Peptides

Applications N-tert-Boc-L-alanine is the protected form of L-Alanine (A481500), a non-essential amino acid that can be found naturally in the human body and is obtained by our diet.
References Anderson, H., et al.: J. Nutr., 99, 82 (1969)

Applications N-Glycylglycine is a derivative of Glycine (G615990), a non-essential amino acid that enhances N-methyl-D-aspartate (NMDA) receptor mediated synaptic potentials in the neocortex of rats. Glycine is also being used as adjuvant therapy for the treatment of schizophrenia.
References Logan, W. & Snyder, S.: Brain Res., 42, 413 (1972); Rosse, R., et al.: Clin. Neuropharmacol., 12, 416 (1989)

Applications H-GLU-LYS-OH (cas# 5891-53-2) is a useful research chemical.

Stability Moisture Sensitive
Applications Used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Heidenreich, O., et al.: J. Biol. Chem., 269, 2131 (1994), Kothe, U., et al.: Anal. Biochem., 356, 148 (2006), Thakkar, A., et al.: Anal. Chem., 78, 5935 (2006),

Applications Insulin (Human) is a peptide hormone regulating the metabolism of carbohydrates and fats. It is used in the treatment of those suffering from the diabetes type I and II metabolic disorders. Regulates the absorption of glucose from the blood to skeletal muscles and fat storage.
References Lai, Y. et al.: Biochem. J., 460, 363 (2014); Hedman, C. et al.: Clin. Endocrinol., 81, 58 (2014);

Applications N-Boc-L-proline is a useful synthetic intermediate. It is used to synthesize Daclatasvir (D101500) which nhibits the HCV protein NS5A. Daclatasvir (D101500) can be used as a drug candidate for the treatment of hepatitis C (HCV).
References Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

Applications Ilomastat is a metalloprotease inhibitor.
References Dietrich, C., et. al.: J. Immunol., 192, 5382 (2014)

Stability Hygroscopic
Applications Fructosyl Glycine is a synthetic glycoamine used in the study of glycoamine analogs and their effect on metastatic carcinoma cells.
References Glinsky, G. et al.: Clin. Exp. Metastas., 14, 253 (1996);

Applications Poly(ethylene Glycol) ~400 is a polymer of ethylene oxide with a molecular weight of ~400 Daltons. Poly(ethylene Glycol) ~400 is considered a low molecular weight polyethylene glycol, and is used as a hydrophilic molecular probe for measuring intestinal permeability. Poly(ethylene Glycol) ~400 is also used as a hydrophilic plasticizer.
References Lu, E., et al.: J. Control. Release, 92, 375 (2003); Ma, T., et al.: Gastroenterology, 98, 39 (1990)

Stability Hygroscopic, Light Sensitive
Applications Doxorubicin Hydrochloride is an antineoplastic agent.
References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);

Applications H-GAMMA-GLU-GLU-OH (cas# 1116-22-9) is a useful research chemical.

Applications Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Applications Ethyl Cyano(hydroxyimino)acetate is used in peptide synthesis and has shown to suppress racemiztion, has high coupling efficiency in both solution and solid phase synthesis and is a non-explosive alternative to 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt).
References Khattab, S.N.: Bull. Chem. Soc. Jpn., 83, 1374 (2010)

Applications L-Alanyl-L-alanyl-L-alanine (cas# 5874-90-8) is a useful research chemical.

Applications AEBSF Hydrochloride is an irreversible serine protease inhibitor.
References Diatchuk, V., et. al.: J. Biol. Chem., 272, 13292 (1997)

Applications Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Manaker, et al.: Antibiot. Ann., 55, 853 (1954), Jain, S., et al.: J. Mol. Biol., 114, 317 (1977), Nakajima, K., et al.: Pept. Chem., 19, 143 (1981), Shereda, R., et al.: J. Biol. Chem., 282, 19247 (2007),

Applications D-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity.
References He, W. et al.: Comp. Biochem. Phys. Part A: Mol. Int. Phys., 166, 308 (2013)

Applications Lactoferrin is a multifunctional protein of transferin family. A glycoprotein present in various secretions including milk, saliva and tears. Antiviral agent, it binds to liproproteins of cell membranes dispersing virus molecules from host cells.
References Sánchez L. et al.: Arch. Dis. CHild., 67, 657 (1992); Harmsen MC. et al.: J. Infect. Dis., 172, 380 (1995);

Applications H-Glu(Val-OH)-OH (CAS# 2746-34-1) is a useful research chemical compound.

