Acides carboxyliques

L-Dihydroorotic acid, found in eukaryotes, is involved in pyrimidine metabolism and several disorders including orotic aciduria.

Applications 2-(4-Hydroxycyclohexyl)acetic acid (cas# 99799-09-4) is a useful research chemical.

Stability Hygroscopic
Applications 4-Nitrobenzoic Acid is used in the synthesis of anti-Trypanosoma cruzi agents in the treatment of chagas disease.
References Palace-Berl, F. et al.: Bioorg, Med. Chem. Lett., 21, 5395 (2013); Zhou, L. et al.: J. Med. Chem., 56, 796 (2013);

Applications 5-(Diphenylphosphinyl)pentanoic Acid, can be used for the preparation of praseodymium coordination polymers with diphenylphosphorylvalerate ligand. It is also a by product in the preparation of prostaglandin analogs.
References Spichal, Z., et al.: Polyhedron, 48, 99 (2012); Zhao Y. et al.: PCT Int. Appl. 43pp.Patent, 2016

Applications Ethoxyacetic acid

Applications 6-[(6-Aminohexyl)amino]-6-oxo-hexanoic acid is a nylon oligomer with flame retardant properties.
References Zahn, Helmut et al.: Chemische Berichte, 92, 1381 (1959)

Applications 5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic Acid has been used in synthesis of; GdDOTAGA(C18)2: an efficient amphiphilic Gd(III) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes; bifunctional prochelators for coupling to bioactive peptides for radiometal labeling; DOTAGA-anhydride, building block for prepn. of DOTA-like chelating agents.
References Filippi M., et al., ChemComm., 51, 17455-17458 (2015); Eisenwiener K. P., et al., Bioorg. Med. Chem. Lett., 10, 2133-2135 (2000); Bernhard C., et al., Chem. Eur. J., 18, 7834-7841 (2012)

Applications Used in the synthesis of substituted terphenyls.
References Strukelj, M., et al.: Science, 267, 1969 (1995), Burroughes, J., et al.: Nature, 347, 589 (1990),

Applications DL-2,4-Diaminobutyric Acid Dihydrochloride (cas# 65427-54-5) is a useful research chemical.

Stability Hygroscopic
Applications Methane disulfonic acid is used in esterification.

Applications Cyclohexanecarboxylic acid

Applications Used for the preparation of bisphosphonic acid derivatives as anti-osteoporosis agents.
References Amin, D., et al.: Drug Res., 46, 759 (1996), Martin, M., et al.: J. Med. Chem., 45, 2904 (2002),

Applications 2-(formylamino)benzoic acid (cas# 3342-77-6) is a useful research chemical.

Applications Ethacrynic Acid Epoxide is an intermediate in the synthesis of Ethacrynic Acid (E676000), a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.
References Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965), Kim., et al.: Am. J. Cardiol., 27, 407 (1971), Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977),

Applications Phenyl N-​(2-​Chloro-​4-​hydroxyphenyl)​carbamate is a reagent used in the prepartion of quinoline-carboxamide compounds including Lenvatinib (L329400), an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.
References Wang, N. et al.: Faming Zhuanli Shenqing (2017), CN 106632033 A 20170510.

Applications Morpholin-​4-​yl Acetic Acid was used in preparation of pyrrolidine-fused fullerene multicarboxylates by photoreaction.
References Gan, L., et al.: J. Org. Chem., 63, 4240 (1998).

Applications 2-Benzoylbenzoic Acid is a reagent that is used in the synthesis of BzATP Triethylammonium Salt, which is a selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.
References Abou-Seri, S. M., et al.: Eur. J. Med. Chem., 107, 165 (2016);

Applications (±)-Jasmonic Acid can be used as reactant/reagent for synthetic preparation of fluorescent-labeled jasmonate and application to fluorescent imaging in cabbage seedlings.
References Liu, S., et al.: Tetrahedron Lett., 53, 4235-4239 (2012)

Applications 2-aminobenzene-1,4-disulfonic acid (cas# 98-44-2) is a useful research chemical.

Applications Formamidine Sulfuric Acid is a reagent used in reduction and synthesis reactions.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ma, Q. et al.: Carbon, 54, 36 (2013);

Applications 2-Azidobenzoic Acid (cas# 31162-13-7) is a useful research chemical.

