Proteasi/Proteasoma
Gli inibitori delle proteasi e del proteasoma sono composti che bloccano l'attività delle proteasi e del proteasoma, che sono coinvolti nella degradazione e nel turnover delle proteine. Questi inibitori sono fondamentali per studiare la regolazione dell'omeostasi proteica, il controllo del ciclo cellulare e l'apoptosi. Gli inibitori delle proteasi e del proteasoma vengono anche utilizzati nel trattamento di malattie come il cancro, dove la degradazione anomala delle proteine svolge un ruolo nella progressione della malattia. Inibendo le proteasi o il proteasoma, questi composti possono indurre la morte cellulare nelle cellule tumorali e sono strumenti critici sia per la ricerca di base che per lo sviluppo terapeutico. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle proteasi e del proteasoma di alta qualità per supportare la tua ricerca in biochimica, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Proteasi/Proteasoma"
- Acetil-CoA carbossilasi(36 prodotti)
- Cisteina proteasi(110 prodotti)
- DPP-4(20 prodotti)
- Glutaminasi(45 prodotti)
- Proteasi HIV(506 prodotti)
- PAI-1(26 prodotti)
- Inibitori della proteasi(50 prodotti)
- Ricettore attivato dalla proteasi(54 prodotti)
- Proteasoma(95 prodotti)
- Proteasi serina(55 prodotti)
- p97(15 prodotti)
Mostrare 3 più sottocategorie
Trovati 1095 prodotti di "Proteasi/Proteasoma"
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Tyrosinase-IN-3
CAS:Tyrosinase-IN-3 inhibits melanin production; potential for skin whitening and food preservation.Formula:C21H23NO5Colore e forma:SolidPeso molecolare:369.41Anticancer agent 82
CAS:Anticancer agent 82, a FiVe1 derivative, selectively targets VIM in cancer cells to disrupt mitosis, with improved oral bioavailability.Formula:C19H18Cl2N4OColore e forma:SolidPeso molecolare:389.28Tyrosinase-IN-6
CAS:Tyrosinase-IN-6 (4B) is a potent tyrosinase inhibitor (IC50=3.80 μM) with good antioxidant activity.Formula:C24H31N3O2Colore e forma:SolidPeso molecolare:393.52Alicapistat
CAS:Alicapistat (ABT-957) is a human calpains 1 and 2 inhibitor. It can potentially be used to treat Alzheimer's disease (AD).Formula:C25H27N3O4Purezza:98%Colore e forma:SolidPeso molecolare:433.5VEL-0230
CAS:VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.Formula:C14H24NNaO5Colore e forma:SolidPeso molecolare:309.33PK44 phosphate
CAS:PK44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 15.8 nM).Formula:C17H19F5N7O5PColore e forma:SolidPeso molecolare:527.349BAY8040
CAS:BAY8040 is a potent selective human neutrophilic elastase inhibitor with excellent potency and selectivity with promising pharmacokinetic characteristics.Formula:C21H16F3N5O2Colore e forma:SolidPeso molecolare:427.38AA10 TG2 inhibitor
CAS:AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).Formula:C32H36N4O5Colore e forma:SolidPeso molecolare:556.65DPP-4-IN-1
CAS:DPP-4-IN-1 inhibits DPP-4 with 49 nM IC50, ideal for diabetes study, akin to Alogliptin.Formula:C19H19ClN6Colore e forma:SolidPeso molecolare:366.85CAY10704
CAS:CAY10704: Potent HCV inhibitor, EC50=17 nM, low cytotoxicity, good in mice, liver-targeted, not hepatotoxic, weak against dengue.Formula:C18H20Cl2N2Colore e forma:SolidPeso molecolare:335.27ASPER-29
CAS:ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.Formula:C31H29BrN2O5SColore e forma:SolidPeso molecolare:621.54Elasnin
