p38 MAPK

ITX5061 is a type II inhibitor of p38 MAPK. It also an antagonist of scavenger …

AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over …

(-)-vibo-Quercitol is a carbaglycosylamine glycosidase inhibitor.

AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows …

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.

SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is …

MW-150 is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active …

Doramapimod is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits …

FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury …

AL 8697 is a specific and orally active p38α MAPK inhibitor (IC50: 6 nM), 14-fold …

PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an …

RWJ-67657 is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and …

Obacunone has cytotoxicity in androgen-dependent human prostate Y cells. Obacunone exerts an antivirulence effect on …

SD 0006 is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment …

Rosin is a natural product,may have therapeutic potential for the treatment of inflammation

Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas …

Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used …

R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.

Talmapimod is a selective, orally active and ATP-competitive inhibitor of p38α(IC50 : 9 nM) .

Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits …

SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has …

Dehydrocorydaline chloride is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of …

Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 …

Acumapimod is an orally active inhibitor of p38α MAPK (IC50 <1 μM).

1. NSC 37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in …

AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.

p38α inhibitor 1 is an inhibitor of p38α .

Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum …

Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the …

Asiatic acid is the aglycone of asiaticoside used in wound healing with antioxidant, anti-inflammatory, and …

p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel …

PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.

Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows …

Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.

AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows …

VX-745, a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β …

8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory …

2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers …

BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 …

Losmapimod (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: …

(-)-Bornyl acetate is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop …

Andrograpanin is a bioactive compound from Andrographis paniculata. Andrograpanin has anti-inflammatory and anti-infectious properties.

1. Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) …

SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective …

SB 203580 is a p38 MAPK inhibitor (IC50: 0.3-0.5 μM). It shows more than 100-fold …

SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing …

SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, …

The BMS-582949 hydrochloride is a highly specific p38α MAPK inhibitor (IC50: 13 nM).

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with …

SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 …

SD 169 is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.

TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.

VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than …

SB 202190 is a selective and cell-permeable inhibitor of p38 MAPK (IC50s: 50/100 nM for …

Ralimetinib Mesylate is the dimesylate salt form of LY2228820, a tri-substituted imidazole derivative and orally …

R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.

PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold …