-16,17-diol has been shown to inhibit recrystallization of ent-kaurene from epoxide and homogenates.</p>

<p>PD166326 is a protein data inhibitor drug that is used to inhibit the bcr-abl kinase, which is responsible for the uncontrolled proliferation of cells in cancer. PD166326 has been shown to inhibit the kinase activity of bcr-abl and increase mitochondrial membrane potential, leading to cell death by apoptosis. The compound has also been shown to inhibit the growth of skin cancer cells in mice. PD166326 binds to an active site on bcr-abl and blocks its ATP binding site, preventing phosphorylation of downstream substrates such as paxillin and caspase 3, which are involved in cell proliferation. This drug has also been shown to be effective against myelogenous leukemia cells in mice.</p>

<p>Ischemia reperfusion injury is a major cause of irreversible brain damage. The enzyme GTPase-activating protein (GAP) has been shown to be involved in the regulation of cell death and may represent a potential therapeutic target for ischemia reperfusion injury. MG132 is an inhibitor of GAP and can protect against brain damage in wild-type mice subjected to cerebral ischemia reperfusion injury. MG132 blocks protein synthesis, leading to apoptotic cell death in cancer cells, while it induces apoptotic cell death in cancer cells. MG132 also inhibits proteasome activity and leads to acute ischemic brain damage in wild-type mice.</p>

<p>Tipepidine hibenzate is an anticancer agent that has been shown to inhibit the growth of cancer cells by inducing apoptosis. It is an analog of indirubin, a potent inhibitor of protein kinases. Tipepidine hibenzate has been found to inhibit the activity of β-glucan kinase, which is involved in the regulation of cell proliferation and differentiation. This drug has been shown to be effective against human cancer cells in vitro and in vivo. It also inhibits the growth of tumors in animal models. Tipepidine hibenzate is excreted mainly in urine and has no significant toxic effects on normal tissues or organs.</p>

<p>VU 0029767 is a drug that has been shown to be an acetylcholinesterase inhibitor. It has been shown to produce depression-like behaviors in mice with cholinergic receptor knockout and chronic pulmonary inflammatory disease, as well as bowel disease. VU 0029767 also shows anti-inflammatory properties, which are caused by M1 receptors and acetylcholine inhibition. This drug is not effective in the treatment of depression or chronic pulmonary inflammatory diseases when administered alone. However, it can be used in combination with other drugs to improve their effectiveness.</p>

<p>GSK369796 Dihydrochloride is a novel antiviral agent that inhibits the viral life cycle by interfering with the synthesis of viral RNA. This drug is an inhibitor of the human immunodeficiency virus (HIV) and the hepatitis C virus (HCV). GSK369796 Dihydrochloride has been shown to be effective in reducing viral load in HIV-infected patients, as well as HCV-infected patients who are resistant to existing therapies. The molecular modeling studies indicate that it has a high affinity for certain chemical structures that are found in natural compounds, such as chlorine atoms. GSK369796 Dihydrochloride can be used for specific treatment of AIDS and hepatitis C. It also shows no significant inhibitory activities against human cells in vitro assays, which means it does not have toxicity in humans. The pharmacokinetic properties of GSK369796 Dihydrochloride have been studied in humans and show good bio</p>

<p>LDN 214117 is a small molecule that has been shown to inhibit the activity of a variety of receptors including G protein-coupled receptors, tyrosine kinase receptors, and chemokine receptors. LDN 214117 binds to the ligand binding site of these receptors and blocks signal transduction. LDN 214117 is not active against mesenchymal stem cells or epidermal growth factor receptor (EGFR) expressing cancer cells, which may be due to its low expression in these cells. This drug has also been shown to have pharmacokinetic properties that allow for oral administration.</p>

<p>ML 240 is a potent inhibitor of cell proliferation and bone growth that has shown promising results in the treatment of cancer. It induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of specific proteins involved in the cell cycle. ML 240 has been tested on several cancer cell lines and has shown to be effective against various types of cancer. It works by blocking the activity of specific inhibitors that regulate protein expression, leading to cell death. ML 240 is a promising candidate for cancer therapy due to its ability to selectively target cancer cells while sparing normal cells.</p>

<p>Rigosertib is a small molecule that inhibits the activity of DNA methyltransferases. Rigosertib has been shown to have synergistic effects with other drugs, including anti-inflammatory agents, and is being studied as a potential treatment for cancer. Rigosertib has minimal toxicity in mice, with no signs of weight loss or hair loss at doses up to 5000 mg/kg, or death at 10,000 mg/kg. In a model system, rigosertib inhibited the growth of leukemia cells without affecting normal cells. Rigosertib may be useful for treating cancers such as breast cancer and prostate cancer because it blocks the tumor's ability to grow by inhibiting cell division.</p>

<p>Please enquire for more information about 4-[3-(4-Morpholinyl)propoxy]-phenol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Recilisib sodium is a synthetic compound, which is a stabilized sodium salt of a novel chemical entity developed through chemical synthesis. Its mode of action involves the modulation of cellular signaling pathways related to the DNA damage response. By enhancing the repair of radiation-induced DNA damage and mitigating apoptosis, it assists in maintaining genomic integrity under stress conditions.</p>

<p>DAMGO is an opioid drug that binds to the δ-opioid receptors in the brain's anterior cingulate cortex. It has a rate constant of 1.7 × 10/M, a high energy metabolism, and significant up-regulation of cyclase activity at doses of 10−8 M. DAMGO also inhibits guanine nucleotide-binding proteins, which are involved in immune responses and the regulation of gene expression. DAMGO may act as a pharmacological agent for infectious diseases such as HIV or bowel disease by binding to toll-like receptor 4 (TLR4) or δ receptors.</p>

<p>GV-196771a is a metabotropic glutamate receptor (mGluR) antagonist. It blocks the action of glutamate, a neurotransmitter that activates mGluRs. GV-196771a has been shown to be effective in the treatment of chronic schizophrenia, as well as symptoms such as anxiety, depression and Parkinson's disease. The drug is also neuroprotective and can prevent damage to neurons caused by toxins or strokes. GV-196771a binds to the mGluR5 receptor and blocks activation by glutamate. This prevents the release of other neurotransmitters that are involved in pain transmission, such as dopamine, norepinephrine, serotonin and acetylcholine.</p>

<p>Ethyl 4-chloro-2-(ethylthio)pyrimidine-5-carboxylate is an inhibitor of the enzyme acetylcholinesterase. It is a ligand for nicotinic acetylcholine receptors and has been shown to activate the ion channel TRPV1, which is involved in pain sensation. The compound also inhibits serine proteases and phospholipases. This chemical has been used as a research tool in cell biology, pharmacology, and life sciences.</p>

<p>Meperfluthrin is a medicinal compound that has shown promising anticancer properties. It has been found to inhibit the activity of certain kinases, which are proteins involved in cell replication and apoptosis. Meperfluthrin is an analog of a Chinese herbal medicine and has been tested in human cancer cells lines. This compound has been shown to be a potent inhibitor of tumor growth and cell proliferation. In addition, meperfluthrin has also demonstrated its ability to induce apoptosis in cancer cells, leading to their death. Meperfluthrin is excreted primarily through urine and may have potential as a therapeutic agent for the treatment of various types of cancer.</p>

<p>Frets-25Glu is a peptide inhibitor of the alpha subunit of the voltage-gated potassium channel. It is a high purity, water-soluble, stable peptide that can be used as a research tool to study the function of ion channels and receptors. Frets-25Glu has been shown to inhibit potassium channel currents in rat dorsal root ganglion neurons and rat dorsal spinal cord neurons. It also binds to the alpha subunit of voltage-gated potassium channels in rat brain tissue.</p>

<p>L-798106 is a potent and selective h1 receptor antagonist that blocks the action of histamine. It has been shown to inhibit the intracellular calcium concentration, which may be due to its inhibition of myosin phosphatase activity. L-798106 also inhibits cancer cells by interfering with cell growth and preventing the production of cancerous proteins. Interestingly, this drug also has a pressor effect on blood pressure, which may be due to its ability to increase camp levels in the mesenteric artery. L-798106 is an antagonist of epoxyeicosatrienoic acids (EETs) and 2-aminoethoxydiphenyl borate (2-APB). These compounds are potent agonists for the h1 receptor, which causes vasoconstriction and increases in blood pressure. L-798106 has been shown to inhibit protein synthesis at polymerase chain reaction (PCR) levels in prostate cancer cells. This drug also decreases</p>

<p>Tabimorelin is a potent analog of the endogenous hormone ghrelin. It binds to the ghrelin receptor and stimulates appetite, thereby increasing food intake and weight gain. Tabimorelin also has been shown to be effective in treating bowel disease, diabetic neuropathy, and symptoms of inflammatory bowel disease. The pharmacological effects of tabimorelin are due to its ability to bind to receptors in the gastrointestinal tract. This drug also has an effect on coordination complex formation by human liver microsomes. Tabimorelin can be used as a diagnostic tool for some types of cancer because it is not metabolized by enzymes in healthy cells, but is metabolized by enzymes in cancer cells. The use of tabimorelin as an analytical method is based on its ability to form coordination complexes with heavy metals such as mercury or lead.</p>

