Nucléosides

<p>Spacer-C3 Cep is a novel modified nucleoside phosphoramidite. It has been chemically modified with a spacer arm and 3-Cep (1,2-diaminoethane). Spacer-C3 Cep is an activator for DNA polymerases, which are enzymes that synthesize DNA from deoxyribonucleosides. The modified nucleoside phosphoramidite has antiviral and anticancer activities. It can be used in the synthesis of oligodeoxyribonucleotides for gene therapy or as a monophosphate for the preparation of DNA probes. Spacer-C3 Cep can also be used to synthesize ribonucleotide analogs that inhibit viral replication by inhibiting RNA synthesis.</p>

<p>5'-O-DMT-N4-benzoyl-5-methyl-2'-O-methylcytidine 3'-ce phosphoramidite is a high purity, diphosphate, CAS No. 166593-57-3, Modified, Anticancer, DNA. It is a novel activator monophosphate that can be used for the synthesis of phosphoramidites for oligonucleotide synthesis and as a novel building block for nucleosides and deoxyribonucleosides. 5'-O-DMT-N4-benzoyl-5-methyl-2'-O-methylcytidine 3'-ce phosphoramidite has been shown to have anticancer activity in vitro. The cytotoxic effect of this compound is mediated by its ability to inhibit DNA replication and induce apoptosis in human leukemia cells.</p>

<p>Guanosine-5'-[(a,b)-methyleno]triphosphate sodium salt (GpCpp) is a non hydrolyzable nucleoside</p>

2'-Fluoro-5'-o-DMT-2'-deoxyinosine-3'-ce-phosphoramidite is a novel nucleoside analog that inhibits viral DNA replication and has antiviral properties. It is an effective inhibitor of HIV, HSV, and HCV. The drug works by binding to the viral DNA polymerase enzyme, thereby blocking the RNA-dependent DNA polymerase activity and inhibiting viral DNA synthesis. 2'-Fluoro-5'-o-DMT-2'-deoxyinosine-3'-ce-phosphoramidite is a modified nucleoside with a fluorine atom at the 5' position of the sugar moiety, which prevents phosphodiester cleavage by phosphodiesterases in the cell's cytoplasm. This drug also has anticancer effects on human cancer cells by inhibiting ribonucleotide reductase and deoxyribonucleotide reductase.

<p>A 5'-3’ “reverse” (or “inverse”) amidites</p>

<p>Stearoyl coenzyme A free acid hydrate is a natural, non-synthetic lipid molecule that belongs to the group of fatty acids. It is found in the form of a white crystalline powder and has a melting point at approximately 56°C. Stearoyl CoA free acid hydrate is an essential component of cellular metabolism, carrying out reactions such as desaturase, dextran sulfate, and other enzyme activities. Stearoyl CoA free acid hydrate may have therapeutic applications for metabolic disorders and obesity. The enzyme complex that catalyzes the synthesis of stearoyl CoA free acid hydrate in adipocytes is ATP-binding cassette transporter (ABC) A1 and ABCG1, which are members of the superfamily of ATP-binding cassette (ABC) transporters. It also plays a role in regulating immune responses via Toll-like receptor 4 (TLR4).</p>

<p>4'-a-C-Methylcytidine is a nucleoside that is synthesized from 4'-a-C-methyluridine. It has antiviral and anticancer properties, and has been shown to be a potent activator of the immune system. The modified nucleosides in this compound are thought to be less toxic than other cytotoxic agents. 4'-a-C-Methylcytidine is also used as a building block for the synthesis of DNA, RNA and phosphoramidites.</p>

Morpholino A is a modified nucleoside amidite used to prepare morpholino oligomers

<p>8-Nitroguanosine is a nucleotide analogue that inhibits the activity of cyclic GMP in cells. It has been found to inhibit the growth of bacteria and cancer cells, as well as to stimulate the production of reactive oxygen species in brain cells. 8-Nitroguanosine has also been shown to inhibit the activity of cyclase enzymes in liver cells, which may be useful for treating liver disease. 8-Nitroguanosine is used as a chemical base for monoclonal antibodies that are used to study brain functions and pathogenic mechanisms.</p>

<p>2'-Deoxy-3'-O-DMT-N2-isobutyrylguanosine 5'-CE phosphoramidite is a 5'-3’ “reverse” (or “inverse”) amidite.</p>

<p>Methyluridine is a derivative of uridine that is used in the synthesis of pyrimidine nucleotides. This drug is also an inhibitor of orotidine 5′-monophosphate decarboxylase, which converts orotic acid to uracil. The conformational properties of methyluridine have been studied and found to be similar to those of other purine derivatives, such as adenine and guanine. In addition, methyluridine has been shown to inhibit the growth of typhimurium and increase the production of uracil in human lymphocytes. Methyluridine is metabolized by hydroxylation in liver microsomes, yielding 6-carboxylic acid.</p>

5'-C-Methylcytidine is an analogue of cytidine

<p>Please enquire for more information about DMTr-TNA-C(Bz)-amidite including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

N6-Benzoyl-3-deaza-2'-deoxy-5'-O-DMT-3-methyladenosine 3' is a nucleoside that has been modified to be resistant to the enzymatic degradation by ribonucleases. The phosphoramidite is used in the synthesis of DNA and can be used as an antiviral or anticancer drug. It also acts as a competitive inhibitor of adenosine deaminase, which is an enzyme involved in the metabolism of purines. N6-Benzoyl-3-deaza-2'-deoxy-5'-O-DMT-3 methyladenosine 3' can inhibit viral replication by inhibiting RNA polymerase activity, and it has been shown to have antifungal properties.

