Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 331 prodotti di "Segnalazione JAK/STAT"

Purezza (%)

100

prodotti per pagina.

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RO8191
CAS:
- 691868-88-9
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
Formula:C₁₄H₅F₆N₅O
Purezza:98% - 98.85%
Colore e forma:Solid
Peso molecolare:373.21
Ref: TM-T22142
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AG490
CAS:
- 133550-30-8
AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.
Formula:C₁₇H₁₄N₂O₃
Purezza:98.6% - 99.85%
Colore e forma:Yellow Solid
Peso molecolare:294.3
Ref: TM-T2600
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BMS-911543
CAS:
- 1271022-90-2
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
Formula:C₂₃H₂₈N₈O
Purezza:97.69% - 99.98%
Colore e forma:Solid
Peso molecolare:432.52
Ref: TM-T6790
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(Z)-LFM-A13
CAS:
- 244240-24-2
(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.
Formula:C₁₁H₈Br₂N₂O₂
Purezza:99.88%
Colore e forma:Solid
Peso molecolare:360
Ref: TM-T6217
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SMI-16a
CAS:
- 587852-28-6
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (
Formula:C₁₃H₁₃NO₃S
Purezza:99.99%
Colore e forma:Solid
Peso molecolare:263.31
Ref: TM-T3989
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Gandotinib
CAS:
- 1229236-86-5
LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).
Formula:C₂₃H₂₅ClFN₇O
Purezza:99.33% - 99.86%
Colore e forma:Solid
Peso molecolare:469.94
Ref: TM-T2638
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Peficitinib
CAS:
- 944118-01-8
Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
Formula:C₁₈H₂₂N₄O₂
Purezza:98.67% - 99.4%
Colore e forma:Solid
Peso molecolare:326.39
Ref: TM-T6933
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WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.
Formula:C₁₆H₁₄Br₂ClN₃O₃
Purezza:99.49%
Colore e forma:Solid
Peso molecolare:491.56
Ref: TM-T4657L
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Momelotinib HCl
CAS:
- 1380317-28-1
Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.
Formula:C₂₃H₂₄Cl₂N₆O₂
Colore e forma:Solid
Peso molecolare:487.38
Ref: TM-T70823
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Deucravacitinib
CAS:
- 1609392-27-9
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.
Formula:C₂₀H₁₉D₃N₈O₃
Purezza:98.52% - >99.99%
Colore e forma:Solid
Peso molecolare:425.46
Ref: TM-T14687
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Abrocitinib
CAS:
- 1622902-68-4
Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
Formula:C₁₄H₂₁N₅O₂S
Purezza:99.09% - 99.91%
Colore e forma:Solid
Peso molecolare:323.41
Ref: TM-TQ0037
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Protosappanin A
CAS:
- 102036-28-2
Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.
Formula:C₁₅H₁₂O₅
Purezza:99.42% - 99.82%
Colore e forma:Solid
Peso molecolare:272.25
Ref: TM-TJS1779
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Napabucasin
CAS:
- 83280-65-3
Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.
Formula:C₁₄H₈O₄
Purezza:98.43% - 99.85%
Colore e forma:Solid
Peso molecolare:240.21
Ref: TM-T3218
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Ritlecitinib
CAS:
- 1792180-81-4
Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.
Formula:C₁₅H₁₉N₅O
Purezza:98.82% - 99.92%
Colore e forma:Solid
Peso molecolare:285.34
Ref: TM-T5382
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Pacritinib hydrochloride
CAS:
- 1228923-43-0
Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.
Formula:C₂₈H₃₂N₄O₃·xClH
Colore e forma:Solid
Ref: TM-T64283
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Tofacitinib Citrate
CAS:
- 540737-29-9
Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).
Formula:C₂₂H₂₈N₆O₈
Purezza:99.19% - 99.75%
Colore e forma:Solid
Peso molecolare:504.49
Ref: TM-T2398
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Ruxolitinib (S enantiomer)
CAS:
- 941685-37-6
Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.
Formula:C₁₇H₁₈N₆
Purezza:99.37% - 99.79%
Colore e forma:Solid
Peso molecolare:306.36
Ref: TM-T6156
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Gusacitinib HCl
CAS:
- 2228989-14-6
Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.
Formula:C₂₄H₂₉ClN₈O₂
Colore e forma:Solid
Peso molecolare:497
Ref: TM-T69766
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AZD1208
CAS:
- 1204144-28-4
AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
Formula:C₂₁H₂₁N₃O₂S
Purezza:97.24% - 99.83%
Colore e forma:Solid
Peso molecolare:379.48
Ref: TM-T2300
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SHR0302
CAS:
- 1445987-21-2
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,
Formula:C₁₈H₂₂N₈O₂S
Purezza:99.11%
Colore e forma:Solid
Peso molecolare:414.48
Ref: TM-T9195