Inhibiteurs

HDAC3/6-IN-2 inhibits HDAC6/3 with IC50s 0.368/0.635 μM; promotes cancer cell apoptosis and histone acetylation.

AS-604850: PI3Kγ inhibitor, ATP-competitive, IC50=2.5μM, 30x> PI3Kδ/β, 18x> PI3Kα.

PROTAC PARP/EGFR ligand 1 enables dual PARP EGFR degrader synthesis via PROTAC.

KHS 101 hydrochloride is a neuronal differentiation inducer

MCAAD-3, a near-infrared Aβ imaging probe, exhibits blood-brain barrier permeability and strong affinity for Aβ polymers (Ki >106 nM).

AT-1002 TFA, a 6-mer synthetic peptide, functions as a tight junction regulator and absorption enhancer.

Firefly Luciferase circRNA, originally isolated from Photinus pyralis (Firefly), expresses a luciferase protein and serves as an optimal marker for monitoring

LH1306 inhibits PD-1/PD-L1 interaction, IC50: 25 nM (HTRF assay); boosts Jurkat cell activation, EC50: 334-4,214 nM.

Sirtratumab vedotin (ASG15-ME) is an antibody-drug conjugate (ADC) that links a SLITRK6-specific human gamma 2 antibody (Igγ2) to the microtubule disruption agent monomethyl auristatin E (MMAE) through a protease-cleavable linker [1].

Microcystin-LF, a phenylalanine variant of Microcystin-LR, is a bacterial metabolite that exhibits cellular toxicity in Caco-2 cells [1] [2].

ER degrader 3 targets estrogen receptor, key in cell regulation, potential for cancer research.

Kbz probe 1, an adaptable probe utilized for examining histone benzoylation and interactions within living cells, showcases extensive versatility.

CYH33 methanesulfonate is a PI3Kα inhibitor with IC50 of 5.9 nM; halts breast and NSCLC cell growth, effective against solid tumors.