Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2490 prodotti di "Cromatina/Epigenetica"
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Fucosterol
CAS:Fucosterol, from E. stolonifera, has anti-diabetic, anti-adipogenic, anti-cancer properties; it affects PPARα and C/EBPα to control fat cell formation.Formula:C29H48OPurezza:98.39% - 99.68%Colore e forma:White PowderPeso molecolare:412.69Darovasertib
CAS:Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).Formula:C22H23F3N8OPurezza:98.72% - ≥95%Colore e forma:SolidPeso molecolare:472.47SIS17
CAS:SIS17: Potent, selective HDAC11 inhibitor (IC50: 0.83 μM), blocks serine hydroxymethyl transferase 2 demyristoylation, spares other HDACs.Formula:C21H38N2OSPurezza:98.22%Colore e forma:SolidPeso molecolare:366.6Apabetalone
CAS:Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery
Formula:C20H22N2O5Purezza:98.08% - ≥98%Colore e forma:SolidPeso molecolare:370.4JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.
Formula:C15H12F2N6O3SPurezza:99.1% - 99.85%Colore e forma:SolidPeso molecolare:394.36A1874
CAS:A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
Formula:C58H62Cl3F2N9O7SPurezza:99.52%Colore e forma:SolidPeso molecolare:1173.59M1001
CAS:M1001 is a HIF-2α agonist.Formula:C17H17N3O2SPurezza:98.83%Colore e forma:SolidPeso molecolare:327.4Cucurbitacin I
CAS:Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
Formula:C30H42O7Purezza:96.69% - 99.8%Colore e forma:SolidPeso molecolare:514.65PKC-θ inhibitor hcl
CAS:PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).Formula:C20H26ClF3N6O3Purezza:98.93%Colore e forma:SolidPeso molecolare:490.91Ref: TM-T5817
1mg88,00€2mg114,00€5mg220,00€10mg356,00€25mg595,00€50mg848,00€100mg1.153,00€500mg2.305,00€BRD4 Inhibitor-24
CAS:BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.
Formula:C13H14N2O4Purezza:99.66%Colore e forma:SolidPeso molecolare:262.26CBP/EP300-IN-1
CAS:CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
Formula:C23H23FN2O5Purezza:99.05%Colore e forma:SolidPeso molecolare:426.44Aurothiomalate sodium
CAS:Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Formula:C4H3AuNa2O4SPurezza:99.66%Colore e forma:SoildPeso molecolare:390.07Ruxolitinib phosphate
CAS:Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formula:C17H21N6O4PPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:404.36Ref: TM-T3043
1g583,00€5mg49,00€10mg62,00€25mg78,00€50mg92,00€100mg138,00€200mg215,00€500mg395,00€1mL*10mM (DMSO)56,00€TFMB-(R)-2-HG
CAS:TFMB-(R)-2-HG, a carcinogen in AML, hinders SCF ER-Hoxb8 differentiation after estrogen loss.Formula:C13H11F3O4Purezza:97.15%Colore e forma:SolidPeso molecolare:288.22Ref: TM-T17065
1mg77,00€5mg166,00€10mg250,00€25mg452,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)140,00€MT-DADMe-ImmA
CAS:MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).Formula:C13H19N5OSPurezza:99.56%Colore e forma:SolidPeso molecolare:293.39Ref: TM-TQ0008
1mg70,00€5mg135,00€10mg225,00€25mg399,00€50mg560,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)169,00€N-Oxalylglycine
CAS:N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.Formula:C4H5NO5Purezza:99.23%Colore e forma:Colourless SolidPeso molecolare:147.09Protein Kinase C 19-31 acetate
PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.Formula:C69H122N26O18Purezza:>99.99%Colore e forma:SolidPeso molecolare:1603.9Isoxazole
CAS:Isoxazole (1,2-oxazole) is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.Formula:C3H3NOPurezza:99.34%Colore e forma:Colorless LiquidPeso molecolare:69.06(+)-JQ-1
CAS:(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility.Formula:C23H25ClN4O2SPurezza:97.57% - 99.97%Colore e forma:SolidPeso molecolare:456.99Ref: TM-T2110
1mg35,00€2mg44,00€5mg60,00€10mg79,00€25mg96,00€50mg144,00€100mg188,00€200mg283,00€500mg512,00€1mL*10mM (DMSO)66,00€AZD-2461
CAS:AZD2461 is a novel PARP inhibitor.Formula:C22H22FN3O3Purezza:98% - 99.87%Colore e forma:SolidPeso molecolare:395.43SRT 1720 dihydrochloride
CAS:SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Formula:C25H25Cl2N7OSPurezza:98.58%Colore e forma:SolidPeso molecolare:542.485-Ph-IAA
CAS:5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.
