Canale del potassio
I canali del potassio sono un gruppo diversificato di proteine di membrana che facilitano il flusso di ioni potassio (K+) attraverso la membrana cellulare. Questi canali svolgono un ruolo cruciale nel mantenimento del potenziale di membrana a riposo, nella regolazione del volume cellulare e nel controllo dell'eccitabilità dei neuroni e delle cellule muscolari. I canali del potassio sono coinvolti in vari processi fisiologici, tra cui la regolazione del ritmo cardiaco, la secrezione di insulina e il rilascio di neurotrasmettitori. La disfunzione dei canali del potassio è legata a condizioni come aritmie, epilessia e ipertensione. Presso CymitQuimica, offriamo una vasta gamma di modulatori dei canali del potassio per supportare la tua ricerca in elettrofisiologia, salute cardiovascolare e neurobiologia.
Trovati 280 prodotti di "Canale del potassio"
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VU6036720
<p>VU6036720 is a potent and selective inhibitor of the isomeric Kir4.1/5.1.VU6036720 inhibits Kir4.1/5.1 activity by decreasing the channel open-circuit</p>Formula:C20H22ClFN4O2SPurezza:98.1%Colore e forma:SoildPeso molecolare:436.93VU591
CAS:VU591 is a selective extra-renal potassium channel inhibitor with an IC₅₀ of 0.24 μM.Formula:C16H12N6O5Purezza:99.29% - 99.53%Colore e forma:SolidPeso molecolare:368.3Cloperastine hydrochloride
CAS:<p>Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.</p>Formula:C20H25Cl2NOPurezza:97.74% - 99.42%Colore e forma:SolidPeso molecolare:366.334-Aminopyridine
CAS:4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side of the cell membrane.Formula:C5H6N2Purezza:91.61%Colore e forma:SolidPeso molecolare:94.11Hydrochlorothiazide
CAS:<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Formula:C7H8ClN3O4S2Purezza:99.43% - 99.50%Colore e forma:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Peso molecolare:297.74Repaglinide
CAS:Repaglinide, a benzoic acid derivative, stimulates insulin, treats type 2 diabetes, and may rarely cause acute liver injury.Formula:C27H36N2O4Purezza:99.73% - >99.99%Colore e forma:White To Off-White SolidPeso molecolare:452.59Halothane
CAS:Halothane (Anestan) 可以减弱内皮依赖性舒张作用。Formula:C2HBrClF3Purezza:99.80% - >99.99%Colore e forma:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustiblePeso molecolare:197.38Oxybutynin
CAS:Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.Formula:C22H31NO3Purezza:97.81% - 99.57%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:357.49Butamben
CAS:Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.Formula:C11H15NO2Purezza:99.43%Colore e forma:Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Peso molecolare:193.24Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Formula:C17H16F6N2OPurezza:99.89%Colore e forma:SolidPeso molecolare:378.31N-Acetylprocainamide
CAS:N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmicFormula:C15H23N3O2Purezza:99.65% - 99.74%Colore e forma:SolidPeso molecolare:277.36VU591 hydrochloride
CAS:VU591 hydrochloride is a selective Kir1.1 (ROMK) blocker with IC50 of 0.24 μM, not affecting Kir7.1, Kir2.1, Kir2.3, or Kir4.1, similar to VU 590.Formula:C16H13ClN6O5Purezza:98.93% - 99.22%Colore e forma:SolidPeso molecolare:404.76Ifenprodil Tartrate
CAS:Ifenprodil is a selective NMDA receptor (glutamate) antagonist.Formula:C21H27NO2C4H6O6Purezza:99.02% - 99.55%Colore e forma:SolidPeso molecolare:400.49Glipizide
CAS:Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.Formula:C21H27N5O4SPurezza:99.67% - 99.75%Colore e forma:SolidPeso molecolare:445.54Diazoxide
CAS:Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.Formula:C8H7ClN2O2SPurezza:99% - 99.83%Colore e forma:SolidPeso molecolare:230.67Amiodarone hydrochloride
CAS:Amiodarone HCl: Antianginal, class III antiarrhythmic. Lengthens heart muscle action, slows heart rate, reduces vascular resistance.Formula:C25H29I2NO3·HClPurezza:99.82% - ≥95%Colore e forma:White To Cream Crystalline PowderPeso molecolare:681.78Astemizole
CAS:<p>Astemizole (Laridal) is a long-acting antihistamine for allergies like rhinitis and asthma, with fewer anticholinergic effects.</p>Formula:C28H31FN4OPurezza:98.24% - 99.67%Colore e forma:White Crystals SolidPeso molecolare:458.57Rosuvastatin calcium
CAS:Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemicFormula:(C22H27FN3O6S)CaPurezza:98.21% - 99.68%Colore e forma:White To Off-White Crystalline SolidPeso molecolare:1001.14NS8593 hydrochloride
CAS:NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .Formula:C17H18ClN3Purezza:99.77%Colore e forma:SolidPeso molecolare:299.8Bupivacaine hydrochloride
