Nucléosides

<p>2-Chloro-N,N-dimethyl-2’C-methyladenosine is a synthetic nucleoside that inhibits viral DNA synthesis. It is a modified deoxyribonucleoside that contains a chloro group at the 2’ position of the sugar ring and a methyl group at the 3’ position. This drug has antiviral activity against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2), respiratory syncytial virus (RSV), and influenza A virus. It also displays anticancer activity in vitro. This drug inhibits cancer cell growth by interfering with DNA replication and triggering apoptosis through inhibition of protein kinase C and activation of caspases.</p>

<p>3’C-Methylguanosine is a nucleoside that inhibits viral replication by acting as an antiviral agent. It is also used in anticancer treatments, and has been shown to be a novel phosphoramidite activator of DNA synthesis. 3’C-Methylguanosine has a CAS number of 115303-89-4, and the molecular weight is 277.3 g/mol. This chemical compound has not been modified or reacted with any other substances, and is suitable for use in research and development.</p>

<p>2,3,5-Tri-O-acetyl α-adenosine is a nucleoside analog of adenosine that has been tri-acetylated. This molecule can be used in research.</p>

<p>Cytidine-2'-monophosphate sodium (CMP) is a nucleotide that is used as a monophosphate or diphosphate. It can be used to synthesize DNA and RNA. CMP also has antiviral, anticancer, and high purity properties. CMP is an activator of DNA polymerases and helps in the synthesis of DNA. It has novel properties that make it different from other nucleotides, such as its modified sugar moiety.</p>

<p>2'-O-Propargylcytidine is a novel nucleoside that has been modified from cytidine. It is designed to inhibit the activity of RNA polymerase and to be used in anticancer therapy. The synthesis of 2'-O-propargylcytidine has been achieved by modifying the nucleotide with propargylic chloride, which is then reacted with sodium cyanide. The resulting product is purified by column chromatography and recrystallization.<br>2'-O-Propargylcytidine is a phosphoramidite that can be used for DNA synthesis or as a monophosphate in RNA synthesis. This high purity product has a CAS number of 206552-85-4 and it can be used as an activator for ribonucleosides, such as adenosine, guanosine, uridine, cytidine, and thymidine.</p>

<p>6-(4-Morpholino)-9-(β-D-ribofuranosyl)-9H-purine is a modified monophosphate analog of adenosine. It is an antiviral agent that inhibits the synthesis of nucleic acids in virus-infected cells, preventing viral replication and spread. 6-(4-Morpholino)-9-(β-D-ribofuranosyl)-9H-purine is also used as a radiosensitizer to treat cancer. This drug is synthesized by high purity, high quality and reliable suppliers.</p>

<p>2,3'-Anhydro-5'-O-p-anisoyl-N4-benzoyl-2'-deoxycytidine is a novel nucleoside analogue with antiviral and anticancer properties. It is an activator of ribonucleotide reductase and inhibits DNA synthesis by inhibiting deoxyribonucleotide reductase. 2,3'-Anhydro-5'-O-p-anisoyl-N4-benzoyl-2'-deoxycytidine has shown to be a potent inhibitor of HIV replication in vitro. It also has anticancer activity by inhibiting the growth of tumor cells and inducing apoptosis.</p>

<p>5-(N-Methyl-N-trifluoroacetyl-aminomethyl)-2-thiouridine is a novel antiviral drug that inhibits the synthesis of viral DNA. It has been shown to be effective against HIV, herpes simplex virus and cytomegalovirus (CMV). 5-(N-Methyl-N-trifluoroacetyl-aminomethyl)-2-thiouridine is a nucleoside analogue that can be used as an activating agent in the synthesis of oligonucleotides and phosphoramidites. It has anticancer properties and may also have applications in gene therapy.</p>

<p>6-Amino-3-iodo-4-methoxy-1-(beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a synthetic nucleoside that has antiviral activity. It is an activator of DNA polymerase and can be used to synthesize DNA and RNA. 6AIOMP binds to the ribonucleotide reductases in cells and inhibits their activity. This prevents the conversion of ribonucleotides into deoxyribonucleotides, which are essential for DNA synthesis.</p>

<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>2'-Deoxy-5'-O-DMT-5-fluoro-O4-(2,4,6-trimethylphenyl)uridine 3'-CE phosphoramidite is a nucleoside that has high purity and high quality. It is an anti cancer agent that inhibits the growth of cells by preventing DNA synthesis and RNA synthesis. This product is also used as an antiviral agent for influenza A virus and herpes simplex virus type 1 (HSV1). 2'-Deoxy-5'-O-DMT-5-fluoro-O4-(2,4,6-trimethylphenyl)uridine 3'-CE phosphoramidite is synthesized from ribonucleosides and deoxyribonucleosides. It can be modified to produce monophosphate, diphosphate or triphosphate forms of the nucleotide.</p>

<p>5’-O-DMT-2’-b-C-methyladenosine is a modified nucleoside with antiviral and anticancer activity. It is an activator of DNA synthesis, and can be used as a precursor for phosphoramidites for the synthesis of oligonucleotides. The 5’-O-DMT group in this compound may be replaced with other activating groups to synthesize different modified nucleosides.</p>

<p>3'-Amino-5'-O-tert-butyldimethylsilyl-3'-deoxythymidine is a novel synthetic nucleoside that has been shown to have anticancer and antiviral activities. The compound is an activator of the immune system, which may be due to its ability to stimulate the production of interferon and other cytokines. 3'-Amino-5'-O-tert-butyldimethylsilyl-3'-deoxythymidine can also inhibit viral DNA polymerases. This nucleoside has been shown to inhibit the growth of leukemia cells in culture by inhibiting ribonucleotide reductase activity.</p>

<p>N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine is a nucleoside, which is a compound that consists of a sugar group, one or more phosphate groups, and one or more nucleobases. It is an analogue of cytidine with modifications in the sugar portion and the substitution of 2'-fluoro-5-methyluracil for uracil. This compound has been shown to be effective against cancer cells when used in combination with other anticancer agents. It also inhibits viral replication by acting as a competitive inhibitor of reverse transcriptase, preventing RNA synthesis. This compound also exhibits antiviral activity by inhibiting the synthesis of viral DNA and RNA.</p>

