Segnalazione JAK/STAT
Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.
Sottocategorie di "Segnalazione JAK/STAT"
Trovati 322 prodotti di "Segnalazione JAK/STAT"
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SAR-20347
CAS:<p>SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).</p>Formula:C21H18ClFN4O4Purezza:98.99% - 99.77%Colore e forma:SolidPeso molecolare:444.84WHI-P97 HCl
<p>WHI-P97 HCl is a potent and selective JAK-3 inhibitor.</p>Formula:C16H14Br2ClN3O3Purezza:99.49%Colore e forma:SolidPeso molecolare:491.56Gandotinib
CAS:<p>LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).</p>Formula:C23H25ClFN7OPurezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:469.94HODHBt
CAS:<p>HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.</p>Formula:C7H5N3O2Purezza:99.45% - 99.95%Colore e forma:Off-White To Yellow SolidPeso molecolare:163.13Quercetagetin
CAS:<p>Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.</p>Formula:C15H10O8Purezza:99.65% - 99.91%Colore e forma:SolidPeso molecolare:318.24Momelotinib HCl
CAS:<p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>Formula:C23H24Cl2N6O2Colore e forma:SolidPeso molecolare:487.38SHR0302
CAS:<p>SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,</p>Formula:C18H22N8O2SPurezza:99.11%Colore e forma:SolidPeso molecolare:414.48Napabucasin
CAS:<p>Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.</p>Formula:C14H8O4Purezza:98.43% - 99.85%Colore e forma:SolidPeso molecolare:240.21TG101209
CAS:<p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>Formula:C26H35N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:509.67WHI-P97
CAS:WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formula:C16H13Br2N3O3Purezza:99.93%Colore e forma:SolidPeso molecolare:455.1TCS-PIM-1-4a
CAS:<p>SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).</p>Formula:C11H6F3NO2SPurezza:99.89%Colore e forma:SolidPeso molecolare:273.23Tofacitinib Citrate
CAS:<p>Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).</p>Formula:C22H28N6O8Purezza:99.19% - 99.75%Colore e forma:SolidPeso molecolare:504.49Pacritinib
CAS:<p>Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).</p>Formula:C28H32N4O3Purezza:99.25% - 99.49%Colore e forma:SolidPeso molecolare:472.58Gusacitinib HCl
CAS:<p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>Formula:C24H29ClN8O2Colore e forma:SolidPeso molecolare:497Ruxolitinib (S enantiomer)
CAS:<p>Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.</p>Formula:C17H18N6Purezza:99.37% - 99.79%Colore e forma:SolidPeso molecolare:306.36Pim1/AKK1-IN-1
CAS:<p>Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.</p>Formula:C20H13N5OPurezza:97.03% - 98.69%Colore e forma:SolidPeso molecolare:339.35CEP-33779
CAS:<p>CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.</p>Formula:C24H26N6O2SPurezza:98.24% - ≥95%Colore e forma:SolidPeso molecolare:462.57ZM39923 hydrochloride
CAS:<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formula:C23H25NO·HClPurezza:98.05%Colore e forma:SolidPeso molecolare:367.91Baricitinib phosphate
CAS:<p>Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.</p>Formula:C16H20N7O6PSPurezza:99.4% - 99.82%Colore e forma:SolidPeso molecolare:469.41RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63Filgotinib
CAS:<p>Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.</p>Formula:C21H23N5O3SPurezza:98.03% - ≥95%Colore e forma:SolidPeso molecolare:425.5BD750
CAS:<p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>Formula:C14H13N3OSPurezza:99.02%Colore e forma:SolidPeso molecolare:271.34FLLL32
CAS:<p>FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).</p>Formula:C28H32O6Purezza:97% - 97.90%Colore e forma:SolidPeso molecolare:464.55Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Formula:C15H12O5Purezza:99.42% - 99.82%Colore e forma:SolidPeso molecolare:272.25PF-06651600 malonate
