CFTR
CFTR è una proteina canale del cloruro che regola il trasporto di ioni cloruro e bicarbonato attraverso le membrane delle cellule epiteliali, svolgendo un ruolo cruciale nel mantenimento dell'equilibrio dei fluidi nei tessuti. Le mutazioni nel gene CFTR portano alla fibrosi cistica, un disturbo genetico caratterizzato dalla produzione di muco denso che può ostruire le vie respiratorie e causare gravi problemi respiratori e digestivi. Presso CymitQuimica, offriamo una selezione di modulatori CFTR per supportare la tua ricerca sulla fibrosi cistica, sul trasporto ionico e sui disturbi genetici.
Trovati 68 prodotti per "CFTR".
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Elexacaftor
CAS:Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.Formula:C26H34F3N7O4SPurezza:98.87% - 99.87%Colore e forma:SolidPeso molecolare:597.65Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurezza:99.05% - 99.75%Colore e forma:White SolidPeso molecolare:494.004WAY-326766
CAS:WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).Formula:C21H23N3O5Purezza:99.87%Colore e forma:SolidPeso molecolare:397.4244H2-Gamendazole
CAS:H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.Formula:C18H13Cl2F3N2O2Purezza:97.39%Colore e forma:SolidPeso molecolare:417.209Cavosonstat
CAS:Cavosonstat (N91115) is an oral GSNOR inhibitor aiding CFTR in cystic fibrosis.Formula:C16H10ClNO3Purezza:99.64%Colore e forma:Yellow SolidPeso molecolare:299.708CFTR activator 2
CAS:CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).Formula:C27H27N3O3Purezza:99.70%Colore e forma:SolidPeso molecolare:441.52Vanzacaftor
CAS:Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.Formula:C32H39N7O4SPurezza:99.14%Colore e forma:White SolidPeso molecolare:617.76Astressin 2B
CAS:CRF2 antagonist with IC50 of 1.3 nM; >500 nM for CRF1. Aids gastric emptying.Formula:C183H307N49O53Purezza:98%Colore e forma:SolidPeso molecolare:4041.69CP-628006
CAS:CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.Formula:C32H35F3N2O2Colore e forma:SolidPeso molecolare:536.639Urocortin III, mouse (free acid)
Urocortin III (mouse) is a CRF2 receptor agonist that slows gastric emptying without affecting colonic transit.Formula:C186H311N51S2Peso molecolare:4171.26(R)-Crinecerfont
CAS:4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomericFormula:C27H28ClFN2OSPurezza:98.51%Colore e forma:Orange SolidPeso molecolare:483.04kCAL01
CAS:kCAL01 is a CAL inhibitor with a Ki value of 2.3 μM and holds potential for research in cystic fibrosis (CF).Formula:C36H57N11O9Colore e forma:SolidPeso molecolare:787.91(Rac)-Tezacaftor
CAS:(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.Formula:C26H27F3N2O6Colore e forma:SolidPeso molecolare:520.5Crofelemer
CAS:Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.Colore e forma:SolidPGD97
CAS:PGD97 is a selective cyclic peptide inhibitor targeting the CAL/CFTR interaction, with its desulfurization-cyclized form exhibiting a KD value of 6 nM for the CAL PDZ domain. It shows a selectivity of at least 130-fold over the NHERF1/2 PDZ domains. PGD97 stabilizes F508del-CFTR on the cell membrane, enhancing CFTR function necessary for normal pulmonary fluid balance. This compound is applicable in cystic fibrosis research.Formula:C74H111N23O14S3Peso molecolare:1643.01Zatonacaftor
CAS:Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].Formula:C24H27N3O4SColore e forma:SolidPeso molecolare:453.55Crinecerfont hydrochloride
CAS:SSR-125543, a potent CRF1 receptor non-peptide antagonist, effective in CAH research, taken orally.Formula:C27H29Cl2FN2OSColore e forma:SolidPeso molecolare:519.501PPQ-102
CAS:PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Formula:C26H22N4O3Purezza:98.80% - ≥95%Colore e forma:Yellow SolidPeso molecolare:438.4779Glibenclamide potassium
CAS:Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.Formula:C23H27ClKN3O5SColore e forma:SolidPeso molecolare:532.09CFTR(inh)-172
CAS:CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.Formula:C18H10F3NO3S2Purezza:98% - 99.72%Colore e forma:SolidPeso molecolare:409.40
