Anticorps pour la recherche sur le cancer

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse GM-CSF. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse GM-CSF. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse GM-CSF, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse GM-CSF. You can calculate the concentration of Mouse GM-CSF in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-33. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IL-33. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IL-33, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IL-33. You can calculate the concentration of Human IL-33 in the samples by comparing the OD of the samples to the standard curve.

<p>Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。</p>

<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>

<p>Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose</p>

<p>FR054 inhibits PGM3, a key enzyme in the HBP, significantly reducing breast cancer cell growth and survival.</p>

<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>

<p>Valepotriates are sedative, enhance memory, have anti-cancer properties, and may reduce anxiety.</p>

<p>Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) is a substrate for affinity chromatography of heme-binding proteins.</p>

<p>POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂，IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。</p>

<p>WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)</p>

<p>Edotreotide (SMT-487) is an Indicator and Reagent. It also is used in the Diagnosis and Staging of Tumors Expressing Somatostatin Receptors.</p>

<p>Songorine (Napellonine) shows anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.</p>

<p>Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).</p>

<p>TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).</p>

<p>RU-301 is a novel pan-tam inhibitor</p>

<p>Syrosingopine is a dual inhibitor of MCT1 and MCT4, 60 times more potent against MCT4, preventing lactate and H+ efflux.Cost-effective and quality-assured.</p>

<p>DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.</p>

<p>β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.</p>

<p>Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect.</p>

<p>Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.</p>

<p>15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM.</p>

<p>D-Tagatose, a rare hexoketose and isomer of d-galactose, is naturally found in Sterculia setigera gum and various dairy products.</p>

<p>HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.</p>

<p>(-)-Epipodophyllotoxin: anticancer, GI50=0.36μM (HeLa), 0.24μM (MCF-7), inhibits spindle assembly.</p>

<p>Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent</p>

<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>

<p>Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.</p>

<p>NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.</p>

<p>Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.</p>

<p>Acetylalkannin (Alkannin acetate), an isohexenylnaphthazarin pigment extracted from Arnebia euchroma, exhibits antimicrobial and cytotoxic properties.</p>

<p>Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.</p>

<p>NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.</p>

<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>

<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>

<p>Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.</p>

Niraparib (MK-4827), a PARP inhibitor, boosts DNA breaks to trigger genomic instability and apoptosis, offering anti-cancer effects.

<p>USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.</p>

<p>LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>

LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.

<p>ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells</p>

<p>I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.</p>

<p>CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity</p>

<p>GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).</p>

<p>ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity</p>

<p>Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.</p>

<p>Umbralisib (TGR 1202) is a PI3Kδ inhibitor.</p>

<p>MTOB, a CtBP substrate, inhibits CtBP-linked cancer activity in cells/mice and regulates TCF-4, affecting CSC proliferation.</p>

<p>Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury</p>

<p>Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3</p>

<p>RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.</p>

<p>YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.</p>

<p>Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-</p>

<p>MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met).</p>

<p>Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.</p>

<p>JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR). JNJ-63576253 can be used for the research of CRPC.</p>

<p>Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.</p>

<p>Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC.</p>

<p>Ketorolac (Acuvail) is an NSAID that blocks prostaglandin synthesis, related to heterocyclic acetic acids.</p>

<p>PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].</p>

<p>(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.</p>

<p>Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).</p>

<p>Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP, binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3.</p>

<p>FLTX1, a Tamoxifen derivative, fluoresces to mark estrogen receptors and acts as a strong antiestrogen in breast cancer without affecting the uterus.</p>

<p>CTX-0294885, a bisanilino pyrimidine, inhibits many kinases; used for Sepharose-based kinase capture.</p>

<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>

<p>MAT2A Inhibitor 4 acts as an inhibitor targeting the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A), offering potential utility in cancer</p>

<p>GNF-5, non-ATP Bcr-Abl inhibitor (IC50: 0.22±0.1 uM, wild-type), improves upon GNF-2 with better pharmacokinetics.</p>

<p>AKR1C3-IN-4: potent, selective AKR1C3 inhibitor, IC50 = 0.56 μM, potential for CRPC research.</p>

<p>Desmethylanethol trithione (ADT-OH), a synthetic H2S donor, modulates tPA effects, reduces stroke damage, and improves recovery in mice.</p>

<p>MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.</p>

<p>BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.</p>

<p>Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand</p>

<p>Supinoxin (RX-5902) is an oral anti-cancer drug targeting p68 RNA helicase, inducing apoptosis in TNBC cells (IC50: 10-20nM).</p>

<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>

<p>Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) &amp; EZH1 (IC50: 392 nM).</p>

<p>LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.</p>

<p>SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.</p>

<p>Xanthatin exhibits cytotoxic, antibacterial, antifungal properties, may treat NSCLC, and inhibits melanoma by targeting Wnt/β-catenin and angiogenesis.</p>

<p>Pitstop2 is an amphipathic protein-bound inhibitor of the clathrin terminal domain. Pitstop2 has antitumor activity. Cost-effective, quality assurance.</p>

<p>NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.</p>

<p>Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.</p>

<p>AG-270 is an allosteric and orally active inhibitor of MAT2A.</p>

<p>Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and</p>

<p>Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr</p>

<p>UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor.</p>

<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>

<p>Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)</p>

<p>BC-DXI-843 is inhibitor of AIMP2-DX2, and is potential for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.</p>

<p>C-7280948 is a PRMT1 inhibitor.</p>

<p>OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).</p>

<p>Fatostatin inhibits SREBP-1/2 by binding to SCAP, blocking their ER-Golgi transport.</p>

<p>Thalidomide derivative compound 114 inhibits protomyosin receptor kinase, targets E3 ligase, potential for disease research.</p>

<p>Murrayone from M. paniculata, a bioactive coumarin, prevents cancer metastasis and reduces ADP-induced platelet aggregation.</p>

<p>ZCL278 is a selective Cdc42 GTPase inhibitor.</p>

<p>Lasofoxifene Tartrate (CP-336156) is a third-generation, non-steroidal selective estrogen receptor modulator.</p>

<p>1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.</p>

<p>Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.</p>

<p>MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.</p>

<p>SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.</p>

<p>AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.</p>