Canale del potassio
I canali del potassio sono un gruppo diversificato di proteine di membrana che facilitano il flusso di ioni potassio (K+) attraverso la membrana cellulare. Questi canali svolgono un ruolo cruciale nel mantenimento del potenziale di membrana a riposo, nella regolazione del volume cellulare e nel controllo dell'eccitabilità dei neuroni e delle cellule muscolari. I canali del potassio sono coinvolti in vari processi fisiologici, tra cui la regolazione del ritmo cardiaco, la secrezione di insulina e il rilascio di neurotrasmettitori. La disfunzione dei canali del potassio è legata a condizioni come aritmie, epilessia e ipertensione. Presso CymitQuimica, offriamo una vasta gamma di modulatori dei canali del potassio per supportare la tua ricerca in elettrofisiologia, salute cardiovascolare e neurobiologia.
Trovati 280 prodotti di "Canale del potassio"
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Propafenone
CAS:<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Formula:C21H27NO3Purezza:99.02%Colore e forma:SolidPeso molecolare:341.44Ropivacaine
CAS:Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.Formula:C17H26N2OPurezza:97.75% - >99.99%Colore e forma:SolidPeso molecolare:274.40VU6036720
<p>VU6036720 is a potent and selective inhibitor of the isomeric Kir4.1/5.1.VU6036720 inhibits Kir4.1/5.1 activity by decreasing the channel open-circuit</p>Formula:C20H22ClFN4O2SPurezza:98.1%Colore e forma:SoildPeso molecolare:436.93Quinine
CAS:Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria.Formula:C20H24N2O2Purezza:99.93% - 99.97%Colore e forma:White Solid PowderPeso molecolare:324.42ML418
CAS:ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.Formula:C19H24ClN3O3Purezza:99.3%Colore e forma:SolidPeso molecolare:377.87Flindokalner
CAS:Flindokalner (BMS-204352) modulates potassium channels, enhances Kv7 subtypes and BKca, inhibits Kv7.1 (Ki=3.7μM), GABAA; has anxiolytic effects in vivo.Formula:C16H10ClF4NO2Purezza:99.96%Colore e forma:SolidPeso molecolare:359.7Proflavine Hemisulfate
CAS:<p>Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt of proflavine, an acridine-derived fluorescent contrast and disinfectant agent.</p>Formula:C13H12N3O2S0Purezza:99.55%Colore e forma:Orange To Red PowderPeso molecolare:258.291-EBIO
CAS:1-EBIO (1-EBIO) is a calium channel agonist.Formula:C9H10N2OPurezza:98.75%Colore e forma:SolidPeso molecolare:162.19Astemizole
CAS:<p>Astemizole (Laridal) is a long-acting antihistamine for allergies like rhinitis and asthma, with fewer anticholinergic effects.</p>Formula:C28H31FN4OPurezza:98.24% - 99.67%Colore e forma:White Crystals SolidPeso molecolare:458.57Tipepidine hydrochloride
CAS:Tipepidine hydrochloride: reversible DA D2 receptor inhibitor, IC50 7.0 μM, with antidepressant effects.Formula:C15H18ClNS2Purezza:99.97%Colore e forma:SolidPeso molecolare:311.89Ropivacaine hydrochloride
CAS:Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activityFormula:C17H26N2O·HClPurezza:99.85% - 99.95%Colore e forma:SolidPeso molecolare:310.86NS8593 hydrochloride
CAS:NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .Formula:C17H18ClN3Purezza:99.77%Colore e forma:SolidPeso molecolare:299.8Topiramate
CAS:<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>Formula:C12H21NO8SPurezza:99.79% - 99.92%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:339.36BMS-191095
CAS:BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.Formula:C22H21ClN4O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:408.88Nicorandil
CAS:Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system.Formula:C8H9N3O4Purezza:98.14% - >99.99%Colore e forma:White Or Off-White PowderPeso molecolare:211.17Indapamide
