P-gp
La P-glicoproteina è una pompa di efflusso dipendente dall'ATP che trasporta una vasta gamma di substrati, inclusi farmaci, tossine e lipidi, fuori dalle cellule. Svolge un ruolo cruciale nella resistenza ai farmaci, in particolare nel cancro, riducendo la concentrazione intracellulare degli agenti chemioterapici. La P-gp è inoltre coinvolta nella barriera ematoencefalica, influenzando l'esposizione del sistema nervoso centrale a vari composti. Presso CymitQuimica, offriamo una gamma di modulatori della P-gp per supportare la tua ricerca sulla resistenza ai farmaci, farmacocinetica e sviluppo terapeutico.
Trovati 64 prodotti per "P-gp".
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Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.Formula:C17H19NO3Purezza:98.41% - 98.51%Colore e forma:Yellow SolidPeso molecolare:285.3377Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurezza:99.57% - 99.96%Colore e forma:SolidPeso molecolare:480.417Encequidar mesylate
CAS:Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.Formula:C39H40N6O10SPurezza:99.84%Colore e forma:SolidPeso molecolare:784.834Atazanavir
CAS:Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Formula:C38H52N6O7Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:704.86Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formula:C38H54N6O11SPurezza:99.31% - 99.40%Colore e forma:SolidPeso molecolare:802.934(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormula:C30H52O3Purezza:97.07% - 98.91%Colore e forma:SolidPeso molecolare:460.7321Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formula:C21H21F2N3OSPurezza:99.58%Colore e forma:White SolidPeso molecolare:401.473Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formula:C26H37ClN2O4Purezza:99.47%Colore e forma:SolidPeso molecolare:477.036Dofequidar fumarate
CAS:Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through theFormula:C34H35N3O7Purezza:99.93%Colore e forma:SolidPeso molecolare:597.6576Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formula:C27H39ClN2O4Purezza:98.70% - 99.98%Colore e forma:SolidPeso molecolare:491.06Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurezza:99.05% - 99.75%Colore e forma:White SolidPeso molecolare:494.004Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formula:C23H27FN4O2Purezza:99.73%Colore e forma:SolidPeso molecolare:410.4845Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formula:C63H111N11O12Purezza:95% - >99.99%Colore e forma:White SolidPeso molecolare:1214.62P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Formula:C19H16N2O5Colore e forma:SolidPeso molecolare:352.34YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Formula:C37H35BrN4O3Purezza:98.05%Colore e forma:SolidPeso molecolare:663.603WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formula:C16H13N5OS2Colore e forma:SolidPeso molecolare:355.44CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Formula:C111H131N23O30SColore e forma:SolidPeso molecolare:2299.43P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formula:C30H28N2O6Purezza:99.85%Colore e forma:SolidPeso molecolare:512.55P-gp inhibitor 14
CAS:Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Formula:C37H38N2O8Colore e forma:SolidPeso molecolare:638.71Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formula:C40H52N4O15S2Purezza:98.13%Colore e forma:Yellow SolidPeso molecolare:892.989