CAS:<p>PF-06651600 is a potent and selective JAK3 inhibitor.</p>Formula:C18H23N5O5Colore e forma:SolidPeso molecolare:389.41Upadacitinib
CAS:<p>Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.</p>Formula:C17H19F3N6OPurezza:98.96% - 99.94%Colore e forma:SolidPeso molecolare:380.37GLPG0634 analog
CAS:<p>GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.</p>Formula:C23H18N6O2Purezza:99.52% - >99.99%Colore e forma:SolidPeso molecolare:410.43Cerdulatinib
CAS:<p>Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.</p>Formula:C20H27N7O3SPurezza:98.74% - 99.49%Colore e forma:SolidPeso molecolare:445.54TCS PIM-1 1
CAS:<p>TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.</p>Formula:C18H11BrN2O2Purezza:97% - 97.98%Colore e forma:SolidPeso molecolare:367.2Ruxolitinib phosphate
CAS:<p>Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.</p>Formula:C17H21N6O4PPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:404.36AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Formula:C19H23N7O2Purezza:99.83% - 99.98%Colore e forma:SolidPeso molecolare:381.43Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurezza:97.31% - 99.96%Colore e forma:SolidPeso molecolare:524.68TP-3654
CAS:<p>TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).</p>Formula:C22H25F3N4OPurezza:99.8% - 99.95%Colore e forma:SolidPeso molecolare:418.46XL019
CAS:<p>XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.</p>Formula:C25H28N6O2Purezza:99.19%Colore e forma:SolidPeso molecolare:444.53Ritlecitinib tosylate
CAS:<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Formula:C22H27N5O4SColore e forma:SolidPeso molecolare:457.549AZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Formula:C21H21N3O2SPurezza:97.24% - 99.83%Colore e forma:SolidPeso molecolare:379.48Cucurbitacin I
CAS:<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Formula:C30H42O7Purezza:96.69% - 99.8%Colore e forma:SolidPeso molecolare:514.65(E/Z)-Zotiraciclib
CAS:<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>Formula:C23H24N4OPurezza:97.75% - 99.92%Colore e forma:SolidPeso molecolare:372.46Abrocitinib
CAS:<p>Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).</p>Formula:C14H21N5O2SPurezza:99.09% - 99.91%Colore e forma:SolidPeso molecolare:323.41(Z)-LFM-A13
CAS:(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Formula:C11H8Br2N2O2Purezza:99.88%Colore e forma:SolidPeso molecolare:360Momelotinib
CAS:<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Formula:C23H22N6O2Purezza:97.47% - 99.56%Colore e forma:SolidPeso molecolare:414.46RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Formula:C17H14Cl2N6OPurezza:97.94%Colore e forma:SolidPeso molecolare:389.24WHI-P154
CAS:<p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>Formula:C16H14BrN3O3Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:376.2Niclosamide sodium
CAS:<p>Niclosamide (BAY2353) sodium: oral antihelminthic, STAT3 inhibitor (IC50 0.25 μM), anti-cancer, and DNA replication blocker.</p>Formula:C13H7Cl2N2NaO4Colore e forma:SolidPeso molecolare:349.1HJ-PI01
CAS:<p>HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.</p>Formula:C14H11NO2Purezza:98.92%Colore e forma:SolidPeso molecolare:225.24Pacritinib hydrochloride
CAS:<p>Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.</p>Formula:C28H32N4O3·xClHColore e forma:SolidBMS-911543
CAS:<p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>Formula:C23H28N8OPurezza:97.69% - 99.98%Colore e forma:SolidPeso molecolare:432.52FM-381
CAS:<p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>Formula:C24H24N6O2Purezza:98.44%Colore e forma:SolidPeso molecolare:428.49JANEX-1
CAS:<p>JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.</p>Formula:C16H15N3O3Purezza:98% - 99.81%Colore e forma:SolidPeso molecolare:297.31AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purezza:98.6% - 99.85%Colore e forma:Yellow SolidPeso molecolare:294.3
