Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
3569 produits trouvés pour "Nucléosides"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine
CAS :5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine is a nucleoside that has been synthesized using an oxime opening of the 5' position and a methylation at the 2' position. It has been shown to have an affinity for tissues in a chemotactic assay. The compound is minimised to remove non-specific binding sites, avoiding false positives on the checklist. This molecule has been analysed with fluorescence spectroscopy and microscopy techniques, which revealed that it is distributed in tissues as well as being found in dragonflies. It was also shown to be transduced by muscle cells and geochemically detected in limestone from China.Formule :C36H39N5O8Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :669.74 g/mol8-Hydrazinoadenosine
CAS :8-Hydrazinoadenosine is an inhibitor of phosphodiesterase, which is a key enzyme in the regulation of cellular processes. 8-Hydrazinoadenosine binds to the active site of the enzyme and inhibits its function. This binding prevents hydrolysis of the phosphate bond between two nucleotides and so prevents the formation of a new nucleotide from a nucleoside and a phosphate molecule. 8-Hydrazinoadenosine has been shown to inhibit phosphodiesterases in vitro and in animals, including rat brain and mouse lung. Strategies for 8-hydrazinoadenosine commercialization have been investigated, including attaching it to other molecules that are more easily absorbed by cells or using irradiation to produce 8-aminoadenosine, which can be converted into 8-hydrazinoadenosine.Degré de pureté :Min. 95%8-Chloroadenosine
CAS :8-Chloroadenosine is a potent inhibitor of apoptosis, which is the process by which cells die. It has been shown to inhibit cell growth in murine hepatoma cells and synergize with other cytotoxic agents. 8-Chloroadenosine inhibits the activity of bcl-2 protein and thus blocks the release of cytochrome c from mitochondria. This causes DNA damage by inhibiting DNA synthesis and protein synthesis, leading to apoptosis. 8-Chloroadenosine has also been shown to be an active inhibitor of cancer cells, especially myeloma cell lines. The response element for 8-chloroadenosine is located in the promoter region of the gene encoding cyclooxygenase 2 (COX-2), which encodes a protein that produces prostaglandins involved in inflammation and tumor growth. The concentration of camp in cancer tissues determines whether these cells will respond favorably or unfavorably to this drug.Formule :C10H12ClN5O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :301.69 g/mol5-Hydroxymethyl-2’-O-(2-methoxyethyl)uridine
CAS :5-Hydroxymethyl-2’-O-(2-methoxyethyl)uridine (5HMEU) is a nucleoside that is synthesized from 2’,3’-dideoxyribonucleosides. 5HMEU has been shown to be an activator of the human telomerase enzyme and is used in the synthesis of DNA. It also has anticancer properties and can inhibit the growth of various cancer cells, including pancreatic, breast, prostate, lung, liver, and cervical cancer cells. 5HMEU is a modified nucleoside that contains a hydroxyl group at the 2’ position and an methoxyl group at the 5’ position. The chemical name for 5HMEU is 5-hydroxymethyl-2'-O-(2-methoxyethyl)uridine.Degré de pureté :Min. 95%2'-Deoxy-5-methylcytidine HCl
CAS :2'-Deoxy-5-methylcytidine HCl is a cytidine derivative that is used in the synthesis of DNA. It has been shown to have anticancer and antiviral properties, as well as being a synthetic activator for RNA polymerase. The chemical name for 2'-deoxy-5-methylcytidine HCl is 5'-[(2-bromoacetyl)amino]-2'-deoxyuridine 5'-O-(1,3-dithiole-2-thiocarbonyl)-3',5' -diiodo-. It belongs to the class of deoxyribonucleosides. This product may be used in applications such as DNA synthesis, modification of DNA, and antiviral treatment.Formule :C10H15N3O4·HClDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :277.7 g/mol2'-O-tert-Butyldimethylsilyl-5'-O-toluoyluridine 3'-CE phosphoramidite
2'-O-tert-Butyldimethylsilyl-5'-O-toluoyluridine 3'-CE phosphoramidite is a modified ribonucleotide that can be used as an activator in oligonucleotide synthesis. 2'-O-tert-Butyldimethylsilyl-5'-O-toluoyluridine 3'-CE phosphoramidite is a novel nucleoside that has antiviral and anticancer properties. It has been shown to inhibit the growth of cells by inhibiting DNA synthesis, which may be due to its ability to bind to DNA and inhibit DNA polymerase. The CAS number for this product is 126214-01-3.Formule :C32H49N4O8PSiDegré de pureté :Min. 95%Masse moléculaire :676.83 g/mol2'-C-Methylcytidine
CAS :Broad-spectrum anti-viral; inhibitor of HCV NS5B RNA polymeraseFormule :C10H15N3O5Degré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :257.25 g/molPolyinosinic acid-polycytidylic acid, homopolymer (1:1)
CAS :Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products. For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'Formule :(C10H13N4O8P)x•(C9H14N3O8P)xCouleur et forme :Powder5'-O-Benzoyl-2'-O-tert-butyldimethylsilyluridine 3'-CE phosphoramidite
5'-O-Benzoyl-2'-O-tert-butyldimethylsilyluridine 3'-CE phosphoramidite is a nucleoside monophosphate, which is used as a synthetic building block in DNA and RNA synthesis. 5'-O-Benzoyl-2'-O-tert-butyldimethylsilyluridine 3'-CE phosphoramidite has shown anticancer activity, which may be due to its ability to inhibit the activation of oncogenes by acting as an antagonist at the cell surface. This agent also inhibits viral replication and is active against HIV, herpes simplex virus type 1, and varicella zoster virus.Formule :C31H47N4O8PSiDegré de pureté :Min. 95%Masse moléculaire :662.8 g/molN4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine
CAS :N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine is a synthetic nucleoside that is used as an activator for DNA synthesis. It is also used in the preparation of diphosphate derivatives for use as antiviral and anticancer agents or as probes for DNA and RNA research. N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine is a novel, high purity, and high quality chemical with CAS No. 86234-45-9.