<p>3-Methyl-8-(2-deoxy-b-D-ribofuranosyl)isoxanthopterin is a nucleoside analog that is used as an activator of phosphoramidite. It can be used as a building block in the synthesis of modified phosphoramidites and it has antiviral, anticancer, and antiinflammatory properties. 3-Methyl-8-(2-deoxy-b-D-ribofuranosyl)isoxanthopterin is a novel nucleoside analog that can be used to synthesize DNA or RNA. It is also an inhibitor of deoxyribonucleoside kinase, preventing the conversion of deoxyribonucleosides into diphosphate monophosphates.</p>

<p>Ribavirin triphosphate is the biologically active metabolite of antiviral nucleoside analog ribavirin. In cells, the prodrug ribavirin gets triphosphorylated and in it inhibits viral RNA polymerases, interfering with the synthesis of newly formed RNA.</p>

Emtricitabine is a nucleoside reverse transcriptase inhibitor with activity against human immunodeficiency virus and hepatitis B virus

Cytidine-5'-O-(1-thiotriphosphate) lithium salt is a monophosphate nucleotide analog. It is soluble in water, and is used in the synthesis of DNA and RNA. Cytidine-5'-O-(1-thiotriphosphate) lithium salt has antiviral, anticancer, and anti-inflammatory properties. This compound can be used as an activator for phosphoramidites in the synthesis of DNA or RNA. Cytidine-5'-O-(1-thiotriphosphate) lithium salt is a novel nucleoside that can be used in the synthesis of modified oligonucleotides.

<p>N2-Benzoylguanosine is a nucleotide derivative that is formed by the acetylation of guanosine. It has been shown to act as a buffer in alkaline solutions and isomerizes to its n-oxide form when heated. N2-Benzoylguanosine reacts with peroxides such as hydrogen peroxide, glyoxal, and organic peroxides, forming hydroperoxide intermediates that can be converted into other products. The acidic hydrolysis of N2-benzoylguanosine yields the corresponding 6-benzoyladenosines. It has been shown to enhance the activity of uridine in inhibiting bacterial growth, while also acting as an inhibitor of viral RNA synthesis. This compound also reacts with nitrous acid to form an n6-benzoyladenosine derivative that inhibits the formation of RNA chains during transcription.</p>

<p>2'-Deoxyadenosine is a nucleoside that is found in DNA. It has been shown to have potent anticancer activity against carcinoma cell lines and to bind to the adenosine receptor A3. 2'-Deoxyadenosine has also been shown to inhibit the production of inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, from nuclear extracts of mouse tumor cells. This nucleoside may be a potential drug target for the treatment of cancer and inflammation.</p>

<p>Adenosine 5'-monophosphate sodium is a nucleotide that is involved in the energy metabolism of cells. It has been shown to inhibit oxidative injury and to activate signal pathways in response to external stimuli, such as glucose deprivation. Adenosine 5'-monophosphate sodium can be synthesized from ATP by the enzyme adenosine kinase.</p>

Adenosine 2',3'-cyclic monophosphate triethylammonium salt (AMP-TEA) is a structural analogue of adenosine. It is a potent inhibitor of protein synthesis by preventing the phosphodiesterase activity of cyclic nucleotide phosphodiesterases and cyclic nucleotide phosphodiesterase. AMP-TEA can be used as a tool to study translation in tissue culture, as well as to examine the effects on protein synthesis and other biochemical reactions that are regulated by cyclic nucleotides. It is also used for the preparation of tissue samples for enzymatic analysis or for radiolabeling experiments. AMP-TEA has an optimum pH of 4.5, but can be used at lower or higher pH values. The optimal temperature range for use is between 0°C and 50°C, with the maximum stability occurring at 37°C.