CAS:Elasnin is a reversible inhibitor of elastase for human granulocyte and pancreatic enzymes with IC50 values of 1.3 and 30 µg/ml, respectively.Formula:C24H40O4Colore e forma:SolidPeso molecolare:392.57Tyrosinase-IN-5
CAS:Tyrosinase-IN-5 (16c) inhibits tyrosinase with 0.02 μM IC50, reduces melanogenesis, and is low-toxicity.Formula:C18H13N3O6Colore e forma:SolidPeso molecolare:367.31BRD-8899
CAS:BRD-8899 is a STK33 inhibitor, with an IC 50 of 11 nM [1].Formula:C17H22N4O3SColore e forma:SolidPeso molecolare:362.45HCV-IN-36
CAS:HCV-IN-36: oral HCV inhibitor, EC50 0.016 μM, CC50 8.78 μM, potent antiviral.Formula:C30H36ClN5Colore e forma:SolidPeso molecolare:502.09GLS1 Inhibitor-3
CAS:GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.Formula:C30H32N10O2SColore e forma:SolidPeso molecolare:596.71MMP-2/9-IN-1
CAS:MMP-2/9-IN-1 (Compound 4a) is a potent dual inhibitor of MMP-2 (IC50: 56 nM) and MMP-9 (IC50: 38 nM). leading to DNA fragmentation.Formula:C14H16IN7SColore e forma:SolidPeso molecolare:441.29(R)-ND-336
CAS:(R)-ND-336: potent, selective MMP-9 inhibitor (K i = 19 nM); inhibits MMP-2 (127 nM), MMP-14 (119 nM); studied for diabetic foot ulcers.Formula:C16H18ClNO3S2Colore e forma:SolidPeso molecolare:371.89L-873724
CAS:L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.Formula:C23H26F3N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:481.53JO146
CAS:JO146为针对沙眼衣原体高温需要蛋白A(CtHtrA)的蛋白酶抑制剂，其对CtHtrA和人中性粒细胞弹性蛋白酶(HNE)的IC50值分别为21.86 μM和1.15 μM，可应用于细菌感染的抑制。Formula:C31H44N3O7PColore e forma:SolidPeso molecolare:601.67Immunoproteasome inhibitor 1
CAS:Potent, reversible immunoproteasome inhibitor; Ki: β5c 1.18 μM, β1i 0.27 μM, β5i 1.91 μM; potential in treating cancer.Formula:C20H26N2O4Colore e forma:SolidPeso molecolare:358.43CAA0225
CAS:CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.Formula:C28H29N3O5Colore e forma:SolidPeso molecolare:487.55MDL 27399
CAS:MDL 27399 suppresses human neutrophil cathepsin G.Formula:C26H36N4O8Colore e forma:SolidPeso molecolare:532.59AM 4299 B
CAS:AM 4299 B is a novel inhibitor of a thiol protease.Formula:C16H27N3O7Purezza:98%Colore e forma:SolidPeso molecolare:373.4Calpain Inhibitor XI
CAS:Calpain Inhibitor XI, a reversible covalent inhibitor of calpain-1, is utilized in the research of neurodegenerative disorders.Formula:C26H40N4O6Colore e forma:SolidPeso molecolare:504.62HCV-IN-35
CAS:HCV-IN-35 is a potent inhibitor of HCV and shows potential for infectious disease research.Formula:C30H36ClN5Colore e forma:SolidPeso molecolare:502.09Calpain-2-IN-1
CAS:Calpain-2-IN-1 is a selective calpain-2 inhibitor with Ki values of 181 nM for calpain-1 and 7.8 nM for calpain-2, applicable for neurodegenerative diseases a.Formula:C28H37N3O7Colore e forma:SolidPeso molecolare:527.61Tyrosinase-IN-10
CAS:Tyrosinase-IN-10 serves as a partially competitive inhibitor of tyrosinase, demonstrating an inhibition concentration (IC50) value of 1.6 μM against the enzyme'Formula:C16H12O4Colore e forma:SolidPeso molecolare:268.26TAPI-0
CAS:TAPI-0 is a matrix metalloprotease (MMP) and TACE inhibitor.Formula:C24H32N4O5Colore e forma:SolidPeso molecolare:456.53NAAA-IN-2
CAS:<p>NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.</p>Formula:C11H13N3O2SColore e forma:SolidPeso molecolare:251.3MMP-1-IN-1
