Prolil-idrossilasi HIF/HIF
Il fattore inducibile dall'ipossia (HIF) è un fattore di trascrizione che svolge un ruolo cruciale nelle risposte cellulari ai bassi livelli di ossigeno (ipossia). L'attività di HIF è strettamente regolata dalle prolyl-idrossilasi HIF, che bersagliano HIF per la degradazione in condizioni normossiche. Gli inibitori della prolyl-idrossilasi HIF possono stabilizzare HIF, promuovendo l'espressione di geni coinvolti nell'angiogenesi, eritropoiesi e metabolismo. Questi inibitori sono di grande interesse per il trattamento di condizioni come anemia, malattie ischemiche e cancro. Presso CymitQuimica, offriamo inibitori di HIF/prolyl-idrossilasi HIF per supportare la tua ricerca in biologia dell'ipossia, terapia anticancro e regolazione metabolica.
Trovati 142 prodotti di "Prolil-idrossilasi HIF/HIF"
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Deferoxamine Mesylate
CAS:<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Formula:C26H52N6O11SPurezza:94.68% - 99.8%Colore e forma:SolidPeso molecolare:656.79Tilorone dihydrochloride
CAS:<p>Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.</p>Formula:C25H36Cl2N2O3Purezza:98% - 99.86%Colore e forma:Orange Yellow Crystal PowderPeso molecolare:483.47Hydralazine hydrochloride
CAS:<p>Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.</p>Formula:C8H9ClN4Purezza:99.85% - 99.86%Colore e forma:Yellow Crystals White Crystalline SolidPeso molecolare:196.64Chloramphenicol
CAS:<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Formula:C11H12Cl2N2O5Purezza:99.6% - 99.84%Colore e forma:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidPeso molecolare:323.13Glucosamine hydrochloride
CAS:<p>Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.</p>Formula:C6H13NO5·HClPurezza:99.77%Colore e forma:White Solid CrystallinePeso molecolare:215.63EHP-101
CAS:<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Formula:C28H35NO3Purezza:98.36%Colore e forma:SolidPeso molecolare:433.58Molidustat
CAS:<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>Formula:C13H14N8O2Purezza:98.79%Colore e forma:SolidPeso molecolare:314.3PT2399
CAS:<p>PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.</p>Formula:C17H10F5NO4SPurezza:98.8% - 99.45%Colore e forma:SolidPeso molecolare:419.32Oltipraz
CAS:<p>Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.</p>Formula:C8H6N2S3Purezza:98.79% - 99.77%Colore e forma:SolidPeso molecolare:226.34Citric acid trilithium salt tetrahydrate
CAS:<p>Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of</p>Formula:C6H13Li3O11Purezza:99.88%Colore e forma:White Crystalline PowderPeso molecolare:281.98Hydroxycitric acid tripotassium hydrate
CAS:<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>Formula:C6H7K3O8Purezza:99.85%Colore e forma:White Solid CrystallinePeso molecolare:324.41(-)-Hydroxycitric acid lactone
CAS:<p>(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which</p>Formula:C6H6O7Purezza:99.91%Colore e forma:SolidPeso molecolare:190.11Minocycline hydrochloride
CAS:<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Formula:C23H28ClN3O7Purezza:99.28% - >99.99%Colore e forma:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecolare:493.94Amifostine
CAS:<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>Formula:C5H15N2O3PSPurezza:99.88%Colore e forma:White SolidPeso molecolare:214.22Glucosamine
CAS:<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>Formula:C6H13NO5Purezza:99.8% - 99.8%Colore e forma:CoaPeso molecolare:179.17Vadadustat
CAS:<p>Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.</p>Formula:C14H11ClN2O4Purezza:99.02% - 99.80%Colore e forma:SolidPeso molecolare:306.7Roxadustat
CAS:<p>Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.</p>Formula:C19H16N2O5Purezza:99% - 99.88%Colore e forma:SolidPeso molecolare:352.34SYP-5
CAS:<p>SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.</p>Formula:C18H16O3SPurezza:98.31%Colore e forma:SolidPeso molecolare:312.38Albendazole
CAS:<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>Formula:C12H15N3O2SPurezza:98.21% - 98.76%Colore e forma:Colorless Crystals SolidPeso molecolare:265.33HIF-2α-IN-2
CAS:<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>Formula:C17H13F2NO4SPurezza:99.24%Colore e forma:SolidPeso molecolare:365.35Enarodustat
CAS:<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>Formula:C17H16N4O4Purezza:99.73% - 99.75%Colore e forma:SolidPeso molecolare:340.33ISM012-042