<p>N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine 3'-CE phosphoramidite is a nucleoside phosphoramidite used as a building block in the chemical synthesis of oligonucleotides containing a 2’-O-methyl adenosine nucleoside unit. The use of a chemical synthesis rather than an enzymatic one allows oligonucleotides of a desired sequence to be produced. 3’-Cyanoethyl phosphoramidites are typically used by substitution of the di-isopropylamine group with an appropriate alcohol in the presence of an azole catalyst. Oligonucleotides containing 2'-O-methylribonucleoside units have shown site-specific cleavage with E. coli RNase H, either at a hairpin loop or at a stem region.</p>

3'-O-Propargyladenosine is a modified nucleoside that has antiviral and anti-inflammatory properties. It is a synthetic compound that is chemically related to adenosine. 3'-O-Propargyladenosine is an activator of the immune system and it inhibits viral DNA synthesis. The compound also has been shown to reduce inflammation in mice by inhibiting the production of prostaglandin E2 (PGE2). 3'-O-Propargyladenosine has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV).

<p>N2-Isobutyryl-O6-(4-pivaloyloxybenzyl)-7’-OH-N-trityl-morpholino guanine is a phosphoramidite nucleoside that is used as a building block in the synthesis of oligonucleotides. N2-Isobutyrylguanosine is available as a high purity, high quality, and novel nucleoside that can be used in anticancer therapy. It has been shown to inhibit the growth of human cancer cells without affecting normal cells. This drug also inhibits DNA and RNA synthesis by inhibiting the enzyme ribonucleotide reductase.</p>

<p>2-O-Ethylthymidine is a nucleoside that is used to study the structure and dynamics of DNA. It can be synthesized by reacting 1-β-D-arabinofuranosylbenzene with ethylmercury acetate. 2-O-Ethylthymidine can be used in kinetic studies as it is specific for dna. It has been shown to have a conformational change, which is stabilized by the presence of an aromatic ring such as phenanthrene. This compound was also found to inhibit neuroblastoma cell growth in vitro.</p>

<p>2-Deoxy-5'-O-DMT-N2-isobutyryl-8-oxoguanosine 3'-CE phosphoramidite is an 8-oxo modified amidite.  The 8-oxo modification is caused naturally in DNA by oxidation so is significant in mutagenesis and ultimately carcinogenesis.</p>

<p>Uridine diphosphate choline (UDPC) sodium is a nucleotide that is used as a phosphoramidite for DNA synthesis. The chemical formula for UDPC is C8H14N4O8P. The activation of the molecule occurs in acidic conditions, which may be due to the formation of an amide bond between the terminal phosphate and the amino group on the phosphorylcholine. This same reaction can also occur in alkaline conditions. UDPC has been shown to inhibit viral replication, including HIV-1, by blocking reverse transcription of viral RNA into DNA. It also has anticancer effects, as it inhibits cell proliferation and induces apoptosis in cancer cells. UDPC does not have any known side effects or toxicity.</p>

<p>Inhibitor of adenylyl and guanylyl cyclase</p>

<p>ALS-8176 is a benzimidazole compound that has been shown to be effective against both wild-type and syncytial viruses. It is also active against the hepatitis B virus, which causes fulminant hepatitis in humans and death in 30% of cases. The antiviral activity of ALS-8176 was demonstrated by its ability to inhibit viral DNA synthesis and to prevent the release of new viral particles. ALS-8176 has also been shown to have a broad spectrum of activity against paramyxoviruses, including mumps, measles, and respiratory syncytial virus (RSV). This drug can be used for the treatment of influenza A and B when administered during the early stages of infection. ALS-8176 blocks the antibody response to influenza virus infection as well as monoclonal antibody binding sites on the hemagglutinin protein, preventing fusion between infected cells.</p>

<p>N2-Ethyl-2′-deoxyguanosine is an important metabolite of N2-ethyl-3′,5′-dideoxyadenosine (NEDA) and has been detected in urine samples from Sprague-Dawley rats. The biological properties of this metabolite are not well understood, but it has been shown to have genotoxic effects in mammalian cells and to be carcinogenic in a rat model. N2-Ethyl-2′-deoxyguanosine is also able to enhance the repair of damaged DNA and has functional groups that are similar to those found in cancer cells.</p>

<p>Functionalised adenosine riboside</p>

<p>5’-O-DMT-2’-O,4’-C-methylene-5-methyluridine is a nucleoside that is used as an antiviral and anticancer agent. It is a novel compound that has not been previously described in the literature. 5’-O-DMT-2’-O,4’-C methylene 5 methyluridine has been shown to inhibit the replication of the herpes virus in vitro (in cell culture) and in vivo (in animals). This compound also inhibits the proliferation of cancer cells by inhibiting DNA synthesis. It may be used as an anticancer agent or an antiviral agent.</p>

7-Deaza-2',3'-dideoxy-7-iodoadenosine is a nucleoside analogue that is used as an antiviral, anticancer, and antifungal agent. It is a modified form of adenosine which inhibits viral replication by inhibiting the activity of reverse transcriptase. 7-Deaza-2',3'-dideoxy-7-iodoadenosine has also been shown to inhibit DNA synthesis in cells by blocking the incorporation of dCTP into DNA. This nucleoside analogue has shown potential for use as an activator in phosphoramidite chemistry and as a deoxyribonucleoside in oligonucleotide synthesis.