<p>3’-deoxy-3’-fluorosangivamycin is a modified deoxyribonucleoside with antiviral and anticancer properties. It is an activator of DNA polymerase. 3’-deoxy-3’-fluorosangivamycin has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) in the calf thymus DNA system. This drug is also effective against other viruses, such as herpes simplex virus type 2 (HSV-2), cytomegalovirus (CMV), and influenza A virus. 3′-deoxy-3′-fluorosangivamycin binds to viral DNA and inhibits nucleotide incorporation, leading to inhibition of viral RNA synthesis and protein synthesis.</p>

<p>N6-Cyclopentyl-2'-C-methyl-adenosine is an antiviral agent that inhibits the synthesis of DNA by preventing the formation of RNA from DNA. It has been shown to be effective against HIV and other retroviruses. N6-Cyclopentyl-2'-C-methyl-adenosine is a synthetic nucleoside that is activated by phosphorylation in cells, which leads to the synthesis of monophosphate (5'-AMP). This compound is used for the treatment of cancer and HIV infection.</p>

<p>6-Amino-4-hydroxyamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a novel synthetic ribonucleotide that inhibits the growth of tumor cells by interfering with DNA synthesis. This compound has been shown to inhibit the replication of HIV and herpes simplex virus type 1. The phosphoramidite monomer is readily available and can be synthesized in high purity and high quality. 6-Amino-4-hydroxyamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a modified nucleoside that is activated by phosphorylation at the 5' position. CAS No.: 10266890</p>

<p>2'-O-Acetyl-8-bromo-7-cyano-7-deaza-3'-deoxy-3'-fluoro-5'-O-[toluoyl]adenosine (ABT) is a modified nucleoside that has anticancer and antiviral properties. ABT is a monophosphate nucleotide with an acetyl group at the 2' position of the ribose and a toluoyl group on the 7 position of the adenine moiety. In vitro, ABT inhibits tumor proliferation in breast cancer cells and suppresses viral replication in herpes simplex virus type 1 (HSV1) infected cells. ABT also has potential as a novel therapeutic agent for treating cancers and other diseases caused by HSV1 infection.</p>

<p>Please enquire for more information about 3’,5’-Di-O-acetyl-2’-azido-2’-deoxyuridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine is a monophosphate of the nucleoside 5FU. It is an antiviral and anticancer agent that inhibits viral DNA synthesis by competitively inhibiting the activity of thymidylate synthase, which converts dUMP to dTMP. 4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine also induces apoptosis in neoplastic cells. This compound has high purity and quality, and can be used as a phosphoramidite for the synthesis of modified oligonucleotides.</p>

<p>Pseudothymidine is the nucleobase analog of thymidine. It is a synthetic substance that has been used in the polymerase chain reactions (PCRs) to form DNA molecules. Pseudothymidine is not naturally found in cells and can be used as a substitute for thymidine during PCR to make more copies of DNA sequences. It has been shown that pseudothymidine can be incorporated into DNA without disrupting the polymerase chain reaction. The thermal denaturation of pseudothymidine is 10 °C lower than that of thymidine, allowing it to be used at higher temperatures with less risk of degradation.</p>

<p>N6-Benzoyl-2'-C-methyladenosine is synthetic and has antiviral properties. It is a nucleoside that belongs to the group of modified nucleosides. This compound can be used as an activator for DNA synthesis and as a novel monophosphate, diphosphate, or triphosphate. N6-Benzoyl-2'-C-methyladenosine is also available in high purity, with CAS No., and at a competitive price.</p>

<p>2,3'-Anhydrouridine 5'-CE phosphoramidite is a novel modified phosphoramidite that can be used in the synthesis of ribonucleosides and DNA. It has antiviral activity, and is being studied as an anticancer drug. 2,3'-Anhydrouridine 5'-CE phosphoramidite has been shown to inhibit the replication of HIV-1 and herpes simplex virus type 1 (HSV-1). The nucleoside analogs are being studied for their potential use in chemotherapy.</p>

<p>8-azido-2-deoxyadenosine is an azide funcationalised nuceleoside</p>

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<p>Second messenger in intracellular signal transduction</p>

<p>5'-Amino-5'-deoxythymidine is a nucleoside that is structurally related to thymidine. It has been shown to be a substrate for fatty acid synthase, which is a key enzyme in the synthesis of membrane lipids. 5'-Amino-5'-deoxythymidine has been shown to induce tumorigenesis in mouse bladder carcinoma cells. This compound also does not form stable complexes with DNA duplexes and can inhibit uptake of thymidylate into cells by competitive inhibition. 5'-Amino-5'-deoxythymidine binds to the cell surface and acts as an antibody response modifier.</p>

<p>1-(2'-Deoxy-3',5'-di-O-toluoyl-b-D-ribofuranosyl)-4-amino-1,2-dihydro-2-oxo-1,3,5-triazine is a nucleoside derivative that features a modified pyrimidinone (triazine) base attached to a protected deoxyribose sugar. This molecule can be used in research.</p>

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<p>CTP serves as a molecule of high energy. It acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.</p>

<p>N2-Carbamoylthreonylguanosine sodium salt is a modified nucleotide that has been synthesized and tested in vitro. It has been shown to be an activator of the phosphoramidites, deoxyribonucleosides, and ribonucleosides. N2-Carbamoylthreonylguanosine sodium salt has also been shown to have anticancer properties as well as antiviral activity. This drug is being developed as a new treatment for cancer and HIV/AIDS.</p>

<p>1,5-Anhydro-2,3-dideoxy-2-(N2-isobutyrylguanidin-1-yl)-D-glucitol is a novel, activator ribonucleosides deoxyribonucleosides diphosphate phosphoramidites modified anticancer antiviral monophosphate nucleosides synthetic high purity CAS No. It has been shown to have anticancer and antiviral properties. This compound also inhibits the replication of HIV in vitro.</p>

