PPAR
I recettori attivati dai proliferatori dei perossisomi (PPARs) sono un gruppo di proteine recettori nucleari che funzionano come fattori di trascrizione regolando l'espressione di geni coinvolti nel metabolismo, in particolare lo stoccaggio degli acidi grassi e il metabolismo del glucosio. Gli inibitori dei PPARs sono strumenti importanti per lo studio dei disturbi metabolici come il diabete, l'obesità e le malattie cardiovascolari. Questi inibitori possono modulare il metabolismo dei lipidi, la sensibilità all'insulina e l'infiammazione, rendendoli preziosi nella ricerca terapeutica. Presso CymitQuimica, offriamo una gamma di inibitori dei PPARs per supportare la tua ricerca in malattie metaboliche, endocrinologia e sviluppo di farmaci.
Trovati 164 prodotti di "PPAR"
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Mifobate
CAS:Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。Formula:C11H17ClO7P2Purezza:99.12%Colore e forma:SolidPeso molecolare:358.65Fenofibrate
CAS:<p>Fenofibrate (Lipanthyl) is a PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms. Fenofibrate exhibits antihyperlipidemic activity. Cost-effective and quality-assured.</p>Formula:C20H21ClO4Purezza:99.13% - 99.95%Colore e forma:Crystals From Isopropanol SolidPeso molecolare:360.83GED-0507-34 Levo
CAS:<p>GED-0507-34 Levo,(S)-3-(4-Aminophenyl)-2-methoxypropanoic acid,an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis.</p>Formula:C10H13NO3Purezza:98.19%Colore e forma:SolidPeso molecolare:195.22Clofibric acid
CAS:<p>Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.</p>Formula:C10H11ClO3Purezza:99.47% - 99.8%Colore e forma:Pale Yellow SolidPeso molecolare:214.65Muraglitazar
CAS:<p>Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.</p>Formula:C29H28N2O7Purezza:99.17%Colore e forma:SolidPeso molecolare:516.54Retinoic acid
CAS:<p>Retinoic acid (Tretinoin) binds to and activates RARs, thereby inducing changes in gene expression that lead to inhibition of tumorigenesis.</p>Formula:C20H28O2Purezza:97.21% - 99.6%Colore e forma:Yellow-Orange PowderPeso molecolare:300.44MA-0204
CAS:<p>MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human,</p>Formula:C25H27F3N2O4Purezza:97.8%Colore e forma:SolidPeso molecolare:476.49LY518674
CAS:<p>LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.</p>Formula:C23H27N3O4Purezza:98.87%Colore e forma:SolidPeso molecolare:409.48Gemfibrozil
CAS:<p>Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.</p>Formula:C15H22O3Purezza:99.53% - 99.88%Colore e forma:Crystals From Hexane SolidPeso molecolare:250.33Anandamide
CAS:<p>Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also</p>Formula:C22H37NO2Purezza:95.037% - 99.22%Colore e forma:Light Yellow OilPeso molecolare:347.53Daidzein
CAS:<p>Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein.</p>Formula:C15H10O4Purezza:98.08%Colore e forma:SolidPeso molecolare:254.24Magnolol
CAS:<p>Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.</p>Formula:C18H18O2Purezza:99.49%Colore e forma:A Bioactive Compound Found In The Bark Of The Houpu MagnoliaPeso molecolare:266.33Oleoylethanolamide
CAS:<p>Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.</p>Formula:C20H39NO2Purezza:99.98%Colore e forma:SolidPeso molecolare:325.53Pioglitazone hydrochloride
CAS:<p>Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic</p>Formula:C19H20N2O3S·HClPurezza:99.64% - >99.99%Colore e forma:White Crystals Or Crystalline PowderPeso molecolare:392.90Bezafibrate
CAS:<p>Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES.</p>Formula:C19H20ClNO4Purezza:99.56% - 99.82%Colore e forma:SolidPeso molecolare:361.82Cloxiquine
CAS:<p>Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.</p>Formula:C9H6ClNOPurezza:99.82% - 99.87%Colore e forma:Light Yellow CrystalsPeso molecolare:179.6GW7647
CAS:<p>GW 7647 is an effective and highly selective PPARα agonist. GW 7647 can reduce the production of nitric oxide in macrophages. Cost-effective and quality-assured.</p>Formula:C29H46N2O3SPurezza:99.3% - 99.34%Colore e forma:SolidPeso molecolare:502.75Fenofibric acid
CAS:<p>Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.</p>Formula:C17H15ClO4Purezza:99.36%Colore e forma:White Or Almost White Crystalline PowderPeso molecolare:318.75NTP42
CAS:<p>NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)</p>Formula:C25H23F2N3O5SPurezza:97.55%Colore e forma:SolidPeso molecolare:515.53NSC-87877
CAS:<p>NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.</p>Formula:C19H13N3O7S2Purezza:97.35%Colore e forma:SolidPeso molecolare:459.45Pioglitazone
CAS:<p>Pioglitazone (U 72107) is a selective and oral PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively . High-Quality, Low-Cost!</p>Formula:C19H20N2O3SPurezza:95% - 99.57%Colore e forma:White PowderPeso molecolare:356.445-Aminosalicylic Acid