CAS:Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.Formula:C16H16ClN3O3SPurezza:98.97% - 99.83%Colore e forma:SolidPeso molecolare:365.83AZD 7009
CAS:<p>AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM.</p>Formula:C23H34N4O5Purezza:98.42% - 98.51%Colore e forma:SoildPeso molecolare:446.54Linoleoyl glycine
CAS:<p>Linoleoyl glycine activates hKCNQ1/hKCNE1 channels, has analgesic properties, and is found in skin, spinal cord, and brain.</p>Formula:C20H35NO3Purezza:98.96%Colore e forma:SolidPeso molecolare:337.5DCPIB
CAS:<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>Formula:C22H28Cl2O4Purezza:99.79% - 99.87%Colore e forma:SolidPeso molecolare:427.36Gliclazide
CAS:<p>Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the</p>Formula:C15H21N3O3SPurezza:99.58%Colore e forma:SolidPeso molecolare:323.41Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Formula:C17H16F6N2OPurezza:99.89%Colore e forma:SolidPeso molecolare:378.31Oxybutynin
CAS:Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.Formula:C22H31NO3Purezza:97.81% - 99.57%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:357.49Rosuvastatin calcium
CAS:Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemicFormula:(C22H27FN3O6S)CaPurezza:98.21% - 99.68%Colore e forma:White To Off-White Crystalline SolidPeso molecolare:1001.14VU591 hydrochloride
CAS:VU591 hydrochloride is a selective Kir1.1 (ROMK) blocker with IC50 of 0.24 μM, not affecting Kir7.1, Kir2.1, Kir2.3, or Kir4.1, similar to VU 590.Formula:C16H13ClN6O5Purezza:98.93% - 99.22%Colore e forma:SolidPeso molecolare:404.76Brompheniramine maleate
CAS:Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.Formula:C16H19BrN2·C4H4O4Purezza:99.80%Colore e forma:Crystal PowderPeso molecolare:435.31Bupivacaine hydrochloride
CAS:Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.Formula:C18H28N2O·HClPurezza:99.89% - 99.9%Colore e forma:SolidPeso molecolare:324.89Hydrochlorothiazide
CAS:<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Formula:C7H8ClN3O4S2Purezza:99.43% - 99.50%Colore e forma:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Peso molecolare:297.74Oxybutynin chloride
CAS:Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties.Formula:C22H32ClNO3Purezza:99.27% - >99.99%Colore e forma:White PowderPeso molecolare:393.96DCEBIO
CAS:<p>DCEBIO, a 1-EBIO derivative, enhances Cl- secretion via hIK1 K+ channel and apical conductance in T84 cells.</p>Formula:C9H8Cl2N2OPurezza:99.89%Colore e forma:SolidPeso molecolare:231.08Tolbutamide
CAS:Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.Formula:C12H18N2O3SPurezza:99.80% - 99.93%Colore e forma:White Crystalline PowderPeso molecolare:270.35Ifenprodil Tartrate
CAS:Ifenprodil is a selective NMDA receptor (glutamate) antagonist.Formula:C21H27NO2C4H6O6Purezza:99.02% - 99.55%Colore e forma:SolidPeso molecolare:400.49VU591
CAS:VU591 is a selective extra-renal potassium channel inhibitor with an IC₅₀ of 0.24 μM.Formula:C16H12N6O5Purezza:99.29% - 99.53%Colore e forma:SolidPeso molecolare:368.3Doxapram hydrochloride hydrate
CAS:Doxapram hydrochloride hydrate (Doxapram HCl) inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 0.41, 37, 9 μM, respectively.Formula:C24H33ClN2O3C24H30N2O2·ClH·H2OPurezza:99.64% - >99.99%Colore e forma:SolidPeso molecolare:432.99Halothane
CAS:Halothane (Anestan) 可以减弱内皮依赖性舒张作用。Formula:C2HBrClF3Purezza:99.80% - >99.99%Colore e forma:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustiblePeso molecolare:197.38Tannic acid
CAS:Tannic acid (Gallotannic acid) is a novel hERG channel blocker.Formula:C76H52O46Purezza:AR - ARColore e forma:Light Yellow To Light Brown Solid Solid Particulate/PowderPeso molecolare:1701.24-Aminopyridine