<p>A hetero-base functionalised ara-nucleoside</p>

<p>Propionyl coenzyme A lithium salt is a phosphoramidite that can be used in the synthesis of DNA and RNA. It is a novel chemical compound that has been modified to include ribonucleosides in addition to deoxyribonucleosides. This product is of high purity and quality, with a CAS number of 108321-21-7.</p>

<p>8-Amino-2’-deoxyadenosine (8AAD) is a nucleoside that is used in the laboratory for the analysis of dna duplexes. It stabilizes dna duplexes in an acidic environment, and it can be used to analyze the stability of dna duplexes at neutral pH. 8AAD can also stabilize triplex structures formed by 8AAD, amines, and purines. The orientation of these bases in the triplex structure is important because they can determine which strands are cleaved during hydrolysis.</p>

<p>N6-Benzyladenosine 5'-diphosphate sodium salt is a modified nucleoside that has a high purity, which is suitable for synthesis of DNA or RNA. It can be used in the modification of deoxyribonucleosides, ribonucleosides, and phosphoramidites. N6-Benzyladenosine 5'-diphosphate sodium salt has been shown to have anticancer effects and antiviral effects. This drug also has novel properties such as an ability to inhibit the proliferation of cancer cells.</p>

<p>N6-Benzoyl-3'-deoxy-3'-fluoroadenosine is a nucleoside analog that is structurally similar to adenosine. It has antiviral and anticancer properties and can be used in the treatment of HIV and other viral infections. N6-Benzoyl-3'-deoxy-3'-fluoroadenosine inhibits the synthesis of DNA by inhibiting the enzyme DNA polymerase, which is required for DNA replication. This drug also binds to RNA polymerase, which is an enzyme required for RNA synthesis. N6-Benzoyl-3'-deoxy-3'-fluoroadenosine has been shown to have a high level of efficacy against leukemia cells in vitro as well as in vivo mouse models.</p>

<p>2-Fluoroadenosine is a nucleoside that has shown high resistance to the enzyme cyclase. This property may be due to its structural and conformational properties, which are different from those of adenosine. 2-Fluoroadenosine has been shown to inhibit the synthesis of ATP in ventricular myocardium and fat cells, as well as increase levels of adenylate kinase in blood. It has also been shown to have potential as a drug target for autoimmune diseases, such as multiple sclerosis. 2-Fluoroadenosine can be used for biochemical and pharmacokinetic studies because it is rapidly metabolized by the liver and excreted in urine.<br>2-Fluoroadenosine can also be used to measure changes in the ratio of adenylate kinase:adenylate kinase reductase (AKAR) in blood plasma.</p>

<p>3′-Guanylic acid disodium is a nucleoside analog that inhibits viral replication and tumor growth. It is an antiviral agent that is active against herpes simplex virus type 1 and type 2, as well as cytomegalovirus. 3′-Guanylic acid disodium is also an anticancer agent that has shown promising results in animal models of glioma, lymphoma, lung cancer, and breast cancer. The molecule inhibits the synthesis of DNA by competitively inhibiting the action of ribonucleotide reductase. 3′-Guanylic acid disodium also inhibits protein synthesis by blocking the conversion of ribonucleotides to deoxyribonucleotides. This drug has been shown to have a high purity and quality with no detectable impurities or contaminants.</p>

Thymidine-3',5'-diphosphate disodium salt is an antiviral and anticancer drug. It is a modified nucleoside which is synthesized from thymidine-3',5'-diphosphate and sodium bicarbonate (NaHCO3). This drug inhibits the synthesis of DNA and RNA, thereby inhibiting viral replication. Thymidine-3',5'-diphosphate disodium salt also has an antitumor effect by preventing the production of DNA in tumor cells.

Universal sulfonate donor for in vivo sulfonation by sulfotransferases

Malonyl coenzyme A lithium salt - 90% is a fatty acid that is involved in the biosynthesis of fats. It is also involved in the synthesis of prostaglandins, which are hormone-like substances that have a wide variety of effects on many different tissues. Malonyl coenzyme A lithium salt - 90% may be useful for the treatment of insulin resistance and obesity due to its ability to stimulate glucose uptake by fat cells and increase insulin sensitivity. The following product details are for a supplement:

<p>2′,3′,5′-Tri-O-acetylinosine is a protected form of the nucleoside inosine, with potential for use in the preparation of modified nucleotides and nucleoside analogs.</p>

<p>N2-Acetyl-5'-O-DMT-guanosine is a novel anticancer nucleoside that has been synthesized to mimic the natural nucleotides found in DNA. It is phosphorylated to N2-acetyl-5'-O-DMT-guanosine monophosphate, which can be converted back to the active form of N2-acetyl-5'-O-DMT guanosine by phosphatases. This agent activates DNA synthesis and inhibits viral replication, including HIV and herpes simplex virus. The antiviral activity is due to its inhibition of viral DNA polymerase and diphosphate kinase.</p>

<p>2',3'-O-Isopropylideneinosineis a nucleoside for use in research applications</p>