Formula:C16H13NO2Purezza:99.37% - 99.973%Colore e forma:SolidPeso molecolare:251.28Protein kinase inhibitor 6
CAS:Protein kinase inhibitor 6 is a protein kinase inhibitor.
Formula:C13H9FN2SPurezza:98.01%Colore e forma:SolidPeso molecolare:244.29MC1568
CAS:MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B.Formula:C17H15FN2O3Purezza:89.82% - ≥95%Colore e forma:SolidPeso molecolare:314.31dBET6
CAS:dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.Formula:C42H45ClN8O7SPurezza:97.57% - 99.12%Colore e forma:SolidPeso molecolare:841.37Ref: TM-T5130
1mg52,00€5mg97,00€10mg169,00€25mg306,00€50mg492,00€100mg712,00€200mg898,00€500mg1.311,00€1mL*10mM (DMSO)157,00€5-AIQ
CAS:5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.Formula:C9H8N2OPurezza:95.95%Colore e forma:SolidPeso molecolare:160.17GSK-LSD1 dihydrochloride
CAS:GSK-LSD1 dihydrochloride: potent LSD1 inhibitor, >1000x selective over MAO-A/B, LSD2, IC50: 16 nM.
Formula:C14H22Cl2N2Purezza:98.72% - >99.99%Colore e forma:SolidPeso molecolare:289.24PF-CBP1 hydrochloride
CAS:PF-CBP1 HCl selectively inhibits CREBBP bromodomain (IC50: 125 nM) and p300 (IC50: 363 nM).Formula:C29H37ClN4O3Purezza:97.11% - 99.02%Colore e forma:SolidPeso molecolare:525.08UMB298
CAS:UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.Formula:C27H31ClN4O2Purezza:99.76%Colore e forma:SolidPeso molecolare:479.01Ref: TM-T9194
1mg48,00€5mg99,00€10mg158,00€25mg264,00€50mg370,00€100mg507,00€200mg657,00€1mL*10mM (DMSO)104,00€(S)-CPI203
CAS:CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurezza:99.01% - 99.92%Colore e forma:SolidPeso molecolare:399.9Ref: TM-T6026
2mg34,00€5mg55,00€10mg89,00€25mg170,00€50mg269,00€100mg424,00€200mg593,00€1mL*10mM (DMSO)58,00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurezza:98% - 98.85%Colore e forma:SolidPeso molecolare:373.21Ref: TM-T22142
1mg43,00€2mg55,00€5mg93,00€10mg137,00€25mg254,00€50mg380,00€100mg573,00€500mg1.189,00€C646
CAS:C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
Formula:C24H19N3O6Purezza:98% - 99.21%Colore e forma:SolidPeso molecolare:445.42Ref: TM-T2452
2mg48,00€5mg69,00€10mg97,00€25mg195,00€50mg380,00€100mg562,00€500mg1.206,00€1mL*10mM (DMSO)69,00€Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formula:C20H26O5Purezza:99.97% - >99.99%Colore e forma:SolidPeso molecolare:346.42Ref: TM-T4672
1mg90,00€5mg203,00€10mg350,00€25mg578,00€50mg797,00€100mg1.071,00€500mg2.187,00€1mL*10mM (DMSO)224,00€Pinometostat
CAS:Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.Formula:C30H42N8O3Purezza:99.19% - 99.86%Colore e forma:SolidPeso molecolare:562.71HDAC8-IN-1
CAS:MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines.Formula:C22H19NO3Purezza:97.13% - 99.19%Colore e forma:SolidPeso molecolare:345.39Ref: TM-T7082