CAS:4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side of the cell membrane.Formula:C5H6N2Purezza:91.61%Colore e forma:SolidPeso molecolare:94.11N-Acetylprocainamide
CAS:N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmicFormula:C15H23N3O2Purezza:99.65% - 99.74%Colore e forma:SolidPeso molecolare:277.36NS3623
CAS:NS3623 is an activator of human ether-a-go-go-related gene potassium channels.Formula:C15H10BrF3N6OPurezza:97.06%Colore e forma:SolidPeso molecolare:427.18Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Formula:C23H28ClN3O7Purezza:99.28% - >99.99%Colore e forma:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecolare:493.94Minoxidil
CAS:Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.Formula:C9H15N5OPurezza:99.885% - >99.99%Colore e forma:Crystals From Methanol-Acetonitrile SolidPeso molecolare:209.25Terfenadine
CAS:Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.Formula:C32H41NO2Purezza:98.76% - 99.75%Colore e forma:SolidPeso molecolare:471.67Repaglinide
CAS:Repaglinide, a benzoic acid derivative, stimulates insulin, treats type 2 diabetes, and may rarely cause acute liver injury.Formula:C27H36N2O4Purezza:99.73% - >99.99%Colore e forma:White To Off-White SolidPeso molecolare:452.59Linopirdine
CAS:Linopirdine (DuP 996) is a TRPV1 agonist.Formula:C26H21N3OPurezza:99.45% - 99.78%Colore e forma:SolidPeso molecolare:391.46Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurezza:99.05% - 99.75%Colore e forma:SolidPeso molecolare:494.00Butamben
CAS:Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.Formula:C11H15NO2Purezza:99.43%Colore e forma:Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Peso molecolare:193.24Clofilium tosylate
CAS:<p>Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.</p>Formula:C28H44ClNO3SPurezza:99.68%Colore e forma:SolidPeso molecolare:510.17Dequalinium chloride
CAS:<p>Dequalinium chloride: topical bacteriostat, blocks apamin-sensitive K+ channels, used for wounds, oral infections, potential antifungal, risk of skin ulcers.</p>Formula:C30H40Cl2N4Purezza:99.79% - 99.9%Colore e forma:SolidPeso molecolare:527.59NS19504
CAS:NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM.Formula:C10H9BrN2SPurezza:99.87%Colore e forma:SolidPeso molecolare:269.16Amiodarone hydrochloride
CAS:Amiodarone HCl: Antianginal, class III antiarrhythmic. Lengthens heart muscle action, slows heart rate, reduces vascular resistance.Formula:C25H29I2NO3·HClPurezza:99.82% - ≥95%Colore e forma:White To Cream Crystalline PowderPeso molecolare:681.78Glipizide
CAS:Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.Formula:C21H27N5O4SPurezza:99.67% - 99.75%Colore e forma:SolidPeso molecolare:445.54NS13001
CAS:<p>NS13001, an oral SK channel modulator, shows promise for SCA2 therapy; EC50: 1.8 µM (SK2), 0.14 µM (SK3).</p>Formula:C17H16ClN7Purezza:99.55%Colore e forma:SolidPeso molecolare:353.81Disopyramide
CAS:Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.Formula:C21H29N3OPurezza:99.62%Colore e forma:SolidPeso molecolare:339.47Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurezza:99% - 99.99%Colore e forma:Off-White To Yellow SolidPeso molecolare:414.77Quinidine hydrochloride monohydrate
CAS:Quinidine hydrochloride monohydrate is an optical isomer of quinine. Quinidine prolongs cellular action potential and decreases automaticity.Formula:C20H27ClN2O3Purezza:94.4% - 99.68%Colore e forma:SolidPeso molecolare:378.89Dronedarone hydrochloride
CAS:Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5S·HClPurezza:99.61%Colore e forma:SolidPeso molecolare:593.22Diazoxide