MMP-1-IN-1 is a highly potent MMP-1 inhibitor with an IC 50 of 0.034 μM .Formula:C14H17ClN2O3Colore e forma:SolidPeso molecolare:296.75(3S,4S)-A2-32-01
(3S,4S)-A2-32-01, a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor .Formula:C19H27NO2Colore e forma:SolidPeso molecolare:301.42Azo-Resveratrol
CAS:Azo-Resveratrol is an analog of Resveratrol used as a potent tyrosinase inhibitor.Formula:C12H10N2O3Colore e forma:SolidPeso molecolare:230.22HCV-IN-34
CAS:HCV-IN-35, an oral HCV blocker, has an EC50 of 0.010 μM and a CC50 of 7.5 μM, indicating strong antiviral effects.Formula:C31H36ClN5Colore e forma:SolidPeso molecolare:514.1Tyrosinase-IN-7
CAS:Tyrosinase-IN-7 is a small-molecule tyrosinase inhibitor (IC50 1.57 μM) that suppresses melanin activity and cell growth with low cytotoxicity.Formula:C15H10O5Purezza:99%Colore e forma:SolidPeso molecolare:270.24BC-05
CAS:BC-05, an orally active inhibitor targeting CD13 and the proteasome, displays potent inhibition with IC50 values of 0.13 μM against human CD13 and 1.39 μM forFormula:C21H29BN2O9Purezza:98%Colore e forma:SolidPeso molecolare:464.27RID-F
CAS:RID-F is an inhibitor of the nonpeptidic proteasome.Formula:C38H50N2O2Purezza:98%Colore e forma:SolidPeso molecolare:566.82AL-9
CAS:AL-9 is a GT-1b and GT-2a replication inhibitor.Formula:C23H22N4O3Purezza:98%Colore e forma:SolidPeso molecolare:402.45PMPA sodium
CAS:PMPA sodium is a potent and selective glutamate carboxypeptidase 2 (GCP II/N-acetylated a-linked dipeptidase/NAALADase) inhibitor.Formula:C6H11Na4O7PPurezza:98%Colore e forma:SolidPeso molecolare:318.08Tyrosinase-IN-11
CAS:Tyrosinase-IN-11: potent inhibitor, IC50 - 50nM/64nM (L-tyrosinase/L-dopa), antioxidant, low toxicity, for hyperpigmentation study.Formula:C15H14O5Colore e forma:SolidPeso molecolare:274.27Kallikrein 5-IN-2
CAS:Kallikrein 5-IN-2 inhibits KLK5 (pIC50=7.1); may normalize skin shedding, lessen inflammation & itching.Formula:C23H22N6OColore e forma:SolidPeso molecolare:398.46VA4 TG2 inhibitor
CAS:VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.Formula:C33H41N5O6SColore e forma:SolidPeso molecolare:635.77AZD5248
CAS:AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1).Formula:C22H22N4O2Colore e forma:SolidPeso molecolare:374.44BMS-363131
CAS:BMS-363131 (BMS363131) is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.Formula:C28H40N6O5Purezza:97.99%Colore e forma:SolidPeso molecolare:540.65α-Glucosidase-IN-5
CAS:α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.Formula:C15H13NO3Colore e forma:SolidPeso molecolare:255.27SAP2-IN-1
CAS:SAP2-IN-1 inhibits secreted aspartate protease 2 (IC50: 0.92 μM), doesn't work in vitro, and helps research infections.Formula:C34H29NO7Colore e forma:SolidPeso molecolare:563.6Glutaminase-IN-4
CAS:Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor (IC50: 2.3 μM).Formula:C23H22N6O2S2Colore e forma:SolidPeso molecolare:478.59L 658758
CAS:L 658758 is an inhibitor of serine proteinase.Formula:C16H20N2O9SColore e forma:SolidPeso molecolare:416.4AGLME
CAS:AGLME is used in a direct enzymatic assay for activated Hageman factor measuring the ability of Hageman factor to hydrolyze the cpd.Formula:C11H21N3O4Colore e forma:SolidPeso molecolare:259.3BI-L 45XX
CAS:BI-L 45XX, an anti-inflammatory benzimidazole derivative, has inhibitory effects on neutrophil function.Formula:C10H9F3N2O2SColore e forma:SolidPeso molecolare:278.25