<p>ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.</p>Formula:C26H28N6O4Colore e forma:SolidPeso molecolare:488.538HIF-1α-IN-6
<p>HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.</p>Purezza:98%Colore e forma:Odour SolidHIV-IN-7
<p>Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.</p>Formula:C32H61N3O10P2Purezza:98%Colore e forma:SolidPeso molecolare:709.79Axl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Formula:C14H19ClO8Purezza:98%Colore e forma:SolidPeso molecolare:350.75(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:<p>(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.</p>Formula:C41H46N6O6SColore e forma:SolidPeso molecolare:750.91HIF-1 α (556-574)
CAS:<p>HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.</p>Formula:C101H150D2N20O34S2Purezza:98%Colore e forma:SolidPeso molecolare:2254.6ML228
CAS:<p>ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.</p>Formula:C27H21N5Purezza:99.54%Colore e forma:SolidPeso molecolare:415.497-Hydroxyneolamellarin A
CAS:<p>7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.</p>Formula:C24H19NO5Colore e forma:SolidPeso molecolare:401.41HIF-1α-IN-2 hydrochloride
<p>HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in</p>Formula:C21H20ClN3OSPurezza:98%Colore e forma:SolidPeso molecolare:397.92Adaptaquin
CAS:<p>Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].</p>Formula:C21H16ClN3O2Purezza:99.75%Colore e forma:SolidPeso molecolare:377.82HIF-1 inhibitor-4
CAS:<p>HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.</p>Formula:C18H19IN2O2Purezza:99.26%Colore e forma:SolidPeso molecolare:422.26VHL-IN-1
<p>VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and</p>Formula:C28H37FN4O4SPurezza:98%Colore e forma:SolidPeso molecolare:544.68Daprodustat
CAS:<p>Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.</p>Formula:C19H27N3O6Purezza:97% - 99.82%Colore e forma:SolidPeso molecolare:393.43NF-κB/HIF-1α-IN-1
<p>NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.</p>Formula:C24H27N7O4Colore e forma:SolidPeso molecolare:477.21245HIF-1 inhibitor-5
<p>HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1</p>Formula:C28H35NO5Colore e forma:SolidPeso molecolare:465.58HSP90-IN-30
<p>HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.</p>Formula:C20H39B12N4O2Peso molecolare:499.41897HIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Colore e forma:Odour SolidIzilendustat
CAS:<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Formula:C22H28ClN3O4Purezza:99.95%Colore e forma:SolidPeso molecolare:433.93Sirtuin modulator 2
CAS:<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Formula:C19H15N3O2SPurezza:99.67%Colore e forma:SolidPeso molecolare:349.41TAT-cyclo-CLLFVY
CAS:<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Formula:C111H188N42O24S2Purezza:98%Colore e forma:SolidPeso molecolare:2559.1HIF1-IN-3
CAS:<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Formula:C26H24N2O3Purezza:99.59%Colore e forma:SolidPeso molecolare:412.48IOX2-NH2-Methyl
<p>IOX2-NH2-Methyl is a modified form of IOX2. IOX2 is a specific inhibitor of PHD2 (prolyl-hydroxylase-2), capable of upregulating HIF-1α expression and suppressing ROS production. IOX2-NH2-Methyl is employed in investigations of platelet and thrombus formation.</p>Formula:C20H19N3O5Purezza:97.64% - 99.31%Colore e forma:SolidPeso molecolare:381.39Zifcasiran
CAS:<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Formula:C737H972F20N211O349P43S8Colore e forma:SolidPeso molecolare:20339.13Mersalyl
CAS:<p>Mersalyl is an organic mercurial diuretic.</p>Formula:C13H16HgNNaO6Colore e forma:SolidPeso molecolare:505.854Fibrostatin C
CAS:<p>Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.</p>Formula:C18H19NO8SColore e forma:SolidPeso molecolare:409.411,4-DPCA
CAS:<p>1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting</p>Formula:C13H8N2O3Purezza:97.77%Colore e forma:SolidPeso molecolare:240.21ZG-2305
<p>ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.</p>Formula:C17H11Cl2N3O5Colore e forma:SolidPeso molecolare:408.19ZG-2033
CAS:<p>ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.</p>Formula:C15H14N2O2SColore e forma:SolidPeso molecolare:286.351,4-DPCA ethyl ester
CAS:<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>Formula:C15H12N2O3Purezza:99.54%Colore e forma:SolidPeso molecolare:268.27