CAS:Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.Formula:C8H7ClN2O2SPurezza:99% - 99.83%Colore e forma:SolidPeso molecolare:230.67BMS-394136
CAS:BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.Formula:C24H21Cl2FN4OPurezza:98.59% - 99.95%Colore e forma:SolidPeso molecolare:471.35ICA-27243
CAS:<p>ICA-27243: Potent KCNQ2/Q3 opener, oral, EC50 0.38 μM; less effective on KCNQ4, KCNQ3/Q5; antiepileptic.</p>Formula:C12H7ClF2N2OPurezza:99.54%Colore e forma:SolidPeso molecolare:268.65VU0134992 hydrochloride
CAS:VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 μM).Formula:C20H32BrClN2O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:447.84IK1 inhibitor PA-6
CAS:IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouseFormula:C31H32N4O2Purezza:98.9%Colore e forma:SolidPeso molecolare:492.61NS5806
CAS:NS5806 activates K+ currents, slows KV4.2/4.3 decay with KChIP2, and boosts KV4.3/KChIP2 peaks (EC50=5.3μM).Formula:C16H8Br2F6N6OPurezza:97.95%Colore e forma:SolidPeso molecolare:574.07Flufenamic acid
CAS:<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Formula:C14H10F3NO2Purezza:98.68%Colore e forma:White To Light Yellow Crystalline PowderPeso molecolare:281.23Eleclazine hydrochloride
CAS:Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).Formula:C21H17ClF3N3O3Purezza:99.86%Colore e forma:SolidPeso molecolare:451.83Ketanserin
CAS:Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.Formula:C22H22FN3O3Purezza:99.19% - 99.73%Colore e forma:SolidPeso molecolare:395.43Hydroxyhexamide
CAS:Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.Formula:C15H22N2O4SPurezza:98.91%Colore e forma:SolidPeso molecolare:326.41Cloperastine hydrochloride
CAS:<p>Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.</p>Formula:C20H25Cl2NOPurezza:97.74% - 99.42%Colore e forma:SolidPeso molecolare:366.33ADWX 1 TFA
ADWX 1 TFA is a novel peptide that potently targets and inhibits the Kv1.3 channel, with an IC50 of 1.89 pM. It specifically suppresses the activity of the Kv1.3 channel, in addition to inhibiting initial calcium signaling and NF-κB activation. This compound has been shown to ameliorate symptoms in rats with experimental autoimmune encephalomyelitis (EAE). ADWX 1 TFA is utilized in research focused on T-cell-mediated autoimmune diseases.Formula:C169H281N57O46S7·xC2HF3O2Colore e forma:SolidPeso molecolare:4071.85 (free base)ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Formula:C169H281N57O46S7Purezza:98%Colore e forma:SolidPeso molecolare:4071.86Potassium Channel Targeted Library
A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;Colore e forma:Odour SolidIon Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Colore e forma:Odour SolidTertiapin LQ
Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.Formula:C106H179N33O24S4Purezza:98%Colore e forma:SolidPeso molecolare:2428.03Aekatperone
Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).Formula:C20H25N5O2SColore e forma:SolidPeso molecolare:399.51GsAF-I
GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28Formula:C160H244N46O42S7Purezza:98%Colore e forma:SolidPeso molecolare:3708.39Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Purezza:96.97%Colore e forma:SolidPhe-Met-Arg-Phe amide trifluoroacetate
CAS:Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.Formula:C33H44F6N8O8SPurezza:98%Colore e forma:SolidPeso molecolare:826.81Dalazatide HCl
Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,Colore e forma:SolidPeso molecolare:4317.53 (Free base)Foslevcromakalim
CAS:Foslevcromakalim (QLS-101) is an KATP opener, converted to its active form by alkaline phosphatase in vivo, reduces intraocular pressure in normotensive mice.Formula:C16H19N2O6PColore e forma:SolidPeso molecolare:366.31Lei-Dab7 TFA