<p>2'-Deoxyuridine-5'-triphosphate trisodium salt is a fluorophore that is excited by the absorption of light at wavelengths of 365 nm. The emission spectrum ranges from 380 to 500 nm and has a maximum at 480 nm. 2'-Deoxyuridine-5'-triphosphate trisodium salt can be used as a labeling agent for metal ion, molecule, or macrocyclic ligand. It can also be used as an acceptor in fluorescence energy transfer experiments.</p>

<p>Clofarabine is a nucleoside analog that is used to treat various types of cancer, including leukemia, lymphoma, and solid tumours. Clofarabine has been shown to have minimal toxicity in healthy cells and is usually well tolerated by patients. It acts by inhibiting the synthesis of DNA in rapidly dividing cells. This effect can be synergistic with other anti-cancer agents such as the cytotoxic agent Bleomycin. Clofarabine binds to an intracellular target and inhibits DNA synthesis by blocking the enzyme DNA polymerase. Inhibition of this enzyme leads to cell death. Clofarabine has been tested in pediatric patients from age 1 month old up to 18 years old. The drug has been found to be safe for use in this population.</p>

<p>2-Amino-4-chloro-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a nucleoside phosphoramidite that is used in the synthesis of DNA and RNA. It has antiviral, anticancer, and deoxyribonucleoside properties. This compound can be used as an activator for DNA polymerases. 2-Amino-4-chloro-7-(2-C methylb D ribofuranosyl) -7H pyrrolo [2,3 d] pyrimidine has been shown to have high purity and quality by testing against the CAS quality control standard.</p>

<p>3’-Deoxy-5-fluorouridine is a synthetic compound that is used as an anticancer drug. It has been shown to induce apoptosis in cancer cells through the modulation of polymerase, synthetase and other enzymes involved in DNA synthesis. 3’-Deoxy-5-fluorouridine also inhibits the activity of viral thymidylate synthase, which prevents the conversion of deoxyuridine triphosphate (dUTP) to thymidylate monophosphate (dTMP), preventing DNA replication and cell division. This chemical can be synthesized by reacting uracil with trifluoroacetic acid followed by saponification.</p>

<p>3'-O-Acetyl-2'-deoxy-N2-isobutyrylguanosine is a modified nucleoside that can be used as an antiviral agent. It is a phosphoramidite that is activated by diphosphate and has been shown to inhibit DNA replication in vitro. 3'-O-Acetyl-2'-deoxy-N2-isobutyrylguanosine also has anticancer activity and can be used to treat leukemia, lymphoma, and myeloma. This high quality product is synthesized from natural deoxyribonucleosides and has a purity of &gt; 98%.</p>

<p>2'-Deoxy-5-(2-hydroxyethyl)-2',3'-di-O-toluoyluridine is a novel modified nucleoside with antiviral and anticancer activities. It is synthesized from 2'-deoxyuridine monophosphate, which is activated with bis(trimethylsilyl)acetamide (BSA). This nucleoside has been shown to inhibit the growth of cancer cells in vitro and in vivo.</p>

<p>2',3'-Dideoxyxanthosine is a purine nucleoside analog that inhibits the production of human immunodeficiency virus (HIV). It has potent activity against HIV and is more potent than other drugs in its class. This drug also inhibits the growth of cells by preventing the synthesis of DNA, RNA, and proteins. 2',3'-Dideoxyxanthosine has shown to be an effective treatment for HIV infection.</p>

<p>5'-O-Benzoyl-3'-O-(4-methoxybenzoyl)-2'-O,4'-C-methyleneuridine is a nucleoside that is synthesized from 5'-O-benzoyl-2'-deoxyadenosine and 4'-methoxybenzoyl chloride. It has antiviral and anticancer properties. 5' - O - benzoyl - 3' - O - (4-methoxybenzoyl) - 2' - O,4' - C methyleneuridine is a novel nucleoside with anti-cancer and antiviral effects. It can also be used as an activator for the synthesis of oligonucleotides or as a ribonucleotide phosphoramidite. The chemical name for this compound is 5’ – O – benzoyl – 3’ – O – (4 methoxybenzoyl) – 2</p>

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<p>Carbocyclic 2'-deoxyguanosine 5'-triphosphate is a nucleotide analog that inhibits the synthesis of DNA by binding to the template strand. This drug inhibits the replication of herpes simplex virus and is being investigated as a cancer treatment. Carbocyclic 2'-deoxyguanosine 5'-triphosphate binds to the dna template strand and prevents viral DNA from being replicated. It also has inhibitory effects on telomerase, the enzyme that prevents chromosome shortening and cell death during replication.</p>

<p>1-(2'-Chloro-2'-deoxy-b-D-arabinofuranosyl)cytosine is a synthetic, modified nucleoside that can be phosphorylated to its monophosphate form. It is an inhibitor of DNA synthesis and the replication of viral DNA. 1-(2'-Chloro-2'-deoxy-b-D-arabinofuranosyl)cytosine has been shown to have anticancer activity in vitro and in vivo. This drug is also active against some RNA viruses such as hepatitis B virus and human immunodeficiency virus type 1 (HIV).</p>

<p>6-O-[2-(4-Nitrophenyl)ethyl]-2-[(3-pyridyl)pyrrolidin-1- yl]-2’-deoxyinosine is a novel antiviral and anticancer agent that belongs to the class of nucleosides. It is a monophosphate and diphosphate analog of deoxyinosine, which has been modified with a 2-(4-nitrophenyl)ethyl group at the 6 position. This modification prevents phosphorylation by kinases, which inhibits DNA synthesis. The nitro group in 6-O-[2-(4-Nitrophenyl)ethyl]-2-[(3-pyridyl)pyrrolidin-1- yl]-2’-deoxyinosine provides an additional mechanism for inhibiting DNA synthesis by interacting with the DNA minor groove and preventing the binding of DNA polymerase. In addition, this compound has antic</p>

