Inhibiteurs

PROTAC MDM2 Degrader-3 uses PROTAC tech to efficiently break down MDM2 with a potent inhibitor and E3 ligase ligand.

PROTAC VEGFR-2 degrader-2 has minimal VEGFR-2 inhibition (IC50 > 1μM) and low anti-proliferative effect on EA.hy926 cells (IC50 > 100μM).

CYH33 methanesulfonate is a PI3Kα inhibitor with IC50 of 5.9 nM; halts breast and NSCLC cell growth, effective against solid tumors.

Antibacterial agent 30 exhibits remarkable in vitro activity against Xoo, as evidenced by its EC50 value of 1.9 μg/mL.

ERK1/2 inhibitor 5 targets MAPK pathway, potentially aiding cancer and inflammation research.

PROTAC BTK Degrader-3 is a potent degrader of Bruton's tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells.

Spiratisanin A is a natural product from Spiraea japonica.

Moxetumomab pasudotox (CAT 8015), an anti-CD22 immunotoxin for researching hairy cell leukemia.

VH032-PEG3-acetylene: a VHL ligand-linker for PROTACs, combines VH032 with PEG3-acetylene.

Glabralide A is a natural product from plants

gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.

Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).

PD-1/PD-L1 binder, Kd 0.51 μM; blocks interaction in flow cytometry at 1 mg/mL; inhibits tumors, extends mouse survival.

Thalidomide-NH-PEG4-Ms: cereblon ligand + linker, for PROTAC BCL-XL degrader XZ739.

1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.

10alpha-Hydroxyepigambogic acid is a useful organic compound for research related to life sciences and the catalog number is T126303.

GEM-5, a gemcitabine conjugate with HIF-1α inhibitor YC-1 (IC50=30 nM), down-regulates HIF-1α, up-regulates p53, and induces A2780 cell apoptosis.

PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2).

α-conotoxin GI, a conopeptide isolated from the venom of the cone snail Conus geographus, is a competitive antagonist of the muscle-type nicotinic acetylcholine

(Rac)-IBT6A HCl: racemic Ibrutinib impurity; for IBT6A dimers/adducts; Ibrutinib is a Btk inhibitor (IC50=0.5nM).

m-PEG11-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

SH379, a 2-methylpyrimidine diterpene derivative, boosts testosterone synthesis enzymes and autophagy via AMPK/mTOR.

Elamipretide TFA (RX-31 TFA) is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide[1].

Compound N060-0121 is a useful organic compound for research related to life sciences and the catalog number is T131219.

eGFP circRNA, originally isolated from the jellyfish Aequorea victoria, is a reporter widely utilized for direct detection in mammalian cell culture due to its

m-PEG12-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

N-Deacetyllapaconitine is a useful organic compound for research related to life sciences and the catalog number is T131546.

SIAIS117: A Brigatinib-VHL-1 ALK PROTAC; degrades ALK G1202R, inhibits SR/H2228 cells, may fight small cell lung cancer.

Melarsonyl dipotassium, also known as melarsonic acid dipotassium, is a potent anthelmintic agent with the ability to effectively inhibit parasites.

Compound 17h is a potent antibacterial against VRE and MRSA, reduces MRSA biofilms, and is stable in liver microsomes.

Yimitasvir (Emitasvir) diphosphate，一种针对丙型肝炎病毒(HCV)非结构蛋白5A (NS5A)的口服活性抑制剂，适用于慢性丙型肝炎病毒感染的研究。

SHP2 degrader-1: highly efficient, induces SHP2 degradation & cell apoptosis, shows promise in SHP2-related disease research.

Questiomycin A derivatives 12 is a Questiomycin A derivative.

ER degrader 3 targets estrogen receptor, key in cell regulation, potential for cancer research.

Thalidomide-O-amido-PEG3-C2-NH2 TFA, a cereblon ligand-PEG linker for PROTAC, is synthesized.

M-PEG1-acid, a soluble PEG derivative, has a terminal carboxylic acid for forming amide bonds with primary amines using activators like EDC, DCC.

Mouse IgG3 kappa Isotype Control is a monoclonal antibody serving as an isotype control specifically for mouse IgG3κ antibodies.

Chol-N3 is a bioorthogonal chol probe capable of integrating with super-resolution fluorescence microscopy (SRM) to enable direct nanoscale imaging of lipid

Stephalonine L is a natural product for research related to life sciences. The catalog number is TN6290 and the CAS number is 2379277-60-6.

