Topoisomerasi
Le topoisomerasi sono enzimi che regolano la topologia del DNA durante processi come la replicazione, la trascrizione e la segregazione cromosomica, introducendo rotture transitorie nei filamenti di DNA per alleviare lo stress torsionale. Gli inibitori della topoisomerasi interferiscono con questo processo, portando all'accumulo di rotture nel DNA e all'induzione della morte cellulare, in particolare nelle cellule a rapida divisione. Questi inibitori sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori della topoisomerasi di alta qualità per supportare la tua ricerca sulla replicazione del DNA, la terapia del cancro e la regolazione del ciclo cellulare.
Trovati 136 prodotti di "Topoisomerasi"
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Isosteviol
CAS:Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.Formula:C20H30O3Purezza:99.72% - 99.97%Colore e forma:SolidPeso molecolare:318.45SW044248
CAS:SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.Formula:C22H23N5O2SPurezza:99.56% - 99.87%Colore e forma:SolidPeso molecolare:421.52Niranthin
CAS:Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.Formula:C24H32O7Purezza:99.8%Colore e forma:SolidPeso molecolare:432.51Ref: TM-TN4660
1mg345,00€5mg762,00€10mg1.144,00€25mg2.008,00€50mg3.213,00€100mg5.139,00€1mL*10mM (DMSO)808,00€Topovale
CAS:Topovale (ARC111) is a potent inhibitor of topoisomerase I.Formula:C23H23N3O5Purezza:99.94%Colore e forma:SolidPeso molecolare:421.45Pirarubicin
CAS:Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.Formula:C32H37NO12Purezza:97.80% - 99.15%Colore e forma:Red Crystalline PowderPeso molecolare:627.64Garenoxacin mesylate hydrate
CAS:Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFormula:C23H20F2N2O4·CH4O3S·H2OPurezza:99.56%Colore e forma:SolidPeso molecolare:540.53Exatecan Mesylate
CAS:Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).Formula:C25H26FN3O7SPurezza:97.32% - 99.9%Colore e forma:SolidPeso molecolare:531.55Indotecan
CAS:Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).Formula:C26H26N2O7Purezza:97% - 98%Colore e forma:SolidPeso molecolare:478.49Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purezza:96.59% - 99.55%Colore e forma:SolidPeso molecolare:383.82Prulifloxacin
CAS:Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.Formula:C21H20FN3O6SPurezza:99.47%Colore e forma:Yellow Or Slightly Yellow PowerPeso molecolare:461.46Rabdosiin
CAS:Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.Formula:C36H30O16Purezza:98.64% - 99.49%Colore e forma:SolidPeso molecolare:718.619-Methoxycamptothecin
CAS:9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Formula:C21H18N2O5Purezza:98.49% - 99.56%Colore e forma:SolidPeso molecolare:378.38Mitoxantrone
CAS:<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formula:C22H28N4O6Purezza:96.29% - 98.74%Colore e forma:Blue PowderPeso molecolare:444.48β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formula:C15H14O3Purezza:99.76% - 99.88%Colore e forma:SolidPeso molecolare:242.27Ellipticine hydrochloride
CAS:Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.Formula:C17H15ClN2Purezza:97.18%Colore e forma:SolidPeso molecolare:282.76Amonafide
CAS:Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.Formula:C16H17N3O2Purezza:99.39%Colore e forma:SolidPeso molecolare:283.33Ref: TM-T6336
1mg39,00€2mg51,00€5mg80,00€10mg87,00€25mg163,00€50mg281,00€100mg467,00€1mL*10mM (DMSO)92,00€Groenlandicine
CAS:Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.Formula:C19H16NO4Purezza:98.59% - 99.77%Colore e forma:SolidPeso molecolare:322.34Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Formula:C33H38N4O6Purezza:98% - 99.92%Colore e forma:SolidPeso molecolare:586.68Dxd
CAS:Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!Formula:C26H24FN3O6Purezza:98.21% - ≥98%Colore e forma:SolidPeso molecolare:493.481,4-Naphthoquinone
CAS:1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Formula:C10H6O2Purezza:99.24% - 99.56%Colore e forma:SolidPeso molecolare:158.15