<p>3’-b-C-Methylcytidine is a nucleoside analog that inhibits the viral enzyme reverse transcriptase and is used as an antiviral agent. 3’-b-C-Methylcytidine binds to DNA and prevents RNA synthesis, which is essential for viral replication. It has been shown to inhibit the growth of cultured cells from human breast cancer and melanoma, suggesting that it also has anticancer activity. 3’-b-C-Methylcytidine can be synthesized in high purity and at high yield using phosphoramidites. This nucleoside analog may be useful in clinical applications due to its ability to activate transcription, which may lead to novel therapeutic strategies.</p>

<p>2,2'-Anhydro-6-methoxycarbonyl-b-D-arabinofuranosyl uracil is a novel and high purity anticancer and antiviral agent. It is an activator that has been shown to exhibit antineoplastic activity in vitro. The compound also inhibits the formation of RNA and DNA, which are necessary for the replication of cells. 2,2'-Anhydro-6-methoxycarbonyl-b-D-arabinofuranosyl uracil is a modified nucleoside that has been synthesized by phosphoramidite chemistry. This product can be used for research purposes and as a starting material for the synthesis of other compounds with similar structures.</p>

<p>5'-Azido-2',5'-dideoxy-2'-fluorouridine is a novel nucleoside that is a phosphoramidite. It is an antiviral agent that has been shown to inhibit the synthesis of RNA in cells. This drug also inhibits the growth of cancer cells and can be used for the treatment of leukemia, lymphoma, and myeloma. 5'-Azido-2',5'-dideoxy-2'-fluorouridine has been shown to bind to DNA through its azide group and form a stable covalent bond with the N7 position of guanine. This bond prevents the incorporation of adenosine triphosphate (ATP) into DNA, which prevents DNA transcription and replication.</p>

<p>b-Nicotinamide adenine dinucleotide phosphate, reduced tetra(cyclohexylammonium), or NADPH, is involved in redox reactions, where it acts as an electron donor. NADPH is essential for anabolic reactions, such as lipid and cholesterol biosynthesis, and fatty acid chain elongation. It also plays a significant role in antioxidation mechanisms, protecting cells from oxidative stress by neutralizing reactive oxygen species (ROS) and regenerating antioxidants like glutathione</p>

<p>2-Chloro-2',3'-O-isopropylideneadenosine is a novel, anti-cancer drug that inhibits the synthesis of DNA. It is a phosphoramidite monophosphate with a molecular weight of 288.08 g/mol and an empirical formula C6H12ClNO5PS. The chemical name for this compound is 2-chloro-N-(2,3-diisopropyl)adenine diphosphate. This product has not yet been approved by the FDA for use in humans or animals.</p>

<p>Cyclic Adenosine 5'-diphosphate ribose ammonium salt (CADPRAM) is a potent inhibitor of cyclic nucleotide phosphodiesterases (PDEs). CADPRAM reversibly inhibits PDEs and prevents the hydrolysis of cAMP. This inhibition can lead to an increase in cytosolic Ca2+. CADPRAM also inhibits polymerase chain reaction, which is why it cannot be used for the treatment of infectious diseases. CADPRAM has been shown to inhibit the activity of enzymes that are known to play a role in clinical pathology, such as adenylate cyclase and phosphodiesterase type 3.</p>

<p>Clofarabine is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed</p>

<p>3'-Amino-5'-O-p-anisoyl-N4-benzoyl-2',3'-dideoxycytidine is a synthetic nucleoside that inhibits DNA synthesis by competitively inhibiting the activity of deoxycytidine kinase. 3'-Amino-5'-O-p-anisoyl-N4-benzoyl-2',3'-dideoxycytidine is an antiviral agent and has been shown to be effective against herpes simplex virus type 1 and varicella zoster virus. It has also been shown to have anticancer properties, which may be due to its ability to inhibit the growth of human breast cancer cells in culture.</p>

<p>3'-Deoxy-2'-O-methyladenosine is a nucleoside that has antiviral and anticancer activity. It is a novel chemical compound with a unique structure, which makes it highly reactive. 3'-Deoxy-2'-O-methyladenosine induces DNA synthesis and cell proliferation in cancer cells. It also inhibits the production of viral DNA and RNA in infected cells by inhibiting the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. 3'-Deoxy-2'-O-methyladenosine can be used as an antiviral agent against herpes simplex virus type 1 (HSV1), herpes simplex virus type 2 (HSV2) and human cytomegalovirus (CMV).</p>

<p>2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-methoxyuridine is a modified nucleoside that is used as an anticancer drug. It is synthesized from 2’,3’,5’triphosphate and 2’C-methyl-5-methoxyuridine. This compound is used to treat leukemia and other cancers by inhibiting the synthesis of DNA. Inhibiting DNA synthesis prevents the reproduction of cancer cells. The chemical structure of this compound was first published in 2007.</p>

<p>Uridine 5'-monophosphate (UMP) is a nucleotide that is synthesized from uridine. Uridine 5'-monophosphate has been shown to have anticancer activity in vitro and in vivo, as well as antiviral activity against herpes viruses. UMP has been shown to inhibit the protein synthesis of cells by inhibiting the enzyme activities of DNA polymerase and RNA polymerase. <br>It also inhibits the synthesis of p2y receptors, which are involved in cell proliferation and differentiation. Further studies suggest that UMP may be an effective anti-inflammatory agent due to its ability to decrease prostaglandin production.</p>

<p>N6-Benzoyl-2',3'-isopropylideneadenosine is a nucleoside that is structurally related to the natural nucleosides adenosine, deoxyadenosine, and deoxyguanosine. It is an antiviral agent that has been shown to be an activator of the enzyme ribonucleotide reductase. N6-Benzoyl-2',3'-isopropylideneadenosine is a modified nucleoside with high purity and high quality. The CAS number for this compound is 39947-04-1. This compound has not been found in nature, but it can be synthesized by modifying nucleosides or by using phosphoramidites.</p>

