Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
3571 produits trouvés pour "Nucléosides"
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5’-ODMT cET-uridine 3’-OCE amidite
CAS :5’-ODMT cET-uridine 3’-OCE amidite is a bicyclic nucleoside that is commonly known as BNA for bicyclic nucleic acid or LNA for locked nucleic acid. It comprises a bridge between the 4' and 2' carbon atoms to lock the ribose ring into a fixed configuration. The BNA or LNA incorporated oligonucleotides are useful to regulate gene expression via antisense mechanisms.Formule :C41H49N4O9PMasse moléculaire :772.82 g/mol2'-Deoxyinosine-5'-monophosphate disodium salt
CAS :2'-Deoxyinosine-5'-monophosphate disodium salt is a synthetic nucleoside, phosphoramidite, and diphosphate that is used in the synthesis of DNA. It has been shown to have antiviral effects against HIV and herpes simplex virus type 2 (HSV-2). This drug also has anticancer activity and is an activator of novel nucleosides.Formule :C10H11N4Na2O7PDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :376.17 g/mol2'-Deoxy-4-thiouridine
CAS :2'-Deoxy-4-thiouridine is a pyrimidine nucleoside for a range of applications
Formule :C9H12N2O4SDegré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :244.27 g/mol5’-ODMT-cET-5-methyluridine 3’-OCE amidite
CAS :5’-ODMT-cET-5-methyluridine 3’-OCE amidite is a bicyclic nucleoside that is commonly known as BNA for bicyclic nucleic acid or LNA for locked nucleic acid. It comprises a bridge between the 4' and 2' carbon atoms to lock the ribose ring into a fixed configuration. The BNA or LNA incorporated oligonucleotides are useful to regulate gene expression via antisense mechanisms.Formule :C42H51N4O9PMasse moléculaire :786.86 g/mol2,4-Diamino-6-hydroxypyridine sulphate
CAS :2,4-Diamino-6-hydroxypyridine sulphate is a nucleoside for use in research applicationsFormule :C4H6N4O•(H2SO4)xDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :224.2 g/molCytidine 5'-diphosphocholine
CAS :Cytidine 5'-diphosphocholine is a nucleotide that is a precursor of uridine 5'-triphosphate and cytidine 5'-monophosphate, which are important for DNA synthesis. Cytidine 5'-diphosphocholine is used in the preparation of samples for experiments. This compound has been shown to induce neuronal death in an experimental model. It has also been shown to inhibit polymerase chain reactions and affect the activity of enzymes such as alpha-7 nicotinic acetylcholine receptors and glutamate decarboxylase. Cytidine 5'-diphosphocholine has been found to have no effect on basic fibroblast cells, but it does have physiological effects on human erythrocytes.Formule :C14H26N4O11P2Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :488.32 g/moldNTP pre-mixes, 10 mM aqueous solution
CAS :dATP, dTTP, dCTP and dGTP pre-mixed in a single vialFormule :C10H16N5O12P3Degré de pureté :Min. 95%Couleur et forme :Clear LiquidMasse moléculaire :491.18 g/mol5-Fluorouridine-5'-triphosphate sodium salt
CAS :5-Fluorouridine-5'-triphosphate sodium salt is an analog of uridine that has been used in the treatment of metastatic colorectal cancer. It is a prodrug that is metabolized to 5-fluorouracil, its active form. 5-Fluorouridine-5'-triphosphate sodium salt inhibits the synthesis of thymidylate, one of the precursors to DNA, and blocks the production of nucleotides. This results in cell lysis and death by apoptosis. The drug also inhibits epidermal growth factor receptor (EGFR), which may contribute to its antitumor effects.Formule :C9H14N2O15P3FDegré de pureté :Min. 95%Masse moléculaire :502.13 g/moldNTP bundle, 4 x 100mM aqueous solution
CAS :Each dNTP supplied in a separate vialDegré de pureté :Min. 99 Area-%Couleur et forme :Clear LiquidQueuosine
CAS :Queuosine is a modified nucleoside found in the tRNA of both eukaryotic and prokaryotic organisms. It is primarily sourced from the gut microbiota and obtained through dietary intake, as humans lack the biosynthetic machinery to produce it endogenously. Queuosine plays a crucial role in cellular processes by contributing to the accuracy of protein synthesis, impacting cellular growth and maintenance. Its importance extends to understanding the molecular mechanisms underpinning various physiological processes and the potential for dysregulation in diseases. Ongoing research is exploring queuosine's implications in cellular metabolism, including its role in cancer biology and neurobiology. Understanding the pathways and effects of queuosine incorporation into tRNA may provide insights into novel therapeutic avenues for targeting metabolic disorders and diseases associated with translational fidelity.Formule :C17H23N5O7Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :409.39 g/mol2'-O-Methylinosine
CAS :2'-O-Methylinosine is a nucleoside that is structurally related to inosine. It has been shown to induce apoptotic cell death in HIV-infected cells by inhibiting the synthesis of rRNA and by inhibiting the activity of the transcriptase enzyme. 2'-O-Methylinosine has also been shown to inhibit the replication of RNA viruses, such as herpes simplex virus and cytomegalovirus, and it can be used as an experimental model for studying apoptosis. 2'-O-Methylinosine can be synthesized from inosine using a chromatographic method that utilizes hydroxylamine. The chemical structure of this nucleoside is amphipathic, which allows it to bind both DNA and RNA strands.Formule :C11H14N4O5Degré de pureté :Min. 99 Area-%Couleur et forme :White PowderMasse moléculaire :282.25 g/mol2'-Deoxy-2'-fluorocytidine-5'-triphosphate tetralithium
CAS :2'-Deoxy-2'-fluorocytidine-5'-triphosphate tetralithium is a modified nucleoside analog where the base is cytosine, the sugar is deoxyribose with a fluoro modification at the 2' position, and the molecule is phosphorylated at the 5' position with a triphosphate group.Formule :C9H11FLi4N3O13P3Degré de pureté :Min. 95%Couleur et forme :White Off-White PowderMasse moléculaire :508.88 g/molGuanosine 5'-monophosphate disodium salt