CAS:Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.Formula:C18H28N2O·HClPurezza:99.89% - 99.9%Colore e forma:SolidPeso molecolare:324.89NS13001
CAS:<p>NS13001, an oral SK channel modulator, shows promise for SCA2 therapy; EC50: 1.8 µM (SK2), 0.14 µM (SK3).</p>Formula:C17H16ClN7Purezza:99.55%Colore e forma:SolidPeso molecolare:353.81Quinidine hydrochloride monohydrate
CAS:Quinidine hydrochloride monohydrate is an optical isomer of quinine. Quinidine prolongs cellular action potential and decreases automaticity.Formula:C20H27ClN2O3Purezza:94.4% - 99.68%Colore e forma:SolidPeso molecolare:378.89Dequalinium chloride
CAS:<p>Dequalinium chloride: topical bacteriostat, blocks apamin-sensitive K+ channels, used for wounds, oral infections, potential antifungal, risk of skin ulcers.</p>Formula:C30H40Cl2N4Purezza:99.79% - 99.9%Colore e forma:SolidPeso molecolare:527.59Minoxidil
CAS:Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.Formula:C9H15N5OPurezza:99.885% - >99.99%Colore e forma:Crystals From Methanol-Acetonitrile SolidPeso molecolare:209.251-EBIO
CAS:1-EBIO (1-EBIO) is a calium channel agonist.Formula:C9H10N2OPurezza:98.75%Colore e forma:SolidPeso molecolare:162.19Linoleoyl glycine
CAS:<p>Linoleoyl glycine activates hKCNQ1/hKCNE1 channels, has analgesic properties, and is found in skin, spinal cord, and brain.</p>Formula:C20H35NO3Purezza:98.96%Colore e forma:SolidPeso molecolare:337.5VU0134992 hydrochloride
CAS:VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 μM).Formula:C20H32BrClN2O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:447.84NS3623
CAS:NS3623 is an activator of human ether-a-go-go-related gene potassium channels.Formula:C15H10BrF3N6OPurezza:97.06%Colore e forma:SolidPeso molecolare:427.18Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurezza:99% - 99.99%Colore e forma:Off-White To Yellow SolidPeso molecolare:414.77Dronedarone hydrochloride
CAS:Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5S·HClPurezza:99.61%Colore e forma:SolidPeso molecolare:593.22Propafenone
CAS:<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Formula:C21H27NO3Purezza:99.02%Colore e forma:SolidPeso molecolare:341.44Linopirdine
CAS:Linopirdine (DuP 996) is a TRPV1 agonist.Formula:C26H21N3OPurezza:99.45% - 99.78%Colore e forma:SolidPeso molecolare:391.46Topiramate
CAS:<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>Formula:C12H21NO8SPurezza:99.79% - 99.92%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:339.36Terfenadine
CAS:Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.Formula:C32H41NO2Purezza:98.76% - 99.75%Colore e forma:SolidPeso molecolare:471.67Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Formula:C23H28ClN3O7Purezza:99.28% - >99.99%Colore e forma:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecolare:493.94Gliclazide
CAS:<p>Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the</p>Formula:C15H21N3O3SPurezza:99.58%Colore e forma:SolidPeso molecolare:323.41ML418
CAS:ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.Formula:C19H24ClN3O3Purezza:99.3%Colore e forma:SolidPeso molecolare:377.87NS19504
CAS:NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM.Formula:C10H9BrN2SPurezza:99.87%Colore e forma:SolidPeso molecolare:269.16Brompheniramine maleate
CAS:Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.Formula:C16H19BrN2·C4H4O4Purezza:99.80%Colore e forma:Crystal PowderPeso molecolare:435.31Clofilium tosylate
CAS:<p>Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.</p>Formula:C28H44ClNO3SPurezza:99.68%Colore e forma:SolidPeso molecolare:510.17Eleclazine hydrochloride
CAS:Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).Formula:C21H17ClF3N3O3Purezza:99.86%Colore e forma:SolidPeso molecolare:451.83Hydroxyhexamide
CAS:Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.Formula:C15H22N2O4SPurezza:98.91%Colore e forma:SolidPeso molecolare:326.41Proflavine Hemisulfate
CAS:<p>Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt of proflavine, an acridine-derived fluorescent contrast and disinfectant agent.</p>Formula:C13H12N3O2S0Purezza:99.55%Colore e forma:Orange To Red PowderPeso molecolare:258.29AZD 7009
CAS:<p>AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM.</p>Formula:C23H34N4O5Purezza:98.42% - 98.51%Colore e forma:SoildPeso molecolare:446.54BMS-191095
CAS:BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.Formula:C22H21ClN4O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:408.88IK1 inhibitor PA-6
CAS:IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouseFormula:C31H32N4O2Purezza:98.9%Colore e forma:SolidPeso molecolare:492.61Tolbutamide
CAS:Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.Formula:C12H18N2O3SPurezza:99.80% - 99.93%Colore e forma:White Crystalline PowderPeso molecolare:270.35BMS-394136
CAS:BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.Formula:C24H21Cl2FN4OPurezza:98.59% - 99.95%Colore e forma:SolidPeso molecolare:471.35Ketanserin
CAS:Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.Formula:C22H22FN3O3Purezza:99.19% - 99.73%Colore e forma:SolidPeso molecolare:395.43Flufenamic acid
CAS:<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Formula:C14H10F3NO2Purezza:98.68%Colore e forma:White To Light Yellow Crystalline PowderPeso molecolare:281.23Ropivacaine
CAS:Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.Formula:C17H26N2OPurezza:97.75% - >99.99%Colore e forma:SolidPeso molecolare:274.40Nicorandil
CAS:Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system.Formula:C8H9N3O4Purezza:98.14% - >99.99%Colore e forma:White Or Off-White PowderPeso molecolare:211.17Tipepidine hydrochloride
CAS:Tipepidine hydrochloride: reversible DA D2 receptor inhibitor, IC50 7.0 μM, with antidepressant effects.Formula:C15H18ClNS2Purezza:99.97%Colore e forma:SolidPeso molecolare:311.89Tannic acid
CAS:Tannic acid (Gallotannic acid) is a novel hERG channel blocker.Formula:C76H52O46Purezza:AR - ARColore e forma:Light Yellow To Light Brown Solid Solid Particulate/PowderPeso molecolare:1701.2NS5806
CAS:NS5806 activates K+ currents, slows KV4.2/4.3 decay with KChIP2, and boosts KV4.3/KChIP2 peaks (EC50=5.3μM).Formula:C16H8Br2F6N6OPurezza:97.95%Colore e forma:SolidPeso molecolare:574.07DCEBIO
CAS:<p>DCEBIO, a 1-EBIO derivative, enhances Cl- secretion via hIK1 K+ channel and apical conductance in T84 cells.</p>Formula:C9H8Cl2N2OPurezza:99.89%Colore e forma:SolidPeso molecolare:231.08Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurezza:99.05% - 99.75%Colore e forma:SolidPeso molecolare:494.00DCPIB
CAS:<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>Formula:C22H28Cl2O4Purezza:99.79% - 99.87%Colore e forma:SolidPeso molecolare:427.36Indapamide
CAS:Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.Formula:C16H16ClN3O3SPurezza:98.97% - 99.83%Colore e forma:SolidPeso molecolare:365.83Flindokalner
CAS:Flindokalner (BMS-204352) modulates potassium channels, enhances Kv7 subtypes and BKca, inhibits Kv7.1 (Ki=3.7μM), GABAA; has anxiolytic effects in vivo.Formula:C16H10ClF4NO2Purezza:99.96%Colore e forma:SolidPeso molecolare:359.7Ropivacaine hydrochloride
CAS:Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activityFormula:C17H26N2O·HClPurezza:99.85% - 99.95%Colore e forma:SolidPeso molecolare:310.86Oxybutynin chloride
CAS:Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties.Formula:C22H32ClNO3Purezza:99.27% - >99.99%Colore e forma:White PowderPeso molecolare:393.96Doxapram hydrochloride hydrate
CAS:Doxapram hydrochloride hydrate (Doxapram HCl) inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 0.41, 37, 9 μM, respectively.Formula:C24H33ClN2O3C24H30N2O2·ClH·H2OPurezza:99.64% - >99.99%Colore e forma:SolidPeso molecolare:432.99ICA-27243
CAS:<p>ICA-27243: Potent KCNQ2/Q3 opener, oral, EC50 0.38 μM; less effective on KCNQ4, KCNQ3/Q5; antiepileptic.</p>Formula:C12H7ClF2N2OPurezza:99.54%Colore e forma:SolidPeso molecolare:268.65Disopyramide
CAS:Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.Formula:C21H29N3OPurezza:99.62%Colore e forma:SolidPeso molecolare:339.47Quinine
CAS:Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria.Formula:C20H24N2O2Purezza:99.93% - 99.97%Colore e forma:White Solid PowderPeso molecolare:324.42KV1.3-IN-1
KV1.3-IN-1 (Compound trans-18), a selective KV1.3 channel inhibitor with IC50 values of 230 nM in Ltk cells and 26.12 nM in PHA-activated T-lymphocytes,Formula:C23H30N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:430.56Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Purezza:96.97%Colore e forma:SolidGuanfu base A
CAS:Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.Formula:C24H31NO6Purezza:99.71% - 99.85%Colore e forma:SolidPeso molecolare:429.5Charybdotoxin
CAS:Specific inhibitor of the big conductance Ca2+-activated K+ channel.Formula:C176H277N57O55S7Purezza:98%Colore e forma:SolidPeso molecolare:4295.95Margatoxin
CAS:KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.Formula:C178H286N52O50S7Purezza:98%Colore e forma:SolidPeso molecolare:4178.96Cesium chloride