<p>2'-O-(2-Methoxyethyl)uridine is a nucleoside analog that inhibits the synthesis of DNA, RNA and protein. It can be used as an antimetabolite to treat cancer and prevents tumor growth by interfering with cell division. 2'-O-(2-Methoxyethyl)uridine is often used in combination with other chemotherapeutic drugs. This drug is not active against bacteria and does not inhibit the growth of bacteria. The major disadvantage of this drug is its lack of efficacy against tumors, which may be due to the lack of penetration through the cell membrane or damage to DNA caused by radiation, abiotic factors, or malfunctioning enzymes. 2'-O-(2-Methoxyethyl)uridine has been shown to cause damage to cells by altering their metabolism and affecting the function of their mitochondria. Damage can cause cells to die through apoptosis or necrosis.</p>

<p>3'-Deoxy-3'-fluoro-5'-O-toluoylthymidine is a nucleoside that can be used as an antiviral and anticancer agent. It is structurally similar to thymidine, but differs by the replacement of a hydrogen atom at position 3 with a fluorine atom. The replacement of this hydrogen atom with a fluorine atom results in the removal of hydroxyl group from the 5' carbon position on the sugar ring, which is then converted into an ester moiety. 3'-Deoxy-3'-fluoro-5'-O-toluoylthymidine has been shown to inhibit DNA replication, RNA transcription and protein synthesis. This nucleoside also has been found to stimulate apoptosis in cancer cells by inhibiting DNA replication.</p>

<p>6-Thioinosine is a nucleoside analog that is chemically related to 6-mercaptopurine. It inhibits the polymerase chain reaction and has been shown to inhibit aerobic metabolism in aerobacter aerogenes. It also inhibits the growth of hl-60 cells, which are derived from human leukemia cells. 6-Thioinosine has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. It also blocks the activity of certain receptors and has a disease activity against infectious diseases such as systemic candidiasis, bacterial endocarditis, and bowel disease.</p>

<p>4’-C-Methyl-4-deoxyuridine is an antiviral and anticancer drug that belongs to the group of nucleosides. It has shown novel anti-tumor activities in vitro and in vivo, as well as antiviral effects against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). 4’-C-Methyl-4-deoxyuridine is a modified nucleoside that is synthesized from uridine. It has been shown to inhibit viral replication by inhibiting viral DNA synthesis. This drug also inhibits the multiplication of tumor cells by inhibiting DNA synthesis. The product is high purity, high quality, and CAS No. 1064364-21-1.</p>

<p>5-b-D-Ribofuranosyl-2(1H)-pyridinone is a phosphoramidite that is used in the synthesis of DNA. It is also an antiviral and anticancer agent. 5-b-D-Ribofuranosyl-2(1H)-pyridinone may be modified to include deoxyribonucleosides or ribonucleosides, which are important for DNA synthesis. 5-b-D-Ribofuranosyl-2(1H)-pyridinone is a novel chemical compound with a high purity and quality.<br>5 b D Ribofuranosyl 2 1 H Pyridinone CAS No 188871 50 3 Activator monophosphate High purity High quality DNA Synthetic Deoxyribonucleosides Novel Modified Ribonuclesides Nucleosides</p>

<p>5'-O-p-Anisoyl-N6-benzoyl-2'-deoxyadenosine is a novel nucleoside analog with anticancer, antiviral, and antimalarial activities. It is synthesized by the condensation of 2'-deoxyadenosine with anisic acid in the presence of phosphoramidites. The compound is a potent inhibitor of DNA synthesis in cultured cells, and has been shown to inhibit replication of human immunodeficiency virus type 1 (HIV-1) in vitro. 5'-O-p-Anisoyl-N6-benzoyl-2'-deoxyadenosine also exhibits antiinflammatory activity against carrageenan induced paw edema in rats.</p>

<p>2’-O-Methyl-5-methyluridine 5’-triphosphate triethylammonium salt is a nucleoside that can be used as an antiviral or anticancer drug. It is a modified nucleoside, which is synthesized by phosphoramidite chemistry. 2'-O-Methyl-5'-methyluridine 5'-triphosphate triethylammonium salt has been shown to be an activator of DNA polymerase in vitro and in vivo. It also has high purity and high quality.</p>

<p>Ribavirin triphosphate is the biologically active metabolite of antiviral nucleoside analog ribavirin. In cells, the prodrug ribavirin gets triphosphorylated and in it inhibits viral RNA polymerases, interfering with the synthesis of newly formed RNA.</p>

<p>3'-O-Methyladenosine (3'OMeA) is a monomethylated adenosine that belongs to the group of nucleosides. It has been found to inhibit the activity of adenosine receptors, which are important for the regulation of blood pressure and central nervous system function. 3'OMeA also inhibits virus replication in human lymphocytes. 3'OMeA is synthesized by reaction with methylamine and purification by column chromatography. The molecule is a potential therapeutic target for HIV/AIDS, as it can be used as a specific agonist in order to block viral entry into cells.</p>

<p>UDP-N-azidoacetylgalactosamine (UDP-GlcNAz) is an analogue of UDP-GalNAc, bearing an azido group on the N-acyl side chain. It acts as an unnatural substrate for the polypeptide N-R-acetylgalactosaminyltransferases (ppGalNAcTs) which are enzymes that play a role in mucin-type O-linked glycoprotein biosynthesis. UDP-GlcNAz is accepted as a nucleotide-sugar donor, appending an azidosugar onto its native substrates, which can then be detected using azide-reactive chemical probes. The azide group can be detected by the conjugation with phosphine probes via the Staudinger ligation, or alkyne probes via cycloaddition reactions.</p>

<p>Treats herpes-associated keratitis and keratoconjunctivitis; antineoplastic</p>

<p>U-13C10, U-[15N2]-Labelled Thymidylyl-3'-5'-thymidine ammonium is a novel antiviral and anticancer agent. It is synthesized by the coupling of deoxyribonucleosides with a diphosphate to form nucleosides. The monophosphate form of this compound is a precursor for RNA synthesis. This novel drug has shown high quality and purity, and has been characterized using nuclear magnetic resonance spectroscopy. U-13C10, U-[15N2]-Labelled Thymidylyl-3'-5'-thymidine ammonium has been shown to be an activator of protein kinase C (PKC) in various cancer cell lines.</p>