1mg34,00€5mg63,00€10mg95,00€25mg172,00€50mg259,00€100mg330,00€200mg467,00€1mL*10mM (DMSO)70,00€CP21R7
CAS:CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.Formula:C19H15N3O2Purezza:96.14% - 99.16%Colore e forma:SolidPeso molecolare:317.34Ref: TM-T3684
1mg40,00€2mg52,00€5mg88,00€10mg127,00€25mg250,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)81,00€GSK2879552 2HCl (1401966-69-5(free base))
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
Formula:C23H30Cl2N2O2Purezza:99.87% - ≥95%Colore e forma:SolidPeso molecolare:437.41Ref: TM-T4418
1mg59,00€2mg86,00€5mg109,00€10mg175,00€25mg293,00€50mg411,00€100mg610,00€500mg1.301,00€PLX51107
CAS:PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).Formula:C26H22N4O3Purezza:99.75%Colore e forma:SolidPeso molecolare:438.48Ref: TM-TQ0253
1mg56,00€2mg81,00€5mg119,00€10mg188,00€25mg329,00€50mg490,00€100mg710,00€1mL*10mM (DMSO)131,00€OUL35
CAS:OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.Formula:C14H12N2O3Purezza:99.2%Colore e forma:SolidPeso molecolare:256.26JAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormula:C19H18N4O3Purezza:99.94% - 99.94%Colore e forma:SolidPeso molecolare:350.37RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Formula:C13H8N4Purezza:99.74%Colore e forma:SolidPeso molecolare:220.23Ref: TM-T9627
1mg42,00€5mg92,00€10mg132,00€25mg231,00€50mg349,00€100mg522,00€200mg710,00€1mL*10mM (DMSO)90,00€AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formula:C29H28F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:535.56Decernotinib
CAS:Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Formula:C18H19F3N6OPurezza:99.28% - >99.99%Colore e forma:SolidPeso molecolare:392.38Ref: TM-T2636
1mg35,00€2mg50,00€5mg74,00€10mg104,00€25mg207,00€50mg311,00€100mg472,00€1mL*10mM (DMSO)84,00€G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purezza:97.3%Colore e forma:SolidPeso molecolare:383.39Ref: TM-T8742
1mg38,00€5mg74,00€10mg101,00€25mg182,00€50mg261,00€100mg366,00€200mg497,00€1mL*10mM (DMSO)82,00€(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formula:C23H24N4OPurezza:97.75% - 99.92%Colore e forma:SolidPeso molecolare:372.46Ref: TM-T21503
1mg46,00€2mg59,00€5mg87,00€10mg119,00€25mg210,00€50mg349,00€100mg507,00€1mL*10mM (DMSO)96,00€FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purezza:97% - 97.90%Colore e forma:SolidPeso molecolare:464.55Ref: TM-T6838
2mg46,00€5mg66,00€10mg93,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)72,00€Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formula:C21H22ClNO4Purezza:97.9% - 99.47%Colore e forma:SolidPeso molecolare:387.865,7-Dihydroxychromone
CAS:1.Formula:C9H6O4Purezza:99.76% - ≥95%Colore e forma:SolidPeso molecolare:178.14Ref: TM-T5S1805
1mg44,00€5mg84,00€10mg119,00€25mg197,00€50mg294,00€100mg437,00€500mg954,00€1mL*10mM (DMSO)75,00€
