IDO
L'indoleamina 2,3-diossigenasi (IDO) è un enzima coinvolto nel catabolismo del triptofano, che porta alla produzione di chinurenina e altri metaboliti. L'IDO svolge un ruolo nella tolleranza immunitaria ed è spesso sovraregolato nel cancro e nelle condizioni infiammatorie croniche. Gli inibitori dell'IDO vengono esplorati come potenziali agenti immunoterapici nel cancro e nelle malattie autoimmuni. Presso CymitQuimica, forniamo inibitori dell'IDO per supportare la tua ricerca in immunologia, oncologia e regolazione metabolica.
Trovati 84 prodotti di "IDO"
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GNF-PF-3777
CAS:<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>Formula:C15H7N3O4Purezza:97.88%Colore e forma:SolidPeso molecolare:293.23LY3381916
CAS:IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.Formula:C23H25FN2O3Purezza:99.3%Colore e forma:SolidPeso molecolare:396.45Ref: TM-T11901
1mg40,00€2mg52,00€5mg87,00€10mg131,00€25mg215,00€50mg344,00€100mg540,00€1mL*10mM (DMSO)74,00€IDO-IN-13
CAS:IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).Formula:C26H17F3N4OPurezza:99.29%Colore e forma:SolidPeso molecolare:458.43Ref: TM-T11616
1mg58,00€5mg113,00€10mg165,00€25mg230,00€50mg338,00€100mg490,00€1mL*10mM (DMSO)131,00€BMT-297376
CAS:BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.Formula:C23H29F2N3O3Colore e forma:SolidPeso molecolare:433.5IDO-IN-15
CAS:IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).Formula:C29H39N5O4Colore e forma:SolidPeso molecolare:521.662NLG802
CAS:<p>NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>Formula:C20H30ClN3O3Purezza:99.61%Colore e forma:SolidPeso molecolare:395.92IDO1-IN-11
CAS:<p>IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.</p>Formula:C22H17ClFN3O3Colore e forma:SolidPeso molecolare:425.84IDO1-IN-7
CAS:IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.Formula:C22H19ClFN3O3Colore e forma:SolidPeso molecolare:427.86IDO1/TDO-IN-8
IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.Formula:C17H14N2SColore e forma:SolidPeso molecolare:278.37PROTAC IDO1 Degrader-1
CAS:First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.Formula:C40H53BrFN9O13Colore e forma:SolidPeso molecolare:966.816CAY10581
CAS:CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50Formula:C22H21NO4Colore e forma:SolidPeso molecolare:363.41XW-032
<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>Colore e forma:Odour Solidhuman TDO2-IN-1
<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>Formula:C30H36N4O5Colore e forma:SolidPeso molecolare:532.631NU227326
CAS:NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).Formula:C53H61FN8O7Colore e forma:SolidPeso molecolare:941.099TDO-IN-2
TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.Formula:C20H15N3O3Colore e forma:SolidPeso molecolare:345.11134β-Cembrenediol
CAS:β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate.Formula:C20H34O2Colore e forma:SolidPeso molecolare:306.49IDO1-IN-23
IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].Purezza:98%Colore e forma:Odour SolidIDO1/TDO-IN-7
IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.Colore e forma:Odour SolidIDO1-IN-24
IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.Formula:C18H22N2O4Peso molecolare:330.15796NU223612
CAS:"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."Formula:C49H55FN6O9Colore e forma:SolidPeso molecolare:890.99IDO1-IN-12
CAS:IDO1-IN-12 is a potent and orally available IDO1 inhibitor.Formula:C21H19F3N2O2Colore e forma:SolidPeso molecolare:388.39IDO1/TDO-IN-4
CAS:IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO.Formula:C14H10N4Purezza:98.88%Colore e forma:SolidPeso molecolare:234.26IDO1 Protein, Mouse, Recombinant (His)
IDO Protein, Mouse, Recombinant (His) is expressed in E.Purezza:≥ 90 % as determined by SDS-PAGE. - ≥ 90 % as determined by SDS-PAGE.Colore e forma:Lyophilized PowderPeso molecolare:46.47 kDa (predicted)(Rac)-IDO1-IN-5
CAS:(Rac)-IDO1-IN-5 is a racemic, potent IDO1 inhibitor; selective for apo-IDO1, it crosses the blood-brain barrier.Formula:C23H25FN2O3Colore e forma:SolidPeso molecolare:396.45IDO1 Protein, Human, Recombinant (His)
IDO Protein, Human, Recombinant (His) is expressed in E.Colore e forma:Lyophilized PowderPeso molecolare:46 kDa (predicted); 44 kDa (reducing conditions)(S)-IDO1-IN-5
CAS:(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 μΜ).Formula:C23H25FN2O3Colore e forma:SolidPeso molecolare:396.45Anti-IDO1 Antibody (9Y885)
Anti-IDO1 Antibody (9Y885) is an antibody targeting IDO1. Anti-IDO1 Antibody (9Y885) can be used in ELISA, IHC.Colore e forma:Odour LiquidIDO1 Protein, Human, Recombinant
IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.Colore e forma:Lyophilized PowderPeso molecolare:45.2 kDa (predicted); 46 kDa (reducing conditions)BMS-986242
CAS:BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.Formula:C24H24ClFN2OPurezza:98.9%Colore e forma:SolidPeso molecolare:410.91Linrodostat
CAS:Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.Formula:C24H24ClFN2OPurezza:99.54% - 99.71%Colore e forma:SolidPeso molecolare:410.91(S)-Indoximod
CAS:(S)-Indoximod (L-Abrine) is an indoleamine-2,3-dioxygenase (IDO) inhibitor for cancer research.Formula:C12H14N2O2Purezza:95.39% - 99.69%Colore e forma:SolidPeso molecolare:218.253-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Formula:C7H6N4Purezza:99.16% - >99.99%Colore e forma:SolidPeso molecolare:146.15Indoximod
CAS:Indoximod (NLG-8189) is a methylated tryptophan that inhibits IDO to boost T cell function by preventing tryptophan depletion.Formula:C12H14N2O2Purezza:97.82% - 99.55%Colore e forma:SolidPeso molecolare:218.25IDO-IN-7
CAS:IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.Formula:C18H22N2OPurezza:99.32% - 99.9%Colore e forma:SolidPeso molecolare:282.38Epacadostat
CAS:Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.Cost-effective and quality-assured.Formula:C11H13BrFN7O4SPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:438.23Ref: TM-T3548
1g757,00€2g1.035,00€5mg47,00€10mg70,00€25mg87,00€50mg111,00€100mg187,00€200mg311,00€500mg525,00€1mL*10mM (DMSO)50,00€IDO-IN-1
CAS:<p>IDO-IN-1: potent IDO inhibitor, IC50 of 59 nM (enzyme), 12 nM (HeLa cells).</p>Formula:C9H7BrFN5O2Purezza:99.91%Colore e forma:SolidPeso molecolare:316.09Navoximod
CAS:Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).Formula:C18H21FN2O2Purezza:99.37%Colore e forma:SolidPeso molecolare:316.37Ref: TM-TQ0071
1mg159,00€5mg329,00€10mg495,00€25mg633,00€50mg787,00€100mg1.103,00€1mL*10mM (DMSO)335,00€Linrodostat mesylate
CAS:Linrodostat (BMS-986205) is an oral IDO1 inhibitor that boosts immune response and has anti-cancer properties.Formula:C25H28ClFN2O4SPurezza:98%Colore e forma:SolidPeso molecolare:507.02IDO1-IN-1
CAS:IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.Formula:C7H7N3SPurezza:99.36%Colore e forma:Slightly Yellow To Beige-Green Crystalline PowderPeso molecolare:165.22LM10
CAS:TDO inhibitor; IC50: human 0.62 μM, mouse 2 μM; selective over IDO, MAOs; hinders TDO+ tumor growth in mice; orally active.Formula:C11H8FN5Purezza:98.78% - 99.94%Colore e forma:SolidPeso molecolare:229.21PCC0208009
CAS:PCC0208009 (IDO-IN-2) is an IDO inhibitor.Formula:C29H35N7OPurezza:99.89%Colore e forma:SolidPeso molecolare:497.63Ref: TM-T4142
1mg47,00€2mg59,00€5mg87,00€10mg150,00€25mg271,00€50mg464,00€100mg640,00€1mL*10mM (DMSO)97,00€IDO5L
CAS:IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).Formula:C9H7ClFN5O2Purezza:99.49% - 99.75%Colore e forma:SolidPeso molecolare:271.64Ref: TM-T2647
10mg50,00€25mg86,00€50mg124,00€100mg187,00€200mg321,00€500mg505,00€1mL*10mM (DMSO)35,00€PF-06840003
CAS:PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.Formula:C12H9FN2O2Purezza:99.10%Colore e forma:SolidPeso molecolare:232.21Ref: TM-T4307
2mg35,00€5mg52,00€10mg93,00€25mg107,00€50mg127,00€100mg188,00€200mg283,00€1mL*10mM (DMSO)58,00€Necrostatin 2 racemate
CAS:Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.Formula:C13H12ClN3O2Purezza:98% - 99.5%Colore e forma:SolidPeso molecolare:277.71Ref: TM-T7504
1mg65,00€5mg107,00€10mg169,00€25mg305,00€50mg527,00€100mg743,00€500mg1.510,00€1mL*10mM (DMSO)140,00€DP00477
CAS:DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 µM.Formula:C17H11ClF3N3OSColore e forma:SolidPeso molecolare:397.8IDO-IN-12
CAS:IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).Formula:C13H11BrFN5O3SPurezza:99.727%Colore e forma:SolidPeso molecolare:416.23Ref: TM-T11615
1mg88,00€5mg180,00€10mg264,00€25mg416,00€50mg540,00€100mg753,00€1mL*10mM (DMSO)188,00€IACS-8968 S-enantiomer
CAS:IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Formula:C17H18F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:381.35IACS-8968
CAS:IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Formula:C17H18F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:381.35IDO1-IN-18
CAS:IDO1-IN-18 (Compound 14) is a potent inhibitor of IDO1. IDO1-IN-18 has potential for cancer disease research.Formula:C23H18F4N2O3Colore e forma:SolidPeso molecolare:446.39IDO-IN-8
CAS:IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Formula:C18H21FN2O2Purezza:98%Colore e forma:SolidPeso molecolare:316.37