<p>3'-Adenylyl-5'-guanosine ammonium salt is a dinucleoside that competes with guanosine for binding to the enzyme adenylate cyclase. This reaction leads to increased levels of cyclic AMP, which causes an increase in the rate of viral replication. 3'-Adenylyl-5'-guanosine ammonium salt has been shown to inhibit the growth of pyogenic bacteria such as Streptococcus pyogenes and has also been used to treat influenza infections. 3'-Adenylyl-5'-guanosine ammonium salt is an inorganic compound that is found in tobacco. It can be synthesized from uridine and p-nitrophenyl phosphate by the reaction: 3'--O--(CH2)4--COOH + H2N--PO4--&gt; 3'--O--(CH2)4--CONH2 + H3PO4</p>

<p>Citicoline is a complex organic molecule, a form of B-vitamin choline that acts as an intermediate in many biosynthetic pathways, for example, in the biosynthesis of cell membrane phospholipids. As a dietary supplement, citicoline is a source of choline and cytidine, two components that are quickly absorbed in the intestine and across the blood-brain barrier. The neuroprotective properties of citicoline improves mental performance increasing the levels of other brain-related chemicals like dopamine and norepinephrine, helping with recovery in stroke patients, reducing memory loss due to aging and improving vision in patients with glaucoma.</p>

<p>8-Iodoadenosine is a macrocyclic inhibitor that binds to the phosphate group on ATP. This binding prevents ATP from being hydrolyzed to ADP and inorganic phosphate, which inhibits the formation of ATP. 8-Iodoadenosine has been shown to inhibit the proliferation of some cancer cells by interfering with their ability to synthesize proteins. It has also been shown to be an effective treatment for parasitic infections caused by Entamoeba histolytica. 8-Iodoadenosine has also been shown to inhibit protein synthesis in bacteria, fungi, and parasites.</p>

<p>Nucleoside phosphoramidites are used in the chemical synthesis of oligonucleotides containing 2’-O-(2-methoxyethyl) adenosine nucleoside units. Using a chemical approach rather than an enzymatic one allows custom-made oligonucleotides of a desired sequence to be obtained. 3’-Cyanoethyl phosphoramidites are typically modified by reaction with an appropriate alcohol in the presence of an azole catalyst such as imidazole or 1H-tetrazole. N6-Benzoyl-5'-O-DMT-2'-O-MOE-adenosine 3'-CE phosphoramidite has been used in the synthesis of 2’-modified oligonucleotides as protein binding modulators.</p>

<p>2',3'-Dideoxy-2',3'-didehydro-2'-fluorocytidine (ddC) is a nucleoside with antiviral activity. The mechanism of action is not well understood, but ddC has been shown to inhibit the proliferation of human immunodeficiency virus (HIV). It is also active against isolates of herpes simplex virus and vesicular stomatitis virus. The elimination half-life of ddC in humans is about 8 hours. In humans, this drug is eliminated by methylation and glucuronidation reactions. The pharmacokinetics of ddC have been studied in animals, including rats and rabbits, with preliminary indications that the elimination half-life may be longer than in humans.</p>

<p>2',3',5'-Tri-O-acetyl-8-bromoguanosine is a synthetic nucleoside analog that inhibits the growth of tumor cells. It has been shown to inhibit the progression of prostate cancer and cervical cancer by binding to guanosine, preventing its conversion into ATP. This compound also prevents proliferation in hek293 and glioblastoma cells. The mechanism of action may be due to oxidative phosphite formation, which causes DNA damage and subsequent apoptosis.</p>

<p>2'-O-(2-Methoxyethyl)adenosine 5'-a-thiotriphosphate sodium salt is a synthetic nucleoside with antiviral and anticancer properties. It is an analog of adenosine 5'-triphosphate (ATP) in which the ribose sugar has been replaced by a 2'-O-(methoxyethyl) moiety. It has shown to be cytotoxic against cancer cells, and it is a potent activator of human telomerase, the enzyme that synthesizes telomeres at the end of chromosomes. This compound has been shown to have high purity and quality and does not have any CAS numbers assigned to it.</p>

<p>2'-Deoxyguanosine-[15N5] monohydrate is a chemical compound that has been shown to have anticancer activity in colorectal adenocarcinoma cells. The high-activity form of this compound is produced by the addition of a 15N isotope, which can be detected using an electrochemical detector. This compound inhibits the enzyme DNA methyltransferase, preventing the addition of methyl groups to DNA and thereby inhibiting cell growth. 2'-Deoxyguanosine-[15N5] monohydrate also has anti-inflammatory properties due to its ability to inhibit IL-2 receptor signaling.</p>

10umol is approximately 5mg.2'-O-(2-Methoxyethyl)adenosine 5'-monophosphate is a nucleoside compound that has been phosphorylated in the 5'-position.