<p>Lehmannine is a basic fibroblast growth factor (bFGF) found in Chinese medicine preparations that has been used to treat rabies, snakebites, and other venomous bites. It was first isolated from the Chinese herb robinia. Lehmannine has been shown to have anthelmintic properties, which may be due to its ability to cause paralysis of the worms' suckers. Lehmannine binds to the receptor sites on the surface of the worm's cells and causes paralysis by preventing muscle contraction. The binding of lehmannine is reversible and it can be detected with high sensitivity at phase transition temperature. Lehmannine also inhibits glutinosa activity.</p>

<p>NVS-CRF-38 is a corticotropin-releasing factor (CRF) analog. It is a conjugated form of the CRF-III peptide, which has been modified to contain a phenylalanine residue at position 3 and an arginine residue at position 9. The test compound binds to the CRF receptor and acts as a partial agonist. NVS-CRF-38 has been shown to have pharmacokinetic properties similar to those of native CRF in rats and humans. In rats, plasma protein binding was ˜80% with no effect by deuterium isotope on drug pharmacokinetics. In humans, it was found that NVS-CRF-38 had high oral bioavailability and good absorption in the small intestine.</p>

<p>UNC2250 is a monoclonal antibody that binds to the death protein, which is involved in apoptosis. It has been shown to be a potent inhibitor of colony-stimulating factor (CSF) and has a novel mechanism of action. UNC2250 binds to the intramolecular hydrogen in the death protein, preventing it from binding to other proteins and inhibiting their activity. This leads to inhibition of cell proliferation and apoptosis induction. UNC2250 also prevents platelet aggregation by inhibiting ADP-induced activation of phospholipase A2.<br>UNC2250 has pharmacokinetic properties that are similar to those of erythropoietin because they both bind to the same receptor on cells. The hydroxyl group on UNC2250 allows it to form hydrogen bonds with water molecules, while the hydrogen bond between UNC2250 and erythropoietin prevents the latter from forming hydrogen bonds with water molecules.</p>

<p>Tetrapotassium, 2-[2-[2-[3-(1,3-benzothiazol-2-yl)-7-[bis(carboxylatomethyl)amino]-2-oxochromen-6-yl]oxyethoxy]-N-(carboxylatomethyl )-4-methylanilino]acetate is a peptide that inhibits the activity of ion channels. It is a potent inhibitor of voltage gated sodium channels and potassium channels. Tetrapotassium, 2-[2-[2-[3-(1,3-benzothiazol-2-yl)-7-[bis(carboxylatomethyl)amino]-2-oxochromen-6-yl]oxyethoxy]-N-(carboxylatomethyl )-4-methylanilino]acetate has been used as a research tool to study protein interactions, activators, ligands</p>

<p>LNK754 is a novel small molecule antagonist of the nicotinic acetylcholine receptor, which has been shown to inhibit the binding of ligands to the receptor. LNK754 binds competitively with acetylcholine and prevents it from binding to the receptor. This inhibition leads to an increase in the activation of potassium channels, which causes membrane hyperpolarization and decreased neuronal excitability. LNK754 has a high purity and can be used as a research tool for studying ion channels or protein interactions.br&gt;<br>br&gt;<br>LNK754 is being developed as a potential treatment for Alzheimer's disease. It inhibits beta-amyloid production by blocking nicotinic acetylcholine receptors on microglia cells, which are responsible for producing this protein. LNK754 also inhibits tau phosphorylation and reduces neuroinflammation.br&gt;<br>br&gt;<br>In addition, LNK754 has been shown to have anti-inflammatory properties by inhibiting prost</p>

<p>OG-L002 is a peptide that belongs to the group of receptor ligands. It can be used as research tool for cell biology, ion channels, and protein interactions. OG-L002 has been shown to inhibit the binding of mouse IgG antibodies to a recombinant human CD3e molecule, which is an important component of the T-cell receptor complex. The compound also exhibits affinity for receptors that belong to the GPCR family, such as GPRC5A and GPRC5B.</p>

<p>BI-1347 is a small molecule that has been shown to be effective in the treatment of leukemia cells and bowel disease. It is a potent inhibitor of the intracellular protein tyrosine phosphatase, which regulates the activation of various growth factors. BI-1347 has also been shown to stimulate epidermal growth factor receptor (EGFR) signaling, leading to increased epidermal growth. This drug has also been shown to have anti-inflammatory properties in animal models for inflammatory bowel disease by inhibiting cytokines that promote inflammation. BI-1347 may be used for cancer prevention or treatment as it inhibits tumor cell proliferation and induces apoptosis.</p>