CAS:<p>Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.</p>Formula:ClCsPurezza:98%Colore e forma:White Solid CrystallinePeso molecolare:168.36Pinacidil monohydrate
CAS:Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.Formula:C13H21N5OPurezza:99.94% - 99.98%Colore e forma:PowderPeso molecolare:263.34Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Colore e forma:Odour SolidVesnarinone HCl
<p>Vesnarinone HCl is an oral PDE3 inhibitor improving heart contractility, affecting calcium and potassium flux. Used in heart failure research.</p>Formula:C22H26ClN3O4Purezza:99.17%Colore e forma:SoildPeso molecolare:431.91Dalazatide HCl
Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,Colore e forma:SolidPeso molecolare:4317.53 (Free base)Aekatperone
Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).Formula:C20H25N5O2SColore e forma:SolidPeso molecolare:399.51Phe-Met-Arg-Phe amide trifluoroacetate
CAS:Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.Formula:C33H44F6N8O8SPurezza:98%Colore e forma:SolidPeso molecolare:826.814-Hydroxytolbutamide
CAS:4-Hydroxytolbutamide is a drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 a sulfonylurea hypoglycemic agent.Formula:C12H18N2O4SPurezza:98%Colore e forma:White To Off-WhitePeso molecolare:286.35Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Formula:C79H131N31O24S4Purezza:98%Colore e forma:SolidPeso molecolare:2027.34GsAF-I
GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28Formula:C160H244N46O42S7Purezza:98%Colore e forma:SolidPeso molecolare:3708.39Mesoridazine Besylate
CAS:<p>Mesoridazine Besylate (Serentil), a piperidine antipsychotic and phenothiazine, treats schizophrenia; it's a thioridazine metabolite.</p>Formula:C27H32N2O4S3Purezza:99.58%Colore e forma:SolidPeso molecolare:544.75Dendrotoxin K TFA
Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1].Formula:C294H462N84O75S6·XC2HF3OC2Purezza:98%Colore e forma:SolidPeso molecolare:6559.66 (free base)RU-TRAAK-2
CAS:<p>RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.</p>Formula:C19H17N3OSPurezza:99.81%Colore e forma:SolidPeso molecolare:335.42HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formula:C337H503N103O97S6Peso molecolare:7736.59176Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Formula:C169H278N54O48S8Purezza:98%Colore e forma:SolidPeso molecolare:4090.87ADWX 1 TFA
ADWX 1 TFA is a novel peptide that potently targets and inhibits the Kv1.3 channel, with an IC50 of 1.89 pM. It specifically suppresses the activity of the Kv1.3 channel, in addition to inhibiting initial calcium signaling and NF-κB activation. This compound has been shown to ameliorate symptoms in rats with experimental autoimmune encephalomyelitis (EAE). ADWX 1 TFA is utilized in research focused on T-cell-mediated autoimmune diseases.Formula:C169H281N57O46S7·xC2HF3O2Colore e forma:SolidPeso molecolare:4071.85 (free base)Potassium Channel Targeted Library
A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;Colore e forma:Odour SolidTertiapin LQ
Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.Formula:C106H179N33O24S4Purezza:98%Colore e forma:SolidPeso molecolare:2428.03BKCa activator-1
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.Formula:C22H23F7N2O3Colore e forma:SolidPeso molecolare:496.418KNa1.1-IN-2
CAS:KNa1.1-IN-2 (Compound Z05) is a selective KNa1.1 channel inhibitor capable of penetrating the blood-brain barrier, and exhibits significant efficacy on hERG channels. It binds to KNa1.1 channels, effectively blocking channel activity caused by Gain-of-function (GOF) mutations, thus intervening in KCNT1-related seizures. Additionally, it inhibits the GOF mutant Y796H, making KNa1.1-IN-2 a promising candidate for research into KCNT1-associated epilepsy disorders.Formula:C24H27NOColore e forma:SolidPeso molecolare:345.48Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formula:C19H23F2N3O2Colore e forma:SolidPeso molecolare:363.4AmmTX3
KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.Formula:C158H262N50O48S6Purezza:98%Colore e forma:SolidPeso molecolare:3822.47ShK-Dap22
CAS:Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Formula:C166H268N54O48S7Purezza:98%Colore e forma:SolidPeso molecolare:4012.7Myomodulin
CAS:Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A theFormula:C36H67N11O8S2Purezza:98%Colore e forma:SolidPeso molecolare:846.12Heteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Formula:C168H238N46O51S6Purezza:98%Colore e forma:SolidPeso molecolare:3910.35Ebio2