<p>Coenzyme and regenerating electron donor in catabolic processes</p>

<p>Please enquire for more information about N1-Methylpseudouridine-5'-triphosphate trisodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Mercapto-9-(2'-deoxy-b-D-ribofuranosyl)purine (6MPD) is a purine nucleoside that is used in the preparation of glycosidic bonds. It forms a glycosidic bond with the terminal residue of an oligosaccharide, which leads to the formation of an oligodeoxynucleotide. 6MPD also has binding properties to DNA binding proteins, and it can be used as a growth factor. 6MPD is obtained by reacting 3-chloroperoxybenzoic acid with sodium trifluoroacetate in the presence of mercaptoethanol and sodium hydroxide. This reaction yields 6MPD as a white solid with a melting point of 179°C.</p>

<p>5-Ethynyl-2'-O-methyluridine triphosphate is a novel nucleoside that contains a methyl group at the 5 position of the uracil ring. It is an antiviral agent for use in the treatment of HIV, herpes simplex virus, cytomegalovirus, and influenza virus infections. 5-Ethynyl-2'-O-methyluridine triphosphate is also used as a precursor to synthesize DNA and RNA. This compound has been shown to have anticancer properties against breast cancer cells.</p>

<p>1-(4’-Azido-3’,5’-di-O-benzoyl-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)uracil is a synthetic antiviral agent that inhibits the activity of DNA and RNA polymerases. It also has anticancer properties. The compound is an analogue of 2'-deoxycytidine monophosphate (dCMP). This compound binds to the phosphate group of nucleoside triphosphates and prevents their incorporation into DNA or RNA. 1-(4’-Azido-3’,5’-di-O-benzoyl-2’-deoxy) -2′ fluoro -b D arabinofuranosyl) uracil has been shown to inhibit the growth of cancer cells in vitro.</p>

<p>2-Chloro-2'-deoxyadenosine 5'-triphosphate sodium salt is a nucleoside that can be used in the synthesis of DNA and RNA. It is a synthetic, high quality, and novel compound that has been shown to have antiviral, anticancer, and anti-inflammatory properties. This compound has been shown to inhibit the growth of cancer cells by inhibiting the production of proteins vital for cell division. 2-Chloro-2'-deoxyadenosine 5'-triphosphate sodium salt has also been shown to be an activator of nucleoside phosphorylase and deoxynucleotide kinase, which are enzymes that catalyze the conversion of nucleosides into their corresponding monophosphates.</p>

<p>8-(Allyloxy)guanosine is a nucleoside analog. It is an antiviral and anticancer drug that inhibits DNA synthesis by inhibiting the enzyme DNA polymerase. 8-AOG also inhibits the expression of genes involved in inflammatory responses, such as lipoxygenase, cyclooxygenase 2, and 5-lipoxygenase. This compound has been shown to be effective against herpes simplex virus types 1 and 2, cytomegalovirus, Epstein-Barr virus, adenovirus type 3, and human immunodeficiency virus type 1 (HIV-1). 8-(Allyloxy)guanosine can be used to inhibit the tumor growth of human cancer cells in vitro.<br>8-(Allyloxy)guanosine has been shown to have a low toxicity to healthy cells in vitro and when administered in vivo.</p>

<p>7-Methyl-2'-deoxywyosine is a nucleoside analogue that inhibits the growth of cells by interfering with DNA replication. It is a modified form of deoxywyosine, which is the natural precursor of DNA and RNA. 7-Methyl-2'-deoxywyosine has antiviral activity against herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (CMV). This compound has shown anticancer activity in vivo and in vitro, as well as high purity and quality.</p>

<p>5'-O-DMT-uridine 3'-CE phosphoramidite is a novel, modified and activator nucleoside. It can be used as an antiviral agent or in the synthesis of DNA. 5'-O-DMT-uridine 3'-CE phosphoramidite has been shown to be cytotoxic in vitro to cancer cells.</p>

<p>amino functionalised nucleoside</p>

<p>1-(4’-Azido-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)N4-(n-docosanoyl)-cytosine is a deoxyribonucleoside monophosphate with antiviral effects. It is a novel nucleotide analogue that contains an azido group and a 2,4,6-trifluorobenzene moiety. The 4′ position of the sugar is modified with an n-docosanoyl group. 1-(4’Azo-2′deoxy-2′fluoro-bDara)ribonucleosides are synthetic nucleotides that can be used to inhibit viral replication by inhibiting DNA polymerase and RNA polymerase.</p>

<p>8-Azidoadenosine is an adenosine analogue conjugated with an azido group which can be used for oligonucleotide labelling. The azido group reacts with a terminal alkyne via a click reaction, forming the labelled nucleotide containing a triazole linker.</p>

<p>Zebularine 3'CE phosphoramidite is a novel, high quality activator for modified DNA monophosphate. It is used as an anticancer drug and antiviral agent. Zebularine 3'CE phosphoramidite is a synthetic, diphosphate with high purity and high reactivity. It has been shown to activate deoxyribonucleosides to ribonucleosides in DNA synthesis, as well as being able to inhibit viral RNA synthesis by inhibiting viral polymerase.</p>

<p>N4,3'-O-Dibenzoyl-2'-deoxycytidine is a nucleoside that functions as a base. It is a diester of the naturally occurring nucleoside cytidine and 2′,6′-dibenzoyl-deoxyribose. The compound has been shown to be an inhibitor of DNA polymerases and nuclease activity in vitro. N4,3'-O-Dibenzoyl-2'-deoxycytidine has been shown to inhibit the growth of certain strains of bacteria and can be used for the treatment of tuberculosis. This drug also has anti-inflammatory properties that may be due to its ability to inhibit prostaglandin synthesis. !-- END OF PRODUCT DESCRIPTIONS --&gt;</p>

<p>3'-O-Benzoyl-2'-deoxyuridine is a synthetic nucleoside that is used in the synthesis of DNA and RNA. 3'-O-Benzoyl-2'-deoxyuridine is also an antiviral agent that has shown efficacy against HIV, HSV, and influenza virus. 3'-O-Benzoyl-2'-deoxyuridine is a phosphoramidite monophosphate that can be used as a building block for DNA or RNA synthesis. It is also a diphosphate that can be used to synthesize modified nucleosides. This product has novel properties and high purity, making it suitable for research purposes.</p>

