Canale TRP/TRPV
canali TRP (Transient Receptor Potential), inclusa la sottofamiglia TRPV, sono un gruppo di canali ionici coinvolti in vari processi sensoriali, come la percezione della temperatura, la sensazione del dolore e l'osmoregolazione. I canali TRP sono ampiamente espressi in diversi tessuti e svolgono un ruolo nelle risposte fisiologiche agli stimoli ambientali. In particolare, i canali TRPV sono coinvolti nel rilevamento dei cambiamenti di temperatura e sono implicati in condizioni come il dolore cronico, l'infiammazione e il cancro. Presso CymitQuimica, offriamo una gamma completa di modulatori dei canali TRP/TRPV per supportare la tua ricerca in biologia sensoriale, gestione del dolore e trasduzione del segnale.
Trovati 96 prodotti di "Canale TRP/TRPV"
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BTD
CAS:BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.Formula:C24H33N3O4SColore e forma:SolidPeso molecolare:459.6Phenazopyridine
CAS:Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections,. against SARM1 and TRPM8.Formula:C11H11N5Purezza:99.98%Colore e forma:SolidPeso molecolare:213.24JNJ-17203212
CAS:JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).Formula:C17H15F6N5OPurezza:99.18%Colore e forma:SolidPeso molecolare:419.32HC067047 Hydrochloride(883031-03-6 free base)
CAS:HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.Formula:C26H29ClF3N3O2Purezza:99.95%Colore e forma:SolidPeso molecolare:507.98Ref: TM-T4680L
1mg88,00€5mg172,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)217,00€ML204 hydrochloride
CAS:ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.Formula:C15H19ClN2Colore e forma:SolidPeso molecolare:262.78MK6-83
CAS:MK6-83 is the transient receptor potential channel ML3 agonist.Formula:C16H20N2O2S2Purezza:99.5%Colore e forma:SolidPeso molecolare:336.47RQ-00203078
CAS:RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.Formula:C21H13ClF6N2O5SPurezza:98% - 99.6%Colore e forma:SolidPeso molecolare:554.85A-967079
CAS:A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively
Formula:C12H14FNOPurezza:98.34% - 99.75%Colore e forma:SolidPeso molecolare:207.24HC-030031
CAS:HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.Formula:C18H21N5O3Purezza:99.69% - ≥95%Colore e forma:SolidPeso molecolare:355.39Evifacotrep
CAS:Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).Formula:C18H12ClF4N5O2Purezza:98.6%Colore e forma:SolidPeso molecolare:441.77Ref: TM-T40042
1mg92,00€5mg178,00€10mg286,00€25mg440,00€50mg655,00€100mg973,00€200mg1.468,00€1mL*10mM (DMSO)152,00€WS-12
CAS:WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)Formula:C18H27NO2Purezza:99.99%Colore e forma:Whitish To White Solid CrystallinePeso molecolare:289.41Chembridge-5861528
CAS:Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.Formula:C19H23N5O3Purezza:99.97%Colore e forma:SolidPeso molecolare:369.42GSK2193874
CAS:GSK2193874 was identified as a selective, orally active TRPV4 blocker.Formula:C37H38BrF3N4OPurezza:99.99% - ≥95%Colore e forma:SolidPeso molecolare:691.62Ref: TM-T5640
1mg43,00€2mg57,00€5mg81,00€10mg127,00€25mg246,00€50mg404,00€100mg602,00€1mL*10mM (DMSO)111,00€Pyr10
CAS:Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.Formula:C18H13F6N3O2SPurezza:99.69% - 99.7%Colore e forma:SolidPeso molecolare:449.37Pico145
CAS:Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.Formula:C23H20ClF3N4O5Purezza:99.06%Colore e forma:SolidPeso molecolare:524.88Ref: TM-T16532
1mg70,00€5mg150,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg1.009,00€1mL*10mM (DMSO)167,00€Ononetin
CAS:Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).Formula:C15H14O4Purezza:98.06%Colore e forma:SolidPeso molecolare:258.27TRPM4-IN-1
CAS:TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.Formula:C15H11Cl2NO4Purezza:97.22%Colore e forma:SolidPeso molecolare:340.16AMG 333
CAS:AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Formula:C20H12F5N3O4Purezza:99.95%Colore e forma:SolidPeso molecolare:453.32PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.
Formula:C26H38N6O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:466.629-Phenanthrol
CAS:9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.Formula:C14H10OPurezza:98.48%Colore e forma:SolidPeso molecolare:194.23
