Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 331 prodotti di "Segnalazione JAK/STAT"

Purezza (%)

100

prodotti per pagina.

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JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.
Colore e forma:Odour Solid
Ref: TM-T200631
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TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.
Colore e forma:Odour Solid
Ref: TM-T206972
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Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.
Colore e forma:Odour Solid
Ref: TM-T200676
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TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.
Formula:C₂₃H₂₁FN₄O₂
Colore e forma:Solid
Peso molecolare:404.16485
Ref: TM-T207637
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JAK-IN-15
CAS:
- 1973485-05-0
JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).
Formula:C₂₂H₂₃FN₄O₃S
Colore e forma:Solid
Peso molecolare:442.51
Ref: TM-T39400
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R8-T198wt
CAS:
- 2305815-72-7
Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.
Formula:C₁₁₁H₂₁₁N₅₉O₂₆S
Purezza:98%
Colore e forma:Solid
Peso molecolare:2820.33
Ref: TM-TP2128
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FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Colore e forma:Liquid
Ref: TM-L1610
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S-Ruxolitinib
CAS:
- 1160597-27-2
S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.
Formula:C₁₇H₁₈N₆
Purezza:98%
Colore e forma:Solid
Peso molecolare:306.37
Ref: TM-T3066
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SJ10542
CAS:
- 2789678-92-6
SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.
Formula:C₄₁H₄₆N₁₂O₅S
Colore e forma:Solid
Peso molecolare:818.95
Ref: TM-T74429
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WDR5 ligand 2
CAS:
- 2737222-78-3
WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.
Formula:C₂₉H₃₁F₃N₄O₄
Colore e forma:Solid
Peso molecolare:556.576
Ref: TM-T205322
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Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
Colore e forma:Odour Solid
Ref: TM-L1600
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STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.
Colore e forma:Odour Solid
Ref: TM-T206598
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AK-2292
AK-2292: potent STAT5 PROTAC degrader, DC50 0.10 μM, degrades STAT5A/B, may shrink leukemia tumors in mice.
Formula:C₅₂H₅₄F₂N₇O₁₀PS₂
Colore e forma:Solid
Peso molecolare:1070.13
Ref: TM-T74749
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SJ1008030
CAS:
- 2863634-96-0
SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.
Formula:C₄₂H₄₃N₁₃O₇S
Colore e forma:Solid
Peso molecolare:873.94
Ref: TM-T74580
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CMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.
Formula:C₄₆H₅₉N₉O₇
Purezza:98%
Colore e forma:Solid
Peso molecolare:850.03
Ref: TM-TP1770
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SJ988497
CAS:
- 2595365-41-4
SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.
Formula:C₃₆H₃₆N₁₀O₅
Colore e forma:Solid
Peso molecolare:688.74
Ref: TM-T74994
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Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related
Colore e forma:Odour Solid
Ref: TM-L2200
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Axltide
CAS:
- 143364-95-8
Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.
Formula:C₆₃H₁₀₇N₁₉O₂₀S₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:1514.77
Ref: TM-TP1713
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APTSTAT3-9R
APTSTAT3-9R-9R blocks STAT3 (Ki: 231 nmol/L), hindering cancer cell growth and resistance.
Formula:C₂₂₃H₃₃₀N₈₀O₅₁
Purezza:98%
Colore e forma:Solid
Peso molecolare:4947.51
Ref: TM-TP2222
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PROTAC STAT3 degrader-2
CAS:
- 2429877-78-9
PROTAC STAT3 degrader-2 selectively breaks down STAT3 (DC50: 3.54μM, Molm-16) with cancer research potential.
Formula:C₅₉H₆₀F₂N₉O₁₃P
Colore e forma:Solid
Peso molecolare:1172.13
Ref: TM-T75099