Lei-Dab7 TFA blocks SK2 channels with 3.8 nM affinity, is >200x selective, and enhances LTP in rat hippocampus.Formula:C143H237F3N46O41S6Colore e forma:SolidPeso molecolare:3506.08Ebio2
Ebio2 is an effective activator of KCNQ2.Formula:C17H19F2N3O2Colore e forma:SolidPeso molecolare:335.349Tertiapin
CAS:Tertiapin (reduced) is a synthetic bee venom peptide characterized by disulfide bonds between Cys3-Cys14 and Cys5-Cys18. It acts as an inhibitor of inward-rectifying potassium channels (potassium Channel) and can also block the activity of calcium-activated large conductance potassium channels. Tertiapin (reduced) is utilized in research related to diseases such as rheumatoid arthritis and multiple sclerosis.Formula:C106H180N34O23S5Colore e forma:SolidPeso molecolare:2459.1BeKm-1
CAS:Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.Formula:C174H261N51O52S6Purezza:98%Colore e forma:SolidPeso molecolare:4091.65ShK-Dap22
CAS:Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Formula:C166H268N54O48S7Purezza:98%Colore e forma:SolidPeso molecolare:4012.7Guangxitoxin 1E
CAS:Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.Formula:C178H248N44O45S7Purezza:98%Colore e forma:SolidPeso molecolare:3948.61Phe-Met-Arg-Phe, amide
CAS:Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.Formula:C29H42N8O4SPurezza:98%Colore e forma:SolidPeso molecolare:598.76Pinacidil monohydrate
CAS:Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.Formula:C13H21N5OPurezza:99.94% - 99.98%Colore e forma:PowderPeso molecolare:263.34MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.Formula:C22H21N7O3SColore e forma:SolidPeso molecolare:463.512Lei-Dab7
CAS:Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Formula:C141H236N46O39S6Purezza:98%Colore e forma:SolidPeso molecolare:3392.06GsAF-II
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodiumFormula:C176H261N47O45S7Purezza:98%Colore e forma:SolidPeso molecolare:3979.7Heteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Formula:C168H238N46O51S6Purezza:98%Colore e forma:SolidPeso molecolare:3910.35AmmTX3
KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.Formula:C158H262N50O48S6Purezza:98%Colore e forma:SolidPeso molecolare:3822.47Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formula:C19H23F2N3O2Colore e forma:SolidPeso molecolare:363.4Dendrotoxin K
CAS:Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.Formula:C294H462N84O75S6Colore e forma:SolidPeso molecolare:6559.66BKCa activator-1
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.Formula:C22H23F7N2O3Colore e forma:SolidPeso molecolare:496.418Guanfu base A
CAS:Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.Formula:C24H31NO6Purezza:99.71% - 99.85%Colore e forma:SolidPeso molecolare:429.5HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formula:C337H503N103O97S6Peso molecolare:7736.59176Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Formula:C179H274N50O55S7Purezza:98%Colore e forma:SolidPeso molecolare:4230Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Formula:C169H278N54O48S8Purezza:98%Colore e forma:SolidPeso molecolare:4090.87Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Formula:C79H131N31O24S4Purezza:98%Colore e forma:SolidPeso molecolare:2027.34Charybdotoxin
CAS:Specific inhibitor of the big conductance Ca2+-activated K+ channel.Formula:C176H277N57O55S7Purezza:98%Colore e forma:SolidPeso molecolare:4295.95Margatoxin
CAS:KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.Formula:C178H286N52O50S7Purezza:98%Colore e forma:SolidPeso molecolare:4178.96