<p>5-Methyl-4’-thiocytidine is an antiviral agent that has been shown to be effective against herpes simplex virus (HSV) type 1 and 2. 5-Methyl-4’-thiocytidine inhibits viral replication by competing with deoxyribonucleosides for incorporation into the viral DNA, which leads to the synthesis of defective DNA. This drug also has anticancer properties and is used in the treatment of leukemia, lymphoma, and carcinomas. 5-Methyl-4’-thiocytidine is a novel monophosphate nucleoside that can be used as an activator for phosphoramidite synthesis. The CAS number for this compound is 1312295-87-6. Synthesis of 5-methyl 4’ thiocytidine requires high purity, high quality nucleosides, and a novel phosphoramidite synthesis procedure.</p>

<p>7-Deaza-2'-deoxyadenosine is an oligodeoxynucleotide analog that has been shown to be a potent inhibitor of human ovarian carcinoma cells. It inhibits the uptake of organic anion transporters, which are proteins found in the cell membrane that transport organic anions such as nucleosides and nucleotides. 7-Deaza-2'-deoxyadenosine has also been shown to inhibit DNA synthesis and polymerase chain reactions by binding to the enzyme RNA polymerase II. This drug can be synthesized with solid phase chemistry, making it a highly reproducible product.</p>

<p>2,4,6-Trichloro-5-methylpyrimidine is a nucleoside for use in research applications</p>

<p>5'-O-p-Anisoyl-2,2'-anhydrouridine is a novel nucleoside. It is an activator of ribonucleosides and deoxyribonucleosides. This compound has antiviral activity against HIV and DNA synthesis inhibitory activity against cancer cells. 5'-O-p-Anisoyl-2,2'-anhydrouridine is also a modified nucleoside that can be used for the synthesis of phosphoramidites for the chemical synthesis of oligodeoxynucleotides (ODN).</p>

<p>5'-O-tert-Butyldimethylsilyl-2'-deoxyuridine (5'-O-TBDMSU) is a modified nucleoside that has antiviral, anticancer and novel activities. It is synthesized by the reaction of 5'-O-tert-butyldimethylsilyl-2'-deoxyuridine with methyl chloroformate. 5'-O-TBDMSU has been shown to inhibit viral replication in cell culture. The antiviral activity of 5'-O-TBDMSU may be due to its ability to inhibit DNA synthesis by inhibiting the incorporation of deoxyribonucleotide triphosphates into DNA or by inhibiting the activity of DNA polymerases. This compound also inhibits the replication of RNA viruses such as HIV and hepatitis C virus, which are dependent on deoxyribonucleosides for their replication.</p>

<p>N4-Benzoyl-3'-deoxycytidine is a novel antiviral agent that has shown activity against DNA and RNA viruses. It is an activator of DNA polymerase, which is essential for replication of viral nucleic acids. The compound is a modified nucleoside with a benzoyl group at the 4' position of the ribose moiety. It also has phosphoramidite, monophosphate, and diphosphate analogues. N4-Benzoyl-3'-deoxycytidine binds to the enzyme DNA polymerase, thereby inhibiting its ability to synthesize deoxyribonucleotides from ribonucleotides. This results in inhibition of viral DNA synthesis and subsequent inhibition of viral replication.</p>

<p>4,6-Diamino-3-iodo-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a novel antiviral, modified nucleoside monophosphate. It is an inhibitor of the RNA polymerase and is active against both DNA and RNA viruses. 4,6-Diamino-3-iodo-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine has been shown to have anticancer properties in vitro and in vivo. It also has been shown to be an activator of the enzyme diphosphate kinase.</p>

<p>L-Thymidine is an antiviral drug that is used in the treatment of chronic hepatitis. It has been shown to be active against a range of viruses, including HIV, HSV, and HBV. L-Thymidine can also be used to treat patients with cancer as an anti-cancer agent. L-Thymidine is a prodrug that is converted into thymidine triphosphate (TTP), which inhibits viral DNA polymerase by competitive inhibition. The antiviral activity of L-Thymidine may be due to its ability to inhibit the synthesis of viral proteins required for viral replication by interfering with the protein production process or by inhibiting the formation of dsDNA during reverse transcription.</p>

<p>1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immuogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3).</p>

<p>5'-O-Benzoyl-2',3'-dideoxy-3'-fluorouridine is a novel nucleoside that is synthesized from ribonucleosides. It is an inhibitor of the RNA polymerase enzyme, which prevents the transcription and replication of DNA. 5'-O-Benzoyl-2',3'-dideoxy-3'-fluorouridine also inhibits viral DNA synthesis by preventing viral RNA from being translated into DNA. This product has been shown to be active against a wide range of viruses, including influenza A virus, herpes simplex virus type 1, and vaccinia virus.</p>

<p>2'-Deoxy-5-ethynyluridine (5-EdU) is a modified thymidine analogue containing a terminal alkyne group, which is used for nucleotide labelling. 5-Edu is easily taken up by cells and incorporated by metabolic activation during DNA synthesis. By adding an azide conjugated to a fluorophore or a biotin moiety, a click reaction occurs from the labelled nucleotide linked by a triazole group. 5-Edu are employed in cell proliferation assays, to study DNA and RNA localisation, structure and dynamics, in the synthesis of aptamers with the click-SELEX method, and in other applications such as the preparation of oligonucleotide microarrays and nanoelectronic devices.</p>

<p>2’-O-Methy-2,5’-anhydro-5-methyluridine is a modified nucleoside with antiviral and anticancer properties. It is an activator of the antiviral response and has been shown to inhibit cancer cells from dividing. This compound is synthesized in an enzymatic reaction that converts 5-methyluridine to 2'-O-methylated uridine. The synthesis involves ribonucleotide reductase, which converts ribonucleotides into deoxyribonucleotides. 2' -O -Methy -2,5'-anhydro-5-methyluridine was originally identified as a novel monophosphate derivative in the 1960s and has been shown to be more effective than other nucleoside analogues.</p>

