Cromatina/Epigenetica

Protein kinase inhibitor 6 is a protein kinase inhibitor.

1,2-Dipalmitoyl-sn-glycerol ((S)-1,2-Dipalmitin) is an analog of the PKC-activating second messenger diacylglycerol (DAG). It weakly activates PKC.

MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.Cost-effective and quality-assured.

5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.

MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)

GSK1379725A is a selective BPTF ligand (Kd = 2.8 μM).

DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.

GSK-LSD1 dihydrochloride: potent LSD1 inhibitor, >1000x selective over MAO-A/B, LSD2, IC50: 16 nM.

Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.

Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),