Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2553 prodotti di "Cromatina/Epigenetica"
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PARP1-IN-11
CAS:PARP1-IN-11 is a potent PARP1 inhibitor (IC50=0.082 μM), also reducing PARP3, TNKS1, and TNKS2 activity.Formula:C16H12N2O4Colore e forma:SolidPeso molecolare:296.28SDR-04
CAS:SDR-04 inhibits BRD4-BD1 with high affinity, suppressing MV4;11 cancer cell growth as a BET inhibitor.Formula:C19H16N4O2Colore e forma:SolidPeso molecolare:332.36CP-690550A
CAS:Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.Formula:C15H21N5O2Colore e forma:SolidPeso molecolare:303.36ABT-472
CAS:ABT-472 is a novel PARP inhibitorFormula:C20H28N4O5Colore e forma:SolidPeso molecolare:404.46CBHA
CAS:m-Carboxycinnamic bishydroxamide: HDAC inhibitor, ID50 = 10 nM (HDAC1), 70 nM (HDAC3), induces apoptosis and tumor growth suppression.Formula:C10H10N2O4Colore e forma:SolidPeso molecolare:222.2CPI-905
CAS:CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.Formula:C18H20N2O5Colore e forma:SolidPeso molecolare:344.36BRD4-BD1-IN-1
CAS:BRD4-BD1-IN-1 (Compound 9a) is a BRD4-BD1 inhibitor(IC50= 38.20 μM).Formula:C16H15BrN4O4Colore e forma:SolidPeso molecolare:407.22TP-238
CAS:"TP-238: Potent CECR2/BPTF dual probe; IC50: 30 nM/350 nM. Inhibits BRD9 (pIC50: 5.9); minimal activity on 338 other kinases."Formula:C22H30N6O3SColore e forma:SolidPeso molecolare:458.58BRD4 Inhibitor-26
BRD4 Inhibitor-26: blocks BRD4 (BD1 and BD2) with IC50 of 0.82 μM & 1.94 μM; used in ovarian cancer research.Formula:C29H27N5O6SColore e forma:SolidPeso molecolare:573.62GNA002
CAS:GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Formula:C42H55NO8Purezza:98%Colore e forma:SolidPeso molecolare:701.89HDAC6/8/BRPF1-IN-1
CAS:HDAC6/8/BRPF1-IN-1 is a cancer-research inhibitor for HDAC6, HDAC8, BRPF1 with IC50: 344-908 nM and Kd: 175.2 nM.Formula:C18H17N3O5SColore e forma:SolidPeso molecolare:387.41Binucleine 2
CAS:Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.Formula:C13H11ClFN5Colore e forma:SolidPeso molecolare:291.71ART-IN-1
CAS:ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].Formula:C14H13NO2SColore e forma:SolidPeso molecolare:259.32MAT2A-IN-7
CAS:MAT2A-IN-7 inhibits MAT2A in various cancers, especially MTAP-deficient cancer cells, with potential for research use.Formula:C17H13ClF3N3O2Colore e forma:SolidPeso molecolare:383.75UMB-32
CAS:UMB-32: Potent, selective BRD4 inhibitor, Kd 550 nM, IC50 637 nM, also targets TAF1.Formula:C21H23N5OColore e forma:SolidPeso molecolare:361.44Bromodomain inhibitor-10
CAS:Bromodomain inhibitor-10 (compound 128) suppresses BRD4-1/2 with Kd 15 nM/2.5 μM and curbs IL12p40 production.Formula:C20H20N4O3Colore e forma:SolidPeso molecolare:364.4FNDR-20123 free base
CAS:FNDR-20123 is a safe, oral first-in-class anti-malarial HDAC inhibitor with low IC50s against Plasmodium and human HDACs.Formula:C21H23N5O2Colore e forma:SolidPeso molecolare:377.44A2AAR/HDAC-IN-2
CAS:A2AAR/HDAC-IN-2: potent dual A2AAR/HDAC inhib., Ki 10.3 nM, IC50 18.5 nM, anti-tumor potential.Formula:C23H26N6O4Colore e forma:SolidPeso molecolare:450.49ZLD1039
CAS:ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.Formula:C36H48N6O3Purezza:99.5%Colore e forma:SolidPeso molecolare:612.8GPI-15427
CAS:GPI-15427: a potent PARP-1 inhibitor, crosses the blood-brain barrier, boosts TMZ's effects on CNS tumors, and sensitizes cancer to radiotherapy.Formula:C20H20N4O2Colore e forma:SolidPeso molecolare:348.4