Ebio2 is an effective activator of KCNQ2.Formula:C17H19F2N3O2Colore e forma:SolidPeso molecolare:335.349Dendrotoxin K
CAS:Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.Formula:C294H462N84O75S6Colore e forma:SolidPeso molecolare:6559.66ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Formula:C169H281N57O46S7Purezza:98%Colore e forma:SolidPeso molecolare:4071.86GsAF-II
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodiumFormula:C176H261N47O45S7Purezza:98%Colore e forma:SolidPeso molecolare:3979.7MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.Formula:C22H21N7O3SColore e forma:SolidPeso molecolare:463.512Lei-Dab7
CAS:Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Formula:C141H236N46O39S6Purezza:98%Colore e forma:SolidPeso molecolare:3392.06Lei-Dab7 TFA
Lei-Dab7 TFA blocks SK2 channels with 3.8 nM affinity, is >200x selective, and enhances LTP in rat hippocampus.Formula:C143H237F3N46O41S6Colore e forma:SolidPeso molecolare:3506.08Guangxitoxin 1E
CAS:Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.Formula:C178H248N44O45S7Purezza:98%Colore e forma:SolidPeso molecolare:3948.61Tertiapin
CAS:Tertiapin (reduced) is a synthetic bee venom peptide characterized by disulfide bonds between Cys3-Cys14 and Cys5-Cys18. It acts as an inhibitor of inward-rectifying potassium channels (potassium Channel) and can also block the activity of calcium-activated large conductance potassium channels. Tertiapin (reduced) is utilized in research related to diseases such as rheumatoid arthritis and multiple sclerosis.Formula:C106H180N34O23S5Colore e forma:SolidPeso molecolare:2459.1BeKm-1
CAS:Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.Formula:C174H261N51O52S6Purezza:98%Colore e forma:SolidPeso molecolare:4091.65Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Formula:C179H274N50O55S7Purezza:98%Colore e forma:SolidPeso molecolare:4230Phe-Met-Arg-Phe, amide
CAS:Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.Formula:C29H42N8O4SPurezza:98%Colore e forma:SolidPeso molecolare:598.76Foslevcromakalim
CAS:Foslevcromakalim (QLS-101) is an KATP opener, converted to its active form by alkaline phosphatase in vivo, reduces intraocular pressure in normotensive mice.Formula:C16H19N2O6PColore e forma:SolidPeso molecolare:366.31KCNQ1 activator-1
CAS:<p>N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.</p>Formula:C22H23N3O4S2Purezza:99.71%Colore e forma:SolidPeso molecolare:457.57Neosolaniol
CAS:Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.Formula:C19H26O8Purezza:98%Colore e forma:SolidPeso molecolare:382.4Nateglinide D5
CAS:Nateglinide D5 is a deuterium labeled Nateglinide.Formula:C19H27NO3Purezza:98%Colore e forma:SolidPeso molecolare:322.45Clamikalant sodium
CAS:Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.Formula:C19H21ClN3NaO5S2Purezza:99.95%Colore e forma:SolidPeso molecolare:493.96Flecainide
CAS:Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.Formula:C17H20F6N2O3Purezza:99.896%Colore e forma:SolidPeso molecolare:414.34Endoxifen Z-isomer hydrochloride
CAS:Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.Formula:C25H28ClNO2Colore e forma:SolidPeso molecolare:409.95Cromakalim
CAS:<p>Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.</p>Formula:C16H18N2O3Purezza:99.39%Colore e forma:SolidPeso molecolare:286.33QO-58
CAS:QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory painFormula:C18H8Cl2F4N4OPurezza:99.17%Colore e forma:SolidPeso molecolare:443.18QO-40
CAS:QO-40 is a KCNQ2/3 potassium channels activator.Formula:C18H11ClF3N3OPurezza:99.57%Colore e forma:SolidPeso molecolare:377.75Ibutilide Fumarate
CAS:Ibutilide Fumarate is a class III antiarrhythmic, prolonging action potentials by enhancing sodium influx, and can extend QT interval.Formula:(C20H36N2O3S)2·C4H4O4Purezza:99.68% - 99.74%Colore e forma:SolidPeso molecolare:885.23Guanosine 5'-diphosphate disodium salt
CAS:<p>5'-GDP-Na2: a nucleoside diphosphate, iron mobilizer, blocks hepcidin-ferroportin, affects IL-6/stat-3.</p>Formula:C10H13N5Na2O11P2Purezza:99.40%Colore e forma:White PowderPeso molecolare:487.16XE 991 dihydrochloride
CAS:XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker.Formula:C26H22Cl2N2OPurezza:98.68%Colore e forma:SolidPeso molecolare:449.37SKA-31
CAS:SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).Formula:C11H8N2SPurezza:99.38%Colore e forma:SolidPeso molecolare:200.26Ropivacaine hydrochloride monohydrate
CAS:<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Formula:C17H29ClN2O2Purezza:99.94% - 99.95%Colore e forma:White SolidPeso molecolare:328.88Cholesterol myristate