CAS :Guanosine 5'-monophosphate disodium salt (GMPDS) is an antiviral agent that inhibits the synthesis of viral nucleic acids by competitive inhibition of the enzyme ribonucleotide reductase. GMPDS has been shown to inhibit the replication of a number of RNA viruses, including influenza A and B, herpes simplex virus type 1, and human immunodeficiency virus type 1. This drug also has been shown to decrease cyclic adenosine monophosphate (cAMP) levels in cells by inhibiting phosphodiesterase activity. GMPDS is used for treatment of infectious diseases such as influenza A, herpes, and HIV-1.Formule :C10H12N5Na2O8PDegré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :407.18 g/mol2'-Deoxyxanthosine
CAS :Produit contrôlé2'-Deoxyxanthosine is a chemical compound with biochemical properties that can be used as a pharmaceutical drug. It is a nucleoside analogue that interferes with DNA synthesis. 2'-Deoxyxanthosine inhibits the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides, and prevents the formation of DNA in cells. This drug is also known to have anti-tumor effects, including angiogenesis inhibition and cytostatic activity. The reaction mechanism of 2'-deoxyxanthosine involves nitrous acid, which reacts with the 2' hydroxyl group of xanthosine to form the nitroso intermediate and then reacts with oxygen to produce nitrite and hydrogen peroxide. The final step in this process is the cleavage of xanthosine by nitrite into xanthine and oxalate. This drug has been shown to be reactive at neutral pH conditionsFormule :C10H12N4O5Degré de pureté :Min. 95%Couleur et forme :White Off-White PowderMasse moléculaire :268.23 g/mol2'-Deoxy-N2-phenoxyacetylguanosine
CAS :2'-deoxy-N2-phenoxyacetylguanosine is a synthetic nucleoside that is used as a substrate in experiments to study the properties of guanine. The compound can be synthesized by the reaction of 2'-deoxy-N2-phenoxyacetaldehyde with guanine. The synthesis starts with the condensation of 2'-deoxyribose and N2-phenoxyacetaldehyde, followed by the oxidation of the resulting anhydride to give aldehyde, which reacts with guanine to form a Schiff base. This then undergoes hydrolysis to yield 2'-deoxy-N2-phenoxyacetylguanosine.Formule :C18H19N5O6Degré de pureté :Min. 95%Masse moléculaire :401.38 g/mol4-(b-D-Ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one
CAS :Ribonucleosides, Deoxyribonucleosides and Activator are a group of synthetic compounds that are used in the synthesis of DNA. Ribonucleosides and Deoxyribonucleosides are nucleotides that contain ribose or deoxyribose as the sugar moiety. Activator is an activator for DNA polymerase, which catalyses the formation of a phosphodiester bond between two adjacent 3'-5' phosphate groups on a single strand of DNA. Ribonuclesides, Deoxyribonucleosides and Activator are used in recombinant DNA technology to synthesize DNA molecules containing modified bases. The CAS number for Ribonuclesides, Deoxyribonucleosides and Activator is 59892-40-9.
Formule :C10H12N4O5Degré de pureté :Min. 95%Masse moléculaire :268.23 g/mol1-(β-D-Arabinofuranosyl)thymine
CAS :1-(β-D-Arabinofuranosyl)thymine is a nucleoside analog. It has a similar structure to thymidine. It has possible applications in research into the specificity and kinetics of thymidine kinases and has demonstrated antiviral activity against some viruses.Formule :C10H14N2O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :258.23 g/mol8-Methyladenosine
CAS :8-Methyladenosine is an acid conjugate that can be found in the urine of healthy people. It is a protonated molecule that binds to a p2 subtype of the G protein-coupled receptor, which is activated by adenosine and 8-methyladenosine. This drug has been used in clinical trials for the treatment of herpes simplex virus and cervical cancer. The intramolecular hydrogen bond between the methyl group and the adenosine ring is responsible for its high binding affinity for this receptor. The glycosidic bond is formed when an 8-methyladenosine molecule attaches to a receptor on a cell surface, forming an intramolecular hydrogen bond with the receptor's amino acid side chain. This bond is broken when a protonated molecule of 8-methyladenosine enters the cell and interacts with the receptor, resulting in activation of this receptor.
Formule :C11H15N5O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :281.27 g/mol2'-Deoxy-2'-fluoroguanosine-5'-triphosphate tetralithium
CAS :2'-Deoxy-2'-fluoroguanosine-5'-triphosphate tetralithium salt is a chemically modified nucleotide used in molecular biology and pharmaceutical research. It is a guanosine analog featuring both a 2'-fluoro substitution on the sugar and a 5'-triphosphate group, with tetralithium as the counterion to improve solubility and stability.Formule :C10H15FN5O13P3·xLiDegré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :525.17 g/mol3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt
CAS :3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt is an antiviral and anticancer agent that inhibits the synthesis of DNA, RNA, and protein. It has shown to be effective against a variety of viruses including HIV-1, herpes simplex virus type 1, influenza A virus, vaccinia virus, and vesicular stomatitis virus. 3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt also inhibits the growth of cancer cells in vitro. This drug is a modified nucleoside with a phosphoramidite backbone and a 3'-azido group at one end. The other end contains a beta D glucuronic acid moiety. The modifications allow for the inhibition of DNA synthesis by blocking the incorporation of deoxyribonucleotides into DNA chains.
Formule :C16H20N5NaO10Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :465.35 g/mol
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