Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2553 prodotti di "Cromatina/Epigenetica"
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CPI-1612
CAS:CPI-1612: Oral EP300/CBP HAT inhibitor, IC50 8.1 nM, has anticancer properties.Formula:C27H26N6OColore e forma:SolidPeso molecolare:450.53CAY10669
CAS:CAY10669 inhibits PCAF (IC50 = 662 μM), is twice as potent as anacardic acid, and reduces H4 acetylation in HepG2 cells at 30-60 μM.Formula:C20H22O4Colore e forma:SolidPeso molecolare:326.39ZLD2218
CAS:ZLD2218, a potent inhibitor of BRD4 with an IC50 value of 107 nM, has been demonstrated to mitigate kidney injury and fibrosis through extensive studies.Formula:C22H18N4OColore e forma:SolidPeso molecolare:354.4PF-00956980
CAS:PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.Formula:C18H26N6OColore e forma:SolidPeso molecolare:342.44CBP/p300-IN-10
CAS:CBP/p300-IN-10, potent EP300/CREBBP inhibitor; IC50: 26 nM/39 nM. Potential for cancer research.Formula:C25H24F5N5O3Colore e forma:SolidPeso molecolare:537.48PRMT5-IN-10
CAS:PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.Formula:C13H17N5O4Colore e forma:SolidPeso molecolare:307.31Depudecin
CAS:Depudecin, a polyketide from Alternaria brassicicola, has an 11-carbon chain with two epoxides and six stereocenters, inhibits HDAC, and is anti-angiogenic.Formula:C11H16O4Colore e forma:SolidPeso molecolare:212.24UNC6212 (Kme2)
UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a K D for CBX5 of 5.7 μM .Formula:C39H53N7O11Colore e forma:SolidPeso molecolare:795.88BAY-598 R-isomer
CAS:BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.Formula:C22H20Cl2F2N6O3Colore e forma:SolidPeso molecolare:525.34MAT2A-IN-4
CAS:MAT2A-IN-4 can be used for the cancer research that is an inhibitor of methionine adenosyltransferase 2A (MAT2A)[1].Formula:C18H16ClN3OColore e forma:SolidPeso molecolare:325.79SYK/JAK-IN-1
CAS:SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.Formula:C24H26N8O3Colore e forma:SolidPeso molecolare:474.52HDAC-IN-43
CAS:HDAC-IN-43: potent HDAC 1/3/6 inhibitor (IC50: 82 nM HDAC1, 45 nM HDAC3, 24 nM HDAC6); weak PI3K/mTOR (IC50: 3.6μM, 3.7μM); anti-proliferative.Formula:C22H28N6O4Colore e forma:SolidPeso molecolare:440.5SIRT1-IN-2
CAS:SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].Formula:C13H15ClN2OColore e forma:SolidPeso molecolare:250.72PARP-2/1-IN-2
CAS:PARP-2/1-IN-2, Veliparib's enantiomer, inhibits PARP-1/2 (Ki: 5/2 nM) with 3 nM EC50 in cell assay.Formula:C13H16N4OColore e forma:SolidPeso molecolare:244.29DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Formula:C29H39Cl3FN9O3Colore e forma:SolidPeso molecolare:687.04UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Formula:C25H36F3N5O4Colore e forma:SolidPeso molecolare:527.589F-amidine
CAS:F-amidine is a bioavailable irreversible PAD4 inactivator.Formula:C14H19FN4O2Colore e forma:SolidPeso molecolare:294.32KD 5170
CAS:KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].Formula:C20H25N3O5S2Colore e forma:SolidPeso molecolare:451.56TUL01101
CAS:TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.Formula:C22H25F2N5O2Colore e forma:SolidPeso molecolare:429.46HDAC6-IN-46
CAS:HDAC6-IN-46 (compound 12) is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 6.2 nM. It is utilized in research related to Alzheimer's disease.Formula:C26H21N3O4Colore e forma:SolidPeso molecolare:439.46