Applications 2-​[(2-​Hydroxyethyl)​octadecylamino]​ethyl ester octadecanoic acid is used as a modifier to Polymer films of LDPE and ethylene-​vinyl acetate copolymers (EVA) to enhance antifog properties.
References Irusta, L., et al.: J. Appl. Polym. Sci., 111, 2299-2307 (2009);

Applications Reagent used in labelled pyrimidine and purine synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),

Applications 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid is an analog of Trioctyl Trimellitate (T804400) which is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.

Applications p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.
References Karimi, F., et al.: J. Chem. Pharm. Res., 7, 1028 (2015); Zheng, F., et al.: Guangdong Huagong, 42, 27 (2015);

Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.

Applications trans-3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid is a reagent used in the synthesis of indanyl insecticides.

Applications 6-(6-(6-Aminohexanamido)hexanamido)hexanoic Acid is used in the making of a preconjugate which serves as immunoreactive conjugate useful as a developer antigen in a competitive inhibition immunoassay for the polymorphic analyte. Also used in the efficient synthesis of a heterobifunctional coupling agent.
References Oh, C. S., et al.: PCT Int. Appl. (1994), WO 9416330 A1 19940721; Reddy, R. E., et al.: Bioconjug. Chem., 16, 1323 (2005)

Applications Dihydroresorcylic Acid is a useful reagent in detecting proteins in living cells.
References Reddie, K., et al.: Mol. Biosys., 4, 521-531 (2008); Seo, Y., et al.: Bioorg. Med. Chem. Lett., 19, 356-359 (2009);

Stability Hygroscopic
Applications Propylphosphonic Acid, is an alkylphosphonic acid, and a building block used in the synthesis of chemical compounds such as extremely toxic nerve agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Deepak P. et al.: J. of Cherom. A. 1141(2), 151-157 (2007);

Applications 4-Morpholineethanesulfonic Acid is used in the synthesis of nanotechnology and nanoparticles, as potential therapy towards Alzheimer’s.
References Liu, G. et al.: Methods. Mol. Biol., 610, 123 (2010); Neugart, F. et al.: Nano. Lett., 7, 3588 (2007)

Applications 4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.
References Phillips, R. et al.: Am. J. Physiol., 152, 523 (1948);

Applications (Z)-11-Tetradecenyl Acetate is a sex pheremone component that can be found in various insect specie, such as O. nubilalis and Asian and European corn borers.
References Leary, G.P., et al.: Proc. Natl. Acad. Sci. U.S.A., 109, 14081 (2012);

Stability Moisture Sensitive
Applications Perfluorobutanesulfonic acid (PFBS) is a stable fluorosurfactant because of the strength of carbon–fluorine bonds. PFBS has served as a replacement for the persistent, toxic, and bioaccumulative perfluorooctanesulfonic acid (PFOS) in 3M's Scotchgard stain repellents. PFBS is neither toxic nor bioaccumulative.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Renner R., et al.: Environ. Sci. Technol., 40, 12 (2006), Betts, K.S., et al.: Environ. Health Perspect., 115, 250 (2007),

Applications 1,3-Adamantanedicarboxylic acid, is a monomer that can be used in polymer science, self assembly and lithography.

Stability Light, Temperature and Moisture sensitive
Applications trans-N-(1E)-1,3-Butadien-1-yl-carbamic Acid 2,2,2-Trichloroethyl Ester (cas# 77627-82-8) is a compound useful in organic synthesis.

Applications Methyl Oxirane-2-carboxylate is an intermediate used in the synthesis of DL-Indole-3-lactic Acid-d5 (I627102), which is the isotope labelled analog of DL-Indole-3-lactic Acid (I627100); a reagent in the synthesis of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one which has weak antibacterial activity against 16 bacterial strains, including Escherichia coli, Bacillus subtilis and Staphylococcus aureus. DL-Indole-3-lactic Acid is also used in the preparation of Monatin, a natural sweet peptidomimetic.
References Nguyen, S.T., et al.: Bioorg. Med. Chem. Lett., 20, 5739 (2010); Nakamura, K., et al.: Peptide Sci., 40, 61 (2003)

Applications Fendizoic Acid is a reagent in the synthesis of fluorinated polyphthalazinone ethers containing perfluorophenylene moieties.
References Lu, Z., et al.: J. Polym. Sci. A1, 42, 925 (2004)

Applications Hexacosanoic acid ((1S,2S,3R)-2,3-dihydroxy-1-hydroxymethyl-heptadecyl)-amide is a ceramide found in the moro blood orange (Citrus sinensis). It is a useful building block used in the preparation of 5-thio-α-GalCers as immunostimulators for IFN-​γ production stimulation in mouse NKT cells.
References Bi, J.; et al.: ACS Med. Chem. Lett., 6, 476 (2015); Valsecchi, M.; et al.: J. Agric. Food Chem., 60, 10103 (2012).