CAS:<p>Cholesterol myristate, a natural steroid in Chinese medicine, affects GABAA, nicotinic receptors, and potassium channels.</p>Formula:C41H72O2Purezza:99.65%Colore e forma:SolidPeso molecolare:597.01Quinidine sulfate dihydrate
CAS:<p>Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor</p>Formula:C40H54N4O10SPurezza:99.85%Colore e forma:White To Light Yellow Crystal PowdePeso molecolare:782.9ML277
CAS:<p>ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).</p>Formula:C23H25N3O4S2Purezza:99.35%Colore e forma:SolidPeso molecolare:471.59APD668
CAS:<p>APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.</p>Formula:C21H24FN5O5SPurezza:99.74% - 99.97%Colore e forma:SolidPeso molecolare:477.51Amifampridine
CAS:Amifampridine blocks nerve potassium channels, extends action potentials, boosts acetylcholine release, and treats rare muscle diseases.Formula:C5H7N3Purezza:99.82%Colore e forma:Slightly Beige PowderPeso molecolare:109.13TKIM
CAS:<p>TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.</p>Formula:C18H14ClN3O2SPurezza:99.47%Colore e forma:SolidPeso molecolare:371.84ICA-069673
CAS:ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).Formula:C11H6ClF2N3OPurezza:99.04% - 99.68%Colore e forma:SolidPeso molecolare:269.63NS309
CAS:NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.Formula:C8H4Cl2N2O2Purezza:97.55%Colore e forma:SolidPeso molecolare:231.04BAPTA-AM
CAS:BAPTA-AM is a calcium chelator that is cell-permeable and selective, blocking hERG, hKv1.3, and hKv1.5 channels (IC50=1.3/1.45/1.23 μM).Formula:C34H40N2O18Purezza:98% - 99.47%Colore e forma:White Powder Or Crystalline PowderPeso molecolare:764.68Quinidine
CAS:Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.Formula:C20H24N2O2Purezza:97.03% - 99.99%Colore e forma:Crystals With 2 5 Mol Water Of Crystallization; Crystals From Dilute Alcohol Physical Description Crystals Or White Powder (Ntp 1992)Peso molecolare:324.42Talatisamine
CAS:Talatisamine and TEA mitigate Aβ oligomer effects on I(K), bolstering cell survival and reducing K(+) loss-induced apoptosis; promising for further study.Formula:C24H39NO5Purezza:98.62% - 99.44%Colore e forma:SolidPeso molecolare:421.57VU0134992
CAS:VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μMFormula:C20H31BrN2O2Purezza:99.86%Colore e forma:SolidPeso molecolare:411.38Endoxifen (Z-isomer)
CAS:Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.Formula:C25H27NO2Purezza:99.19% - 99.81%Colore e forma:SolidPeso molecolare:373.49Paederosidic acid methyl ester
CAS:<p>Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.</p>Formula:C19H26O12SPurezza:99.67% - 99.91%Colore e forma:SolidPeso molecolare:478.4720(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formula:C42H72O13Purezza:98.11% - 99.93%Colore e forma:SolidPeso molecolare:785.01KCNQ2/3 activator-1
CAS:<p>KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator.</p>Formula:C23H29FN2OPurezza:99.16% - 99.47%Colore e forma:SolidPeso molecolare:368.492,2,2-Trichloroethanol
CAS:2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.Formula:C2H3Cl3OPurezza:99.74%Colore e forma:LiquidPeso molecolare:149.4Yoda 1
CAS:<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Formula:C13H8Cl2N4S2Purezza:98% - 99.98%Colore e forma:SolidPeso molecolare:355.27Quinine hydrochloride dihydrate
CAS:<p>Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.</p>Formula:C20H24N2O2·HCl·2H2OPurezza:99.91%Colore e forma:White To Light Yellow Crystal PowderPeso molecolare:396.91Kv2-IN-A1
CAS:Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.Formula:C20H17ClN4OSPurezza:98.83%Colore e forma:SolidPeso molecolare:396.89Almitrine mesylate
CAS:Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.Formula:C28H37F2N7O6S2Purezza:99.96%Colore e forma:CoaPeso molecolare:669.76Azimilide Dihydrochloride
CAS:Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the IKs and IKr with antiarrhythmic activity.Formula:C23H30Cl3N5O3Purezza:97.59% - ≥95%Colore e forma:SolidPeso molecolare:530.88ML365
CAS:ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).Formula:C22H20N2O3Purezza:98.78%Colore e forma:SolidPeso molecolare:360.41VU0071063
CAS:VU0071063 is a Kir6.2/SUR1 activator.Formula:C18H22N4O2Purezza:99.33%Colore e forma:SolidPeso molecolare:326.39Quinine dihydrochloride
CAS:Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae).Formula:C20H26Cl2N2O2Purezza:99.79% - 99.97%Colore e forma:White SolidPeso molecolare:397.34Sematilide hydrochloride