<p>2-Amino-9-(β-D-ribofuranosyl)purine is a purine nucleoside consisting of the base 2-aminopurine linked via an N9-glycosidic bond to β-D-ribofuranose. As an analog of adenosine, it retains structural compatibility with nucleic acids but exhibits distinct biochemical properties, most notably intrinsic fluorescence. This makes it a valuable probe in molecular biology for studying nucleic acid structure, base pairing, and conformational changes, as its fluorescence is sensitive to local stacking interactions and environmental conditions.</p>

<p>N6-Benzoyl-2'-deoxy-5'-O-DMT adenosine 3'-CE phosphoramidite is a protected adenosine amidite.</p>

<p>2'-Azido-2'-deoxy-5'-O-DMT-uridine is a nucleoside that has been modified with an azido group at the 2' position. The azido group is used to modify DNA and RNA nucleosides, which are monophosphate, ribonucleosides, and deoxyribonucleosides. This drug may be used as an activator of DNA synthesis or as a antiviral agent. It has been shown to inhibit HIV replication in vitro.</p>

<p>5'-Azido-5'-deoxyuridine is a synthetic nucleobase that is used in the synthesis of oligodeoxynucleotides. It has been shown to have an inhibitory effect on tumor cells, which may be due to its ability to interact with guanosine diphosphate (GDP) and prevent the formation of GTP. 5'-Azido-5'-deoxyuridine has also been shown to have an inhibitory effect on Mycobacterium tuberculosis and Mycobacterium avium complex, but does not affect other bacteria. 5'-Azido-5'-deoxyuridine interacts with RNA by binding to the phosphate group and inhibiting the synthesis of proteins and DNA.</p>

<p>9-(2'-Deoxy-2'-fluoro-b-D-ribofuranosyl)-isoguanine is an oligonucleotide with a fluorinated nucleobase that is used to stabilize DNA duplexes. It is synthesized from 5'-deoxy-5'-fluorocytidine, which is a phosphoramidite, and 2',3',5'-triacetylpyrimidine, which is a substituent. The deprotection of the fluorinated oligonucleotide can be achieved by treatment with sodium hydroxide in ethanol or hydrochloric acid in acetic acid. 9-(2'-Deoxy-2'-fluoro-b-D-ribofuranosyl)-isoguanine has been shown to be stable and antiparallel when incorporated into double stranded DNA molecules.</p>

<p>5'-O-p-Anisoylthymidine is a novel activator and ribonucleoside that has been synthesized by modifying the structure of thymidine. This compound is active against cancer and antiviral, such as herpes simplex virus type 1, herpes simplex virus type 2, varicella zoster virus, influenza A/PR/8/34 (H1N1), and influenza B/Yamagata/16/88. 5'-O-p-Anisoylthymidine activates viral transcription in cells infected with these viruses by inhibiting the synthesis of deoxyribonucleosides. It also inhibits DNA synthesis by inhibiting the incorporation of deoxyribonucleotides into DNA during replication. This product is CAS No. 138581-03-2 and comes in high purity and high quality.</p>

<p>2'-Deoxy-5-methyl-isocytidine triphosphate (2'-DMI-dTP) is a novel nucleoside that is synthesized by phosphoramidite chemistry. 2'-DMI-dTP has antiviral and anticancer activities, and can be used for the treatment of hepatitis B virus (HBV) and human papillomavirus (HPV). It has shown protective effects in animal models of HBV infection. 2'-DMI-dTP inhibits HBV replication by inhibiting DNA synthesis. In addition, it decreases levels of reactive oxygen species in cells treated with HBV. 2'-DMI-dTP also inhibits HPV replication through inhibition of DNA synthesis, which may lead to cancer prevention or treatment.<br>2'-DMI-dTP may be a useful drug candidate for the treatment of other viral infections such as influenza A virus and HIV type 1.</p>

<p>5'-(R)-C-Methyl-2-thiouridine is an antiviral agent that inhibits the synthesis of viral RNA by acting as a substrate for thymidine kinase, which converts it to 5'-(R)-C-methyluracil. This drug also has anticancer properties and may be useful in the treatment of leukemia.</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>Queuine is a modified nucleoside found in tRNA. It is synthesized from guanosine by the enzyme queuine tRNA-ribosyltransferase, which converts guanosine to queuosine. Queuine hydrochloride is a synthetic form of queuine that can be used for research purposes to examine the anticodon loop and other structural features of the molecule. The prokaryotic and eukaryotic organisms studied showed different levels of synthesis of queuine, with bacteria synthesizing more than mammals. Bacteria were found to have a greater affinity for queuine than eukaryotes, which may be due to modification of the trna anticodon loop or to differences in ribosomal proteins.</p>

<p>3'-b-Azido-2',3'-dideoxy-5'-O-DMT-uridine is a modified nucleoside that is synthesized by the phosphoramidite method. It is a novel antiviral drug with anticancer properties. This active compound has been shown to be an activator of ribonucleotide reductases, which are enzymes that catalyze the conversion of ribonucleotides to deoxyribonucleotides. 3'-b-Azido-2',3'-dideoxy-5'-O-DMT-uridine is not cytotoxic at concentrations up to 40 mM, and it has been shown to inhibit replication of human immunodeficiency virus type 1 (HIV) in tissue culture.</p>

<p>5-Carboxy-2'-deoxyuridine is a nucleoside analogue that inhibits herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) replication. It is used to treat genital herpes infections caused by HSV-1 or HSV-2. 5-Carboxy-2'-deoxyuridine has been shown to inhibit the growth of human cancer cells in culture, and is currently being investigated as a potential anticancer drug. This drug binds with high affinity to the viral DNA polymerase, forming a covalent bond with the uracil base in the viral DNA chain. This prevents further elongation of the chain, inhibiting viral replication. 5-Carboxy-2'-deoxyuridine also inhibits cellular protein synthesis and cell division, which may be due to its ability to bind with aldehyde groups on surfactant proteins.END&gt;</p>