Applications 2-Ethylhexanoic Acid is used in biological studies as flavor precursor extraction from different grape varieties and its effect on wine aroma during alcohol fermentation
References Loscos, N., et al.: J. Agric. Food Chem., 55, 6674 (2007)

Applications Levulinic Acid is derived from the degredation of cellulose and is a potential precursor to biofuels. Levulinic acid is also a photosensitizer for photodynamic therapy.
References Serrano-Ruiz, J.C., et al.: Catalysis., 195, 162 (2012); Liedtke, A.J. et al.: Tetrahedron., 68, 10049 (2012);

Applications Maleic Acid is used in the synthesis of pyridoindolones as potent inhibitors of Aurora kinases. Also is a reagent in the preparation of TiO2/carbon nanotube composites.
References Le, L. et al.: ChemMedChem., 8, 289 (2013); Yao, Y. et al.: Env. Sci. Tech., 42, 4952 (2008)l

Applications 2-(Hydroxyimino)-3-phenylpropanoic acid (cas# 3682-17-5) is a useful research chemical.

Applications 4-(ETHOXYCARBONYL)BENZOIC ACID (cas# 713-57-5) is a useful research chemical.

Stability Moisture Sensitive
Applications Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of trifluoroacylated compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References HugenBerg, V., J. Fluorine. Chem., 131, 942 (2010); Belyakova, Z.V., et al.: Russ. J. Gen. Chem., 79, 2634 (2009); Wu, J.L., et al.: Jingxi. Huagong. Zhongjianti., 40, 64 (2010);

Impurity Sulfadimethoxine EP Impurity C
Stability Hygroscopic
Applications 4-Acetamidobenzenesulfonic Acid (Sulfadimethoxine EP Impurity C) is a metabolite of Sulfanilic acid.
References Saab, N., et al.: Eur. J. Med. Chem., 34, 745 (1999), Kim, H., et al.: J. Pharm. Biomed. Anal., 27, 51 (2002), Santelli-Rouvier, C., et al.: Eur. J. Med. Chem., 39, 735 (2004),

Applications Crotonic Acid is found in water extracts from carrot seeds (Daucus carota L.) and is shown to have strong herbicidal properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jasicka-Misiak, I., et al.: Phytochemistry, 66, 1485 (2005)

Applications 1,1-Cyclohexanediacetic acid monoamide is an impurity of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Gabapentin is used as an anticonvulsant.
References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)

Applications m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.
References Zhang, K., et al.; Bioorg. Med. Chem. Lett., 24, 5154 (2014);

Applications Cis-Pinic Acid is used to develop an exposure system for the toxicological evaluation of particles derived from coal-fired power plants. It is formed from α-pinene (P466605) oxidation.
References Ruiz, P., et al.: Inhal. Toxicol., 19, 607 (2007); Kristensen, K., et al.: Atmos. Chem. Phy., 13, 3763 (2013)

Applications 3-Hydroxysuberic Acid is a derivative of sebacic acid (S211410) a urinary metabolite that has been identified as an anti-fatigue biomarker.
References Ma, C. et. al.: J. Pharmaceut. Biomed. Anal. 105, 84 (2015)

Applications Bis(2,4,4-trimethylpentyl)phosphinic acid (cas# 83411-71-6) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3-(1-Cyanoethyl)benzoic Acid is an intermediate for the synthetic preparation of various pharmaceutical compounds. 3-(1-Cyanoethyl)benzoic Acid was used in studies examining the enantioselectivity of nitrile hydratases.
References Rzeznicka, K., et al.: App. Microbiol. Biotechnol., 85, 1417 (2010); Van Pelt. S., et al.: Org. Biomole. Chem., 9, 3011 (2011);

Applications 4-Hydroxyphenylarsonic Acid could be useful for synthesizing flower-​like CoFe2O4 particles that are an attractive sorbent for removing aromatic organoarsenicals from wastewater.
References Liu, J., et al.: J. Colloid Interface Sci., 568, 63 (2020)

Applications (+)-Dibenzoyl-D-Tartaric Acid Monohydrate (cas# 80822-15-7) is a useful research chemical.