CAS:Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.Formula:C14H24ClN3O3SPurezza:99.14%Colore e forma:SolidPeso molecolare:349.87Dofetilide
CAS:Dofetilide (UK 68789), a class III antiarrhythmic sulfonamide, blocks Ikr cardiac channels, prolongs action potential, and treats atrial fibrillation/flutter.Formula:C19H27N3O5S2Purezza:97.85% - 99.06%Colore e forma:Off-White Or Yellowish Crystalline PowderPeso molecolare:441.56AUT1
CAS:AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).Formula:C18H19N3O4Purezza:99.8% - 99.95%Colore e forma:SolidPeso molecolare:341.36Iptakalim Hydrochloride
CAS:Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholineFormula:C9H22ClNPurezza:98%Colore e forma:SolidPeso molecolare:179.731GSK369796 Dihydrochloride
CAS:GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate.Formula:C20H24Cl3N3OPurezza:>99.99%Colore e forma:SolidPeso molecolare:428.78PAP-1
CAS:PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).Formula:C21H18O5Purezza:99.35% - 99.75%Colore e forma:White SolidPeso molecolare:350.36Nigericin sodium salt
CAS:Nigericin sodium salt, an antibiotic and NLRP3 activator from S. hygroscopicus, inhibits Golgi and gram-positive bacteria, blocking viral activation.Formula:C40H67NaO11Purezza:98.2% - 99.52%Colore e forma:SolidPeso molecolare:746.94Atpenin A5
CAS:Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM).Formula:C15H21Cl2NO5Purezza:97.33% - 99.91%Colore e forma:SolidPeso molecolare:366.24LY 303511 hydrochloride
CAS:LY 303511 hydrochloride is a potent mTOR inhibitorFormula:C19H19ClN2O2Purezza:98.47%Colore e forma:SolidPeso molecolare:342.82Mitiglinide Calcium
CAS:Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-Formula:(C19H24NO3)2·CaPurezza:99.83%Colore e forma:White Crystal PosderPeso molecolare:668.88Flupirtine maleate
CAS:<p>Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. Flupirtine is an NMDA receptor antagonist.</p>Formula:C15H17FN4O2·C4H4O4Purezza:99.5% - 99.9%Colore e forma:Off-White Crystalline PowderPeso molecolare:420.39Senicapoc
CAS:Senicapoc (ICA-17043) blocks Gardos channel, reduces RBC dehydration, IC50: 11 nM for rubidium flux, 30 nM for dehydration. Used in Sickle Cell therapy.Formula:C20H15F2NOPurezza:95.7% - 99.47%Colore e forma:SolidPeso molecolare:323.34E-4031 dihydrochloride
CAS:E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formula:C21H29Cl2N3O3SPurezza:99.31% - 99.87%Colore e forma:SolidPeso molecolare:474.44Allocryptopine
CAS:<p>Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively.</p>Formula:C21H23NO5Purezza:99.41% - ≥95%Colore e forma:SolidPeso molecolare:369.41KS176
CAS:KS176: selective BCRP inhibitor, potent against breast cancer drug resistance; ineffective on P-gp, MRP1.Formula:C22H19N3O5Purezza:99.61% - 99.61%Colore e forma:SolidPeso molecolare:405.45-Hydroxydecanoate sodium
CAS:5-Hydroxydecanoate sodium: KATP channel blocker, IC50 ~30μM; mitochondrial substrate; antioxidant.Formula:C10H19NaO3Purezza:99.24% - 99.89%Colore e forma:SolidPeso molecolare:210.25VU0810464
CAS:VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator.Formula:C18H21ClFN3OPurezza:99.62%Colore e forma:SolidPeso molecolare:349.83Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formula:C18H20O5Purezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:316.35Mitiglinide calcium hydrate
CAS:Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes.Formula:C38H52CaN2O8Purezza:98.97% - 99.96%Colore e forma:White SolidPeso molecolare:704.91A2793
CAS:A2793 is a dual inhibitor of TWIK-associated acid-sensitive K+ channel 1 (TASK-1)/TRESK, with an IC50 for mTRESK of 6.8 μM.Formula:C13H12ClNO3Purezza:98.54%Colore e forma:SolidPeso molecolare:265.69O-Nornuciferine
CAS:O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.Formula:C18H19NO2Purezza:99.86%Colore e forma:SolidPeso molecolare:281.35ML213
CAS:ML213 (CID-3111211) is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM,Formula:C17H23NOPurezza:>99.99%Colore e forma:SolidPeso molecolare:257.37Levcromakalim
CAS:Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel.Formula:C16H18N2O3Purezza:99.74%Colore e forma:SolidPeso molecolare:286.33NS 11021
CAS:NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channelsFormula:C16H9BrF6N6SPurezza:97.26%Colore e forma:SolidPeso molecolare:511.24Tetraethylammonium bromide
CAS:<p>Tetraethylammonium bromide (TEA bromide) can selectively block potassium channels.</p>Formula:C8H20BrNPurezza:98%Colore e forma:White SolidPeso molecolare:210.16ML133 hydrochloride
