Topoisomerasi
Le topoisomerasi sono enzimi che regolano la topologia del DNA durante processi come la replicazione, la trascrizione e la segregazione cromosomica, introducendo rotture transitorie nei filamenti di DNA per alleviare lo stress torsionale. Gli inibitori della topoisomerasi interferiscono con questo processo, portando all'accumulo di rotture nel DNA e all'induzione della morte cellulare, in particolare nelle cellule a rapida divisione. Questi inibitori sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori della topoisomerasi di alta qualità per supportare la tua ricerca sulla replicazione del DNA, la terapia del cancro e la regolazione del ciclo cellulare.
Trovati 126 prodotti per "Topoisomerasi".
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Banoxantrone-D12 dihydrochloride
CAS:Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Formula:C22H30Cl2N4O6Purezza:98%Colore e forma:SolidPeso molecolare:529.48Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formula:C21H21N3O2Colore e forma:SolidPeso molecolare:347.41Chimmitecan
CAS:Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.Formula:C23H20N2O5Purezza:98.35%Colore e forma:Yellow SolidPeso molecolare:404.42Topoisomerase II inhibitor 19
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and a topoisomerase II inhibitor with an IC50 of 0.34 μM. It induces damage in ctDNA.Formula:C27H16ClN3OSPeso molecolare:465.07026Topoisomerase IIα-IN-9
CAS:Topoisomerase IIα-IN-9 ,with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Topoisomerase IIα-IN-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C14H14O4SColore e forma:SolidPeso molecolare:278.32Merbarone
CAS:Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.Formula:C11H9N3O3SPurezza:99.51%Colore e forma:SolidPeso molecolare:263.27Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formula:C22H21N3O5Purezza:97.49%Colore e forma:SolidPeso molecolare:407.42Pixantrone dimaleate
CAS:Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formula:C25H27N5O10Purezza:98.70% - 99.11%Colore e forma:Blue SolidPeso molecolare:557.21EIDD-1931
CAS:EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.Formula:C9H13N3O6Purezza:99.14% - 99.73%Colore e forma:SolidPeso molecolare:259.22Aurintricarboxylic acid
CAS:Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formula:C22H14O9Purezza:85% - 97.1%Colore e forma:Deep Red Coarse Crystalline PowderPeso molecolare:422.34Voreloxin hydrochloride
CAS:Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formula:C18H20ClN5O4SPurezza:99.84%Colore e forma:SolidPeso molecolare:437.9Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formula:C30H48O3Purezza:98.22% - 99.7%Colore e forma:White SolidPeso molecolare:456.70Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formula:C26H27NO9·HClPurezza:98.91% - 99.96%Colore e forma:SolidPeso molecolare:533.95Topotecan
CAS:Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Formula:C23H23N3O5Purezza:96.14% - 98.23%Colore e forma:Yellow SolidPeso molecolare:421.45Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formula:C15H12O3Purezza:98.07% - 99.18%Colore e forma:White SolidPeso molecolare:240.25Ref: TM-T16522
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg767,00€SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purezza:98% - 99.97%Colore e forma:Yellow SolidPeso molecolare:392.40Bisantrene
CAS:Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Formula:C22H22N8Purezza:96.22% - 97.13%Colore e forma:Orange SolidPeso molecolare:398.469-Hydroxycamptothecin
CAS:9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.Formula:C20H16N2O5Purezza:98.28%Colore e forma:Yellow SolidPeso molecolare:364.35Razoxane
CAS:Razoxane is used as an antimitotic agent with immunosuppressive properties.Formula:C11H16N4O4Purezza:99.75%Colore e forma:SolidPeso molecolare:268.27
