Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 331 prodotti di "Segnalazione JAK/STAT"

Purezza (%)

100

prodotti per pagina.

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Upadacitinib
CAS:
- 1310726-60-3
Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.
Formula:C₁₇H₁₉F₃N₆O
Purezza:98.96% - 99.94%
Colore e forma:Solid
Peso molecolare:380.37
Ref: TM-T7503
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GLPG0634 analog
CAS:
- 1206101-20-3
GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
Formula:C₂₃H₁₈N₆O₂
Purezza:99.52% - >99.99%
Colore e forma:Solid
Peso molecolare:410.43
Ref: TM-T3076
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Cerdulatinib
CAS:
- 1198300-79-6
Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.
Formula:C₂₀H₂₇N₇O₃S
Purezza:98.74% - 99.49%
Colore e forma:Solid
Peso molecolare:445.54
Ref: TM-T2487
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Pacritinib hydrochloride
CAS:
- 1228923-43-0
Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.
Formula:C₂₈H₃₂N₄O₃·xClH
Colore e forma:Solid
Ref: TM-T64283
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(Z)-LFM-A13
CAS:
- 244240-24-2
(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.
Formula:C₁₁H₈Br₂N₂O₂
Purezza:99.88%
Colore e forma:Solid
Peso molecolare:360
Ref: TM-T6217
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XL019
CAS:
- 945755-56-6
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.
Formula:C₂₅H₂₈N₆O₂
Purezza:99.19%
Colore e forma:Solid
Peso molecolare:444.53
Ref: TM-T3072
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Ruxolitinib phosphate
CAS:
- 1092939-17-7
Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.
Formula:C₁₇H₂₁N₆O₄P
Purezza:98% - >99.99%
Colore e forma:Solid
Peso molecolare:404.36
Ref: TM-T3043
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TP-3654
CAS:
- 1361951-15-6
TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).
Formula:C₂₂H₂₅F₃N₄O
Purezza:99.8% - 99.95%
Colore e forma:Solid
Peso molecolare:418.46
Ref: TM-T4523
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Fedratinib
CAS:
- 936091-26-8
Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.
Formula:C₂₇H₃₆N₆O₃S
Purezza:97.31% - 99.96%
Colore e forma:Solid
Peso molecolare:524.68
Ref: TM-T1995
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HJ-PI01
CAS:
- 6192-43-4
HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.
Formula:C₁₄H₁₁NO₂
Purezza:98.92%
Colore e forma:Solid
Peso molecolare:225.24
Ref: TM-T9583
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Cucurbitacin I
CAS:
- 2222-07-3
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
Formula:C₃₀H₄₂O₇
Purezza:96.69% - 99.8%
Colore e forma:Solid
Peso molecolare:514.65
Ref: TM-TQ0196
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RO495
CAS:
- 1258296-60-4
RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays
Formula:C₁₇H₁₄Cl₂N₆O
Purezza:97.94%
Colore e forma:Solid
Peso molecolare:389.24
Ref: TM-T22416
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BMS-911543
CAS:
- 1271022-90-2
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
Formula:C₂₃H₂₈N₈O
Purezza:97.69% - 99.98%
Colore e forma:Solid
Peso molecolare:432.52
Ref: TM-T6790
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FM-381
CAS:
- 2226521-65-7
FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.
Formula:C₂₄H₂₄N₆O₂
Purezza:98.44%
Colore e forma:Solid
Peso molecolare:428.49
Ref: TM-T5091
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Abrocitinib
CAS:
- 1622902-68-4
Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
Formula:C₁₄H₂₁N₅O₂S
Purezza:99.09% - 99.91%
Colore e forma:Solid
Peso molecolare:323.41
Ref: TM-TQ0037
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WHI-P154
CAS:
- 211555-04-3
WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.
Formula:C₁₆H₁₄BrN₃O₃
Purezza:98% - 99.67%
Colore e forma:Solid
Peso molecolare:376.2
Ref: TM-T1985
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AG490
CAS:
- 133550-30-8
AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.
Formula:C₁₇H₁₄N₂O₃
Purezza:98.6% - 99.85%
Colore e forma:Yellow Solid
Peso molecolare:294.3
Ref: TM-T2600
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Protosappanin A
CAS:
- 102036-28-2
Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.
Formula:C₁₅H₁₂O₅
Purezza:99.42% - 99.82%
Colore e forma:Solid
Peso molecolare:272.25
Ref: TM-TJS1779
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Deucravacitinib
CAS:
- 1609392-27-9
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.
Formula:C₂₀H₁₉D₃N₈O₃
Purezza:98.52% - >99.99%
Colore e forma:Solid
Peso molecolare:425.46
Ref: TM-T14687
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Niclosamide sodium
CAS:
- 40321-86-6
Niclosamide (BAY2353) sodium: oral antihelminthic, STAT3 inhibitor (IC50 0.25 μM), anti-cancer, and DNA replication blocker.
Formula:C₁₃H₇Cl₂N₂NaO₄
Colore e forma:Solid
Peso molecolare:349.1
Ref: TM-T72519