Applications N-Boc-D-leucine is an N-Boc-protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci in culture. D-Leucine causes analgesia in humans and also exhibits inhibitory activity in bacterial cell cultures.
References Chuan, Y., et al.: Chin. J. Anim. Vet. Sci., 4, 003 (1985); Fox, S., et al.: J. Biol. Chem., 155, 465 (1944); Gillillad, S. & Speck, M.: J. Dairy Sci., 51, 1573 (1968); Schoenheimer, R., et al.: J. Biol. Chem., 130, 703 (1939); Seltzer, S., et al.: Pain, 11, 141 (1981)

Applications N-CBZ-Glycyl-glycyl-L-arginine 7-Amido-4-methylcoumarin Hydrochloride is a fluorogenic substrate for uPA (urokinase).
References Zimmerman, M., et al. Proc. Natl. Acad. Sci. USA 75, 750 (1978);

Applications 6-Azidohexanoic Acid is a reagent that is useful for click chemistry.
References Alleti, R.,et al.: J. Org. Chem., 75, 5895 (2010); Daumar, P., et al.: Bioconjug. Chem., 23, 1557 (2012)

Applications An obstetric drug used to control postpartum hemorrhaging.
References Sanz-Nebot, V., et al.: Anal. Bioanal. Chem., 377, 306 (2003), Gimpl, G., et al.: Eur. J. Pharmacol., 510, 9 (2005), Handler, J., et al.: Theriogenol., 66, 1397 (2006), Klenerova, V., et al.: J. Physiol. Pharmacol., 60, 57 (2009),

Applications Cyclo(Leu-Gly) is an antimicrobial compound produced by Latobacillus plantarum.
References Niku-Paavola, M., et al.: J. Appl. Microbiol., 86, 29 (1999)

Stability Moisture Sensitive
Applications L-Cysteine is a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. L-Cysteine is commonly used as a precursor in the food and pharmaceutical industries. L-Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours.
References Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005); Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010);

Stability Air Sensitive
Applications L-Cysteinylglycine, is a biologically important compound since it is formed during the γ-glutamyl cycle. It is a cysteinyl peptide, that can be used in the studies of many peptides and important proteins.
References Marvin D., et al.: New J. Org. Synth., 12, 185 (1980); Sheehan, J. C., et al.: New Synth. Cysteinyl Peptide, 1159 (1958);

Stability Hygroscopic
Applications H-Asp-Leu-OH (cas# 3062-14-4) is a useful research chemical.

Stability Hygroscopic
Applications H-ALA-ASP-OH (cas# 20727-65-5) is a useful research chemical.

Applications E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.
References Wilcox, D. et al.: Biochem. J., 285, 495 (1992); McGowan, E.B. et al.: Biochem. Biophys. Res. Comm., 158, 432 (1989); Tsubokawa, T. et al.: J. Neurosci. Res., 84, 832 (2006);

Applications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.

Applications Boc-L-Nitroarginine, can be used in peptide chemistry. It has been also shown to act as NO synthase inhibitor, and thus used in the study of The effects of methylene blue (MB) for treatment of sepsis induced by bowel perforation.
References Galili, Y. Euro. surg. Rese. vol. 29, P:390-395 (19997);

Applications N-Glycylproline was found to exhibit anti-ischemic effects on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia.
References Bashun, Z.N., et al.: Neurochem. J., 7, 39 (2013);

Applications L-Carnosine is a naturally-occurring histidine-containing compound and the biological role of this dipeptide is to act as cytosolic buffering agents. Other roles ascribed to L-Carnosine include actions as neurotransmitters, modulation of enzymic activities and chelation of heavy metals.
References Quinn, P.J., et al.: Mol. Aspects. Med., 13, 379 (1992); Aruoma, O.I., et al.: Biochem. J., 264, 863 (1989);

Applications N-L-GAMMA-GLUTAMYL-L-LEUCINE (cas# 2566-39-4) is a useful research chemical.

Applications tert-Butoxycarbonyl-D-proline is Boc protected D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.
References Jung, M., et al.: Bioorg. Med. Chem. Lett., 7, 1655 (1997); Lee, D., et al.: J. Med. Chem,, 44, 2015 (2001)