Applications 3-Carboxyphenylboronic Acid is used in phenylboronic acid-decorated gelatin nanoparticles for enhanced tumor targeting and penetration.
References Wang, X., et al.: Nanotechnology, 27, 385101 (2016); Wang, X., et al.: Eur. J. Pharm. Biopharm., 113, 168 (2017)

Applications DL-p-Hydroxyphenyllactic Acid is used as a reagent in the synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid, an important intermediate of rosmarinic acid biosynthesis.
References Matsuno, M., et al.: Chem. Pharm. Bull., 49, 1644 (2001)

Applications Trimethyl Orthoacetate is used as a reagent in the synthesis of Pseudomonic Acid D Sodium (P839520); an antibiotic isolated from Pseudomonas fluorescens.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Banks, R.M., et al.: J. Antibiot., 41, 609 (1988); Sridhar, Y., et al.: Org. Biomol. Chem., 12, 2950 (2014)

Impurity Sertraline EP Impurity E
Applications (R)-(-)-Mandelic Acid (Sertraline EP Impurity E) is an antiseptic (urinary).
References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007), Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009),

Applications 4-(2-Amino-ethyl)-benzoic Acid is a useful reagent for the preparation of amino acid derivatives with anticancer activity.
References Kim, S., et al.: PCT Int. Appl. (2020), WO 2020204548 A1

Stability Moisture Sensitive
Applications Tripropyl phosphate is an organophosphorus flame retardant and plasticizer.
References Bacaloni, A., et al.: Environ. Sci. Technol., 42, 1898 (2008)

Applications 2,4-Dioxo-4-phenylbutanoic acid

Applications Heptadecanedioic Acid (cas# 2424-90-0) is a useful research chemical.

Applications Phosphoric Acid Tris(2-​methylpropyl) Ester is found in the groundwater downgradient of a landfill (Grindsted, Denmark). It is also a flame retardant and plasticizer.
References Holm, J., et al.: Environ. Sci. Technol., 29, 1415 (1995); Rodil, R., et al.: J. Chrmoat. A, 1216, 2958 (2009); Carcia-Lopez, M., et al.: J. Chromat., A, 1166, 9 (2007)

Applications Phthalic Acid Bis(3,7-dimethyloctyl) Ester is a diester derivative of Phthalic Acid (P384480) and can be used as a plasticizer for PVC-type compositions.
References Takeuchi, H., et al. Jpn. Kokai Tokkyo Koho. JP 2001002829 A 20010109. Jan 9, 2001

Applications D-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity.
References He, W. et al.: Comp. Biochem. Phys. Part A: Mol. Int. Phys., 166, 308 (2013)

Applications butyl carbamate (cas# 592-35-8) is a useful research chemical.

Applications (E)-Cyano(methoxyimino)-acetic Acid is a degradation product of Cymoxanil (C988995), which is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.
References Morrica, P., et al.: J. Agric. Food Chem. 52, 99 (2004); Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012)

Applications Mesitoic acid can be used for its antioxidant.
References Thomas, P.S., et.al.: Medicines, 4, 1-7, (2017);

Applications 4-(4-PHENYLBUTOXY)BENZOIC ACID (cas# 30131-16-9) is a useful research chemical.

Applications (S)-2-Acetamido-5-ureidopentanoic Acid (cas# 33965-42-3) is a useful research chemical.

Applications Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene. A synthetic intermediate in the preparation of CNS depressants.
References Mungur, R., et al.: J. Biomed. Biotechnol., 2, 198 (2005), Young, J., et al.: Bioorg. Med. Chem. Lett., 17, 5310 (2007),

Applications (2E)-3-Phenyl-2-propenoic Acid is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines. Also used in the N-methylation of amides and O-methylation of carboxylic acids.
References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);

Applications ethyl 2-azidoacetate (cas# 637-81-0) is a useful research chemical.

Applications 6-Chloronicotinic Acid, is an organic building block used for the synthesis of various biologically active compounds, including inhibitors. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.
References Xie, Y., et al.: Bioorg. Med. Chem. Lett., 23, 2306 (2013); Shiroya, U., et al.: Med. Chem. Res., 22, 5227 (2013);