Sinoporphyrin sodium hinders cell growth, induces early apoptosis, disrupts F-actin, impairs movement, and may treat cancer; it's a photosensitizer.

HX103: Fluorogenic EGFR-TKI probe; inhibits various EGFR mutations; predicts NSCLC treatment response. IC50: 1.3-977 nM.

Diacetoxyscirpenol: a fungal mycotoxin causing blood disorders in humans/animals.

(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.

(3,4-Dihydroxy-5-methoxybenzoyl)taraxerol is a natural products from plants

Yimitasvir, an oral NS5A inhibitor, treats chronic hepatitis C. Used for research.

Antibacterial agent 28 targets MRSA with 0.5-2 μg/mL MIC, showing high potential.

Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.

BMS-378806 is an HIV inhibitor with EC50: 0.85-26.5nM for various strains.

A031: PROTAC AR degrader, IC50 < 0.25 μM, inhibits prostate cancer growth in zebrafish.

Nutlin carboxylic acid is a Nutlin 3-based MDM2 ligand; used with a linker to create PROTACs.

Elamipretide acetate (MTP 131), a small tetrapeptide, targets mitochondria to reduce toxic species and stabilize cardiolipin.

Ephedrine levulinate: alkaloid, stimulates alpha/beta-adrenergic receptors, boosts norepinephrine release.

LH1306 inhibits PD-1/PD-L1 interaction, IC50: 25 nM (HTRF assay); boosts Jurkat cell activation, EC50: 334-4,214 nM.

STING agonist-9 (Compound 45): potent, EC50 1.2 nM h-STING, 32.82 μM m-STING; antitumor [1].

Podoblastin A (D-mannitol) is a useful organic compound for research related to life sciences and the catalog number is TSP-41077145.

Lupinine hydrochloride is a bioactive chemical.

NT 2 Toxin is a useful organic compound for research related to life sciences. The catalog number is T124258 and the CAS number is 76348-84-0.

Firefly Luciferase circRNA, originally isolated from Photinus pyralis (Firefly), expresses a luciferase protein and serves as an optimal marker for monitoring

AT-1002 TFA, a 6-mer synthetic peptide, functions as a tight junction regulator and absorption enhancer.

RdRP-IN-3, a potential anti-influenza drug candidate, functions by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).

Microcystin-LF, a phenylalanine variant of Microcystin-LR, is a bacterial metabolite that exhibits cellular toxicity in Caco-2 cells [1] [2].

FGFR-IN-1 targets FGFR1-3 with IC50 <100 nM. (US20130338134A1, ex 219)

Mitoquinone-cyclodextrin is a mitochondria-targeted, 1:1 mix of Mitoquinone mesylate and cyclodextrin, aiming to combat oxidative damage.

(5R)-Platyphyllone has a wide range of applications in life science related research.

Activates Notch pathway, boosts NSC self-renewal and neurogenesis, enhances mice memory.

Apoptosis Inducer 4 (Compound 12b) is a compound that induces apoptosis and exhibits anticancer properties [1].

Kbz probe 1, an adaptable probe utilized for examining histone benzoylation and interactions within living cells, showcases extensive versatility.

PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.

AS-604850: PI3Kγ inhibitor, ATP-competitive, IC50=2.5μM, 30x> PI3Kδ/β, 18x> PI3Kα.

HJM-561 is a potent and selective EGFR PROTAC with oral bioavailability, capable of overcoming osimertinib-resistant EGFR triple mutations and demonstrating

Questiomycin A derivatives 14 is a Questiomycin A derivative.

Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.

HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.

Valiloxibic acid is a prodrug for GHB, a natural psychoactive neurotransmitter and weak GABAB agonist.

Phosal 50 PG is a co-solvent used as an emulsifier and stabilizer in the pharmaceutical and cosmetic industries.Phosal 50 PG is used as a dietary supplement.

CF502 (STING agonist-23) is a non-nucleotide that activates STING pathway, boosts immune responses, and shows activity against SARS-CoV.

Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.

Heterocyclic compounds-pyridine,

Ceritinib D7 (LDK378 D7) is a deuterium-labeled Ceritinib. Ceritinib is an ATP-competitive inhibitor of ALK tyrosine kinase.

Danoprevir sodium is an NS3/4A protease inhibitor used in the treatment of Hepatitis C

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.