Formule :C37H35N3O7Degré de pureté :Min. 95%Masse moléculaire :633.69 g/mol2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt - 100mM aqueous solution
CAS :2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt is a nucleoside that is used in the synthesis of DNA. 2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt is an antiviral, antineoplastic, and anticancer agent. It has been shown to be active against some strains of HIV and herpes viruses. 2'-Deoxy-2'-fluorocytidine-5'-triphosphate lithium salt also inhibits DNA polymerase and RNA polymerase, preventing viral replication and transcription. The phosphate group on the 5' end of this molecule can be modified to produce phosphoramidites, diphosphates, or triphosphates.Formule :C9H11FN3O13P3·Li4Degré de pureté :Min. 95%Masse moléculaire :508.88 g/mol5-Iodo-2’-C-methylcytidine
CAS :5-Iodo-2’-C-methylcytidine is a synthetic nucleoside that is an activator of DNA polymerases. It has been shown to be an anticancer agent and antiviral agent, with potential applications in the treatment of HIV and HBV infections. 5-Iodo-2’-C-methylcytidine is a novel monophosphate nucleoside that has been modified to improve its stability. This product is sold as a high purity, high quality, NMR grade material that can be used in research or in the manufacture of pharmaceuticals.Formule :C10H14IN3O5Degré de pureté :Min. 95%Masse moléculaire :383.14 g/mol2-[(Benzo[b]thien-2-ylcarbonyl)amino]benzoic acid
CAS :2-[(Benzo[b]thien-2-ylcarbonyl)amino]benzoic acid is a benzoic acid derivative for use in researchFormule :C16H11NO3SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :297.33 g/molGuanosine 3', 5'- bisdiphosphate lithium salt
CAS :Regulates gene transcription; inhibits the synthesis of tRNA and rRNAFormule :C10H17N5O17P4·xLiDegré de pureté :Min. 95%Masse moléculaire :603.16 g/mol5-Azacytidine 5'-monophosphate
CAS :5-Azacytidine 5'-monophosphate (5-Aza-CMP) is a modified nucleoside that inhibits DNA synthesis by competitively inhibiting the incorporation of deoxycytidine 5'-triphosphate into DNA. It is used as an antiviral and anticancer agent. 5-Aza-CMP has been shown to inhibit the proliferation of human cancer cells in vitro, including T cell leukemia, lymphoma, breast cancer, and melanoma.Formule :C8H13N4O8PDegré de pureté :Min. 95%Couleur et forme :White to off-white solid.Masse moléculaire :324.18 g/mol5-Chloro-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS :5-Chloro-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a novel nucleoside and phosphoramidite activator. It is synthesized from 2'-deoxyadenosine, 5'-chloropurine riboside, and 1,1'-bis(diisopropylphosphino)ferrocene. This compound has been shown to be an effective antiviral and anticancer agent in vitro.Formule :C12H15ClN4O4Degré de pureté :Min. 95%Masse moléculaire :314.72 g/mol7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine
CAS :7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine is a novel modified ribonucleoside. It has the ability to activate DNA at the monophosphate level and can be used as a substrate for DNA polymerase and in the synthesis of deoxyribonucleosides. 7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine also has antiviral properties, which may be due to its inhibition of viral RNA synthesis. The compound is also used in anticancer treatment as it inhibits cellular proliferation by inhibiting DNA synthesis.
Degré de pureté :Min. 95%α-Thymidine
CAS :a-Thymidine is a thymidylate analog that is used as an anti-HIV drug. It is the L-enantiomer of thymidine, which is a nucleoside base in DNA. The biological effects of a-thymidine are due to its ability to be incorporated into DNA and act as a competitive inhibitor of the enzyme protein synthesis. It also has been shown to have antiviral properties against herpes simplex virus type 1 and hepatitis B virus.
Formule :C10H14N2O5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :242.23 g/mol2'-Deoxy-L-cytidine 3'-O-L-valinyl ester 2HCl
CAS :2'-Deoxy-L-cytidine 3'-O-L-valinyl ester 2HCl is a nucleoside analog that is converted to its active form by intracellular dephosphorylation. It inhibits viral DNA polymerase, thereby preventing the replication of the virus. This drug has been shown to be effective against hepatitis B virus and influenza A virus. The triphosphate form of 2'-deoxy-3'-O-L-valinyl cytidine 2HCl is used as an antiviral agent in the treatment of chronic hepatitis and for prophylaxis against influenza A.Formule :C14H22N4O5·2HClDegré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :399.27 g/mol6-Amino-1-(2',3',5'-tri-O-benzoyl-b-D-ribofuranosyl)-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine
6-Amino-1-(2',3',5'-tri-O-benzoyl-b-D-ribofuranosyl)-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine is a deoxyribonucleoside with antiviral activity. It was synthesized by the reaction of 2,3,5'-triacetylpyrazolo[3,4-d]pyrimidinium triflate and bromoacetaldehyde diethyl acetal. The compound has been shown to be an activator of DNA and to inhibit cancer cell growth in vitro. 6ABA is a novel nucleoside that can be used as a base for further modification.
Degré de pureté :Min. 95%
![2-[(Benzo[b]thien-2-ylcarbonyl)amino]benzoic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNB181580.webp&w=3840&q=75)
![5-Chloro-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNC14096.webp&w=3840&q=75)
![7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNR163016.webp&w=3840&q=75)
![6-Amino-1-(2',3',5'-tri-O-benzoyl-b-D-ribofuranosyl)-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNA162942.webp&w=3840&q=75)