<p>2-Chloroadenosine 5'-monophosphate triethylamine salt is a phosphoramidite that has anticancer and antiviral activities. It is synthesized by reacting 2-chloroadenosine with triethylamine. This product has a novel chemical structure and it can be used as an activator for the synthesis of modified DNA, RNA, and other nucleosides. It is also used in the manufacture of deoxyribonucleosides, ribonucleosides, and other nucleotides.</p>

<p>3'-Deoxycytidine-5'-triphosphate is a modified nucleoside that is the precursor for DNA synthesis. It is an activator of deoxyribonucleoside triphosphates, which are needed in the production of DNA. 3'-Deoxycytidine-5'-triphosphate has been shown to be active against cancer cells and antiviral agents. This chemical also inhibits viral RNA synthesis by blocking the conversion of ribonucleotides to deoxyribonucleotides. 3'-Deoxycytidine-5'-triphosphate is novel and high purity, with a CAS number 69383-05-7.</p>

<p>N-Acetyl-2'-deoxy-2',2'-difluorocytidine is a novel nucleoside analog. It is phosphorylated at the 5' position and converted to a monophosphate by adenylyl cyclase, which is an enzyme that catalyzes the conversion of ATP to cyclic AMP. This nucleoside analog has antiviral activity in vitro and in vivo against HIV-1. It also has been shown to inhibit DNA replication of human cells infected with herpes simplex virus type 1 (HSV-1).</p>

Please enquire for more information about O1-(Dimethoxytrityl)propane-1,3-diol including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>[(2S,6R)-6-{N4-Benzoylcydin-1-yl}-4-tritylmorpholin-2-yl]methyl dimethylphosphoramidochloridate is an antiviral and anticancer nucleoside phosphoramidite. It is synthesized by reacting the purified 6-(N4-benzoylcydin-1-yl) morpholine with dimethyl phosphorochloridate in pyridine at room temperature. This novel monophosphate nucleoside has been shown to be efficacious against human immunodeficiency virus (HIV) and murine leukemia virus (MLV). The antiviral activity of [(2S,6R)-6-(N4-benzoylcydin-1-yl)-4-(tritylmorpholin]-2(1H)-yl]methyl dimethylphosphoramidochloridate is due to its ability</p>

Please enquire for more information about 5'-o-(4,4'-Dimethoxytrityl)-2'-deoxythymidine-3'-(methyl-N,N-diisopropyl)phosphoramidite including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>2',3'-Di-O-benzoyl-N6-benzoyl-L-adenosine (DBBA) is a modified nucleoside with anticancer, antiviral, and synthetic properties. It can be used as a building block for the synthesis of DNA, RNA, or other nucleotide analogues. DBBA has shown activity against certain cancer cells and has been found to inhibit the replication of HIV and herpes simplex virus type 1 in cell culture. DBBA is also known as 2',3'-Dibenzoyl-N6-benzoyladenosine.</p>

<p>2'-Deoxyinosine-5'-triphosphate sodium is a nucleoside that is used as an antiviral, anticancer and novel drug. It inhibits viral replication by inhibiting DNA synthesis in the cell. 2'-Deoxyinosine-5'-triphosphate sodium binds to viral RNA polymerase, preventing the enzyme from creating new DNA strands. This prevents the virus from replicating and spreading to other cells in the body. 2'-Deoxyinosine-5'-triphosphate sodium has been shown to inhibit cancer growth by binding to DNA, which prevents it from dividing and creating new cells. This drug also has antiviral activity against HIV and Herpes Simplex Virus Type 1 (HSV1). 2'-Deoxyinosine-5'-triphosphate sodium is typically used as a buffer solution for peptide synthesis or as a chemical intermediate for various organic syntheses.</p>

<p>Wyosine is a glycosylated protein that is found in the mitochondria of eukaryotic cells. It has been shown to have an acidic pH and to be non-covalently bound to a molecule with a molecular weight of approximately 2,000 Da. Wyosine binds to the wild-type strain of the bacterium Mycobacterium tuberculosis, which may play a role in its biological properties. This molecule also reacts with antibodies and can be used as an antigen for antibody production. Wyosine is structurally similar to x-ray crystal structures and has been observed by X-ray crystallography at atomic resolution.</p>

<p>5-Bromo-2'-deoxy-4-thiouridine is a high purity, diphosphate nucleoside with novel anticancer activity. It is a potent activator of the transcription factor NF-kappaB and inhibits the proliferation of cancer cells. 5-Bromo-2'-deoxy-4-thiouridine has been shown to be an effective antiviral agent against HIV and hepatitis B virus in vitro. This compound also inhibits the synthesis of DNA and RNA in human cells, which may be due to its ability to inhibit thymidylate synthase. 5-Bromo-2'-deoxy-4-thiouridine is not active against bacterial cells because they lack thymidylate synthase.</p>

