Segnalazione JAK/STAT
Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.
Sottocategorie di "Segnalazione JAK/STAT"
Trovati 363 prodotti per "Segnalazione JAK/STAT".
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Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formula:C63H107N19O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1514.77STAT3 degrader-1
CAS:STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].Formula:C58H63F5N9O12PSColore e forma:SolidPeso molecolare:1236.2TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Colore e forma:Odour SolidS-Ruxolitinib
CAS:S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.Formula:C17H18N6Purezza:98%Colore e forma:SolidPeso molecolare:306.37Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedColore e forma:Odour SolidRef: TM-L2200
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaPovorcitinib phosphate
CAS:Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Formula:C23H25F5N7O5PPurezza:99.57%Colore e forma:SolidPeso molecolare:605.45Ref: TM-T39113L
1mg46,00€5mg96,00€1mL*10mM (DMSO)128,00€10mg145,00€25mg236,00€50mg339,00€100mg460,00€200mg622,00€FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Colore e forma:LiquidRef: TM-L1610
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaMMT3-72
CAS:MMT3-72 is a weak JAK1 inhibitor with superior efficacy and reduced p-STAT3 in DSS-induced colitis [1].Formula:C40H42N8O9SPeso molecolare:810.87APTSTAT3-9R
APTSTAT3-9R-9R blocks STAT3 (Ki: 231 nmol/L), hindering cancer cell growth and resistance.Formula:C223H330N80O51Purezza:98%Colore e forma:SolidPeso molecolare:4947.51SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormula:C43H45N13O9SPurezza:98%Colore e forma:SolidPeso molecolare:919.96JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formula:C30H33FN4O3SColore e forma:SolidPeso molecolare:548.67STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.Colore e forma:Odour SolidWDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Formula:C29H31F3N4O4Colore e forma:SolidPeso molecolare:556.576Golotimod hydrochloride
CAS:Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity.Formula:C16H20ClN3O5Purezza:99.64% - 99.86%Colore e forma:SolidPeso molecolare:369.8Ref: TM-T11449
200mgPrezzo su richiesta500mgPrezzo su richiesta5mg92,00€10mg148,00€50mg359,00€100mg480,00€Fulipiftide
CAS:Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.Formula:C144H227N41O47Colore e forma:SolidPeso molecolare:3284.59PROTAC STAT3 degrader-2
CAS:PROTAC STAT3 degrader-2 selectively breaks down STAT3 (DC50: 3.54μM, Molm-16) with cancer research potential.Formula:C59H60F2N9O13PColore e forma:SolidPeso molecolare:1172.13CMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.Formula:C46H59N9O7Purezza:98%Colore e forma:SolidPeso molecolare:850.03PM-81I
CAS:PM-81I: Potent STAT6 inhibitor for allergic and pulmonary conditions, cancer research. Reduces STAT6 phosphorylation.Formula:C43H58F2N3O10PColore e forma:SolidPeso molecolare:845.91TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Formula:C23H21FN4O2Colore e forma:SolidPeso molecolare:404.16485SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColore e forma:SolidPeso molecolare:818.95
