Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 330 prodotti di "Segnalazione JAK/STAT"

Purezza (%)

100

prodotti per pagina.

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SD-436
CAS:
- 2497585-50-7
SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 μM), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models.
Formula:C₅₈H₆₂F₄N₉O₁₄PS
Purezza:99.34%
Colore e forma:Solid
Peso molecolare:1248.2
Ref: TM-T203395
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Ilunocitinib
CAS:
- 1187594-14-4
Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.
Formula:C₁₇H₁₇N₇O₂S
Purezza:99.88%
Colore e forma:Solid
Peso molecolare:383.43
Ref: TM-T38571
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CHZ868
CAS:
- 1895895-38-1
CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.
Formula:C₂₂H₁₉F₂N₅O₂
Purezza:99.38%
Colore e forma:Solid
Peso molecolare:423.42
Ref: TM-TQ0061
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Itacitinib adipate
CAS:
- 1334302-63-4
Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.
Formula:C₃₂H₃₃F₄N₉O₅
Colore e forma:Solid
Peso molecolare:699.66
Ref: TM-T11687
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AK-1690
CAS:
- 2984505-88-4
AK-1690 is a potent and selective STAT6 PROTAC degrader that induces degradation of STAT6 proteins in cells and depletes STAT6 proteins in mouse tissues.
Formula:C₅₁H₅₆F₂N₅O₁₁PS
Purezza:99.95%
Colore e forma:Solid
Peso molecolare:1016.05
Ref: TM-T201032
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5,15-DPP
CAS:
- 22112-89-6
5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist with IC 50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively [1].
Formula:C₃₂H₂₂N₄
Colore e forma:Solid
Peso molecolare:462.54
Ref: TM-T21501
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Ifidancitinib
CAS:
- 1236667-40-5
Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.
Formula:C₂₀H₁₈FN₅O₃
Purezza:98.05%
Colore e forma:Solid
Peso molecolare:395.39
Ref: TM-T38623
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FLLL32
CAS:
- 1226895-15-3
FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
Formula:C₂₈H₃₂O₆
Purezza:97% - 97.90%
Colore e forma:Solid
Peso molecolare:464.55
Ref: TM-T6838
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Filgotinib
CAS:
- 1206161-97-8
Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
Formula:C₂₁H₂₃N₅O₃S
Purezza:98.03% - ≥95%
Colore e forma:Solid
Peso molecolare:425.5
Ref: TM-T1929
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RGB-286638 free base
CAS:
- 784210-88-4
RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.
Formula:C₂₉H₃₅N₇O₄
Purezza:98% - 99.91%
Colore e forma:Solid
Peso molecolare:545.63
Ref: TM-T2378
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ZM39923 hydrochloride
CAS:
- 1021868-92-7
ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.
Formula:C₂₃H₂₅NO·HCl
Purezza:98.05%
Colore e forma:Solid
Peso molecolare:367.91
Ref: TM-T6145
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SHR0302
CAS:
- 1445987-21-2
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,
Formula:C₁₈H₂₂N₈O₂S
Purezza:99.11%
Colore e forma:Solid
Peso molecolare:414.48
Ref: TM-T9195
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Ritlecitinib
CAS:
- 1792180-81-4
Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.
Formula:C₁₅H₁₉N₅O
Purezza:98.82% - 99.92%
Colore e forma:Solid
Peso molecolare:285.34
Ref: TM-T5382
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JAK3-IN-6
CAS:
- 1443235-95-7
JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM
Formula:C₁₉H₁₈N₄O₃
Purezza:99.94% - 99.94%
Colore e forma:Solid
Peso molecolare:350.37
Ref: TM-T5492
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Protosappanin A
CAS:
- 102036-28-2
Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.
Formula:C₁₅H₁₂O₅
Purezza:99.42% - 99.82%
Colore e forma:Solid
Peso molecolare:272.25
Ref: TM-TJS1779
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AG490
CAS:
- 133550-30-8
AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.
Formula:C₁₇H₁₄N₂O₃
Purezza:98.6% - 99.85%
Colore e forma:Yellow Solid
Peso molecolare:294.3
Ref: TM-T2600
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SAR-20347
CAS:
- 1450881-55-6
SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).
Formula:C₂₁H₁₈ClFN₄O₄
Purezza:98.99% - 99.77%
Colore e forma:Solid
Peso molecolare:444.84
Ref: TM-T4210
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RO8191
CAS:
- 691868-88-9
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
Formula:C₁₄H₅F₆N₅O
Purezza:98% - 98.85%
Colore e forma:Solid
Peso molecolare:373.21
Ref: TM-T22142
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SMI-16a
CAS:
- 587852-28-6
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (
Formula:C₁₃H₁₃NO₃S
Purezza:99.99%
Colore e forma:Solid
Peso molecolare:263.31
Ref: TM-T3989
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WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.
Formula:C₁₆H₁₄Br₂ClN₃O₃
Purezza:99.49%
Colore e forma:Solid
Peso molecolare:491.56
Ref: TM-T4657L