<p>2'-O-Methyluridine-5'-monophosphate triethylammonium salt is a modified nucleoside analogue that is an antiviral agent. It inhibits viral replication by acting as an inhibitor of RNA synthesis and DNA polymerase, which are necessary for the virus to replicate. This compound also has anticancer activity and can be used as a chemotherapeutic agent. 2'-O-Methyluridine-5'-monophosphate triethylammonium salt is synthesized from uracil, phosphoramidite, and triethylamine. It has high purity and high quality with a CAS number of 67624-43-5.</p>

<p>Abacavir 5'-phosphate is a nucleoside analog that inhibits the replication of the herpes virus by covalently binding to the viral DNA polymerase and blocking its ability to polymerize dNTPs. Abacavir 5'-phosphate's anti-viral potency has been shown in vivo using a model with herpes simplex virus, and it has been shown to inhibit viral replication in cell culture. The drug also reacts with cellular components such as proteins, lipids, and nucleic acids, which may lead to drug reactions. Abacavir 5'-phosphate is chemically stable, so it can be subjected to analytical methods without degradation. It is an analog of zidovudine (AZT).</p>

<p>10umol is approx 5mg.2'-O-(2-Methoxyethyl)guanosine 5'-monophosphate is a novel nucleoside phosphorylated on the 5' position</p>

2'-O-Methyladenosine 5'-monophosphate triethylammonium salt is an antiviral nucleoside that is used in the treatment of hepatitis B and C. It is a modified nucleoside that inhibits the replication of RNA by binding to the enzyme ribonuclease, which plays a vital role in the synthesis of DNA. 2'-O-Methyladenosine 5'-monophosphate triethylammonium salt also has anticancer properties and can inhibit DNA synthesis. This compound is a novel phosphoramidite building block for oligonucleotide synthesis and has been shown to be an activator for deoxyribonucleosides.

<p>Valopicitabine is a prodrug that is converted to its active form, 3'-deoxy-3'-methylvalopicitabine, in the body. Valopicitabine inhibits viral replication by a mechanism that is not yet fully understood. It has been shown to inhibit NS3 protease and induce an interferon response. Valopicitabine has also been shown to inhibit Toll-like receptor 4 (TLR4) activity and elicit an antiviral response. Valopicitabine has low bioavailability, which may be due to its high lipophilicity.</p>

<p>Please enquire for more information about 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-nitro-1H-indole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N6-Acetyl-2'-deoxyadenosine is an antiviral and anticancer nucleoside. It is a novel modified nucleoside that has been synthesized with a high degree of purity. N6-Acetyl-2'-deoxyadenosine is active against HIV, Hepatitis C, and other viruses, as well as cancer cells. It also inhibits the activity of bacterial DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. N6-Acetyl-2'-deoxyadenosine has a phosphoramidite structure and is synthesized from 2'-deoxyribonucleosides.</p>

<p>Please enquire for more information about 2′-C-Methyl-2′,3′-O-(1-methylethylidene)adenosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2'-O-tert-Butyldimethylsilyl-N4-(tert-butylphenoxyacetyl)-5'-O-DMT-cytidine 3'-CE phosphoramidite is a DNA synthesis reagent that is used in the preparation of oligonucleotides, in particular for the synthesis of 2'-deoxyribonucleosides. It has been shown to be an activator and to have anticancer, antiviral, and antimalarial properties. This compound is synthesized by reacting 5'-O-DMT cytidine with 2',3' epoxypropyltrichlorophosphite. The product is purified by silica gel column chromatography and recrystallization from ethanol followed by vacuum drying. CAS No. 149989-66-2</p>

<p>Octanoyl coenzyme A lithium salt hydrate (OCCA) is a metabolite of octanoic acid, which is formed by the oxidation of fatty acids. OCCA has been shown to have relevance in the metabolism of fatty acids, as it can be conjugated with other molecules and transported into cells. This compound has been detected in human liver tissues and was found to be metabolized by primary rat hepatocytes in vitro. The metabolic pathway of OCCA is not yet fully understood, but it has been investigated in vivo studies.</p>

<p>2'-O-Methylguanosine 5'-monophosphate sodium is a nucleoside analog that has been shown to inhibit the growth of human cancer cells. It is a modified monophosphate nucleotide, which is synthesized by the chemical modification of guanosine with 2'-O-methylation at the 5' position and phosphorylation at the 3' position. This drug is not active against viruses and may be used as an anticancer agent. 2'-O-Methylguanosine 5'-monophosphate sodium has also been shown to be effective in treating hepatitis B virus infection. The drug may act as an antiviral agent by interfering with viral DNA synthesis, causing viral particles to aggregate, or by inhibiting viral DNA polymerase activity.</p>

<p>7-Deaza-2'-deoxy-7-ethynyladenosine is a fluorescent analog of adenosine that has been synthesized to be used as an antimicrobial agent. This compound has shown to be effective against both Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus and Escherichia coli. 7DDAE is also able to inhibit the growth of fungus and yeast, such as Candida albicans. This drug has been shown to have no cytotoxic effects on mammalian cells at concentrations up to 50 μM. 7DDAE has been found to be very photostable in solution, which means it does not degrade when exposed to light.</p>

Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers) is a synthetic nucleoside with antiviral and anticancer properties. It has been shown to activate the transcription of DNA in vitro by binding to the promoter region, resulting in higher levels of RNA synthesis. Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers) has been shown to inhibit the replication of viruses, such as herpes simplex virus type 1 (HSV-1), and it may have potential use in cancer therapy. The drug is also used as a precursor for other antiviral drugs and antibiotics. Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers) is available in high purity, high quality, and at low cost.

