Canale TRP/TRPV
canali TRP (Transient Receptor Potential), inclusa la sottofamiglia TRPV, sono un gruppo di canali ionici coinvolti in vari processi sensoriali, come la percezione della temperatura, la sensazione del dolore e l'osmoregolazione. I canali TRP sono ampiamente espressi in diversi tessuti e svolgono un ruolo nelle risposte fisiologiche agli stimoli ambientali. In particolare, i canali TRPV sono coinvolti nel rilevamento dei cambiamenti di temperatura e sono implicati in condizioni come il dolore cronico, l'infiammazione e il cancro. Presso CymitQuimica, offriamo una gamma completa di modulatori dei canali TRP/TRPV per supportare la tua ricerca in biologia sensoriale, gestione del dolore e trasduzione del segnale.
Trovati 112 prodotti per "Canale TRP/TRPV".
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TRPV4 agonist-1 free base
CAS:TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).Formula:C25H22F2N4O2Purezza:99.79%Colore e forma:SolidPeso molecolare:448.4646Vocacapsaicin hydrochloride
CAS:Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.Formula:C26H42ClN3O4Purezza:99.66% - 99.80%Colore e forma:SolidPeso molecolare:496.08BI-749327
CAS:BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).Formula:C23H21F3N4O2Purezza:99.68% - 99.84%Colore e forma:SolidPeso molecolare:442.4336IA-Alkyne
CAS:IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.Formula:C8H12INOPurezza:99.76%Colore e forma:White SolidPeso molecolare:265.091GFB-8438
CAS:GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).Formula:C16H14ClF3N4O2Purezza:99.58%Colore e forma:SolidPeso molecolare:386.76TRPM8 antagonist 3
CAS:TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).Formula:C13H12N2O4SPurezza:99.74%Colore e forma:White SolidPeso molecolare:292.31(Iso)-TRPV4 antagonist 5
CAS:(Iso)-TRPV4 antagonist 5 are selective oral TRPV4 blockers for pulmonary edema research.Formula:C25H27FN6O3Purezza:99.23% - 99.63%Peso molecolare:478.52PF-04745637
CAS:PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Formula:C27H32ClF3N2O2Purezza:98.39% - 98.88%Colore e forma:SolidPeso molecolare:509.003CBP-1018
CAS:CBP-1018 is a peptide-drug conjugate (PDC) composed of a dual-targeting ligand for FRα/TRPV6, linked to Monomethylauristatin E. It holds promise for research in the field of breast cancer.Formula:C132H192N30O38SPeso molecolare:2839.18(S)-ABT 102
CAS:N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Formula:C21H24N4OPurezza:99.65% - 99.77%Colore e forma:White SolidPeso molecolare:348.4415TRPV4 antagonist 5
CAS:TRPV4 antagonist 5(GSK2798745 derivatives) are solid-form derivatives of GSK2798745, selective TRPV4 blockers and antagonists for cardiac and respiratory disorders.Formula:C25H27PN6O3Purezza:98.80% - 99.40%Colore e forma:Yellow SolidPeso molecolare:478.53L-R4W2
CAS:Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.Formula:C46H71N21O6Purezza:98%Colore e forma:SolidPeso molecolare:1014.2CBP-1008
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.Colore e forma:Odour SolidCyclic ADP-Ribose (ammonium salt)
Cyclic ADP-Ribose (ammonium salt) (cADPR) is an NAD⁺ metabolite that triggers Ca²⁺ release from ER stores via ryanodine receptors, relevant to inflammation research.Formula:C15H21N5O13P2·xNH3Colore e forma:White SolidTRPV1 antagonist 6
TRPV1 antagonist 6 (compound 51) is a modality-selective TRPV1 antagonist that exhibits antagonistic activity against capsaicin activation with an IC50 of 2.85 nM and demonstrates an inhibition rate of 28.48% against proton activation at a concentration of 3 µM.Formula:C26H28ClN5O3Peso molecolare:493.18807TRPA1-IN-2
CAS:TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.Formula:C24H25F3N4OPurezza:98.93%Colore e forma:SoildPeso molecolare:442.4767RN-1665
CAS:RN-1665 is a potent and selective TRPV4 receptor antagonist.Formula:C20H24F5N3O3S2Purezza:99.96%Colore e forma:SoildPeso molecolare:513.54Oleoyl Serotonin
CAS:Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.Formula:C28H44N2O2Purezza:99.88%Colore e forma:SolidPeso molecolare:440.6612AP 18
CAS:AP-18 is a potent and selective TRPA1 inhibitor.Formula:C11H12ClNOPurezza:99.76% - 99.96%Colore e forma:SolidPeso molecolare:209.67NGD-8243
CAS:NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for preventionFormula:C21H12F6N4Purezza:95.26%Colore e forma:White SolidPeso molecolare:434.3372