CAS:ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1, has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.Formula:C19H19NO·HClPurezza:99.48%Colore e forma:SolidPeso molecolare:313.82SKF-96365 hydrochloride
CAS:SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal YFormula:C22H27ClN2O3Purezza:99.47% - 99.92%Colore e forma:SolidPeso molecolare:402.91Rimtuzalcap
CAS:Rimtuzalcap (CAD-1883), a selective modulator for SK channels, may treat movement disorders like SCA and ET.Formula:C18H24F2N6OPurezza:99.64%Colore e forma:SolidPeso molecolare:378.42A2764 dihydrochloride
CAS:A2764 dihydrochloride is a highly selective inhibitor of TRESK.Formula:C15H21Cl3N2OPurezza:99.05%Colore e forma:SolidPeso molecolare:351.7(±)-Naringenin
CAS:(±)-Naringenin (Naringenine) is a natural product.Formula:C15H12O5Purezza:98.06%Colore e forma:SolidPeso molecolare:272.25Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Formula:C20H19NO4Purezza:93.77%Colore e forma:SolidPeso molecolare:337.37Nateglinide
CAS:Nateglinide is an oral drug for type 2 diabetes, stimulating insulin release; may cause rare acute liver injury.Formula:C19H27NO3Purezza:99.93% - 99.94%Colore e forma:White Crystalline PowderPeso molecolare:317.42Oxypeucedanin
CAS:<p>1.</p>Formula:C16H14O5Purezza:98.66% - 98.85%Colore e forma:SolidPeso molecolare:286.28Guanosine 5'-diphosphate
CAS:<p>Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.</p>Formula:C10H15N5O11P2Purezza:98.46% - 99.52%Colore e forma:SolidPeso molecolare:443.2ML 297
CAS:ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively).Formula:C17H14F2N4OPurezza:97.85%Colore e forma:SolidPeso molecolare:328.32NS1643
CAS:NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.Formula:C15H10F6N2O3Purezza:98.37% - 99.31%Colore e forma:SolidPeso molecolare:380.24GAL-021
CAS:<p>GAL-021 an intravenous BKCa-channel blocker.</p>Formula:C11H22N6OPurezza:97.71% - 99.66%Colore e forma:SolidPeso molecolare:254.33Daurisoline
CAS:Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker.Formula:C37H42N2O6Purezza:98% - 99.96%Colore e forma:Light Yellow PowderPeso molecolare:610.74NS-1619
CAS:NS1619 have cardio-protective effects after ischemia-reperfusion injury.Formula:C15H8F6N2O2Purezza:97.66% - 98%Colore e forma:SolidPeso molecolare:362.23GW9508
CAS:<p>GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.</p>Formula:C22H21NO3Purezza:97.89% - 99.19%Colore e forma:SolidPeso molecolare:347.41JNJ 303
CAS:JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).Formula:C21H29ClN2O4SPurezza:99.28%Colore e forma:SolidPeso molecolare:440.98TRAM-34
CAS:<p>TRAM-34 (Triarylmethane-34), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel, does not block cytochrome P450.</p>Formula:C22H17ClN2Purezza:99.01% - 99.91%Colore e forma:SolidPeso molecolare:344.84ML335
CAS:ML335 is a selective activator of TREK-1 and TREK-2.Formula:C15H14Cl2N2O3SPurezza:99.73% - 99.79%Colore e forma:SolidPeso molecolare:373.25ICA 110381
CAS:ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsyFormula:C12H8Cl2N2OPurezza:97.72%Colore e forma:SolidPeso molecolare:267.11Flecainide hydrochloride
CAS:Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.Formula:C17H21ClF6N2O3Purezza:97.79%Colore e forma:SolidPeso molecolare:450.81Minoxidil sulfate
CAS:Minoxidil sulfate (U-58838) is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil.Formula:C9H15N5O4SPurezza:99.01% - 99.72%Colore e forma:White Crystalline SolidPeso molecolare:289.31ASP2905
CAS:ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene.Formula:C20H17FN8Purezza:97.29%Colore e forma:SolidPeso molecolare:388.4AM-92016 hydrochloride
CAS:AM-92016 is a specific blocker of rectifier potassium current.Formula:C19H24Cl2N2O4S·HClPurezza:98.68%Colore e forma:SolidPeso molecolare:483.84NS6180
CAS:<p>NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.</p>Formula:C16H12F3NOSPurezza:99.83% - ≥95%Colore e forma:SolidPeso molecolare:323.33Tetraethylammonium chloride
CAS:Tetraethylammonium chloride is a quaternary ammonium compound.Formula:C8H20ClNPurezza:≥95%Colore e forma:White Solid Solid Particulate/PowderPeso molecolare:165.7RY785
CAS:<p>RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.</p>Formula:C21H20N4O2SPurezza:99.78%Colore e forma:SolidPeso molecolare:392.47Enflurane
CAS:Enflurane (Efrane), a volatile anaesthetic, inhibits Ca2+-activated K+ channels and is used to gauge anesthesia levels in gas chromatography.Formula:C3H2ClF5OPurezza:99.64%Colore e forma:Clear Colorless Liquid Ordinary Temperature And Pressure Bp 56 8°C Density 1 50 G Cm-3 At Room Temperature Used As AnPeso molecolare:184.49