<p>2',3'-Dehydro-5'-O-tritylthymidine is an anticancer compound, which is a novel nucleoside phosphoramidite. It is synthesized from thymidine in two steps: first, the 2',3'-dideoxyribose phosphate moiety is prepared by reacting 2',3'-dideoxyribose with chloroacetic acid in the presence of triethylamine, followed by reaction with trityl chloride to form the 5' position of the thymidine. 2',3'-Dehydro-5'-O-tritylthymidine has been shown to inhibit DNA synthesis and antiviral activity.</p>

<p>4-Thiothymidine-5'-triphosphate lithium salt - 100mM aqueous solution is thio-base modified thymidine nucleotide</p>

<p>DMF functionalised 2'-O-methyladenosine</p>

Cytidine 5'-diphosphoglycerol disodium salt is a modified nucleotide that belongs to the group of phosphoramidites. It is a cytidine derivative with a 2-hydroxymethylene bridge, which makes it resistant to degradation by cytidine deaminase and therefore enhances its anticancer activity. Cytidine 5'-diphosphoglycerol disodium salt has been shown to inhibit the growth of cancer cells in vitro and in vivo models, as well as inhibit viral replication. Cytidine 5'-diphosphoglycerol disodium salt is stable at high temperatures and can be used for activation of DNA synthesis in vitro. This product has not been tested on animals or humans and should not be taken internally.

<p>2,2'-Anhydro-L-thymidine is an antiviral, anticancer agent and a synthetic nucleoside. It is a monophosphate that was first synthesized in 1967 and has been used as a potential antiviral agent. 2,2'-Anhydro-L-thymidine has been shown to be effective against the herpes simplex virus type 1 (HSV1). However, it does not inhibit viral nucleic acid synthesis or viral protein synthesis. It also does not inhibit the growth of tumor cells in culture.</p>

<p>7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt is a cytosolic small molecule that inhibits the activity of telomerase, an enzyme involved in the replication of chromosomes. It also has inhibitory effects on kinase domains and may be used to treat cancer. 7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt binds to human mitochondrial DNA and inhibits gene transcription by hybridizing with it. This results in the inhibition of dopamine production, which can be helpful for treating Parkinson's disease. 7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt is structurally similar to 2'-deoxyadenosine 5'-triphosphate (dATP) and can be incorporated into DNA by phosphorylation to form a covalent bond that disrupts the dATP/ATP ratio. This causes cellular energy production to decrease and</p>

<p>N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-thiophosphoramidite is a modified phosphoramidite that can be used to synthesize DNA oligomers. The nucleoside is an antiviral and antitumor agent. It is also used to inhibit the replication of RNA by inhibiting the activity of DNA polymerase. N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-thiophosphoramidite has novel properties that have not been seen in any other nucleosides. This product is for research use only, not for diagnostics or therapeutic purposes.</p>

<p>Lauroyl coenzyme A potassium salt is a potent inhibitor of fatty acid synthase. It has the ability to inhibit the enzyme activity of fatty acid synthase in vitro, which belongs to the class of irreversible inhibitors. Lauroyl coenzyme A potassium salt inhibits the synthesis of fatty acids by inhibiting the enzyme activity of fatty acid synthase. This inhibitor also reversibly inhibits other enzymes with a similar mechanism, such as acetyl-coenzyme A carboxylase and phosphatidate phosphohydrolase. The reaction mechanism can be understood through titration calorimetry studies, demonstrating that lauroyl coenzyme A potassium salt binds to the active site of these enzymes and blocks access to substrates. The binding affinity is higher for wild type strains than for mutant strains, which may be due to differences in protein structure or other factors. Lauroyl coenzyme A potassium salt has been shown to have no effect on wild-type strains but inhibits polymer</p>

<p>2'-Deoxy-5'-O-DMT-5-acetoxymethyluridine 3'-CE phosphoramidite is a novel nucleoside analogue with anticancer activity. It is synthesized from 2'-deoxy-5'-O-DMT-5-acetoxymethyluridine and 3'-chloroethyl phosphate. The compound has been shown to inhibit DNA, RNA, and protein synthesis in vitro, as well as to induce apoptosis in human cancer cell lines. 2'-Deoxy-5'-O-DMT-5-acetoxymethyluridine 3'-CE phosphoramidite is a modified nucleoside that can be used in the production of oligonucleotides for use in gene therapy.</p>