CAS:<p>5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!</p>Formula:C7H7NO3Purezza:98.88% - 99.49%Colore e forma:Purplish-Tan Solid PowderPeso molecolare:153.14Rosiglitazone maleate
CAS:<p>Rosiglitazone maleate (BRL 49653) is an oral antidiabetic and potential anticancer agent.</p>Formula:C22H23N3O7SPurezza:99.33% - 99.51%Colore e forma:Off-White SolidPeso molecolare:473.50β-Amyrone
CAS:<p>beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM.</p>Formula:C30H48OPurezza:99.55%Colore e forma:SolidPeso molecolare:424.7Candesartan
CAS:<p>Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.</p>Formula:C24H20N6O3Purezza:98.3% - 99.55%Colore e forma:Colorless Solid CrystallinePeso molecolare:440.47MK-0533
CAS:<p>MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.</p>Formula:C28H24F3NO6Purezza:99.03%Colore e forma:SoildPeso molecolare:527.49Arhalofenate
CAS:<p>Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.</p>Formula:C19H17ClF3NO4Purezza:98.97%Colore e forma:SolidPeso molecolare:415.79EHP-101
CAS:<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Formula:C28H35NO3Purezza:98.36%Colore e forma:SolidPeso molecolare:433.58Sulotroban potassium
<p>Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.</p>Formula:C16H16KNO5SPurezza:98.02%Colore e forma:SoildPeso molecolare:373.46Mavodelpar free acid hydrochloride
<p>Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.</p>Formula:C31H31ClFNO5Purezza:98.13%Colore e forma:SoildPeso molecolare:552.03Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
CAS:<p>Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM.</p>Formula:C24H23NO5SPurezza:99.59%Colore e forma:SoildPeso molecolare:437.51GW590735
CAS:<p>GW590735: PPARα agonist, EC50=4 nM, >500x selective over PPARδ/γ, for dyslipidemia research.</p>Formula:C23H21F3N2O4SPurezza:99.53%Colore e forma:SolidPeso molecolare:478.48PPARγ agonist 16
CAS:<p>PPARγ agonist16 (Compound 4G) is a PPARγ agonist that competitively binds to the ligand-binding domain (LBD) of PPARγ with an IC50 of 1790 nM. It reduces ear swelling in mouse models and exhibits antihyperglycemic activity in mice with Streptozotocin-induced diabetes.</p>Formula:C19H14BrNO4SColore e forma:SolidPeso molecolare:432.29Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidWAY-620472
CAS:<p>WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.</p>Formula:C23H21N5OSPurezza:98.07%Colore e forma:SolidPeso molecolare:415.51PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Colore e forma:Odour SolidGQ-16
CAS:<p>GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.</p>Formula:C19H16BrNO3SPurezza:99.84%Colore e forma:SolidPeso molecolare:418.3PPARγ agonist 15
<p>PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.</p>Formula:C21H16N4O3S2Colore e forma:SolidPeso molecolare:436.51MCC-555
CAS:<p>MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.</p>Formula:C21H16FNO3SPurezza:99.07% - 99.82%Colore e forma:SolidPeso molecolare:381.42PPARγ-IN-3
<p>PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.</p>Formula:C23H28FN7O3Colore e forma:SolidPeso molecolare:469.51Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Formula:C21H22N2O6Colore e forma:SolidPeso molecolare:398.409CUDA
CAS:<p>CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.</p>Formula:C19H36N2O3Purezza:97.585%Colore e forma:SolidPeso molecolare:340.5CC618
CAS:<p>CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.</p>Formula:C20H15F6N3O3S2Purezza:99.94%Colore e forma:SolidPeso molecolare:523.47AZD-9574
CAS:<p>AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs.</p>Formula:C21H22F2N6O2Purezza:98.46% - 99.39%Colore e forma:SolidPeso molecolare:428.44Sulotroban
CAS:<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Formula:C16H17NO5SPurezza:98.86% - 99.88%Colore e forma:SolidPeso molecolare:335.378-iso Prostaglandin F1β
CAS:<p>8-iso Prostaglandin F1β,inducet vasoconstrictor effects in (PA), (PV) and (MA) through the activation of TXA2R, tyrosine kinase and Rho kinase.</p>Formula:C20H36O5Colore e forma:SolidPeso molecolare:356.5Anti-osteoporosis agent-10
<p>Anti-osteoporosis agent-10 is an inhibitor of osteoporosis that suppresses the formation of osteoclasts with an IC50 of 0.042 μM. It also exhibits antagonistic activity towards PPARγ, with an EC50 value of 0.75 μM.</p>Colore e forma:Odour SolidLipid Metabolism Compound Library
<p>A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).</p>Colore e forma:Odour Solid8-iso Prostaglandin F1α
CAS:<p>8-iso Prostaglandin F1α induces vasoconstrictor effects in (PA),(PV) and (MA) through activation of TXA2R, tyrosine kinases and Rho kinases.</p>Formula:C20H36O5Colore e forma:SolidPeso molecolare:356.5E0924G
CAS:<p>E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.</p>Formula:C12H12N2O3Colore e forma:SolidPeso molecolare:232.24
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