Nucléosides

2',3'-Di-O-benzoyluridine is a nucleoside for use in research applications

2',3'-O-Isopropylidenecytidine is a nucleoside for use in research applications

2'-O-methyluridine is an antiviral nucleoside that is used as a phosphoramidite in the synthesis of oligonucleotides. It has been shown to inhibit viral replication, and has been found to be effective in treating HIV-1 by inhibiting reverse transcriptase. N3-Methyl-2'-O-methyluridine also inhibits DNA synthesis and cell proliferation, and may be useful for the treatment of cancer. This modified nucleoside has been synthesized from uracil and contains a methyl group at the 3' position. The methyl group prevents 2'-O-methyluridine from being activated by cellular thymidylate synthase, which normally converts deoxyribonucleotides into ribonucleotides. This novel nucleotide has not yet been used in clinical trials but it may provide an alternative to other drugs used for cancer treatments.

4-Bromo-3,5-dichloropyridine is a reactive intermediate that is used as a reagent in organic synthesis. It has low basicity and reacts with lithium to form the lithium salt. The salt can be deprotonated to form the bromide anion, which is more reactive than the chloride anion. 4-Bromo-3,5-dichloropyridine can also be used for the selective isomerization of ketones and related compounds. Bromine is added to prevent side reactions with oxygen. The intermediates are generated at the site of reaction by using an excess of diisopropylamide over bromination agent.

2'-O-Methyluridine is a chemical compound that is used in the synthesis of RNA. It is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands. 2'-O-Methyluridine has been shown to inhibit growth in some types of cancer cells, including colorectal adenocarcinoma cells. It may also be useful as a chemotherapeutic agent against HIV, as it inhibits virus replication by inhibiting reverse transcription and DNA synthesis.

β-Nicotinamide adenine dinucleotide reduced form, most commonly known as NADH, is a cofactor involved in the electron transport chain, in the metabolism of amino acids and many other cellular processes such as the synthesis of ATP. It is also a substrate for glutathione peroxidase and superoxide dismutase. The reduced form of NADH can be used as an indicator for glutathione peroxidase activity. In addition, it has been shown to have antioxidant properties by reducing reactive oxygen species (ROS) and inhibiting lipid peroxidation. This product has been used in formulations of synthetic drugs for the treatment of women with long-term effects of menopause, such as osteoporosis and cardiovascular disease. It has also been used in the production of alginate gel, which can be used to create scaffolds for tissue engineering applications. Lately, in bioorganic chemistry, NADH has been used as a source of hydride species for reduction reactions.

5'-O-DMT-N2-isobutyrylguanosine is a novel phosphoramidite monophosphate, which has been modified with an isobutyryl group. This compound was synthesized in order to be used as a nucleoside analogue and antimetabolite for the treatment of cancer. It also has antiviral properties and inhibits the replication of DNA by inhibiting transcription. 5'-O-DMT-N2-isobutyrylguanosine is an anticancer agent that can be used to treat tumors that are resistant to other chemotherapy drugs. It also inhibits the growth of cells by preventing the synthesis of proteins needed for cell division.